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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:norathyriol
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Accession:CHEBI:7622 term browser browse the term
Definition:A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3, 6 and 7. Isolated from Garcinia mangostana and Maclura pomifera, it exhibits inhibitory activity against protein kinase C.
Synonyms:exact_synonym: 1,3,6,7-tetrahydroxy-9H-xanthen-9-one
 related_synonym: 1,3,6,7-Tetrahydroxyxanthone;   Formula=C13H8O6;   InChI=1S/C13H8O6/c14-5-1-9(17)12-11(2-5)19-10-4-8(16)7(15)3-6(10)13(12)18/h1-4,14-17H;   InChIKey=ZHTQCPCDXKMMLU-UHFFFAOYSA-N;   SMILES=Oc1cc(O)c2c(c1)oc1cc(O)c(O)cc1c2=O
 alt_id: CHEBI:66635
 xref: CAS:3542-72-1;   KEGG:C10086;   KNApSAcK:C00002968
 xref_mesh: MESH:C069053
 xref: PMID:13995190;   PMID:15256712;   PMID:20513373;   PMID:22084399;   PMID:23361275;   PMID:7511107;   PMID:9384257;   Patent:CN102657640;   Reaxys:270886



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norathyriol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO norathyriol results in increased expression of ABCB1 protein CTD PMID:20513373 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects binding
decreases activity
ISO norathyriol binds to MAPK1 protein
norathyriol results in decreased activity of MAPK1 protein
CTD PMID:22084399 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases activity ISO norathyriol results in decreased activity of MAPK3 protein CTD PMID:22084399 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO norathyriol inhibits the reaction [GW 7647 results in increased activity of PPARA protein] CTD PMID:18393431 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO norathyriol inhibits the reaction [(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid results in increased activity of PPARD protein] CTD PMID:18393431 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO norathyriol inhibits the reaction [ciglitazone results in increased activity of PPARG protein] CTD PMID:18393431 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link

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  CHEBI ontology 19860
    role 19832
      application 19675
        pharmaceutical 19517
          drug 19517
            antineoplastic agent 17813
              norathyriol 6
                tripteroside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19860
    subatomic particle 19858
      composite particle 19858
        hadron 19858
          baryon 19858
            nucleon 19858
              atomic nucleus 19858
                atom 19858
                  main group element atom 19804
                    p-block element atom 19804
                      carbon group element atom 19745
                        carbon atom 19741
                          organic molecular entity 19741
                            organic molecule 19692
                              organic cyclic compound 19503
                                organic heterocyclic compound 18875
                                  oxacycle 17892
                                    dibenzopyran 280
                                      xanthenes 274
                                        xanthones 210
                                          norathyriol 6
                                            tripteroside 0
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