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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:norathyriol
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Accession:CHEBI:7622 term browser browse the term
Definition:A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3, 6 and 7. Isolated from Garcinia mangostana and Maclura pomifera, it exhibits inhibitory activity against protein kinase C.
Synonyms:exact_synonym: 1,3,6,7-tetrahydroxy-9H-xanthen-9-one
 related_synonym: 1,3,6,7-Tetrahydroxyxanthone;   Formula=C13H8O6;   InChI=1S/C13H8O6/c14-5-1-9(17)12-11(2-5)19-10-4-8(16)7(15)3-6(10)13(12)18/h1-4,14-17H;   InChIKey=ZHTQCPCDXKMMLU-UHFFFAOYSA-N;   SMILES=Oc1cc(O)c2c(c1)oc1cc(O)c(O)cc1c2=O
 alt_id: CHEBI:66635
 xref: CAS:3542-72-1;   KEGG:C10086;   KNApSAcK:C00002968
 xref_mesh: MESH:C069053
 xref: PMID:13995190;   PMID:15256712;   PMID:20513373;   PMID:22084399;   PMID:23361275;   PMID:7511107;   PMID:9384257;   Patent:CN102657640;   Reaxys:270886


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norathyriol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO norathyriol results in increased expression of ABCB1 protein CTD PMID:20513373 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects binding
decreases activity		 ISO norathyriol binds to MAPK1 protein
norathyriol results in decreased activity of MAPK1 protein		 CTD PMID:22084399 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases activity ISO norathyriol results in decreased activity of MAPK3 protein CTD PMID:22084399 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO norathyriol inhibits the reaction [GW 7647 results in increased activity of PPARA protein] CTD PMID:18393431 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO norathyriol inhibits the reaction [(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid results in increased activity of PPARD protein] CTD PMID:18393431 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO norathyriol inhibits the reaction [ciglitazone results in increased activity of PPARG protein] CTD PMID:18393431 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19896
      application 19732
        pharmaceutical 19559
          drug 19559
            antineoplastic agent 17702
              norathyriol 6
                tripteroside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19867
                    p-block element atom 19867
                      carbon group element atom 19812
                        carbon atom 19807
                          organic molecular entity 19807
                            organic group 18971
                              organic divalent group 18952
                                organodiyl group 18952
                                  carbonyl group 18905
                                    carbonyl compound 18905
                                      ketone 17193
                                        cyclic ketone 15708
                                          xanthones 184
                                            norathyriol 6
                                              tripteroside 0
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