CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: norathyriol
Accession: CHEBI:7622
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Definition: A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3, 6 and 7. Isolated from Garcinia mangostana and Maclura pomifera, it exhibits inhibitory activity against protein kinase C.
Synonyms: exact_synonym: 1,3,6,7-tetrahydroxy-9H-xanthen-9-one
related_synonym: 1,3,6,7-Tetrahydroxyxanthone; Formula=C13H8O6; InChI=1S/C13H8O6/c14-5-1-9(17)12-11(2-5)19-10-4-8(16)7(15)3-6(10)13(12)18/h1-4,14-17H; InChIKey=ZHTQCPCDXKMMLU-UHFFFAOYSA-N; SMILES=Oc1cc(O)c2c(c1)oc1cc(O)c(O)cc1c2=O
alt_id: CHEBI:66635
xref: CAS:3542-72-1; KEGG:C10086; KNApSAcK:C00002968
xref_mesh: MESH:C069053
xref: PMID:13995190; PMID:15256712; PMID:20513373; PMID:22084399; PMID:23361275; PMID:7511107; PMID:9384257; Patent:CN102657640; Reaxys:270886
G
Abcb1a
ATP binding cassette subfamily B member 1A
increases expression
ISO
norathyriol results in increased expression of ABCB1 protein
CTD
PMID:20513373
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Mapk1
mitogen activated protein kinase 1
affects binding decreases activity
ISO
norathyriol binds to MAPK1 protein norathyriol results in decreased activity of MAPK1 protein
CTD
PMID:22084399
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
decreases activity
ISO
norathyriol results in decreased activity of MAPK3 protein
CTD
PMID:22084399
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Ppara
peroxisome proliferator activated receptor alpha
multiple interactions
ISO
norathyriol inhibits the reaction [GW 7647 results in increased activity of PPARA protein]
CTD
PMID:18393431
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Ppard
peroxisome proliferator-activated receptor delta
multiple interactions
ISO
norathyriol inhibits the reaction [GW0742 results in increased activity of PPARD protein]
CTD
PMID:18393431
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
norathyriol inhibits the reaction [ciglitazone results in increased activity of PPARG protein]
CTD
PMID:18393431
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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