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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sodium sulfide (anhydrous)
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Accession:CHEBI:76208 term browser browse the term
Definition:A sulfide salt with formula Na2S. The pentahydrate and (particularly) the nonahydrate are also known. In gel form, sodium sulfide is used to soften toenails to assist in trimming (and so relive pain) of ingrowing toenails.
Synonyms:related_synonym: Formula=Na2S;   InChI=1S/2Na.S/q2*+1;-2;   InChIKey=GRVFOGOEDUUMBP-UHFFFAOYSA-N;   Na2S;   SMILES=[Na+].[Na+].[S--];   anh. sodium sulfide;   disodium monosulfide;   disodium sulfide;   sodium monosulfide;   sodium sulfuret;   sodium sulphide
 alt_id: CHEBI:76183
 xref: CAS:1313-82-2
 xref_mesh: MESH:C033479
 xref: PMID:12793804;   PMID:14848282;   PMID:19810706;   Reaxys:11323291;   Wikipedia:Sodium_sulfide



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sodium sulfide (anhydrous) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cldn11 claudin 11 multiple interactions ISO [Hydrogen Sulfide results in increased abundance of sodium sulfide] which results in decreased expression of CLDN11 protein; Fatty Acids, Omega-3 inhibits the reaction [[Hydrogen Sulfide results in increased abundance of sodium sulfide] which results in decreased expression of CLDN11 protein] CTD PMID:33068716 NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050
JBrowse link
G Cldn5 claudin 5 multiple interactions ISO [Hydrogen Sulfide results in increased abundance of sodium sulfide] which results in decreased expression of CLDN5 mRNA; [Hydrogen Sulfide results in increased abundance of sodium sulfide] which results in decreased expression of CLDN5 protein CTD PMID:33068716 NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [Hydrogen Sulfide results in increased abundance of sodium sulfide] which results in decreased expression of CTNNB1 mRNA; Fatty Acids, Omega-3 inhibits the reaction [[Hydrogen Sulfide results in increased abundance of sodium sulfide] which results in decreased expression of CTNNB1 mRNA] CTD PMID:33068716 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO [Hydrogen Sulfide results in increased abundance of sodium sulfide] which results in decreased expression of GJA1 mRNA; Fatty Acids, Omega-3 inhibits the reaction [[Hydrogen Sulfide results in increased abundance of sodium sulfide] which results in decreased expression of GJA1 mRNA] CTD PMID:33068716 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions EXP [[sodium sulfide results in increased abundance of Hydrogen Sulfide] which co-treated with Paraquat] results in decreased expression of IDH2 protein; [sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in decreased expression of and results in decreased activity of IDH2 protein] CTD PMID:32064027 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Il6 interleukin 6 multiple interactions EXP sodium sulfide inhibits the reaction [cobaltous chloride results in increased secretion of IL6 protein] CTD PMID:23624824 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP NFE2L2 protein affects the reaction [[sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in decreased expression of SIRT3 protein]] CTD PMID:32064027 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ocln occludin multiple interactions ISO [Hydrogen Sulfide results in increased abundance of sodium sulfide] which results in decreased expression of OCLN protein; Fatty Acids, Omega-3 inhibits the reaction [[Hydrogen Sulfide results in increased abundance of sodium sulfide] which results in decreased expression of OCLN protein] CTD PMID:33068716 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Sirt3 sirtuin 3 multiple interactions EXP [sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in decreased expression of SIRT3 protein]; NFE2L2 protein affects the reaction [[sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in decreased expression of SIRT3 protein]] CTD PMID:32064027 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
JBrowse link
G Sod1 superoxide dismutase 1 increases metabolic processing ISO sodium sulfide results in increased metabolism of SOD1 protein CTD PMID:15096637 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Hydrogen Sulfide results in increased abundance of sodium sulfide] which results in decreased expression of TJP1 protein]; [Hydrogen Sulfide results in increased abundance of sodium sulfide] which results in decreased expression of TJP1 mRNA; [Hydrogen Sulfide results in increased abundance of sodium sulfide] which results in decreased expression of TJP1 protein; Fatty Acids, Omega-3 inhibits the reaction [[Hydrogen Sulfide results in increased abundance of sodium sulfide] which results in decreased expression of TJP1 mRNA]; Fatty Acids, Omega-3 inhibits the reaction [[Hydrogen Sulfide results in increased abundance of sodium sulfide] which results in decreased expression of TJP1 protein] CTD PMID:33068716 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Vcl vinculin multiple interactions ISO [Hydrogen Sulfide results in increased abundance of sodium sulfide] which results in decreased expression of VCL mRNA; Fatty Acids, Omega-3 inhibits the reaction [[Hydrogen Sulfide results in increased abundance of sodium sulfide] which results in decreased expression of VCL mRNA] CTD PMID:33068716 NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20039
    chemical entity 20038
      molecular entity 20036
        inorganic molecular entity 19745
          inorganic salt 12437
            inorganic sodium salt 9304
              sodium sulfide (anhydrous) 12
                sodium sulfide nonahydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20039
    subatomic particle 20037
      composite particle 20037
        hadron 20037
          baryon 20037
            nucleon 20037
              atomic nucleus 20037
                atom 20037
                  main group element atom 19938
                    main group molecular entity 19938
                      s-block molecular entity 19726
                        alkali metal molecular entity 11549
                          sodium molecular entity 9686
                            elemental sodium 9686
                              sodium(1+) 9686
                                sodium salt 9686
                                  inorganic sodium salt 9304
                                    sodium sulfide (anhydrous) 12
                                      sodium sulfide nonahydrate 0
paths to the root