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ONTOLOGY REPORT - ANNOTATIONS


Term:loxoprofen
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Accession:CHEBI:76172 term browser browse the term
Definition:A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-oxocyclopentyl)methyl]phenyl group. A prodrug that is rapidly converted to its active trans-alcohol metabolite following oral administration.
Synonyms:exact_synonym: 2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid
 related_synonym: (+-)-((2-oxocyclopentyl)methyl)hydratropic acid;   Formula=C15H18O3;   InChI=1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8,10,13H,2-4,9H2,1H3,(H,17,18);   InChIKey=YMBXTVYHTMGZDW-UHFFFAOYSA-N;   SMILES=CC(C(O)=O)c1ccc(CC2CCCC2=O)cc1;   loxoprofene;   loxoprofeno;   loxoprofenum
 xref: CAS:68767-14-6 "ChemIDplus";   CAS:68767-14-6 "KEGG DRUG";   Drug_Central:1615 "DrugCentral";   HMDB:HMDB0041920;   KEGG:D08149;   LINCS:LSM-5054
 xref_mesh: MESH:C040656
 xref: Patent:EP1767218;   Patent:WO2008020270;   Reaxys:2860055 "Reaxys";   Wikipedia:Loxoprofen
 cyclic_relationship: is_conjugate_acid_of CHEBI:76199


show annotations for term's descendants       view all columns           Sort by:
 
loxoprofen term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6480464
G Muc2 mucin 2, oligomeric mucus/gel-forming JBrowse link 1 214,663,929 214,693,197 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      application 19225
        pro-agent 8768
          prodrug 8565
            loxoprofen 3
              (2S)-2-(4-\{[(1R,2S)-2-hydroxycyclopentyl]methyl\}phenyl)propanoic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic group 18338
                              organic divalent group 18329
                                organodiyl group 18329
                                  carbonyl group 18218
                                    carbonyl compound 18218
                                      carboxylic acid 17918
                                        monocarboxylic acid 17254
                                          fatty acid 15818
                                            saturated fatty acid 15785
                                              propionic acid 3642
                                                loxoprofen 3
                                                  (2S)-2-(4-\{[(1R,2S)-2-hydroxycyclopentyl]methyl\}phenyl)propanoic acid 0
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