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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:76162 term browser browse the term
Definition:A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causing severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein.
Synonyms:exact_synonym: 2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]propanoic acid
 related_synonym: 1-Oxo-2-(p-((alpha-methyl)carboxymethyl)phenyl)isoindoline;   2-(4-(1-Carboxyethyl)phenyl)-1-isoindolinone;   Formula=C17H15NO3;   InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21);   InChIKey=RJMIEHBSYVWVIN-UHFFFAOYSA-N;   K 4277;   SMILES=CC(C(O)=O)c1ccc(cc1)N1Cc2ccccc2C1=O;   alpha-(4-(1-Oxo-2-isoindolinyl)phenyl)propionic acid;   indoprofene;   indoprofeno;   indoprofenum
 xref: CAS:31842-01-0;   Drug_Central:1442;   KEGG:D04530;   LINCS:LSM-1564
 xref_mesh: MESH:D007216
 xref: PMID:1017174;   PMID:22282415;   PMID:22349325;   PMID:2519164;   PMID:2753348;   PMID:2775332;   PMID:369767;   PMID:378745;   PMID:392647;   PMID:47280;   PMID:550151;   PMID:6436749;   PMID:6578800;   PMID:7042369;   PMID:7341277;   PMID:7349186;   PMID:7428321;   Patent:NZ586198;   Patent:WO2008011083;   Reaxys:1543920;   Wikipedia:Indoprofen

show annotations for term's descendants           Sort by:
indoprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Indoprofen results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Indoprofen CTD PMID:15117964 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Indoprofen CTD PMID:15117964 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        anti-inflammatory agent 14948
          anti-inflammatory drug 13611
            non-steroidal anti-inflammatory drug 12694
              indoprofen 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            carbamoyl group 17132
                                              carboxamide 17132
                                                lactam 8026
                                                  gamma-lactam 6265
                                                    indoprofen 3
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