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Accession:CHEBI:76162 term browser browse the term
Definition:A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causing severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein.
Synonyms:exact_synonym: 2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]propanoic acid
 related_synonym: 1-Oxo-2-(p-((alpha-methyl)carboxymethyl)phenyl)isoindoline;   2-(4-(1-Carboxyethyl)phenyl)-1-isoindolinone;   Formula=C17H15NO3;   InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21);   InChIKey=RJMIEHBSYVWVIN-UHFFFAOYSA-N;   K 4277;   SMILES=CC(C(O)=O)c1ccc(cc1)N1Cc2ccccc2C1=O;   alpha-(4-(1-Oxo-2-isoindolinyl)phenyl)propionic acid;   indoprofene;   indoprofeno;   indoprofenum
 xref: CAS:31842-01-0 "ChemIDplus";   CAS:31842-01-0 "KEGG DRUG";   Drug_Central:1442 "DrugCentral";   KEGG:D04530;   LINCS:LSM-1564
 xref_mesh: MESH:D007216
 xref: PMID:1017174 "Europe PMC";   PMID:22282415 "Europe PMC";   PMID:22349325 "Europe PMC";   PMID:2519164 "Europe PMC";   PMID:2753348 "Europe PMC";   PMID:2775332 "Europe PMC";   PMID:369767 "Europe PMC";   PMID:378745 "Europe PMC";   PMID:392647 "Europe PMC";   PMID:47280 "Europe PMC";   PMID:550151 "Europe PMC";   PMID:6436749 "Europe PMC";   PMID:6578800 "Europe PMC";   PMID:7042369 "Europe PMC";   PMID:7341277 "Europe PMC";   PMID:7349186 "Europe PMC";   PMID:7428321 "Europe PMC";   Patent:NZ586198;   Patent:WO2008011083;   Reaxys:1543920 "Reaxys";   Wikipedia:Indoprofen

show annotations for term's descendants       view all columns           Sort by:
indoprofen term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 JBrowse link 9 95,285,592 95,302,822 RGD:6480464
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 JBrowse link 9 95,221,474 95,302,822 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        anti-inflammatory agent 14907
          anti-inflammatory drug 13590
            non-steroidal anti-inflammatory drug 12666
              indoprofen 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        carboacyl group 16943
                                          univalent carboacyl group 16943
                                            carbamoyl group 16622
                                              carboxamide 16622
                                                lactam 2855
                                                  gamma-lactam 346
                                                    indoprofen 3
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.