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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:76162 term browser browse the term
Definition:A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causing severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein.
Synonyms:exact_synonym: 2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]propanoic acid
 related_synonym: 1-Oxo-2-(p-((alpha-methyl)carboxymethyl)phenyl)isoindoline;   2-(4-(1-Carboxyethyl)phenyl)-1-isoindolinone;   Formula=C17H15NO3;   InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21);   InChIKey=RJMIEHBSYVWVIN-UHFFFAOYSA-N;   K 4277;   SMILES=CC(C(O)=O)c1ccc(cc1)N1Cc2ccccc2C1=O;   alpha-(4-(1-Oxo-2-isoindolinyl)phenyl)propionic acid;   indoprofene;   indoprofeno;   indoprofenum
 xref: CAS:31842-01-0;   Drug_Central:1442;   KEGG:D04530;   LINCS:LSM-1564
 xref_mesh: MESH:D007216
 xref: PMID:1017174;   PMID:22282415;   PMID:22349325;   PMID:2519164;   PMID:2753348;   PMID:2775332;   PMID:369767;   PMID:378745;   PMID:392647;   PMID:47280;   PMID:550151;   PMID:6436749;   PMID:6578800;   PMID:7042369;   PMID:7341277;   PMID:7349186;   PMID:7428321;   Patent:NZ586198;   Patent:WO2008011083;   Reaxys:1543920;   Wikipedia:Indoprofen

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indoprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Indoprofen results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Indoprofen CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Indoprofen CTD PMID:15117964 NCBI chr 9:88,727,094...88,808,465 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      application 19486
        anti-inflammatory agent 15835
          anti-inflammatory drug 13630
            non-steroidal anti-inflammatory drug 12717
              indoprofen 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      carboxylic acid 18376
                                        carboacyl group 17490
                                          univalent carboacyl group 17490
                                            carbamoyl group 17304
                                              carboxamide 17304
                                                lactam 8311
                                                  gamma-lactam 6592
                                                    indoprofen 3
paths to the root