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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:flunixin
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Accession:CHEBI:76138 term browser browse the term
Definition:A pyridinemonocarboxylic acid that is nicotinic acid substituted at position 2 by a 2-methyl-3-(trifluoromethyl)phenylamino group. A relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties; used in veterinary medicine (usually as the meglumine salt) for treatment of horses, cattle and pigs.
Synonyms:exact_synonym: 2-{[2-methyl-3-(trifluoromethyl)phenyl]amino}nicotinic acid
 related_synonym: 2-((2-methyl-3-(trifluoromethyl)phenyl)amino)-3-pyridinecarboxylic acid;   2-(alpha(3),alpha(3),alpha(3)-trifluoro-2,3-xylidino)nicotinic acid;   Formula=C14H11F3N2O2;   InChI=1S/C14H11F3N2O2/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12/h2-7H,1H3,(H,18,19)(H,20,21);   InChIKey=NOOCSNJCXJYGPE-UHFFFAOYSA-N;   SMILES=Cc1c(Nc2ncccc2C(O)=O)cccc1C(F)(F)F;   Sch 14714;   flunixine;   flunixino;   flunixinum
 xref: CAS:38677-85-9;   KEGG:D04215
 xref_mesh: MESH:C014557
 xref: PMID:26512724;   PMID:26695354;   PMID:27242945;   PMID:27731498;   PMID:27958751;   PMID:2816;   Patent:US2008014272;   Patent:US5637617;   Reaxys:492802;   VSDB:1802;   Wikipedia:Flunixin
 cyclic_relationship: is_conjugate_acid_of CHEBI:76153



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flunixin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity EXP flunixin results in decreased activity of PTGS1 protein CTD PMID:12967936 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      biological role 19711
        biochemical role 19429
          metabolite 19416
            nicotinic acid 259
              flunixin 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18798
                                    carbonyl compound 18798
                                      carboxylic acid 18518
                                        monocarboxylic acid 17852
                                          pyridinemonocarboxylic acid 407
                                            nicotinic acid 259
                                              flunixin 1
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