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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:flunixin
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Accession:CHEBI:76138 term browser browse the term
Definition:A pyridinemonocarboxylic acid that is nicotinic acid substituted at position 2 by a 2-methyl-3-(trifluoromethyl)phenylamino group. A relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties; used in veterinary medicine (usually as the meglumine salt) for treatment of horses, cattle and pigs.
Synonyms:exact_synonym: 2-{[2-methyl-3-(trifluoromethyl)phenyl]amino}nicotinic acid
 related_synonym: 2-((2-methyl-3-(trifluoromethyl)phenyl)amino)-3-pyridinecarboxylic acid;   2-(alpha(3),alpha(3),alpha(3)-trifluoro-2,3-xylidino)nicotinic acid;   Formula=C14H11F3N2O2;   InChI=1S/C14H11F3N2O2/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12/h2-7H,1H3,(H,18,19)(H,20,21);   InChIKey=NOOCSNJCXJYGPE-UHFFFAOYSA-N;   SMILES=Cc1c(Nc2ncccc2C(O)=O)cccc1C(F)(F)F;   Sch 14714;   flunixine;   flunixino;   flunixinum
 xref: CAS:38677-85-9;   KEGG:D04215
 xref_mesh: MESH:C014557
 xref: PMID:26512724;   PMID:26695354;   PMID:27242945;   PMID:27731498;   PMID:27958751;   PMID:2816;   Patent:US2008014272;   Patent:US5637617;   Reaxys:492802;   VSDB:1802;   Wikipedia:Flunixin
 cyclic_relationship: is_conjugate_acid_of CHEBI:76153



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flunixin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity EXP flunixin results in decreased activity of PTGS1 protein CTD PMID:12967936 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19848
    role 19824
      biological role 19822
        biochemical role 19533
          metabolite 19519
            nicotinic acid 271
              flunixin 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    p-block element atom 19796
                      carbon group element atom 19741
                        carbon atom 19737
                          organic molecular entity 19737
                            heteroorganic entity 19495
                              organochalcogen compound 19257
                                organooxygen compound 19175
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      monocarboxylic acid 18006
                                        pyridinemonocarboxylic acid 418
                                          nicotinic acid 271
                                            flunixin 1
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