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ONTOLOGY REPORT - ANNOTATIONS


Term:benoxaprofen
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Accession:CHEBI:76114 term browser browse the term
Definition:A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group. It was used as a non-steroidal anti-inflammatory drug until 1982 when it was withdrawn from the market due to adverse side-effects including liver necrosis, photosensitivity, and carcinogenicity in animals.
Synonyms:exact_synonym: 2-[2-(4-chlorophenyl)-1,3-benzoxazol-5-yl]propanoic acid
 related_synonym: (1)-2-(4-Chlorophenyl)benzoxazole-5-propionic acid;   2-(4-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid;   2-(p-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid;   DL-benoxaprofen;   Formula=C16H12ClNO3;   InChI=1S/C16H12ClNO3/c1-9(16(19)20)11-4-7-14-13(8-11)18-15(21-14)10-2-5-12(17)6-3-10/h2-9H,1H3,(H,19,20);   InChIKey=MITFXPHMIHQXPI-UHFFFAOYSA-N;   Lilly 90459;   SMILES=CC(C(O)=O)c1ccc2oc(nc2c1)-c1ccc(Cl)cc1;   benoxaprofene;   benoxaprofeno;   benoxaprofenum
 xref: CAS:51234-28-7 "ChemIDplus";   CAS:51234-28-7 "KEGG DRUG";   CAS:51234-28-7 "NIST Chemistry WebBook";   DrugBank:DB04812;   Drug_Central:311 "DrugCentral";   KEGG:D03080
 xref_mesh: MESH:C011677
 xref: PMID:19439485 "Europe PMC";   PMID:19773537 "Europe PMC";   PMID:21128314 "Europe PMC";   PMID:22514582 "Europe PMC";   PMID:23250699 "Europe PMC";   PMID:2413686 "Europe PMC";   PMID:2833969 "Europe PMC";   PMID:2947294 "Europe PMC";   PMID:3981515 "Europe PMC";   PMID:6407402 "Europe PMC";   PMID:6526401 "Europe PMC";   PMID:6645654 "Europe PMC";   PMID:6813936 "Europe PMC";   PMID:6993669 "Europe PMC";   PMID:6993670 "Europe PMC";   PMID:6993671 "Europe PMC";   PMID:6993672 "Europe PMC";   PMID:7044799 "Europe PMC";   PMID:7044801 "Europe PMC";   PMID:7084283 "Europe PMC";   PMID:7084287 "Europe PMC";   PMID:7221526 "Europe PMC";   Patent:DE2324443;   Patent:US3912748;   Patent:US4391814;   Patent:US6338855;   Patent:WO2008020270;   Reaxys:1085080 "Reaxys";   Wikipedia:Benoxaprofen


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benoxaprofen term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:6480464
G Alox12 arachidonate 12-lipoxygenase, 12S type JBrowse link 10 56,851,734 56,864,049 RGD:6480464
G Alox5 arachidonate 5-lipoxygenase JBrowse link 4 148,398,004 148,446,308 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 JBrowse link 5 134,492,734 134,507,158 RGD:6480464
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase JBrowse link 11 82,945,104 82,978,364 RGD:6480464
G Gusb glucuronidase, beta JBrowse link 12 30,202,066 30,215,583 RGD:6480464
G Lhb luteinizing hormone subunit beta JBrowse link 1 101,409,992 101,413,725 RGD:6480464
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 JBrowse link 9 95,285,592 95,302,822 RGD:6480464
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 JBrowse link 9 95,161,157 95,302,822 RGD:6480464
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 JBrowse link 14 22,597,103 22,619,968 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        aetiopathogenetic role 18766
          hepatotoxic agent 14277
            benoxaprofen 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        monocarboxylic acid 17256
                                          fatty acid 15814
                                            saturated fatty acid 15782
                                              propionic acid 3641
                                                benoxaprofen 12
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