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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benoxaprofen
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Accession:CHEBI:76114 term browser browse the term
Definition:A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group. It was used as a non-steroidal anti-inflammatory drug until 1982 when it was withdrawn from the market due to adverse side-effects including liver necrosis, photosensitivity, and carcinogenicity in animals.
Synonyms:exact_synonym: 2-[2-(4-chlorophenyl)-1,3-benzoxazol-5-yl]propanoic acid
 related_synonym: (1)-2-(4-Chlorophenyl)benzoxazole-5-propionic acid;   2-(4-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid;   2-(p-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid;   DL-benoxaprofen;   Formula=C16H12ClNO3;   InChI=1S/C16H12ClNO3/c1-9(16(19)20)11-4-7-14-13(8-11)18-15(21-14)10-2-5-12(17)6-3-10/h2-9H,1H3,(H,19,20);   InChIKey=MITFXPHMIHQXPI-UHFFFAOYSA-N;   Lilly 90459;   SMILES=CC(C(O)=O)c1ccc2oc(nc2c1)-c1ccc(Cl)cc1;   benoxaprofene;   benoxaprofeno;   benoxaprofenum
 xref: CAS:51234-28-7;   DrugBank:DB04812;   Drug_Central:311;   KEGG:D03080
 xref_mesh: MESH:C011677
 xref: PMID:19439485;   PMID:19773537;   PMID:21128314;   PMID:22514582;   PMID:23250699;   PMID:2413686;   PMID:2833969;   PMID:2947294;   PMID:3981515;   PMID:6407402;   PMID:6526401;   PMID:6645654;   PMID:6813936;   PMID:6993669;   PMID:6993670;   PMID:6993671;   PMID:6993672;   PMID:7044799;   PMID:7044801;   PMID:7084283;   PMID:7084287;   PMID:7221526;   Patent:DE2324443;   Patent:US3912748;   Patent:US4391814;   Patent:US6338855;   Patent:WO2008020270;   Reaxys:1085080;   Wikipedia:Benoxaprofen



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benoxaprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin decreases response to substance ISO ALB protein results in decreased susceptibility to benoxaprofen CTD PMID:6699424 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type decreases activity EXP benoxaprofen results in decreased activity of ALOX12 protein CTD PMID:3928952 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
decreases activity
ISO
EXP
[benoxaprofen results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [benoxaprofen results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid CTD PMID:2724698 PMID:2849922 PMID:3020588 PMID:3928952 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases activity
EXP
ISO
benoxaprofen results in increased expression of CYP1A1 protein
benoxaprofen results in decreased activity of CYP1A1 protein
CTD PMID:2069584 PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP benoxaprofen results in increased expression of CYP1A2 protein CTD PMID:2069584 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO benoxaprofen results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP benoxaprofen results in increased expression of CYP4A1 protein CTD PMID:2069584 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression EXP benoxaprofen results in increased expression of EHHADH protein CTD PMID:2069584 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
JBrowse link
G Gusb glucuronidase, beta increases secretion ISO benoxaprofen results in increased secretion of GUSB protein CTD PMID:6737371 NCBI chr12:26,701,191...26,714,718
Ensembl chr12:26,697,951...26,726,905
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP benoxaprofen inhibits the reaction [LHB protein results in increased abundance of Pregnenolone]; benoxaprofen inhibits the reaction [LHB protein results in increased abundance of Testosterone] CTD PMID:6430271 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 affects response to substance ISO UGT1A3 affects the susceptibility to benoxaprofen CTD PMID:17880178 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 affects response to substance ISO UGT1A9 affects the susceptibility to benoxaprofen CTD PMID:17880178 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 affects response to substance
increases glucuronidation
ISO UGT2B7 affects the susceptibility to benoxaprofen
UGT2B7 protein alternative form results in increased glucuronidation of benoxaprofen
CTD PMID:8423545 PMID:17880178 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link

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  CHEBI ontology 20089
    role 20042
      biological role 20011
        aetiopathogenetic role 19302
          hepatotoxic agent 16234
            benoxaprofen 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic acid 18597
                                        monocarboxylic acid 17843
                                          fatty acid 16480
                                            saturated fatty acid 16128
                                              propionic acid 3753
                                                benoxaprofen 13
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