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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thioflavine T
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Accession:CHEBI:76023 term browser browse the term
Definition:An organic chloride salt having 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium as the counterion. It is widely used to visualise and quantify the presence of amyloids, both in vitro and in vivo.
Synonyms:exact_synonym: 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium chloride
 related_synonym: 2-(4-(Dimethylamino)phenyl)-3,6-dimethylbenzothiazolium chloride;   C.I. 49005;   C.I. Basic Yellow 1;   Formula=C17H19ClN2S;   InChI=1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1;   InChIKey=JADVWWSKYZXRGX-UHFFFAOYSA-M;   SMILES=C=1(C=2C=CC(N(C)C)=CC2)SC=3C=C(C)C=CC3[N+]1C.[Cl-];   ThT;   Thioflavin T;   basic yellow 1
 alt_id: CHEBI:88013
 xref: CAS:2390-54-7
 xref_mesh: MESH:C009462
 xref: PMID:22976818;   PMID:23069995;   PMID:23151310;   PMID:23215453;   PMID:23454128;   PMID:23458420;   PMID:23479447;   PMID:23517370;   PMID:23662608;   PMID:23747341;   PMID:23807235;   PMID:23844566;   PMID:23903702;   PMID:23909872;   PMID:23934820;   PMID:24002823;   PMID:25483916;   PMID:25712665;   PMID:25794693;   PMID:26087242;   Patent:WO2006006172;   Patent:WO2007011834;   Reaxys:3922452;   Wikipedia:Thioflavin_T


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thioflavine T term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
affects binding
ISO [Dichlorvos results in increased phosphorylation of ACHE protein] inhibits the reaction [thioflavin T binds to ACHE protein]; [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased phosphorylation of ACHE protein] inhibits the reaction [thioflavin T binds to ACHE protein]; [thioflavin T binds to ACHE protein] inhibits the reaction [ACHE protein results in increased hydrolysis of Acetylthiocholine]; thioflavin T binds to and results in decreased activity of ACHE protein; thioflavin T inhibits the reaction [hopeahainol A binds to ACHE protein] CTD PMID:18423506, PMID:18602908, PMID:20493829, PMID:27297626 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21450
    role 21426
      application 20876
        dye 1289
          histological dye 147
            thioflavine T 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 21450
    subatomic particle 21434
      composite particle 21434
        hadron 21434
          baryon 21434
            nucleon 21434
              atomic nucleus 21434
                atom 21434
                  main group element atom 21329
                    p-block element atom 21329
                      halogen 19317
                        chlorine atom 18909
                          chlorine molecular entity 18909
                            elemental chlorine 8162
                              monoatomic chlorine 8141
                                chloride 8141
                                  chloride salt 8141
                                    organic chloride salt 690
                                      thioflavine T 1
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