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ONTOLOGY REPORT - ANNOTATIONS


Term:riociguat
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Accession:CHEBI:76018 term browser browse the term
Definition:A carbamate ester that is the methyl ester of {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamic acid. It is used for treatment of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension
Synonyms:exact_synonym: methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate
 related_synonym: Adempas;   BAY 63-2521;   Formula=C20H19FN8O2;   InChI=1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26);   InChIKey=WXXSNCNJFUAIDG-UHFFFAOYSA-N;   Methyl N-(4,6-diamino-2-{1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate;   SMILES=COC(=O)N(C)c1c(N)nc(nc1N)-c1nn(Cc2ccccc2F)c2ncccc12;   riociguatum
 xref: CAS:625115-55-1 "ChemIDplus";   CAS:625115-55-1 "KEGG DRUG";   Drug_Central:4807 "DrugCentral";   KEGG:D09572
 xref_mesh: MESH:C542595
 xref: PMCID:PMC3363218 "Europe PMC";   PMID:19129292 "Europe PMC";   PMID:20424448 "Europe PMC";   PMID:20801938 "Europe PMC";   PMID:20956169 "Europe PMC";   PMID:21391889 "Europe PMC";   PMID:21789188 "Europe PMC";   PMID:22719060 "Europe PMC";   PMID:22900035 "Europe PMC";   PMID:22912874 "Europe PMC";   PMID:22936711 "Europe PMC";   PMID:23204120 "Europe PMC";   PMID:23397304 "Europe PMC";   PMID:23775260 "Europe PMC";   PMID:23883377 "Europe PMC";   PMID:23883378 "Europe PMC";   PMID:23883383 "Europe PMC";   PMID:23939482 "Europe PMC";   PMID:23963798 "Europe PMC";   PMID:23978639 "Europe PMC";   PMID:23997048 "Europe PMC";   PMID:23997053 "Europe PMC";   PMID:24015306 "Europe PMC";   PMID:24092345 "Europe PMC";   Patent:US2009286781;   Patent:WO2007009607;   Patent:WO2011147810;   Reaxys:12581953 "Reaxys";   Wikipedia:Riociguat


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riociguat term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Kcnk3 potassium two pore domain channel subfamily K member 3 JBrowse link 6 27,154,274 27,190,209 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19596
    role 19539
      biological role 19537
        biochemical role 19055
          effector 92
            soluble guanylate cyclase activator 2
              riociguat 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19596
    subatomic particle 19592
      composite particle 19592
        hadron 19592
          baryon 19592
            nucleon 19592
              atomic nucleus 19592
                atom 19592
                  main group element atom 19471
                    main group molecular entity 19471
                      s-block molecular entity 19244
                        hydrogen molecular entity 19234
                          hydrides 18152
                            inorganic hydride 17088
                              pnictogen hydride 17046
                                nitrogen hydride 16867
                                  azane 16546
                                    ammonia 16543
                                      organic amino compound 16542
                                        aromatic amine 13541
                                          aminopyrimidine 1026
                                            riociguat 2
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