Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:vortioxetine
go back to main search page
Accession:CHEBI:76016 term browser browse the term
Definition:An N-arylpiperazine in which the aryl group is specified as 2-[(2,4-dimethylphenyl)sulfanyl]phenyl. Used (as its hydrobromide salt) for treatment of major depressive disorder.
Synonyms:exact_synonym: 1-{2-[(2,4-dimethylphenyl)sulfanyl]phenyl}piperazine
 related_synonym: Formula=C18H22N2S;   Lu AA21004;   vortioxetina;   vortioxetinum
 xref: CAS:508233-74-7;   Drug_Central:4806;   KEGG:D10184
 xref_mesh: MESH:C557874
 xref: PMID:21767441;   PMID:22171087;   PMID:22209361;   PMID:22448783;   PMID:22475889;   PMID:22495621;   PMID:22496396;   PMID:22572889;   PMID:22612991;   PMID:22898365;   PMID:22901346;   PMID:22901736;   PMID:22963932;   PMID:22978748;   PMID:23089374;   PMID:23252878;   PMID:23380522;   PMID:23428337;   PMID:23531115;   PMID:23588319;   PMID:23721744;   PMID:23903233;   PMID:23916504;   PMID:23975654;   PMID:24016840;   Patent:WO2008113359;   Reaxys:11341374;   Wikipedia:Vortioxetine
 cyclic_relationship: is_conjugate_base_of CHEBI:76017



show annotations for term's descendants           Sort by:
 
vortioxetine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 affects binding ISO vortioxetine binds to ADRB1 protein CTD PMID:21486038 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO vortioxetine binds to and results in increased activity of HTR1A protein CTD PMID:21486038 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B multiple interactions ISO vortioxetine binds to and affects the activity of HTR1B protein CTD PMID:21486038 NCBI chr 8:82,513,572...82,534,892
Ensembl chr 8:82,517,360...82,534,549
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions ISO
EXP
Ondansetron affects the reaction [vortioxetine binds to and affects the activity of HTR3A protein]; vortioxetine binds to and affects the activity of HTR3A protein
vortioxetine binds to and results in decreased activity of HTR3A protein
CTD PMID:21486038 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO vortioxetine binds to and results in decreased activity of HTR7 protein CTD PMID:21486038 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO
EXP
vortioxetine binds to and results in decreased activity of SLC6A4 protein CTD PMID:21486038 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19659
    role 19634
      biological role 19633
        pharmacological role 18933
          neurotransmitter agent 16564
            serotonergic drug 4257
              serotonergic agonist 982
                vortioxetine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    main group molecular entity 19649
                      s-block molecular entity 19457
                        hydrogen molecular entity 19450
                          hydrides 18928
                            inorganic hydride 17765
                              pnictogen hydride 17748
                                nitrogen hydride 17633
                                  azane 17403
                                    ammonia 17402
                                      organic amino compound 17402
                                        tertiary amino compound 9087
                                          N-arylpiperazine 3023
                                            vortioxetine 6
paths to the root