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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:vortioxetine
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Accession:CHEBI:76016 term browser browse the term
Definition:An N-arylpiperazine in which the aryl group is specified as 2-[(2,4-dimethylphenyl)sulfanyl]phenyl. Used (as its hydrobromide salt) for treatment of major depressive disorder.
Synonyms:exact_synonym: 1-{2-[(2,4-dimethylphenyl)sulfanyl]phenyl}piperazine
 related_synonym: Formula=C18H22N2S;   Lu AA21004;   vortioxetina;   vortioxetinum
 xref: CAS:508233-74-7;   Drug_Central:4806;   KEGG:D10184
 xref_mesh: MESH:C557874
 xref: PMID:21767441;   PMID:22171087;   PMID:22209361;   PMID:22448783;   PMID:22475889;   PMID:22495621;   PMID:22496396;   PMID:22572889;   PMID:22612991;   PMID:22898365;   PMID:22901346;   PMID:22901736;   PMID:22963932;   PMID:22978748;   PMID:23089374;   PMID:23252878;   PMID:23380522;   PMID:23428337;   PMID:23531115;   PMID:23588319;   PMID:23721744;   PMID:23903233;   PMID:23916504;   PMID:23975654;   PMID:24016840;   Patent:WO2008113359;   Reaxys:11341374;   Wikipedia:Vortioxetine
 cyclic_relationship: is_conjugate_base_of CHEBI:76017


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vortioxetine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 affects binding ISO vortioxetine binds to ADRB1 protein CTD PMID:21486038 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO vortioxetine binds to and results in increased activity of HTR1A protein CTD PMID:21486038 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B multiple interactions ISO vortioxetine binds to and affects the activity of HTR1B protein CTD PMID:21486038 NCBI chr 8:82,513,572...82,534,892
Ensembl chr 8:82,517,360...82,534,549
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions ISO
EXP
Ondansetron affects the reaction [vortioxetine binds to and affects the activity of HTR3A protein]; vortioxetine binds to and affects the activity of HTR3A protein
vortioxetine binds to and results in decreased activity of HTR3A protein
CTD PMID:21486038 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO vortioxetine binds to and results in decreased activity of HTR7 protein CTD PMID:21486038 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO
EXP
vortioxetine binds to and results in decreased activity of SLC6A4 protein CTD PMID:21486038 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        pharmacological role 18842
          neurotransmitter agent 16452
            serotonergic drug 3980
              serotonergic agonist 984
                vortioxetine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    main group molecular entity 19708
                      s-block molecular entity 19493
                        hydrogen molecular entity 19488
                          hydrides 18845
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        tertiary amino compound 8677
                                          N-arylpiperazine 2768
                                            vortioxetine 6
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