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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:vortioxetine
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Accession:CHEBI:76016 term browser browse the term
Definition:An N-arylpiperazine in which the aryl group is specified as 2-[(2,4-dimethylphenyl)sulfanyl]phenyl. Used (as its hydrobromide salt) for treatment of major depressive disorder.
Synonyms:exact_synonym: 1-{2-[(2,4-dimethylphenyl)sulfanyl]phenyl}piperazine
 related_synonym: Formula=C18H22N2S;   Lu AA21004;   vortioxetina;   vortioxetinum
 xref: CAS:508233-74-7;   Drug_Central:4806;   KEGG:D10184
 xref_mesh: MESH:C557874
 xref: PMID:21767441;   PMID:22171087;   PMID:22209361;   PMID:22448783;   PMID:22475889;   PMID:22495621;   PMID:22496396;   PMID:22572889;   PMID:22612991;   PMID:22898365;   PMID:22901346;   PMID:22901736;   PMID:22963932;   PMID:22978748;   PMID:23089374;   PMID:23252878;   PMID:23380522;   PMID:23428337;   PMID:23531115;   PMID:23588319;   PMID:23721744;   PMID:23903233;   PMID:23916504;   PMID:23975654;   PMID:24016840;   Patent:WO2008113359;   Reaxys:11341374;   Wikipedia:Vortioxetine
 cyclic_relationship: is_conjugate_base_of CHEBI:76017


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vortioxetine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 affects binding ISO vortioxetine binds to ADRB1 protein CTD PMID:21486038 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO vortioxetine binds to and results in increased activity of HTR1A protein CTD PMID:21486038 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B multiple interactions ISO vortioxetine binds to and affects the activity of HTR1B protein CTD PMID:21486038 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions ISO
EXP
Ondansetron affects the reaction [vortioxetine binds to and affects the activity of HTR3A protein]; vortioxetine binds to and affects the activity of HTR3A protein
vortioxetine binds to and results in decreased activity of HTR3A protein
CTD PMID:21486038 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO vortioxetine binds to and results in decreased activity of HTR7 protein CTD PMID:21486038 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO
EXP
vortioxetine binds to and results in decreased activity of SLC6A4 protein CTD PMID:21486038 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        pharmacological role 18797
          neurotransmitter agent 16425
            serotonergic drug 3957
              serotonergic agonist 978
                vortioxetine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        tertiary amino compound 8630
                                          N-arylpiperazine 2740
                                            vortioxetine 6
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