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Accession:CHEBI:76010 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (4R,12aS)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1.
Synonyms:exact_synonym: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
 related_synonym: Formula=C20H19F2N3O5;   InChI=1S/C20H19F2N3O5/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28)/t10-,15+/m1/s1;   InChIKey=RHWKPHLQXYSBKR-BMIGLBTASA-N;   S/GSK1349572;   SMILES=C[C@@H]1CCO[C@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N12
 xref: CAS:1051375-16-6 "ChemIDplus";   CAS:1051375-16-6 "KEGG DRUG";   Drug_Central:4805 "DrugCentral";   KEGG:D10066;   PDBeChem:DLU;   PMID:22018760 "Europe PMC";   PMID:22205735 "Europe PMC";   PMID:22878423 "Europe PMC";   PMID:22905856 "Europe PMC";   PMID:23075918 "Europe PMC";   PMID:23132334 "Europe PMC";   PMID:23225901 "Europe PMC";   PMID:23295935 "Europe PMC";   PMID:23306000 "Europe PMC";   PMID:23413040 "Europe PMC";   PMID:23432922 "Europe PMC";   PMID:23455469 "Europe PMC";   PMID:23669385 "Europe PMC";   PMID:23777012 "Europe PMC";   PMID:23798668 "Europe PMC";   PMID:23807273 "Europe PMC";   PMID:23817375 "Europe PMC";   PMID:23824675 "Europe PMC";   PMID:23830355 "Europe PMC";   PMID:23845180 "Europe PMC";   PMID:23885999 "Europe PMC";   PMID:23942060 "Europe PMC";   PMID:24052331 "Europe PMC";   PMID:24074642 "Europe PMC";   PMID:24096683 "Europe PMC";   Patent:EP2602260;   Patent:WO2006116764;   Reaxys:12732602 "Reaxys";   Wikipedia:Dolutegravir
 cyclic_relationship: is_conjugate_acid_of CHEBI:76014

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  CHEBI ontology 19669
    chemical entity 19667
      atom 19665
        nonmetal atom 19531
          halogen 17734
            fluorine atom 11225
              fluorine molecular entity 11225
                organofluorine compound 10603
                  dolutegravir 0
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  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        carboacyl group 16943
                                          univalent carboacyl group 16943
                                            carbamoyl group 16622
                                              carboxamide 16622
                                                monocarboxylic acid amide 13180
                                                  dolutegravir 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.