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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nizatidine
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Accession:CHEBI:7601 term browser browse the term
Definition:A member of the class of 1,3-thiazoles having a dimethylaminomethyl substituent at position 2 and an alkylthiomethyl moiety at position 4.
Synonyms:exact_synonym: N-{2-[({2-[(dimethylamino)methyl]-1,3-thiazol-4-yl}methyl)sulfanyl]ethyl}-N'-methyl-2-nitroethene-1,1-diamine
 related_synonym: Acinon;   Axid;   Formula=C12H21N5O2S2;   InChI=1S/C12H21N5O2S2/c1-13-11(6-17(18)19)14-4-5-20-8-10-9-21-12(15-10)7-16(2)3/h6,9,13-14H,4-5,7-8H2,1-3H3;   InChIKey=SGXXNSQHWDMGGP-UHFFFAOYSA-N;   N-(4-(6-Methylamino-7-nitro-2-thia-5-aza-6-hepten-1-yl)-2-thiazolylmethyl)-N,N-dimethylamine;   SMILES=CNC(NCCSCc1csc(CN(C)C)n1)=C[N+]([O-])=O;   nizatidina;   nizatidinum
 xref: CAS:76963-41-2;   DrugBank:DB00585;   Drug_Central:1955;   HMDB:HMDB0014723;   KEGG:C07270;   KEGG:D00440;   LINCS:LSM-3031
 xref_mesh: MESH:D016567
 xref: PMID:12520631;   PMID:20435237;   PMID:20881754;   PMID:21858296;   PMID:22374468;   PMID:22846371;   PMID:23556039;   PMID:23611167;   PMID:23836529;   PMID:24253609;   PMID:24375669;   PMID:24601855;   Reaxys:4846056;   Wikipedia:Nizatidine



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nizatidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha increases expression ISO Nizatidine results in increased expression of CALCA protein CTD PMID:12495560 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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G Tac1 tachykinin, precursor 1 increases expression ISO Nizatidine results in increased expression of TAC1 protein CTD PMID:12495560 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19812
    role 19763
      biological role 19763
        pharmacological role 18850
          neurotransmitter agent 16461
            cholinergic drug 4867
              nizatidine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    p-block element atom 19710
                      carbon group element atom 19631
                        carbon atom 19621
                          organic molecular entity 19621
                            organic molecule 19562
                              organic cyclic compound 19356
                                organic heterocyclic compound 18596
                                  heteroarene 16543
                                    monocyclic heteroarene 13446
                                      azole 12638
                                        thiazoles 1717
                                          1,3-thiazoles 1160
                                            nizatidine 2
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