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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nizatidine
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Accession:CHEBI:7601 term browser browse the term
Definition:A member of the class of 1,3-thiazoles having a dimethylaminomethyl substituent at position 2 and an alkylthiomethyl moiety at position 4.
Synonyms:exact_synonym: N-{2-[({2-[(dimethylamino)methyl]-1,3-thiazol-4-yl}methyl)sulfanyl]ethyl}-N'-methyl-2-nitroethene-1,1-diamine
 related_synonym: Acinon;   Axid;   Formula=C12H21N5O2S2;   InChI=1S/C12H21N5O2S2/c1-13-11(6-17(18)19)14-4-5-20-8-10-9-21-12(15-10)7-16(2)3/h6,9,13-14H,4-5,7-8H2,1-3H3;   InChIKey=SGXXNSQHWDMGGP-UHFFFAOYSA-N;   N-(4-(6-Methylamino-7-nitro-2-thia-5-aza-6-hepten-1-yl)-2-thiazolylmethyl)-N,N-dimethylamine;   SMILES=CNC(NCCSCc1csc(CN(C)C)n1)=C[N+]([O-])=O;   nizatidina;   nizatidinum
 xref: CAS:76963-41-2;   DrugBank:DB00585;   Drug_Central:1955;   HMDB:HMDB0014723;   KEGG:C07270;   KEGG:D00440;   LINCS:LSM-3031
 xref_mesh: MESH:D016567
 xref: PMID:12520631;   PMID:20435237;   PMID:20881754;   PMID:21858296;   PMID:22374468;   PMID:22846371;   PMID:23556039;   PMID:23611167;   PMID:23836529;   PMID:24253609;   PMID:24375669;   PMID:24601855;   Reaxys:4846056;   Wikipedia:Nizatidine


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nizatidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha increases expression ISO Nizatidine results in increased expression of CALCA protein CTD PMID:12495560 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Tac1 tachykinin, precursor 1 increases expression ISO Nizatidine results in increased expression of TAC1 protein CTD PMID:12495560 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      biological role 19878
        pharmacological role 19113
          neurotransmitter agent 16817
            cholinergic drug 5370
              nizatidine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    p-block element atom 19846
                      carbon group element atom 19784
                        carbon atom 19781
                          organic molecular entity 19781
                            organic molecule 19735
                              organic cyclic compound 19528
                                organic heterocyclic compound 18895
                                  heteroarene 17170
                                    monocyclic heteroarene 15017
                                      azole 14514
                                        thiazoles 1801
                                          1,3-thiazoles 1232
                                            nizatidine 2
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