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ONTOLOGY REPORT - ANNOTATIONS


Term:dimethyl fumarate
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Accession:CHEBI:76004 term browser browse the term
Definition:An enoate ester resulting from the formal condensation of both carboxy groups of fumaric acid with methanol. Used for treatment of adults with relapsing forms of multiple sclerosis.
Synonyms:exact_synonym: dimethyl (2E)-but-2-enedioate
 related_synonym: (E)-But-2-enedioic acid dimethyl ester;   1,2-bis(methoxycarbonyl)-trans-ethylene;   Dimethyl trans-ethylenedicarboxylate;   Formula=C6H8O4;   Fumaric acid, dimethyl ester;   InChI=1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+;   InChIKey=LDCRTTXIJACKKU-ONEGZZNKSA-N;   SMILES=COC(=O)\\C=C\\C(=O)OC;   Tecfidera;   trans-1,2-Ethylenedicarboxylic acid dimethyl ester;   trans-Butenedioic acid dimethyl ester
 xref: CAS:624-49-7;   DrugBank:DB08908;   Drug_Central:4757;   HMDB:HMDB0031257;   KEGG:D03846
 xref_mesh: MESH:C056020
 xref: PMID:23946617;   PMID:24061646;   PMID:24131282;   Patent:US2008089861;   Patent:WO2011100589;   Reaxys:774590;   Wikipedia:Dimethyl_fumarate


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dimethyl fumarate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acta2 actin, alpha 2, smooth muscle, aorta JBrowse link 19 34,240,336 34,255,585 RGD:6480464
G Atp6v0d2 ATPase, H+ transporting, lysosomal V0 subunit D2 JBrowse link 4 19,876,838 19,922,566 RGD:6480464
G Bach1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 JBrowse link 16 87,698,954 87,733,346 RGD:6480464
G Ccl2 chemokine (C-C motif) ligand 2 JBrowse link 11 82,035,577 82,037,452 RGD:6480464
G Cd68 CD68 antigen JBrowse link 11 69,664,213 69,666,170 RGD:6480464
G Csf1r colony stimulating factor 1 receptor JBrowse link 18 61,105,572 61,131,139 RGD:6480464
G Ctsk cathepsin K JBrowse link 3 95,499,210 95,509,387 RGD:6480464
G Fth1 ferritin heavy polypeptide 1 JBrowse link 19 9,980,600 9,985,111 RGD:6480464
G Ftl1 ferritin light polypeptide 1 JBrowse link 7 45,457,944 45,459,886 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 9 77,754,535 77,794,489 RGD:6480464
G Gclm glutamate-cysteine ligase, modifier subunit JBrowse link 3 122,245,487 122,267,215 RGD:6480464
G Gpx4 glutathione peroxidase 4 JBrowse link 10 80,047,166 80,056,439 RGD:6480464
G Gsr glutathione reductase JBrowse link 8 33,653,238 33,698,162 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 8 75,093,618 75,100,593 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 9 21,015,940 21,028,814 RGD:6480464
G Ifng interferon gamma JBrowse link 10 118,441,046 118,445,894 RGD:6480464
G Ikbkb inhibitor of kappaB kinase beta JBrowse link 8 22,659,205 22,706,589 RGD:6480464
G Il6ra interleukin 6 receptor, alpha JBrowse link 3 89,869,324 89,913,196 RGD:6480464
G mt-Co3 cytochrome c oxidase III, mitochondrial JBrowse link MT 8,607 9,390 RGD:6480464
G mt-Cytb cytochrome b, mitochondrial JBrowse link MT 14,145 15,288 RGD:6480464
G mt-Nd1 NADH dehydrogenase 1, mitochondrial JBrowse link MT 2,751 3,707 RGD:6480464
G mt-Nd2 NADH dehydrogenase 2, mitochondrial JBrowse link MT 3,914 4,951 RGD:6480464
G mt-Nd5 NADH dehydrogenase 5, mitochondrial JBrowse link MT 11,742 13,565 RGD:6480464
G Mterf1a mitochondrial transcription termination factor 1a JBrowse link 5 3,864,565 3,893,933 RGD:6480464
G Mterf3 mitochondrial transcription termination factor 3 JBrowse link 13 66,906,577 66,933,083 RGD:6480464
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 JBrowse link 2 75,675,513 75,704,663 RGD:6480464
G Nqo1 NAD(P)H dehydrogenase, quinone 1 JBrowse link 8 107,388,225 107,403,205 RGD:6480464
G Pdgfb platelet derived growth factor, B polypeptide JBrowse link 15 79,995,865 80,024,614 RGD:6480464
G Polg2 polymerase (DNA directed), gamma 2, accessory subunit JBrowse link 11 106,768,204 106,779,537 RGD:6480464
G Polrmt polymerase (RNA) mitochondrial (DNA directed) JBrowse link 10 79,736,125 79,746,604 RGD:6480464
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) JBrowse link 19 5,637,442 5,648,134 RGD:6480464
G Ssbp1 single-stranded DNA binding protein 1 JBrowse link 6 40,471,414 40,481,823 RGD:6480464
G Tfam transcription factor A, mitochondrial JBrowse link 10 71,225,468 71,238,328 RGD:6480464
G Tfb1m transcription factor B1, mitochondrial JBrowse link 17 3,519,250 3,557,796 RGD:6480464
G Tfb2m transcription factor B2, mitochondrial JBrowse link 1 179,528,052 179,546,305 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 7 25,687,002 25,705,077 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 JBrowse link 14 78,277,446 78,308,043 RGD:6480464
G Twnk twinkle mtDNA helicase JBrowse link 19 45,005,663 45,012,764 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21322
    role 21309
      biological role 21307
        immunomodulator 14008
          dimethyl fumarate 39
Path 2
Term Annotations click to browse term
  CHEBI ontology 21322
    subatomic particle 21318
      composite particle 21318
        hadron 21318
          baryon 21318
            nucleon 21318
              atomic nucleus 21318
                atom 21318
                  main group element atom 21193
                    p-block element atom 21193
                      carbon group element atom 20991
                        carbon atom 20881
                          organic molecular entity 20881
                            organic group 19225
                              organic divalent group 19215
                                organodiyl group 19215
                                  carbonyl group 19189
                                    carbonyl compound 19189
                                      dicarboxylic acids and O-substituted derivatives 10520
                                        dicarboxylic acid 10512
                                          C4-dicarboxylic acid 811
                                            butenedioic acid 525
                                              fumaric acid 48
                                                dimethyl fumarate 39
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.