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ONTOLOGY REPORT - ANNOTATIONS


Term:dimethyl fumarate
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Accession:CHEBI:76004 term browser browse the term
Definition:An enoate ester resulting from the formal condensation of both carboxy groups of fumaric acid with methanol. Used for treatment of adults with relapsing forms of multiple sclerosis.
Synonyms:exact_synonym: dimethyl (2E)-but-2-enedioate
 related_synonym: (E)-But-2-enedioic acid dimethyl ester;   1,2-bis(methoxycarbonyl)-trans-ethylene;   Dimethyl trans-ethylenedicarboxylate;   Formula=C6H8O4;   Fumaric acid, dimethyl ester;   InChI=1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+;   InChIKey=LDCRTTXIJACKKU-ONEGZZNKSA-N;   SMILES=COC(=O)\\C=C\\C(=O)OC;   Tecfidera;   trans-1,2-Ethylenedicarboxylic acid dimethyl ester;   trans-Butenedioic acid dimethyl ester
 xref: CAS:624-49-7;   DrugBank:DB08908;   Drug_Central:4757;   HMDB:HMDB0031257;   KEGG:D03846
 xref_mesh: MESH:C056020
 xref: PMID:23946617;   PMID:24061646;   PMID:24131282;   Patent:US2008089861;   Patent:WO2011100589;   Reaxys:774590;   Wikipedia:Dimethyl_fumarate


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dimethyl fumarate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACTA2 actin alpha 2, smooth muscle JBrowse link 10 88,935,074 88,991,397 RGD:6480464
G ATP6V0D2 ATPase H+ transporting V0 subunit d2 JBrowse link 8 86,098,910 86,154,225 RGD:6480464
G BACH1 BTB domain and CNC homolog 1 JBrowse link 21 29,298,922 29,361,896 RGD:6480464
G CCL2 C-C motif chemokine ligand 2 JBrowse link 17 34,255,285 34,257,203 RGD:6480464
G CD68 CD68 molecule JBrowse link 17 7,579,638 7,582,111 RGD:6480464
G CSF1R colony stimulating factor 1 receptor JBrowse link 5 150,053,291 150,113,372 RGD:6480464
G CTSK cathepsin K JBrowse link 1 150,796,208 150,808,260 RGD:6480464
G FTH1 ferritin heavy chain 1 JBrowse link 11 61,964,285 61,967,634 RGD:6480464
G FTL ferritin light chain JBrowse link 19 48,963,941 48,966,879 RGD:6480464
G GCLC glutamate-cysteine ligase catalytic subunit JBrowse link 6 53,497,341 53,545,101 RGD:6480464
G GCLM glutamate-cysteine ligase modifier subunit JBrowse link 1 93,885,199 93,910,370 RGD:6480464
G GPX4 glutathione peroxidase 4 JBrowse link 19 1,103,994 1,106,779 RGD:6480464
G GSR glutathione-disulfide reductase JBrowse link 8 30,678,061 30,727,999 RGD:6480464
G HMOX1 heme oxygenase 1 JBrowse link 22 35,381,096 35,394,207 RGD:6480464
G ICAM1 intercellular adhesion molecule 1 JBrowse link 19 10,271,120 10,286,615 RGD:6480464
G IFNG interferon gamma JBrowse link 12 68,154,768 68,159,740 RGD:6480464
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 8 42,270,727 42,332,460 RGD:6480464
G IL6R interleukin 6 receptor JBrowse link 1 154,405,343 154,469,450 RGD:6480464
G MT-CO3 mitochondrially encoded cytochrome c oxidase III JBrowse link MT 9,207 9,990 RGD:6480464
G MT-CYB mitochondrially encoded cytochrome b JBrowse link MT 14,747 15,887 RGD:6480464
G MT-ND1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 JBrowse link MT 3,307 4,262 RGD:6480464
G MT-ND2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 JBrowse link MT 4,470 5,511 RGD:6480464
G MT-ND5 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 JBrowse link MT 12,337 14,148 RGD:6480464
G MTERF1 mitochondrial transcription termination factor 1 JBrowse link 7 91,870,929 91,880,733 RGD:6480464
G MTERF3 mitochondrial transcription termination factor 3 JBrowse link 8 96,239,398 96,261,613 RGD:6480464
G NFE2L2 nuclear factor, erythroid 2 like 2 JBrowse link 2 177,230,303 177,265,131 RGD:6480464
G NQO1 NAD(P)H quinone dehydrogenase 1 JBrowse link 16 69,709,401 69,726,560 RGD:6480464
G PDGFB platelet derived growth factor subunit B JBrowse link 22 39,223,359 39,244,982 RGD:6480464
G POLG2 DNA polymerase gamma 2, accessory subunit JBrowse link 17 64,477,785 64,497,054 RGD:6480464
G POLRMT RNA polymerase mitochondrial JBrowse link 19 617,221 633,557 RGD:6480464
G RELA RELA proto-oncogene, NF-kB subunit JBrowse link 11 65,653,596 65,662,972 RGD:6480464
G SSBP1 single stranded DNA binding protein 1 JBrowse link 7 141,738,321 141,750,488 RGD:6480464
G TFAM transcription factor A, mitochondrial JBrowse link 10 58,385,143 58,399,230 RGD:6480464
G TFB1M transcription factor B1, mitochondrial JBrowse link 6 155,229,871 155,314,497 RGD:6480464
G TFB2M transcription factor B2, mitochondrial JBrowse link 1 246,540,561 246,566,261 RGD:6480464
G TGFB1 transforming growth factor beta 1 JBrowse link 19 41,330,323 41,353,922 RGD:6480464
G TNF tumor necrosis factor JBrowse link 6 31,575,565 31,578,336 RGD:6480464
G TNFSF11 TNF superfamily member 11 JBrowse link 13 42,562,736 42,608,013 RGD:6480464
G TWNK twinkle mtDNA helicase JBrowse link 10 100,987,543 100,994,403 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24146
    role 24039
      biological role 24005
        immunomodulator 14952
          dimethyl fumarate 39
Path 2
Term Annotations click to browse term
  CHEBI ontology 24146
    subatomic particle 24100
      composite particle 24100
        hadron 24100
          baryon 24100
            nucleon 24100
              atomic nucleus 24100
                atom 24100
                  main group element atom 23929
                    p-block element atom 23929
                      carbon group element atom 23662
                        carbon atom 23618
                          organic molecular entity 23618
                            organic group 22089
                              organic divalent group 22063
                                organodiyl group 22063
                                  carbonyl group 22038
                                    carbonyl compound 22038
                                      dicarboxylic acids and O-substituted derivatives 10660
                                        dicarboxylic acid 10653
                                          C4-dicarboxylic acid 807
                                            butenedioic acid 526
                                              fumaric acid 48
                                                dimethyl fumarate 39
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.