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ONTOLOGY REPORT - ANNOTATIONS


Term:dimethyl fumarate
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Accession:CHEBI:76004 term browser browse the term
Definition:An enoate ester resulting from the formal condensation of both carboxy groups of fumaric acid with methanol. Used for treatment of adults with relapsing forms of multiple sclerosis.
Synonyms:exact_synonym: dimethyl (2E)-but-2-enedioate
 related_synonym: (E)-But-2-enedioic acid dimethyl ester;   1,2-bis(methoxycarbonyl)-trans-ethylene;   Dimethyl trans-ethylenedicarboxylate;   Formula=C6H8O4;   Fumaric acid, dimethyl ester;   InChI=1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+;   InChIKey=LDCRTTXIJACKKU-ONEGZZNKSA-N;   SMILES=COC(=O)\\C=C\\C(=O)OC;   Tecfidera;   trans-1,2-Ethylenedicarboxylic acid dimethyl ester;   trans-Butenedioic acid dimethyl ester
 xref: CAS:624-49-7 "ChemIDplus";   CAS:624-49-7 "KEGG DRUG";   CAS:624-49-7 "NIST Chemistry WebBook";   DrugBank:DB08908;   Drug_Central:4757 "DrugCentral";   HMDB:HMDB0031257;   KEGG:D03846
 xref_mesh: MESH:C056020
 xref: PMID:23946617 "Europe PMC";   PMID:24061646 "Europe PMC";   PMID:24131282 "Europe PMC";   Patent:US2008089861;   Patent:WO2011100589;   Reaxys:774590 "Reaxys";   Wikipedia:Dimethyl_fumarate


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dimethyl fumarate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acta2 actin alpha 2, smooth muscle JBrowse link 1 252,537,614 252,550,394 RGD:6480464
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 JBrowse link 5 33,843,591 33,892,446 RGD:6480464
G Bach1 BTB domain and CNC homolog 1 JBrowse link 11 27,364,913 27,398,713 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Cd68 Cd68 molecule JBrowse link 10 56,268,726 56,270,605 RGD:6480464
G Csf1r colony stimulating factor 1 receptor JBrowse link 18 56,414,493 56,458,300 RGD:6480464
G Ctsk cathepsin K JBrowse link 2 196,655,469 196,666,447 RGD:6480464
G Fth1 ferritin heavy chain 1 JBrowse link 1 226,030,940 226,033,228 RGD:6480464
G Ftl1 ferritin light chain 1 JBrowse link 1 101,448,190 101,450,034 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:6480464
G Gclm glutamate cysteine ligase, modifier subunit JBrowse link 2 225,827,504 225,847,876 RGD:6480464
G Gpx4 glutathione peroxidase 4 JBrowse link 7 12,516,357 12,519,154 RGD:6480464
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6480464
G Mt-co3 mitochondrially encoded cytochrome c oxidase III JBrowse link MT 8,599 9,382 RGD:6480464
G Mt-cyb mitochondrially encoded cytochrome b JBrowse link MT 14,136 15,278 RGD:6480464
G Mt-nd1 mitochondrially encoded NADH dehydrogenase 1 JBrowse link MT 2,740 3,694 RGD:6480464
G Mt-nd2 mitochondrially encoded NADH dehydrogenase 2 JBrowse link MT 3,904 4,942 RGD:6480464
G Mt-nd5 mitochondrially encoded NADH dehydrogenase 5 JBrowse link MT 11,736 13,565 RGD:6480464
G Mterf1 mitochondrial transcription termination factor 1 JBrowse link 4 27,365,310 27,372,374 RGD:6480464
G Mterf3 mitochondrial transcription termination factor 3 JBrowse link 7 71,275,544 71,293,842 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:6480464
G Polg2 DNA polymerase gamma 2, accessory subunit JBrowse link 10 94,968,836 94,979,259 RGD:6480464
G Polrmt RNA polymerase mitochondrial JBrowse link 7 12,840,907 12,851,153 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Ssbp1 single stranded DNA binding protein 1 JBrowse link 4 68,634,844 68,645,112 RGD:6480464
G Tfam transcription factor A, mitochondrial JBrowse link 20 18,594,057 18,606,106 RGD:6480464
G Tfb1m transcription factor B1, mitochondrial JBrowse link 1 44,433,116 44,474,674 RGD:6480464
G Tfb2m transcription factor B2, mitochondrial JBrowse link 13 97,820,493 97,838,275 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfsf11 TNF superfamily member 11 JBrowse link 15 60,482,527 60,512,704 RGD:6480464
G Twnk twinkle mtDNA helicase JBrowse link 1 264,756,060 264,762,892 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      biological role 19599
        immunomodulator 12649
          dimethyl fumarate 38
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic group 18338
                              organic divalent group 18329
                                organodiyl group 18329
                                  carbonyl group 18218
                                    carbonyl compound 18218
                                      dicarboxylic acids and O-substituted derivatives 10171
                                        dicarboxylic acid 10164
                                          C4-dicarboxylic acid 677
                                            butenedioic acid 516
                                              fumaric acid 47
                                                dimethyl fumarate 38
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.