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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dimethyl fumarate
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Accession:CHEBI:76004 term browser browse the term
Definition:An enoate ester resulting from the formal condensation of both carboxy groups of fumaric acid with methanol. Used for treatment of adults with relapsing forms of multiple sclerosis.
Synonyms:exact_synonym: dimethyl (2E)-but-2-enedioate
 related_synonym: (E)-But-2-enedioic acid dimethyl ester;   1,2-bis(methoxycarbonyl)-trans-ethylene;   Dimethyl trans-ethylenedicarboxylate;   Formula=C6H8O4;   Fumaric acid, dimethyl ester;   InChI=1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+;   InChIKey=LDCRTTXIJACKKU-ONEGZZNKSA-N;   SMILES=COC(=O)\\C=C\\C(=O)OC;   Tecfidera;   trans-1,2-Ethylenedicarboxylic acid dimethyl ester;   trans-Butenedioic acid dimethyl ester
 xref: CAS:624-49-7;   DrugBank:DB08908;   Drug_Central:4757;   HMDB:HMDB0031257;   KEGG:D03846
 xref_mesh: MESH:C056020
 xref: PMID:23946617;   PMID:24061646;   PMID:24131282;   Patent:US2008089861;   Patent:WO2011100589;   Reaxys:774590;   Wikipedia:Dimethyl_fumarate


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dimethyl fumarate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Dimethyl Fumarate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:30703375 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA] CTD PMID:30742845 NCBI chr 5:33,843,591...33,892,446
Ensembl chr 5:33,843,519...33,892,462
JBrowse link
G Bach1 BTB domain and CNC homolog 1 affects localization ISO Dimethyl Fumarate affects the localization of BACH1 protein CTD PMID:27277809 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of CCL2 mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to CCL2 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
Dimethyl Fumarate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCL2 mRNA]
Dimethyl Fumarate results in decreased expression of CCL2 mRNA
CTD PMID:26683377, PMID:27277809 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO Dimethyl Fumarate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD68 mRNA] CTD PMID:27277809 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions ISO Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA]; Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
JBrowse link
G Ctsk cathepsin K multiple interactions ISO Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression
multiple interactions
ISO Dimethyl Fumarate results in increased expression of FTH1 mRNA; Dimethyl Fumarate results in increased expression of FTH1 protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTH1 mRNA]
CTD PMID:28289076 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Ftl1 ferritin light chain 1 increases expression
multiple interactions
ISO Dimethyl Fumarate results in increased expression of FTL mRNA; Dimethyl Fumarate results in increased expression of FTL protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL protein]
CTD PMID:28289076 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO
EXP
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLC mRNA]
Dimethyl Fumarate results in increased expression of GCLC protein
CTD PMID:27277809, PMID:30248482 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
ISO
EXP
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLM mRNA]
Dimethyl Fumarate results in increased expression of GCLM protein
CTD PMID:27277809 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpx4 glutathione peroxidase 4 increases metabolic processing ISO Dimethyl Fumarate results in increased metabolism of GPX4 protein CTD PMID:29917289 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Gsr glutathione-disulfide reductase increases expression
multiple interactions
EXP
ISO
Dimethyl Fumarate results in increased expression of GSR protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GSR mRNA]
CTD PMID:27277809 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
Dimethyl Fumarate results in increased expression of HMOX1 mRNA; Dimethyl Fumarate results in increased expression of HMOX1 protein
Acetylcysteine inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; HMOX1 protein inhibits the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 mRNA]
[Dimethyl Fumarate results in decreased abundance of Glutathione] which results in increased expression of HMOX1 protein; [Dimethyl Fumarate results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein; Glutathione inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]
CTD PMID:20961405, PMID:23942037, PMID:26683377, PMID:27277809, PMID:28790194 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to ICAM1 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
Dimethyl Fumarate results in decreased expression of ICAM1 mRNA
CTD PMID:26683377 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO Dimethyl Fumarate inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]
Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; tin protoporphyrin IX inhibits the reaction [Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]
CTD PMID:15663561, PMID:23942037 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of CCL2 mRNA]; Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of TNF mRNA] CTD PMID:26683377 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Dimethyl Fumarate results in decreased expression of IL6R protein CTD PMID:28134847 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III increases expression
multiple interactions
ISO Dimethyl Fumarate results in increased expression of COX3 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of COX3 mRNA]
CTD PMID:27277809 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of CYTB mRNA] CTD PMID:27277809 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND1 mRNA] CTD PMID:27277809 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
JBrowse link
G Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND2 mRNA] CTD PMID:27277809 NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942
JBrowse link
G Mt-nd5 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND5 mRNA] CTD PMID:27277809 NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565
JBrowse link
G Mterf1 mitochondrial transcription termination factor 1 increases expression
multiple interactions
ISO Dimethyl Fumarate results in increased expression of MTERF1A mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of MTERF1A mRNA]
CTD PMID:27277809 NCBI chr 4:27,365,310...27,372,374
Ensembl chr 4:27,365,376...27,372,372
JBrowse link
G Mterf3 mitochondrial transcription termination factor 3 increases expression
multiple interactions
ISO Dimethyl Fumarate results in increased expression of MTERF3 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of MTERF3 mRNA]
CTD PMID:27277809 NCBI chr 7:71,275,544...71,293,842
Ensembl chr 7:71,273,275...71,293,823
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
affects localization
ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of COX3 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of CYTB mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GSR mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of MTERF1A mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of MTERF3 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND2 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND5 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of POLG2 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of POLRMT mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of SSBP1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFAM mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFB1M mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFB2M mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TWNK mRNA]; NFE2L2 protein inhibits the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; NFE2L2 protein promotes the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]
Dimethyl Fumarate affects the localization of NFE2L2 protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTH1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]
CTD PMID:23942037, PMID:27277809, PMID:28289076, PMID:28790194 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
multiple interactions
increases expression
ISO
EXP
Dimethyl Fumarate results in increased activity of NQO1 protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of NQO1 mRNA]
Dimethyl Fumarate results in increased expression of NQO1 mRNA; Dimethyl Fumarate results in increased expression of NQO1 protein
[Dimethyl Fumarate results in increased activity of NQO1 protein] which results in increased susceptibility to Mitomycin; [Dimethyl Fumarate results in increased activity of NQO1 protein] which results in increased susceptibility to Streptonigrin
CTD PMID:15655414, PMID:16045903, PMID:27277809, PMID:28790194, PMID:30248482 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO [Dimethyl Fumarate results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein CTD PMID:20961405 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Polg2 DNA polymerase gamma 2, accessory subunit increases expression
multiple interactions
ISO Dimethyl Fumarate results in increased expression of POLG2 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of POLG2 mRNA]
CTD PMID:27277809 NCBI chr10:94,968,836...94,979,259
Ensembl chr10:94,968,836...94,979,259
JBrowse link
G Polrmt RNA polymerase mitochondrial increases expression
multiple interactions
ISO Dimethyl Fumarate results in increased expression of POLRMT mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of POLRMT mRNA]
CTD PMID:27277809 NCBI chr 7:12,840,907...12,851,153
Ensembl chr 7:12,840,938...12,851,153
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Dimethyl Fumarate binds to and affects the localization of and results in decreased activity of RELA protein; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to CCL2 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to ICAM1 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:26683377 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ssbp1 single stranded DNA binding protein 1 increases expression
multiple interactions
ISO Dimethyl Fumarate results in increased expression of SSBP1 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of SSBP1 mRNA]
CTD PMID:27277809 NCBI chr 4:68,634,844...68,645,112
Ensembl chr 4:68,634,929...68,645,172
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression
multiple interactions
ISO Dimethyl Fumarate results in increased expression of TFAM mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFAM mRNA]
CTD PMID:27277809 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tfb1m transcription factor B1, mitochondrial multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFB1M mRNA] CTD PMID:27277809 NCBI chr 1:44,433,116...44,474,674
Ensembl chr 1:44,433,116...44,474,674
JBrowse link
G Tfb2m transcription factor B2, mitochondrial increases expression
multiple interactions
ISO Dimethyl Fumarate results in increased expression of TFB2M mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFB2M mRNA]
CTD PMID:27277809 NCBI chr13:97,820,493...97,838,275
Ensembl chr13:97,820,493...97,838,228
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Dimethyl Fumarate inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:30703375 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of TNF mRNA]]; Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of TNF mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to CCL2 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to ICAM1 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased activity of RELA protein]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of TNF mRNA]
Dimethyl Fumarate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF mRNA]
Dimethyl Fumarate results in decreased expression of TNF mRNA
CTD PMID:26683377, PMID:27277809 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA]; Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Twnk twinkle mtDNA helicase multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TWNK mRNA] CTD PMID:27277809 NCBI chr 1:264,756,060...264,762,892
Ensembl chr 1:264,756,499...264,762,892
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        immunomodulator 13689
          dimethyl fumarate 39
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      dicarboxylic acids and O-substituted derivatives 10271
                                        dicarboxylic acid 10264
                                          C4-dicarboxylic acid 806
                                            butenedioic acid 524
                                              fumaric acid 48
                                                dimethyl fumarate 39
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.