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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trametinib
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Accession:CHEBI:75998 term browser browse the term
Definition:A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment.
Synonyms:exact_synonym: N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide
 related_synonym: Formula=C26H23FIN5O4;   GSK 1120212;   InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34);   InChIKey=LIRYPHYGHXZJBZ-UHFFFAOYSA-N;   JTP 74057;   SMILES=CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O;   trametinibum
 xref: CAS:871700-17-3;   Chemspider:9881833;   DrugBank:DB08911;   Drug_Central:4802;   KEGG:D10175;   LINCS:LSM-1143
 xref_mesh: MESH:C560077
 xref: PMCID:PMC7715110;   PMID:21523318;   PMID:22245957;   PMID:23035153;   PMID:23237773;   PMID:23248257;   PMID:23290787;   PMID:23432625;   PMID:23438367;   PMID:23441129;   PMID:23533766;   PMID:23583440;   PMID:23587417;   PMID:23649971;   PMID:23658559;   PMID:23709751;   PMID:23807941;   PMID:23844038;   PMID:23846731;   PMID:23893461;   PMID:23971497;   PMID:23977666;   PMID:24055054;   PMID:26119340;   PMID:33922284;   PMID:34034619;   PMID:34145930;   PMID:34156985;   PMID:34282746;   PMID:34355652;   PMID:34413035;   PMID:34421360;   PMID:34484797;   PMID:34516041;   PMID:34590600;   PMID:34592184;   Patent:WO2005121142;   Patent:WO2011038082;   Patent:WO2011038085;   Patent:WO2011047238;   Reaxys:12497153;   Wikipedia:Trametinib



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trametinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of AADAT mRNA CTD PMID:36139627 NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332
JBrowse link
G Abhd11 abhydrolase domain containing 11 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ABHD11 mRNA CTD PMID:36139627 NCBI chr12:21,682,206...21,685,331
Ensembl chr12:21,682,202...21,685,398
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the expression of ACACA mRNA] CTD PMID:29950559 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ACHE mRNA CTD PMID:36139627 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acly ATP citrate lyase multiple interactions ISO trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the expression of ACLY mRNA] CTD PMID:29950559 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Acp7 acid phosphatase 7, tartrate resistant multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ACP7 mRNA CTD PMID:36139627 NCBI chr 1:83,896,485...83,923,436
Ensembl chr 1:83,898,153...83,920,634
JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ACSL5 mRNA CTD PMID:36139627 NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607
JBrowse link
G Acsm3 acyl-CoA synthetase medium-chain family member 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ACSM3 mRNA CTD PMID:36139627 NCBI chr 1:174,133,260...174,159,966
Ensembl chr 1:174,133,288...174,160,184
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ACTA2 mRNA CTD PMID:36139627 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Actbl2 actin, beta-like 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ACTBL2 mRNA CTD PMID:36139627 NCBI chr 2:42,858,020...42,860,767
Ensembl chr 2:42,858,020...42,860,767
JBrowse link
G Acy3 aminoacylase 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ACY3 mRNA CTD PMID:36139627 NCBI chr 1:201,279,751...201,285,803
Ensembl chr 1:201,279,851...201,283,175
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ADAMTS1 mRNA CTD PMID:36139627 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
JBrowse link
G Adamts16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ADAMTS16 mRNA CTD PMID:36139627 NCBI chr 1:32,430,436...32,562,481
Ensembl chr 1:32,430,436...32,560,494
JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ADAMTS4 mRNA CTD PMID:36139627 NCBI chr13:83,670,556...83,680,045
Ensembl chr13:83,670,183...83,680,065
JBrowse link
G Adamts6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ADAMTS6 mRNA CTD PMID:36139627 NCBI chr 2:35,421,483...35,633,305
Ensembl chr 2:35,421,510...35,633,298
JBrowse link
G Adgrg1 adhesion G protein-coupled receptor G1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ADGRG1 mRNA CTD PMID:36139627 NCBI chr19:10,003,963...10,041,122
Ensembl chr19:10,003,975...10,041,108
JBrowse link
G Adgrl3 adhesion G protein-coupled receptor L3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ADGRL3 mRNA CTD PMID:36139627 NCBI chr14:26,336,320...27,104,060
Ensembl chr14:26,368,277...27,105,860
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ADRB2 mRNA CTD PMID:36139627 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Afap1l1 actin filament associated protein 1-like 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of AFAP1L1 mRNA CTD PMID:36139627 NCBI chr18:55,183,786...55,244,174
Ensembl chr18:55,183,786...55,244,146
JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of AGR2 mRNA CTD PMID:36139627 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371
JBrowse link
G Akap5 A-kinase anchoring protein 5 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of AKAP5 mRNA CTD PMID:36139627 NCBI chr 6:95,051,527...95,061,075
Ensembl chr 6:95,051,537...95,061,578
JBrowse link
G Akna AT-hook transcription factor multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of AKNA mRNA CTD PMID:36139627 NCBI chr 5:76,777,415...76,824,380
Ensembl chr 5:76,777,415...76,816,017
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO trametinib results in increased phosphorylation of AKT1 protein
[omipalisib co-treated with trametinib] results in decreased phosphorylation of AKT1 protein
CTD PMID:22733540 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt3 AKT serine/threonine kinase 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of AKT3 mRNA CTD PMID:36139627 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ALDH1A2 mRNA CTD PMID:36139627 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ALDOC mRNA CTD PMID:36139627 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
JBrowse link
G Aloxe3 arachidonate lipoxygenase 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ALOXE3 mRNA CTD PMID:36139627 NCBI chr10:53,830,219...53,854,328
Ensembl chr10:53,831,264...53,854,328
JBrowse link
G Alpg alkaline phosphatase, germ cell multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ALPG mRNA CTD PMID:36139627 NCBI chr 9:87,748,721...87,761,500
Ensembl chr 9:87,753,648...87,757,836
JBrowse link
G Amn1 antagonist of mitotic exit network 1 homolog multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of AMN1 mRNA CTD PMID:36139627 NCBI chr 4:182,155,140...182,182,085
Ensembl chr 4:182,155,142...182,182,016
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of AMPD3 mRNA CTD PMID:36139627 NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887
JBrowse link
G Ang angiogenin multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ANG mRNA CTD PMID:36139627 NCBI chr15:24,317,733...24,323,361 JBrowse link
G Angptl4 angiopoietin-like 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ANGPTL4 mRNA CTD PMID:36139627 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
JBrowse link
G Ank3 ankyrin 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ANK3 mRNA CTD PMID:36139627 NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
JBrowse link
G Ankef1 ankyrin repeat and EF-hand domain containing 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ANKEF1 mRNA CTD PMID:36139627 NCBI chr 3:123,847,817...123,883,060
Ensembl chr 3:123,847,817...123,883,059
JBrowse link
G Ankrd2 ankyrin repeat domain 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ANKRD2 mRNA CTD PMID:36139627 NCBI chr 1:240,847,111...240,856,563
Ensembl chr 1:240,847,072...240,856,566
JBrowse link
G Ankrd24 ankyrin repeat domain 24 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ANKRD24 mRNA CTD PMID:36139627 NCBI chr 7:8,061,634...8,081,142
Ensembl chr 7:8,061,953...8,081,142
JBrowse link
G Ankrd37 ankyrin repeat domain 37 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ANKRD37 mRNA CTD PMID:36139627 NCBI chr16:46,269,025...46,271,971
Ensembl chr16:46,268,443...46,271,963
JBrowse link
G Ankrd65 ankyrin repeat domain 65 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ANKRD65 mRNA CTD PMID:36139627 NCBI chr 5:166,398,359...166,400,616
Ensembl chr 5:166,397,748...166,400,953
JBrowse link
G Ano7 anoctamin 7 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ANO7 mRNA CTD PMID:36139627 NCBI chr 9:93,917,524...93,945,323
Ensembl chr 9:93,917,524...93,945,323
JBrowse link
G Anpep alanyl aminopeptidase, membrane multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ANPEP mRNA CTD PMID:36139627 NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789
JBrowse link
G Aoc3 amine oxidase, copper containing 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of AOC3 mRNA CTD PMID:36139627 NCBI chr10:86,272,757...86,280,702 JBrowse link
G Apln apelin multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of APLN mRNA CTD PMID:36139627 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:127,203,823...127,213,391
JBrowse link
G Apobr apolipoprotein B receptor multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of APOBR mRNA CTD PMID:36139627 NCBI chr 1:181,168,982...181,173,528
Ensembl chr 1:181,168,916...181,173,528
JBrowse link
G Apol3 apolipoprotein L3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of APOL3 mRNA CTD PMID:36139627 NCBI chr 7:109,288,725...109,297,728
Ensembl chr 7:109,288,725...109,297,723
JBrowse link
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 multiple interactions ISO trametinib inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein] CTD PMID:25780039 NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692
JBrowse link
G Arfgef3 ARFGEF family member 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ARFGEF3 mRNA CTD PMID:36139627 NCBI chr 1:13,245,578...13,404,319
Ensembl chr 1:13,244,830...13,404,084
JBrowse link
G Arhgap31 Rho GTPase activating protein 31 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ARHGAP31 mRNA CTD PMID:36139627 NCBI chr11:62,038,635...62,151,564
Ensembl chr11:62,038,635...62,151,564
JBrowse link
G Arhgap8 Rho GTPase activating protein 8 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ARHGAP8 mRNA CTD PMID:36139627 NCBI chr 7:115,842,223...115,902,094
Ensembl chr 7:115,850,654...115,902,093
JBrowse link
G Armh1 armadillo-like helical domain containing 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ARMH1 mRNA CTD PMID:36139627 NCBI chr 5:130,680,955...130,722,062
Ensembl chr 5:130,682,485...130,722,062
JBrowse link
G Atg9b autophagy related 9B multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ATG9B mRNA CTD PMID:36139627 NCBI chr 4:10,784,934...10,793,832
Ensembl chr 4:10,786,114...10,793,651
JBrowse link
G Atp10d ATPase phospholipid transporting 10D (putative) multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ATP10D mRNA CTD PMID:36139627 NCBI chr14:35,911,728...36,012,549
Ensembl chr14:35,912,141...36,012,564
JBrowse link
G Atp13a3 ATPase 13A3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ATP13A3 mRNA CTD PMID:36139627 NCBI chr11:70,364,998...70,442,005
Ensembl chr11:70,365,322...70,441,235
JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ATP2A3 mRNA CTD PMID:36139627 NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748
JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ATP6V0D2 mRNA CTD PMID:36139627 NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354
JBrowse link
G Avil advillin multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of AVIL mRNA CTD PMID:36139627 NCBI chr 7:62,825,459...62,844,103
Ensembl chr 7:62,826,025...62,844,071
JBrowse link
G Bach2 BTB domain and CNC homolog 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of BACH2 mRNA CTD PMID:36139627 NCBI chr 5:46,632,338...46,982,676
Ensembl chr 5:46,638,317...46,977,877
JBrowse link
G Bambi BMP and activin membrane-bound inhibitor multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of BAMBI mRNA CTD PMID:36139627 NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060
JBrowse link
G Barx2 BARX homeobox 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of BARX2 mRNA CTD PMID:36139627 NCBI chr 8:30,251,132...30,319,105
Ensembl chr 8:30,251,132...30,319,013
JBrowse link
G Batf3 basic leucine zipper ATF-like transcription factor 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of BATF3 mRNA CTD PMID:36139627 NCBI chr13:102,689,657...102,701,241
Ensembl chr13:102,689,657...102,701,139
JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions
increases expression
ISO [trametinib co-treated with omipalisib] results in increased expression of BCL2L11 protein
trametinib results in increased expression of BCL2L11 protein
CTD PMID:22733540 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bcl2l14 Bcl2-like 14 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of BCL2L14 mRNA CTD PMID:36139627 NCBI chr 4:167,217,561...167,258,723
Ensembl chr 4:167,219,871...167,258,086
JBrowse link
G Bco2 beta-carotene oxygenase 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of BCO2 mRNA CTD PMID:36139627 NCBI chr 8:50,882,174...50,907,676
Ensembl chr 8:50,882,181...50,915,467
JBrowse link
G Bex2 brain expressed X-linked 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of BEX2 mRNA CTD PMID:36139627 NCBI chr  X:99,219,015...99,220,411
Ensembl chr  X:99,219,014...99,220,958
JBrowse link
G Bicdl2 BICD family like cargo adaptor 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of BICDL2 mRNA CTD PMID:36139627 NCBI chr10:12,691,610...12,700,049
Ensembl chr10:12,691,610...12,700,049
JBrowse link
G Bin2 bridging integrator 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of BIN2 mRNA CTD PMID:36139627 NCBI chr 7:131,742,001...131,768,208
Ensembl chr 7:131,742,002...131,786,285
JBrowse link
G Blnk B-cell linker multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of BLNK mRNA CTD PMID:36139627 NCBI chr 1:239,753,640...239,821,113
Ensembl chr 1:239,753,648...239,821,113
JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of BMP6 mRNA CTD PMID:36139627 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Borcs8 BLOC-1 related complex subunit 8 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of BORCS8 mRNA CTD PMID:36139627 NCBI chr16:19,274,305...19,280,969
Ensembl chr16:19,274,023...19,280,339
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase multiple interactions ISO betulin affects the reaction [BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]]; BRAF protein affects the reaction [[APS-2-79 results in increased susceptibility to trametinib] which results in increased phosphorylation of MAPK1 protein]; BRAF protein affects the reaction [[APS-2-79 results in increased susceptibility to trametinib] which results in increased phosphorylation of MAPK3 protein]; BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]; fatostatin affects the reaction [BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the cleavage of SREBF1 protein]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the expression of ACACA mRNA]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the expression of ACLY mRNA]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the expression of FASN mRNA]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the phosphorylation of MAPK1 protein]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the phosphorylation of MAPK3 protein] CTD PMID:27556948 PMID:29950559 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Btc betacellulin multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of BTC mRNA CTD PMID:36139627 NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049
JBrowse link
G Btg2 BTG anti-proliferation factor 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of BTG2 mRNA CTD PMID:36139627 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
JBrowse link
G C13h1orf116 similar to human chromosome 1 open reading frame 116 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of C1ORF116 mRNA CTD PMID:36139627 NCBI chr13:42,187,442...42,201,432
Ensembl chr13:42,188,609...42,201,426
JBrowse link
G C16h4orf47 similar to human chromosome 4 open reading frame 47 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of C4ORF47 mRNA CTD PMID:36139627 NCBI chr16:46,291,075...46,315,616
Ensembl chr16:46,291,311...46,315,625
JBrowse link
G C1r complement C1r multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of C1R mRNA CTD PMID:36139627 NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484
JBrowse link
G C1s complement C1s multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of C1S mRNA CTD PMID:36139627 NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303
JBrowse link
G C7 complement C7 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of C7 mRNA CTD PMID:36139627 NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CACNA1D mRNA CTD PMID:36139627 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CACNA1F mRNA CTD PMID:36139627 NCBI chr  X:14,868,096...14,896,413
Ensembl chr  X:14,868,024...14,896,413
JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CACNB4 mRNA CTD PMID:36139627 NCBI chr 3:36,906,771...37,169,191
Ensembl chr 3:36,910,427...37,168,944
JBrowse link
G Calb2 calbindin 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CALB2 mRNA CTD PMID:36139627 NCBI chr19:38,114,435...38,141,438
Ensembl chr19:38,114,424...38,141,438
JBrowse link
G Capn12 calpain 12 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CAPN12 mRNA CTD PMID:36139627 NCBI chr 1:84,171,059...84,183,161
Ensembl chr 1:84,171,059...84,183,119
JBrowse link
G Capn8 calpain 8 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CAPN8 mRNA CTD PMID:36139627 NCBI chr13:94,252,218...94,316,146
Ensembl chr13:94,253,054...94,316,146
JBrowse link
G Car9 carbonic anhydrase 9 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CA9 mRNA CTD PMID:36139627 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
JBrowse link
G Casp1 caspase 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CASP1 mRNA CTD PMID:36139627 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP3 protein; trametinib promotes the reaction [physapubescin B results in increased expression of CASP3 protein modified form] CTD PMID:22733540 PMID:33035574 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions ISO [GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP7 protein CTD PMID:22733540 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp9 caspase 9 multiple interactions ISO trametinib promotes the reaction [physapubescin B results in increased expression of CASP9 protein modified form] CTD PMID:33035574 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Catspere catsper channel auxiliary subunit epsilon multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CATSPERE mRNA CTD PMID:36139627 NCBI chr13:89,799,669...89,954,723
Ensembl chr13:89,819,244...89,950,979
JBrowse link
G Ccdc110 coiled-coil domain containing 110 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CCDC110 mRNA CTD PMID:36139627 NCBI chr16:46,315,745...46,337,050
Ensembl chr16:46,315,745...46,337,021
JBrowse link
G Ccdc87 coiled-coil domain containing 87 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CCDC87 mRNA CTD PMID:36139627 NCBI chr 1:202,135,021...202,137,717
Ensembl chr 1:202,134,963...202,138,337
JBrowse link
G Ccdc89 coiled-coil domain containing 89 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CCDC89 mRNA CTD PMID:36139627 NCBI chr 1:144,386,252...144,387,514
Ensembl chr 1:144,386,158...144,389,850
JBrowse link
G Ccdc96 coiled-coil domain containing 96 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CCDC96 mRNA CTD PMID:36139627 NCBI chr14:74,276,568...74,279,072
Ensembl chr14:74,276,960...74,278,888
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CCL22 mRNA CTD PMID:36139627 NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO trametinib promotes the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA]; trametinib promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA] CTD PMID:25780039 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccm2l CCM2 like scaffold protein multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CCM2L mRNA CTD PMID:36139627 NCBI chr 3:141,533,470...141,549,136
Ensembl chr 3:141,533,511...141,549,140
JBrowse link
G Ccne2 cyclin E2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CCNE2 mRNA CTD PMID:36139627 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CCR1 mRNA CTD PMID:36139627 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Cd22 CD22 molecule multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CD22 mRNA CTD PMID:36139627 NCBI chr 1:86,116,376...86,132,782
Ensembl chr 1:86,117,459...86,132,322
JBrowse link
G Cd274 CD274 molecule multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CD274 mRNA CTD PMID:36139627 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450
JBrowse link
G Cd72 Cd72 molecule multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CD72 mRNA CTD PMID:36139627 NCBI chr 5:57,697,361...57,704,980
Ensembl chr 5:57,697,367...57,704,725
JBrowse link
G Cd74 CD74 molecule multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CD74 mRNA CTD PMID:36139627 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
JBrowse link
G Cd82 Cd82 molecule multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CD82 mRNA CTD PMID:36139627 NCBI chr 3:79,387,361...79,431,847
Ensembl chr 3:79,385,887...79,431,809
JBrowse link
G Cdcp1 CUB domain containing protein 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CDCP1 mRNA CTD PMID:36139627 NCBI chr 8:122,828,685...122,865,345
Ensembl chr 8:122,828,685...122,865,388
JBrowse link
G Cdh15 cadherin 15 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CDH15 mRNA CTD PMID:36139627 NCBI chr19:50,903,757...50,927,151
Ensembl chr19:50,903,638...50,927,105
JBrowse link
G Cdh3 cadherin 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CDH3 mRNA CTD PMID:36139627 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CDKN1A mRNA CTD PMID:36139627 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CDKN1C mRNA CTD PMID:36139627 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
JBrowse link
G Cenps centromere protein S multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CENPS mRNA CTD PMID:36139627 NCBI chr 5:159,563,917...159,573,534 JBrowse link
G Cfap45 cilia and flagella associated protein 45 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CFAP45 mRNA CTD PMID:36139627 NCBI chr13:84,989,474...85,012,880
Ensembl chr13:84,981,728...85,012,878
JBrowse link
G Cfap92 cilia and flagella associated protein 92 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CFAP92 mRNA CTD PMID:36139627 NCBI chr 4:120,126,565...120,181,575
Ensembl chr 4:120,126,567...120,181,546
JBrowse link
G Cfh complement factor H multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CFH mRNA CTD PMID:36139627 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
G Chd7 chromodomain helicase DNA binding protein 7 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CHD7 mRNA CTD PMID:36139627 NCBI chr 5:21,812,007...21,995,358
Ensembl chr 5:21,812,070...21,995,358
JBrowse link
G Chgb chromogranin B multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CHGB mRNA CTD PMID:36139627 NCBI chr 3:120,043,824...120,057,169
Ensembl chr 3:120,043,738...120,057,166
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CHRM4 mRNA CTD PMID:36139627 NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CHRNA10 mRNA CTD PMID:36139627 NCBI chr 1:156,487,279...156,494,277
Ensembl chr 1:156,487,279...156,491,476
JBrowse link
G Ciart circadian associated repressor of transcription multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CIART mRNA CTD PMID:36139627 NCBI chr 2:183,419,819...183,424,845
Ensembl chr 2:183,419,819...183,423,313
JBrowse link
G Cldn9 claudin 9 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CLDN9 mRNA CTD PMID:36139627 NCBI chr10:12,714,137...12,715,568 JBrowse link
G Cnih2 cornichon family AMPA receptor auxiliary protein 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CNIH2 mRNA CTD PMID:36139627 NCBI chr 1:202,399,416...202,405,110
Ensembl chr 1:202,399,419...202,405,089
JBrowse link
G Col13a1 collagen type XIII alpha 1 chain multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of COL13A1 mRNA CTD PMID:36139627 NCBI chr20:29,783,965...29,924,116
Ensembl chr20:29,783,965...29,924,032
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of COL1A2 mRNA CTD PMID:36139627 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Col5a3 collagen type V alpha 3 chain multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of COL5A3 mRNA CTD PMID:36139627 NCBI chr 8:19,304,564...19,349,809
Ensembl chr 8:19,304,571...19,349,853
JBrowse link
G Col6a3 collagen type VI alpha 3 chain multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of COL6A3 mRNA CTD PMID:36139627 NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471
JBrowse link
G Col9a2 collagen type IX alpha 2 chain multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of COL9A2 mRNA CTD PMID:36139627 NCBI chr 5:134,607,616...134,624,678
Ensembl chr 5:134,607,616...134,624,677
JBrowse link
G Colq collagen like tail subunit of asymmetric acetylcholinesterase multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of COLQ mRNA CTD PMID:36139627 NCBI chr16:6,731,850...6,824,973
Ensembl chr16:6,731,858...6,787,107
JBrowse link
G Cpe carboxypeptidase E multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CPE mRNA CTD PMID:36139627 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233
JBrowse link
G Cracr2b calcium release activated channel regulator 2B multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CRACR2B mRNA CTD PMID:36139627 NCBI chr 1:196,558,407...196,563,961
Ensembl chr 1:196,558,588...196,563,771
JBrowse link
G Creb3l1 cAMP responsive element binding protein 3-like 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CREB3L1 mRNA CTD PMID:36139627 NCBI chr 3:77,952,589...77,993,513
Ensembl chr 3:77,952,540...77,993,456
JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CREB3L3 mRNA CTD PMID:36139627 NCBI chr 7:8,622,614...8,631,053
Ensembl chr 7:8,622,614...8,631,048
JBrowse link
G Creg2 cellular repressor of E1A-stimulated genes 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CREG2 mRNA CTD PMID:36139627 NCBI chr 9:41,872,000...41,945,413
Ensembl chr 9:41,902,304...41,945,095
JBrowse link
G Crybg1 crystallin beta-gamma domain containing 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CRYBG1 mRNA CTD PMID:36139627 NCBI chr20:47,425,030...47,496,918
Ensembl chr20:47,426,183...47,621,392
JBrowse link
G Crym crystallin, mu multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CRYM mRNA CTD PMID:36139627 NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633
JBrowse link
G Csad cysteine sulfinic acid decarboxylase multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CSAD mRNA CTD PMID:36139627 NCBI chr 7:133,308,571...133,337,914
Ensembl chr 7:133,308,574...133,337,615
JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CSF3 mRNA CTD PMID:36139627 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
JBrowse link
G Ctsc cathepsin C multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CTSC mRNA CTD PMID:36139627 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
JBrowse link
G Ctsl cathepsin L multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CTSL mRNA CTD PMID:36139627 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Ctso cathepsin O multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CTSO mRNA CTD PMID:36139627 NCBI chr 2:167,230,407...167,254,761
Ensembl chr 2:167,230,330...167,253,702
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CX3CL1 mRNA CTD PMID:36139627 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO trametinib promotes the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; trametinib promotes the reaction [Poly I-C results in increased expression of CXCL10 mRNA] CTD PMID:25780039 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CYP26B1 mRNA CTD PMID:36139627 NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DDIT4L mRNA CTD PMID:36139627 NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375
JBrowse link
G Ddx60 DEXD/H-box helicase 60 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of DDX60 mRNA CTD PMID:36139627 NCBI chr16:28,077,000...28,197,903
Ensembl chr16:28,076,999...28,179,526
JBrowse link
G Dennd3 DENN domain containing 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DENND3 mRNA CTD PMID:36139627 NCBI chr 7:105,415,870...105,473,583
Ensembl chr 7:105,415,677...105,473,592
JBrowse link
G Depp1 DEPP autophagy regulator 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DEPP1 mRNA CTD PMID:36139627 NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
JBrowse link
G Deptor DEP domain containing MTOR-interacting protein multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DEPTOR mRNA CTD PMID:36139627 NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773
JBrowse link
G Dhrs2 dehydrogenase/reductase 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of DHRS2 mRNA CTD PMID:36139627 NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644
JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of DIO2 mRNA CTD PMID:36139627 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DKK3 mRNA CTD PMID:36139627 NCBI chr 1:166,237,969...166,281,271
Ensembl chr 1:166,238,238...166,280,590
JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DLC1 mRNA CTD PMID:36139627 NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439
JBrowse link
G Dmkn dermokine multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DMKN mRNA CTD PMID:36139627 NCBI chr 1:86,013,237...86,031,243
Ensembl chr 1:86,014,188...86,030,006
JBrowse link
G Dnaaf8 dynein axonemal assembly factor 8 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of DNAAF8 mRNA CTD PMID:36139627 NCBI chr10:10,600,747...10,614,891
Ensembl chr10:10,600,734...10,614,891
JBrowse link
G Dnah11 dynein, axonemal, heavy chain 11 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DNAH11 mRNA CTD PMID:36139627 NCBI chr 6:138,839,175...139,155,554
Ensembl chr 6:138,839,177...139,155,536
JBrowse link
G Doc2b double C2 domain beta multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DOC2B mRNA CTD PMID:36139627 NCBI chr10:60,628,029...60,653,267
Ensembl chr10:60,628,029...60,653,267
JBrowse link
G Dok3 docking protein 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DOK3 mRNA CTD PMID:36139627 NCBI chr17:9,109,633...9,115,188
Ensembl chr17:9,109,597...9,115,188
JBrowse link
G Drc3 dynein regulatory complex subunit 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of DRC3 mRNA CTD PMID:36139627 NCBI chr10:45,149,094...45,200,659
Ensembl chr10:45,157,354...45,199,369
JBrowse link
G Duox1 dual oxidase 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of DUOX1 mRNA CTD PMID:36139627 NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563
JBrowse link
G Duox2 dual oxidase 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DUOX2 mRNA CTD PMID:36139627 NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902
JBrowse link
G Duoxa1 dual oxidase maturation factor 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DUOXA1 mRNA CTD PMID:36139627 NCBI chr 3:109,249,815...109,260,511
Ensembl chr 3:109,249,923...109,260,499
JBrowse link
G Dusp4 dual specificity phosphatase 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DUSP4 mRNA CTD PMID:36139627 NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
JBrowse link
G Dusp5 dual specificity phosphatase 5 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DUSP5 mRNA CTD PMID:36139627 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
JBrowse link
G Dusp6 dual specificity phosphatase 6 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DUSP6 mRNA CTD PMID:36139627 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G E2f2 E2F transcription factor 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of E2F2 mRNA CTD PMID:36139627 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
JBrowse link
G E2f7 E2F transcription factor 7 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of E2F7 mRNA CTD PMID:36139627 NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734
JBrowse link
G Efemp2 EGF containing fibulin extracellular matrix protein 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of EFEMP2 mRNA CTD PMID:36139627 NCBI chr 1:202,781,692...202,789,784
Ensembl chr 1:202,781,665...202,789,414
JBrowse link
G Efna3 ephrin A3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of EFNA3 mRNA CTD PMID:36139627 NCBI chr 2:174,729,192...174,738,111
Ensembl chr 2:174,729,764...174,738,736
JBrowse link
G Egf epidermal growth factor multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of EGF mRNA CTD PMID:36139627 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Eif4e3 eukaryotic translation initiation factor 4E family member 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of EIF4E3 mRNA CTD PMID:36139627 NCBI chr 4:132,258,502...132,301,808
Ensembl chr 4:132,258,502...132,301,808
JBrowse link
G Elf5 E74 like ETS transcription factor 5 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ELF5 mRNA CTD PMID:36139627 NCBI chr 3:89,808,836...89,836,977
Ensembl chr 3:89,797,880...89,836,973
JBrowse link
G Elmod1 ELMO domain containing 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ELMOD1 mRNA CTD PMID:36139627 NCBI chr 8:54,298,363...54,355,348
Ensembl chr 8:54,298,363...54,355,140
JBrowse link
G Eno2 enolase 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ENO2 mRNA CTD PMID:36139627 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
JBrowse link
G Eno4 enolase 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ENO4 mRNA CTD PMID:36139627 NCBI chr 1:258,096,406...258,119,811
Ensembl chr 1:258,096,432...258,128,984
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ENPP1 mRNA CTD PMID:36139627 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
JBrowse link
G Entpd2 ectonucleoside triphosphate diphosphohydrolase 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ENTPD2 mRNA CTD PMID:36139627 NCBI chr 3:8,213,575...8,219,094
Ensembl chr 3:8,213,663...8,226,866
JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of EPAS1 mRNA CTD PMID:36139627 NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Epha3 Eph receptor A3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of EPHA3 mRNA CTD PMID:36139627 NCBI chr11:1,138,485...1,474,102
Ensembl chr11:1,140,985...1,473,900
JBrowse link
G Epha8 Eph receptor A8 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of EPHA8 mRNA CTD PMID:36139627 NCBI chr 5:149,166,107...149,193,498
Ensembl chr 5:149,166,697...149,193,399
JBrowse link
G Eppk1 epiplakin 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of EPPK1 mRNA CTD PMID:36139627 NCBI chr 7:107,816,919...107,842,946
Ensembl chr 7:107,817,693...107,831,159
JBrowse link
G Erap1 endoplasmic reticulum aminopeptidase 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ERAP1 mRNA CTD PMID:36139627 NCBI chr 2:3,931,817...3,970,735
Ensembl chr 2:3,931,904...3,972,447
JBrowse link
G Erfl ETS repressor factor like multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ERFL mRNA CTD PMID:36139627 NCBI chr 1:80,521,378...80,526,262
Ensembl chr 1:80,521,854...80,526,262
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ERO1A mRNA CTD PMID:36139627 NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
JBrowse link
G Esrp1 epithelial splicing regulatory protein 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ESRP1 mRNA CTD PMID:36139627 NCBI chr 5:24,427,611...24,482,157
Ensembl chr 5:24,428,717...24,482,062
JBrowse link
G Etv2 ETS variant transcription factor 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ETV2 mRNA CTD PMID:36139627 NCBI chr 1:85,890,562...85,894,025
Ensembl chr 1:85,890,559...85,893,431
JBrowse link
G Etv4 ETS variant transcription factor 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ETV4 mRNA CTD PMID:36139627 NCBI chr10:86,706,749...86,721,974
Ensembl chr10:86,706,749...86,721,974
JBrowse link
G Evi2a ecotropic viral integration site 2A multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of EVI2A mRNA CTD PMID:36139627 NCBI chr10:64,485,760...64,489,660
Ensembl chr10:64,485,200...64,489,843
JBrowse link
G Exoc3l1 exocyst complex component 3-like 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of EXOC3L1 mRNA CTD PMID:36139627 NCBI chr19:33,166,836...33,174,371
Ensembl chr19:33,166,837...33,172,486
JBrowse link
G Exoc3l4 exocyst complex component 3-like 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of EXOC3L4 mRNA CTD PMID:36139627 NCBI chr 6:130,452,680...130,466,684
Ensembl chr 6:130,452,661...130,466,683
JBrowse link
G Exph5 exophilin 5 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of EXPH5 mRNA CTD PMID:36139627 NCBI chr 8:53,698,825...53,775,371
Ensembl chr 8:53,698,852...53,773,169
JBrowse link
G F2rl1 F2R like trypsin receptor 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of F2RL1 mRNA CTD PMID:36139627 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
JBrowse link
G Fam107b family with sequence similarity 107, member B multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of FAM107B mRNA CTD PMID:36139627 NCBI chr17:74,478,608...74,685,027
Ensembl chr17:74,478,608...74,684,989
JBrowse link
G Fam166a family with sequence similarity 166, member A multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of FAM166A mRNA CTD PMID:36139627 NCBI chr 3:8,030,548...8,038,370
Ensembl chr 3:8,033,246...8,037,961
JBrowse link
G Fam186b family with sequence similarity 186, member B multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of FAM186B mRNA CTD PMID:36139627 NCBI chr 7:130,408,830...130,424,261
Ensembl chr 7:130,408,830...130,424,261
JBrowse link
G Fam241a family with sequence similarity 241 member A multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FAM241A mRNA CTD PMID:36139627 NCBI chr 2:216,344,563...216,375,193
Ensembl chr 2:216,343,822...216,375,242
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the expression of FASN mRNA] CTD PMID:29950559 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fat2 FAT atypical cadherin 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of FAT2 mRNA CTD PMID:36139627 NCBI chr10:39,364,072...39,456,324
Ensembl chr10:39,364,073...39,456,216
JBrowse link
G Fbxo36 F-box protein 36 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FBXO36 mRNA CTD PMID:36139627 NCBI chr 9:86,042,522...86,107,220
Ensembl chr 9:86,040,862...86,107,229
JBrowse link
G Fdxr ferredoxin reductase multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of FDXR mRNA CTD PMID:36139627 NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658
JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FGF19 mRNA CTD PMID:36139627 NCBI chr 1:200,056,656...200,059,944
Ensembl chr 1:200,056,644...200,060,287
JBrowse link
G Fhip1a FHF complex subunit HOOK interacting protein 1A multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FHIP1A mRNA CTD PMID:36139627 NCBI chr 2:171,016,951...171,265,715
Ensembl chr 2:171,021,246...171,265,848
JBrowse link
G Flacc1 flagellum associated containing coiled-coil domains 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FLACC1 mRNA CTD PMID:36139627 NCBI chr 9:60,315,581...60,343,692
Ensembl chr 9:60,315,582...60,343,648
JBrowse link
G Flnc filamin C multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FLNC mRNA CTD PMID:36139627 NCBI chr 4:58,034,088...58,061,882
Ensembl chr 4:58,034,189...58,061,844
JBrowse link
G Fmn1 formin 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FMN1 mRNA CTD PMID:36139627 NCBI chr 3:100,101,103...100,485,652
Ensembl chr 3:100,134,549...100,479,220
JBrowse link
G Fndc11 fibronectin type III domain containing 11 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FNDC11 mRNA CTD PMID:36139627 NCBI chr 3:168,330,607...168,333,111
Ensembl chr 3:168,330,602...168,334,617
JBrowse link
G Foxd4 forkhead box D4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of FOXD4 mRNA CTD PMID:36139627 NCBI chr 1:222,557,494...222,559,189
Ensembl chr 1:222,557,360...222,559,159
JBrowse link
G Foxq1 forkhead box Q1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FOXQ1 mRNA CTD PMID:36139627 NCBI chr17:32,912,744...32,915,377
Ensembl chr17:32,912,744...32,915,377
Ensembl chr17:32,912,744...32,915,377
JBrowse link
G Frmd4b FERM domain containing 4B multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FRMD4B mRNA CTD PMID:36139627 NCBI chr 4:129,895,401...130,222,070
Ensembl chr 4:129,895,708...130,084,197
JBrowse link
G Fscn1 fascin actin-bundling protein 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FSCN1 mRNA CTD PMID:36139627 NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211
JBrowse link
G Fut11 fucosyltransferase 11 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FUT11 mRNA CTD PMID:36139627 NCBI chr15:3,598,768...3,602,328
Ensembl chr15:3,598,758...3,602,356
JBrowse link
G Fyb2 FYN binding protein 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of FYB2 mRNA CTD PMID:36139627 NCBI chr 5:119,677,116...119,800,911
Ensembl chr 5:119,677,204...119,800,910
JBrowse link
G Gab2 GRB2-associated binding protein 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GAB2 mRNA CTD PMID:36139627 NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GAD1 mRNA CTD PMID:36139627 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gal3st1 galactose-3-O-sulfotransferase 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GAL3ST1 mRNA CTD PMID:36139627 NCBI chr14:78,868,049...78,886,402
Ensembl chr14:78,870,793...78,886,388
JBrowse link
G Galnt7 polypeptide N-acetylgalactosaminyltransferase 7 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of GALNT7 mRNA CTD PMID:36139627 NCBI chr16:32,578,643...32,703,189
Ensembl chr16:32,578,690...32,702,690
JBrowse link
G Gas6 growth arrest specific 6 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of GAS6 mRNA CTD PMID:36139627 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
JBrowse link
G Gask1b golgi associated kinase 1B multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GASK1B mRNA CTD PMID:36139627 NCBI chr 2:165,047,689...165,112,479
Ensembl chr 2:165,047,684...165,112,477
JBrowse link
G Gbp2 guanylate binding protein 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GBP2 mRNA CTD PMID:36139627 NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571
JBrowse link
G Gckr glucokinase regulator multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GCKR mRNA CTD PMID:36139627 NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
JBrowse link
G Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GCNT3 mRNA CTD PMID:36139627 NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562
JBrowse link
G Gdap1 ganglioside-induced differentiation-associated-protein 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of GDAP1 mRNA CTD PMID:36139627 NCBI chr 5:1,932,613...1,951,691
Ensembl chr 5:1,932,613...2,030,061
JBrowse link
G Ghr growth hormone receptor multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of GHR mRNA CTD PMID:36139627 NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735
JBrowse link
G Gipc3 GIPC PDZ domain containing family, member 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GIPC3 mRNA CTD PMID:36139627 NCBI chr 7:8,374,941...8,383,281 JBrowse link
G Gipr gastric inhibitory polypeptide receptor multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GIPR mRNA CTD PMID:36139627 NCBI chr 1:78,804,287...78,814,462
Ensembl chr 1:78,805,593...78,814,462
JBrowse link
G Gjb3 gap junction protein, beta 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GJB3 mRNA CTD PMID:36139627 NCBI chr 5:139,649,227...139,655,083
Ensembl chr 5:139,649,195...139,654,980
JBrowse link
G Gjb4 gap junction protein, beta 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GJB4 mRNA CTD PMID:36139627 NCBI chr 5:139,675,776...139,679,551
Ensembl chr 5:139,675,780...139,679,667
JBrowse link
G Gldc glycine decarboxylase multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GLDC mRNA CTD PMID:36139627 NCBI chr 1:227,883,247...227,962,119
Ensembl chr 1:227,883,249...227,962,097
JBrowse link
G Glul glutamate-ammonia ligase multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GLUL mRNA CTD PMID:36139627 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Gna11 G protein subunit alpha 11 increases response to substance ISO GNA11 protein mutant form results in increased susceptibility to trametinib CTD PMID:22733540 NCBI chr 7:8,163,752...8,177,636
Ensembl chr 7:8,162,750...8,179,812
JBrowse link
G Gnaq G protein subunit alpha q multiple interactions
increases response to substance
ISO [GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP3 protein; [GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP7 protein; GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]
GNAQ protein mutant form results in increased susceptibility to trametinib
CTD PMID:22733540 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
JBrowse link
G Gpnmb glycoprotein nmb multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GPNMB mRNA CTD PMID:36139627 NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
JBrowse link
G Gpr146 G protein-coupled receptor 146 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GPR146 mRNA CTD PMID:36139627 NCBI chr12:15,251,936...15,267,217
Ensembl chr12:15,251,813...15,267,206
JBrowse link
G Gpr37l1 G protein-coupled receptor 37-like 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of GPR37L1 mRNA CTD PMID:36139627 NCBI chr13:46,598,574...46,605,421
Ensembl chr13:46,598,578...46,605,421
JBrowse link
G Gpr39 G protein-coupled receptor 39 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of GPR39 mRNA CTD PMID:36139627 NCBI chr13:37,115,258...37,327,312
Ensembl chr13:37,115,102...37,328,267
JBrowse link
G Gpr87 G protein-coupled receptor 87 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GPR87 mRNA CTD PMID:36139627 NCBI chr 2:143,439,741...143,440,901
Ensembl chr 2:143,439,735...143,458,190
JBrowse link
G Gramd1b GRAM domain containing 1B multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GRAMD1B mRNA CTD PMID:36139627 NCBI chr 8:40,654,492...40,893,869
Ensembl chr 8:40,659,182...40,893,925
JBrowse link
G Grb7 growth factor receptor bound protein 7 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GRB7 mRNA CTD PMID:36139627 NCBI chr10:83,443,387...83,453,057
Ensembl chr10:83,444,004...83,453,052
JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GRIN2D mRNA CTD PMID:36139627 NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793
JBrowse link
G Gsdmc gasdermin C multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of GSDMC mRNA CTD PMID:36139627 NCBI chr 7:95,594,015...95,606,106
Ensembl chr 7:95,594,015...95,611,344
JBrowse link
G Gtf2ird2 GTF2I repeat domain containing 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of GTF2IRD2 mRNA CTD PMID:36139627 NCBI chr12:22,498,360...22,551,293
Ensembl chr12:22,498,091...22,536,263
JBrowse link
G Guca1b guanylate cyclase activator 1B multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GUCA1B mRNA CTD PMID:36139627 NCBI chr 9:13,599,619...13,607,455
Ensembl chr 9:13,599,619...13,607,455
JBrowse link
G H1f2 H1.2 linker histone, cluster member multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of H1-2 mRNA CTD PMID:36139627 NCBI chr17:41,391,106...41,392,611
Ensembl chr17:41,388,477...41,392,635
JBrowse link
G Hal histidine ammonia lyase multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HAL mRNA CTD PMID:36139627 NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
JBrowse link
G Hapln2 hyaluronan and proteoglycan link protein 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HAPLN2 mRNA CTD PMID:36139627 NCBI chr 2:173,488,909...173,496,824
Ensembl chr 2:173,491,160...173,496,588
JBrowse link
G Has3 hyaluronan synthase 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HAS3 mRNA CTD PMID:36139627 NCBI chr19:34,768,421...34,782,170
Ensembl chr19:34,771,982...34,782,592
JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HBEGF mRNA CTD PMID:36139627 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
JBrowse link
G Hecw2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HECW2 mRNA CTD PMID:36139627 NCBI chr 9:55,359,462...55,753,106
Ensembl chr 9:55,365,203...55,580,327
JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HERC6 mRNA CTD PMID:36139627 NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HEY1 mRNA CTD PMID:36139627 NCBI chr 2:93,096,706...93,100,316
Ensembl chr 2:93,095,498...93,100,312
JBrowse link
G Heyl hes-related family bHLH transcription factor with YRPW motif-like multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HEYL mRNA CTD PMID:36139627 NCBI chr 5:135,508,160...135,525,152
Ensembl chr 5:135,508,160...135,525,152
JBrowse link
G Hic1 HIC ZBTB transcriptional repressor 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HIC1 mRNA CTD PMID:36139627 NCBI chr10:60,014,520...60,019,475
Ensembl chr10:60,011,528...60,019,475
JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HILPDA mRNA CTD PMID:36139627 NCBI chr 4:57,871,076...57,875,206
Ensembl chr 4:57,871,110...57,874,557
JBrowse link
G Hist1h2ah histone cluster 1 H2A family member H multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of H2AC11 mRNA CTD PMID:36139627 NCBI chr17:41,384,521...41,385,018 JBrowse link
G Hivep2 HIVEP zinc finger 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HIVEP2 mRNA CTD PMID:36139627 NCBI chr 1:8,358,205...8,555,993
Ensembl chr 1:8,359,289...8,555,993
JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HK2 mRNA CTD PMID:36139627 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
JBrowse link
G Hkdc1 hexokinase domain containing 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HKDC1 mRNA CTD PMID:36139627 NCBI chr20:30,335,322...30,373,792
Ensembl chr20:30,335,628...30,373,867
JBrowse link
G Hoga1 4-hydroxy-2-oxoglutarate aldolase 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HOGA1 mRNA CTD PMID:36139627 NCBI chr 1:240,856,991...240,884,243
Ensembl chr 1:240,857,126...240,884,568
JBrowse link
G Hoxa13 homeo box A13 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HOXA13 mRNA CTD PMID:36139627 NCBI chr 4:81,358,956...81,361,091
Ensembl chr 4:81,358,956...81,361,091
JBrowse link
G Hoxb9 homeo box B9 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HOXB9 mRNA CTD PMID:36139627 NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818
JBrowse link
G Hoxc4 homeo box C4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HOXC4 mRNA CTD PMID:36139627 NCBI chr 7:134,135,279...134,173,133
Ensembl chr 7:134,170,591...134,173,133
JBrowse link
G Hpcal4 hippocalcin-like 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HPCAL4 mRNA CTD PMID:36139627 NCBI chr 5:135,454,477...135,466,417
Ensembl chr 5:135,454,540...135,466,416
JBrowse link
G Hs3st3b1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HS3ST3B1 mRNA CTD PMID:36139627 NCBI chr10:48,561,473...48,593,970
Ensembl chr10:48,561,473...48,593,970
JBrowse link
G Hsd17b14 hydroxysteroid (17-beta) dehydrogenase 14 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HSD17B14 mRNA CTD PMID:36139627 NCBI chr 1:96,029,290...96,039,088
Ensembl chr 1:96,029,284...96,039,883
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HSPA1A mRNA CTD PMID:36139627 NCBI chr20:3,870,765...3,873,221 JBrowse link
G Htra1 HtrA serine peptidase 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HTRA1 mRNA CTD PMID:36139627 NCBI chr 1:185,497,815...185,547,380
Ensembl chr 1:185,497,735...185,547,379
JBrowse link
G Hunk hormonally upregulated Neu-associated kinase multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HUNK mRNA CTD PMID:36139627 NCBI chr11:29,641,051...29,758,392
Ensembl chr11:29,640,775...29,757,526
JBrowse link
G Hyal1 hyaluronidase 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HYAL1 mRNA CTD PMID:36139627 NCBI chr 8:108,250,654...108,254,526
Ensembl chr 8:108,250,667...108,260,210
JBrowse link
G Ifi35 interferon-induced protein 35 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of IFI35 mRNA CTD PMID:36139627 NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO trametinib promotes the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; trametinib promotes the reaction [Poly I-C results in increased expression of IFNB1 mRNA] CTD PMID:25780039 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ifnlr1 interferon, lambda receptor 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of IFNLR1 mRNA CTD PMID:36139627 NCBI chr 5:147,919,547...147,942,328
Ensembl chr 5:147,919,908...147,942,332
JBrowse link
G Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of IGF2BP3 mRNA CTD PMID:36139627 NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of IGFBP1 mRNA CTD PMID:36139627 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of IL1B mRNA CTD PMID:36139627 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rapl1 interleukin 1 receptor accessory protein-like 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of IL1RAPL1 mRNA CTD PMID:36139627 NCBI chr  X:51,371,969...52,876,726
Ensembl chr  X:51,378,215...52,876,772
JBrowse link
G Il6r interleukin 6 receptor multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of IL6R mRNA CTD PMID:36139627 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Inka1 inka box actin regulator 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of INKA1 mRNA CTD PMID:36139627 NCBI chr 8:108,674,263...108,675,953
Ensembl chr 8:108,674,263...108,675,953
JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of INPP5D mRNA CTD PMID:36139627 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746
JBrowse link
G Insyn1 inhibitory synaptic factor 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of INSYN1 mRNA CTD PMID:36139627 NCBI chr 8:58,904,153...58,914,850
Ensembl chr 8:58,904,153...58,914,843
JBrowse link
G Iqank1 IQ motif and ankyrin repeat containing 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of IQANK1 mRNA CTD PMID:36139627 NCBI chr 7:107,724,962...107,759,163
Ensembl chr 7:107,724,997...107,759,162
JBrowse link
G Iqcn IQ motif containing N multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of IQCN mRNA CTD PMID:36139627 NCBI chr16:18,716,519...18,733,971
Ensembl chr16:18,716,519...18,726,261
JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of IRAK2 mRNA CTD PMID:36139627 NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602
JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of IRF1 mRNA CTD PMID:36139627 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO trametinib promotes the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein] CTD PMID:25780039 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
JBrowse link
G Ism2 isthmin 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ISM2 mRNA CTD PMID:36139627 NCBI chr 6:106,921,213...106,944,291
Ensembl chr 6:106,926,175...106,944,514
JBrowse link
G Itga10 integrin subunit alpha 10 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ITGA10 mRNA CTD PMID:36139627 NCBI chr 2:184,182,869...184,202,172
Ensembl chr 2:184,182,869...184,202,172
JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ITGA2 mRNA CTD PMID:36139627 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Itgax integrin subunit alpha X multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ITGAX mRNA CTD PMID:36139627 NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ITGB3 mRNA CTD PMID:36139627 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Itgb4 integrin subunit beta 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ITGB4 mRNA CTD PMID:36139627 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012
JBrowse link
G Jak3 Janus kinase 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of JAK3 mRNA CTD PMID:36139627 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
JBrowse link
G Jam2 junctional adhesion molecule 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of JAM2 mRNA CTD PMID:36139627 NCBI chr11:23,830,820...23,880,071
Ensembl chr11:23,831,106...23,880,063
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [omipalisib co-treated with trametinib] results in increased phosphorylation of JUN protein; JUN results in decreased susceptibility to [omipalisib co-treated with trametinib] CTD PMID:22733540 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of KCNJ4 mRNA CTD PMID:36139627 NCBI chr 7:111,047,097...111,074,151
Ensembl chr 7:111,047,094...111,074,151
JBrowse link
G Kcnk5 potassium two pore domain channel subfamily K member 5 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of KCNK5 mRNA CTD PMID:36139627 NCBI chr15:4,122,442...4,164,718
Ensembl chr15:4,122,442...4,164,718
JBrowse link
G Kdm7a lysine demethylase 7A multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of KDM7A mRNA CTD PMID:36139627 NCBI chr 4:67,899,407...67,974,264
Ensembl chr 4:67,904,307...67,966,998
JBrowse link
G Kiaa1755 KIAA1755 ortholog multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of KIAA1755 mRNA CTD PMID:36139627 NCBI chr 3:146,850,558...146,884,238
Ensembl chr 3:146,850,557...146,884,871
JBrowse link
G Kif17 kinesin family member 17 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of KIF17 mRNA CTD PMID:36139627 NCBI chr 5:150,482,288...150,521,471
Ensembl chr 5:150,481,578...150,519,638
JBrowse link
G Klf7 KLF transcription factor 7 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of KLF7 mRNA CTD PMID:36139627 NCBI chr 9:65,437,535...65,484,720
NCBI chr 9:65,433,683...65,526,372
Ensembl chr 9:65,437,167...65,526,261
JBrowse link
G Klhdc7a kelch domain containing 7A multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of KLHDC7A mRNA CTD PMID:36139627 NCBI chr 5:152,217,016...152,224,771
Ensembl chr 5:152,221,033...152,224,551
JBrowse link
G Klhdc7b kelch domain containing 7B multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of KLHDC7B mRNA CTD PMID:36139627 NCBI chr 7:120,452,081...120,456,094
Ensembl chr 7:120,453,932...120,455,737
JBrowse link
G Krt15 keratin 15 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of KRT15 mRNA CTD PMID:36139627 NCBI chr10:85,066,797...85,070,614
Ensembl chr10:85,066,802...85,171,799
JBrowse link
G Krt7 keratin 7 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of KRT7 mRNA CTD PMID:36139627 NCBI chr 7:132,528,863...132,545,052
Ensembl chr 7:132,528,895...132,545,052
JBrowse link
G Krt86 keratin 86 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of KRT86 mRNA CTD PMID:36139627 NCBI chr 7:132,591,489...132,598,142
Ensembl chr 7:132,591,545...132,598,021
JBrowse link
G Lad1 ladinin 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LAD1 mRNA CTD PMID:36139627 NCBI chr13:47,249,605...47,263,967
Ensembl chr13:47,249,605...47,263,967
JBrowse link
G Lama2 laminin subunit alpha 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LAMA2 mRNA CTD PMID:36139627 NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:17,672,536...18,320,530
JBrowse link
G Lama4 laminin subunit alpha 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LAMA4 mRNA CTD PMID:36139627 NCBI chr20:42,392,268...42,533,347
Ensembl chr20:42,392,268...42,533,347
JBrowse link
G Lamc2 laminin subunit gamma 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LAMC2 mRNA CTD PMID:36139627 NCBI chr13:65,284,664...65,344,200
Ensembl chr13:65,284,664...65,344,200
JBrowse link
G Laptm5 lysosomal protein transmembrane 5 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of LAPTM5 mRNA CTD PMID:36139627 NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807
JBrowse link
G Lat2 linker for activation of T cells family, member 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of LAT2 mRNA CTD PMID:36139627 NCBI chr12:22,104,163...22,118,294
Ensembl chr12:22,104,219...22,118,288
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LCP1 mRNA CTD PMID:36139627 NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LDLR mRNA CTD PMID:36139627 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Ldlrad1 low density lipoprotein receptor class A domain containing 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LDLRAD1 mRNA CTD PMID:36139627 NCBI chr 5:121,984,245...122,000,941
Ensembl chr 5:121,991,690...122,000,944
JBrowse link
G Ldlrad4 low density lipoprotein receptor class A domain containing 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of LDLRAD4 mRNA CTD PMID:36139627 NCBI chr18:61,519,253...61,848,403
Ensembl chr18:61,521,428...61,843,238
JBrowse link
G Lemd1 LEM domain containing 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LEMD1 mRNA CTD PMID:36139627 NCBI chr13:43,631,705...43,697,765
Ensembl chr13:43,665,926...43,697,948
JBrowse link
G Lgals9 galectin 9 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LGALS9 mRNA CTD PMID:36139627 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Lgi3 leucine-rich repeat LGI family, member 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LGI3 mRNA CTD PMID:36139627 NCBI chr15:45,605,611...45,612,739
Ensembl chr15:45,605,611...45,612,739
JBrowse link
G Lhx1 LIM homeobox 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LHX1 mRNA CTD PMID:36139627 NCBI chr10:69,396,829...69,403,617
Ensembl chr10:69,396,829...69,403,617
JBrowse link
G Lhx6 LIM homeobox 6 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LHX6 mRNA CTD PMID:36139627 NCBI chr 3:19,432,439...19,456,268
Ensembl chr 3:19,433,494...19,456,061
JBrowse link
G Lipg lipase G, endothelial type multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LIPG mRNA CTD PMID:36139627 NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260
JBrowse link
G Liph lipase H multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LIPH mRNA CTD PMID:36139627 NCBI chr11:79,032,229...79,081,625
Ensembl chr11:79,033,312...79,081,625
JBrowse link
G LOC103690190 histone H2A type 1-E multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of H2AC6 mRNA CTD PMID:36139627 NCBI chr17:42,707,863...42,708,420 JBrowse link
G LOC684841 similar to CG31613-PA multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of H3C10 mRNA CTD PMID:36139627
G LOC688553 hypothetical protein LOC688553 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of C7ORF57 mRNA CTD PMID:36139627 NCBI chr14:83,748,478...83,768,293
Ensembl chr14:83,748,478...83,767,435
JBrowse link
G Lonrf3 LON peptidase N-terminal domain and ring finger 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LONRF3 mRNA CTD PMID:36139627 NCBI chr  X:115,565,214...115,603,886
Ensembl chr  X:115,565,267...115,598,809
JBrowse link
G Lox lysyl oxidase multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LOX mRNA CTD PMID:36139627 NCBI chr18:45,964,311...46,041,477
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Lratd2 LRAT domain containing 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LRATD2 mRNA CTD PMID:36139627 NCBI chr 7:92,376,713...92,387,045
Ensembl chr 7:92,362,194...92,388,189
JBrowse link
G Lrrc37a leucine rich repeat containing 37A multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of LRRC37A3 mRNA CTD PMID:36139627 NCBI chr10:88,395,837...88,433,519
Ensembl chr10:88,396,663...88,433,323
JBrowse link
G Lsr lipolysis stimulated lipoprotein receptor multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of LSR mRNA CTD PMID:36139627 NCBI chr 1:86,185,769...86,201,952
Ensembl chr 1:86,186,431...86,201,952
JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of LTBP1 mRNA CTD PMID:36139627 NCBI chr 6:20,029,629...20,425,339
Ensembl chr 6:20,029,629...20,425,349
JBrowse link
G Ltbp2 latent transforming growth factor beta binding protein 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LTBP2 mRNA CTD PMID:36139627 NCBI chr 6:104,429,947...104,530,498
Ensembl chr 6:104,429,947...104,526,208
JBrowse link
G Lyst lysosomal trafficking regulator multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LYST mRNA CTD PMID:36139627 NCBI chr17:86,241,384...86,443,501
Ensembl chr17:86,241,384...86,443,480
JBrowse link
G Lzts1 leucine zipper tumor suppressor 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of LZTS1 mRNA CTD PMID:36139627 NCBI chr16:20,542,756...20,598,204
Ensembl chr16:20,542,809...20,598,203
JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MAD1L1 mRNA CTD PMID:36139627 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703
JBrowse link
G Maff MAF bZIP transcription factor F multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MAFF mRNA CTD PMID:36139627 NCBI chr 7:110,912,499...110,923,851
Ensembl chr 7:110,912,499...110,923,851
JBrowse link
G Map1a microtubule-associated protein 1A multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of MAP1A mRNA CTD PMID:36139627 NCBI chr 3:108,263,217...108,283,936
Ensembl chr 3:108,263,151...108,282,899
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO trametinib affects the expression of and affects the lipidation of MAP1LC3B protein CTD PMID:30339727 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 decreases response to substance
multiple interactions
ISO MAP2K1 protein mutant form results in decreased susceptibility to trametinib
[MAP2K1 protein mutant form results in decreased susceptibility to trametinib] inhibits the reaction [trametinib results in decreased phosphorylation of MAPK1 protein]; [MAP2K1 protein mutant form results in decreased susceptibility to trametinib] inhibits the reaction [trametinib results in decreased phosphorylation of MAPK3 protein]
CTD PMID:29768711 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map4k1 mitogen activated protein kinase kinase kinase kinase 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of MAP4K1 mRNA CTD PMID:36139627 NCBI chr 1:84,270,951...84,292,496
Ensembl chr 1:84,271,069...84,292,493
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO [APS-2-79 results in increased susceptibility to trametinib] which results in increased phosphorylation of MAPK1 protein; [MAP2K1 protein mutant form results in decreased susceptibility to trametinib] inhibits the reaction [trametinib results in decreased phosphorylation of MAPK1 protein]; [omipalisib co-treated with trametinib] results in decreased phosphorylation of MAPK1 protein; BRAF protein affects the reaction [[APS-2-79 results in increased susceptibility to trametinib] which results in increased phosphorylation of MAPK1 protein]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the phosphorylation of MAPK1 protein]; trametinib inhibits the reaction [physapubescin B results in increased phosphorylation of MAPK1 protein]
trametinib inhibits the reaction [camostat results in increased phosphorylation of MAPK1 protein]; trametinib inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; trametinib inhibits the reaction [Poly I-C results in increased phosphorylation of MAPK1 protein]
CTD PMID:22733540 PMID:25104499 PMID:25780039 PMID:27556948 PMID:29768711 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO [APS-2-79 results in increased susceptibility to trametinib] which results in increased phosphorylation of MAPK3 protein; [MAP2K1 protein mutant form results in decreased susceptibility to trametinib] inhibits the reaction [trametinib results in decreased phosphorylation of MAPK3 protein]; [omipalisib co-treated with trametinib] results in decreased phosphorylation of MAPK3 protein; BRAF protein affects the reaction [[APS-2-79 results in increased susceptibility to trametinib] which results in increased phosphorylation of MAPK3 protein]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the phosphorylation of MAPK3 protein]; trametinib inhibits the reaction [physapubescin B results in increased phosphorylation of MAPK3 protein]
trametinib inhibits the reaction [camostat results in increased phosphorylation of MAPK3 protein]; trametinib inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; trametinib inhibits the reaction [Poly I-C results in increased phosphorylation of MAPK3 protein]
CTD PMID:22733540 PMID:25104499 PMID:25780039 PMID:27556948 PMID:29768711 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Marchf4 membrane associated ring-CH-type finger 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MARCHF4 mRNA CTD PMID:36139627 NCBI chr 9:74,078,437...74,196,070
Ensembl chr 9:74,078,434...74,198,199
JBrowse link
G Mast4 microtubule associated serine/threonine kinase family member 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MAST4 mRNA CTD PMID:36139627 NCBI chr 2:33,893,241...34,483,600
Ensembl chr 2:33,894,436...34,483,723
JBrowse link
G Matn2 matrilin 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of MATN2 mRNA CTD PMID:36139627 NCBI chr 7:65,494,996...65,644,613
Ensembl chr 7:65,494,834...65,645,113
JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MCTP1 mRNA CTD PMID:36139627 NCBI chr 2:6,071,408...6,761,833
Ensembl chr 2:6,065,808...6,761,833
JBrowse link
G Mdga1 MAM domain containing glycosylphosphatidylinositol anchor 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of MDGA1 mRNA CTD PMID:36139627 NCBI chr20:7,900,327...7,963,471
Ensembl chr20:7,904,358...7,963,471
JBrowse link
G Meis1 Meis homeobox 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of MEIS1 mRNA CTD PMID:36139627 NCBI chr14:93,155,426...93,294,373
Ensembl chr14:93,155,419...93,294,265
JBrowse link
G Mest mesoderm specific transcript multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of MEST mRNA CTD PMID:36139627 NCBI chr 4:59,354,445...59,364,919
Ensembl chr 4:59,354,447...59,366,145
JBrowse link
G MGC105649 hypothetical LOC302884 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of C15ORF48 mRNA CTD PMID:36139627 NCBI chr 3:109,719,952...109,723,507
Ensembl chr 3:109,719,897...109,724,006
Ensembl chr 3:109,719,897...109,724,006
JBrowse link
G MGC94891 hypothetical protein LOC681210 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of C6ORF118 mRNA CTD PMID:36139627 NCBI chr 1:51,740,328...51,764,041
Ensembl chr 1:51,740,330...51,763,989
JBrowse link
G Mid1 midline 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MID1 mRNA CTD PMID:36139627 NCBI chr  X:24,116,674...24,491,205
Ensembl chr  X:24,120,293...24,248,353
JBrowse link
G Milr1 mast cell immunoglobulin-like receptor 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MILR1 mRNA CTD PMID:36139627 NCBI chr10:91,684,288...91,705,284
Ensembl chr10:91,687,831...91,705,282
JBrowse link
G Mlph melanophilin multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MLPH mRNA CTD PMID:36139627 NCBI chr 9:91,507,410...91,542,984
Ensembl chr 9:91,507,591...91,542,983
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MMP1 mRNA CTD PMID:36139627 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp12 matrix metallopeptidase 12 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MMP12 mRNA CTD PMID:36139627 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MMP13 mRNA CTD PMID:36139627 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MMP14 mRNA CTD PMID:36139627 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mmp19 matrix metallopeptidase 19 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of MMP19 mRNA CTD PMID:36139627 NCBI chr 7:1,221,229...1,229,555
Ensembl chr 7:1,221,343...1,229,555
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MMP3 mRNA CTD PMID:36139627 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MMP9 mRNA CTD PMID:36139627 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Morn3 MORN repeat containing 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MORN3 mRNA CTD PMID:36139627 NCBI chr12:33,505,654...33,529,918
Ensembl chr12:33,514,230...33,529,931
JBrowse link
G Mpzl2 myelin protein zero-like 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of MPZL2 mRNA CTD PMID:36139627 NCBI chr 8:45,348,285...45,359,298
Ensembl chr 8:45,348,285...45,359,298
JBrowse link
G Mrap2 melanocortin 2 receptor accessory protein 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of MRAP2 mRNA CTD PMID:36139627 NCBI chr 8:88,088,293...88,144,636
Ensembl chr 8:88,088,272...88,143,886
JBrowse link
G Muc3a mucin 3A, cell surface associated multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MUC3A mRNA CTD PMID:36139627 NCBI chr12:19,455,783...19,462,165
Ensembl chr12:19,446,094...19,460,522
JBrowse link
G Muc5b mucin 5B, oligomeric mucus/gel-forming multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MUC5B mRNA CTD PMID:36139627 NCBI chr 1:196,916,861...196,948,830
Ensembl chr 1:196,916,825...196,949,250
JBrowse link
G Mybph myosin binding protein H multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MYBPH mRNA CTD PMID:36139627 NCBI chr13:45,653,156...45,660,893
Ensembl chr13:45,653,234...45,660,893
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO trametinib results in decreased expression of MYC protein CTD PMID:22733540 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myh15 myosin, heavy chain 15 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MYH15 mRNA CTD PMID:36139627 NCBI chr11:51,621,924...51,763,037
Ensembl chr11:51,622,413...51,762,971
JBrowse link
G Myo10 myosin X multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MYO10 mRNA CTD PMID:36139627 NCBI chr 2:76,100,962...76,304,164
Ensembl chr 2:76,100,987...76,303,030
JBrowse link
G Myo15a myosin XVA multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MYO15A mRNA CTD PMID:36139627 NCBI chr10:45,277,619...45,335,953
Ensembl chr10:45,278,737...45,335,340
JBrowse link
G Myo15b myosin XVB multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MYO15B mRNA CTD PMID:36139627 NCBI chr10:101,088,904...101,126,159
Ensembl chr10:101,104,209...101,125,693
JBrowse link
G Myo5c myosin VC multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of MYO5C mRNA CTD PMID:36139627 NCBI chr 8:75,989,497...76,066,485
Ensembl chr 8:75,989,528...76,066,483
JBrowse link
G Myo7b myosin VIIb multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MYO7B mRNA CTD PMID:36139627 NCBI chr18:23,588,307...23,669,841
Ensembl chr18:23,588,307...23,669,809
JBrowse link
G N4bp3 Nedd4 binding protein 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of N4BP3 mRNA CTD PMID:36139627 NCBI chr10:35,898,031...35,906,704
Ensembl chr10:35,899,096...35,907,001
JBrowse link
G Nav3 neuron navigator 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NAV3 mRNA CTD PMID:36139627 NCBI chr 7:45,052,206...45,840,471
Ensembl chr 7:45,054,296...45,840,698
JBrowse link
G Ndrg1 N-myc downstream regulated 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NDRG1 mRNA CTD PMID:36139627 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
JBrowse link
G Ndrg4 NDRG family member 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NDRG4 mRNA CTD PMID:36139627 NCBI chr19:9,351,408...9,387,398
Ensembl chr19:9,351,404...9,386,914
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NDUFV2 mRNA CTD PMID:36139627 NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of NEDD9 mRNA CTD PMID:36139627 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019
JBrowse link
G Nes nestin multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NES mRNA CTD PMID:36139627 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Neurl3 neuralized E3 ubiquitin protein ligase 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NEURL3 mRNA CTD PMID:36139627 NCBI chr 9:38,494,486...38,503,352
Ensembl chr 9:38,494,489...38,502,649
JBrowse link
G Ngef neuronal guanine nucleotide exchange factor multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NGEF mRNA CTD PMID:36139627 NCBI chr 9:88,146,956...88,244,454
Ensembl chr 9:88,146,956...88,244,914
JBrowse link
G Ngfr nerve growth factor receptor increases expression
affects response to substance
ISO trametinib results in increased expression of NGFR protein
NGFR protein affects the susceptibility to trametinib
CTD PMID:30339727 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nhsl1 NHS-like 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NHSL1 mRNA CTD PMID:36139627 NCBI chr 1:12,956,525...13,188,580
Ensembl chr 1:12,956,021...13,187,547
JBrowse link
G Nhsl2 NHS-like 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NHSL2 mRNA CTD PMID:36139627 NCBI chr  X:66,969,953...67,209,464
Ensembl chr  X:66,970,151...67,200,911
JBrowse link
G Nim1k NIM1 serine/threonine protein kinase multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NIM1K mRNA CTD PMID:36139627 NCBI chr 2:51,670,764...51,714,782
Ensembl chr 2:51,670,772...51,714,762
JBrowse link
G Nipal4 NIPA-like domain containing 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NIPAL4 mRNA CTD PMID:36139627 NCBI chr10:30,583,926...30,600,640
Ensembl chr10:30,583,926...30,600,640
JBrowse link
G Nkx2-1 NK2 homeobox 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NKX2-1 mRNA CTD PMID:36139627 NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791
JBrowse link
G Nlgn1 neuroligin 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NLGN1 mRNA CTD PMID:36139627 NCBI chr 2:108,256,236...109,181,530
Ensembl chr 2:108,257,824...109,002,464
JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NLRP1 mRNA CTD PMID:36139627 NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180
JBrowse link
G Nmnat2 nicotinamide nucleotide adenylyltransferase 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of NMNAT2 mRNA CTD PMID:36139627 NCBI chr13:65,105,950...65,277,350
Ensembl chr13:65,105,950...65,278,484
JBrowse link
G Nog noggin multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NOG mRNA CTD PMID:36139627 NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339
JBrowse link
G Notch4 notch receptor 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NOTCH4 mRNA CTD PMID:36139627 NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465
JBrowse link
G Npas1 neuronal PAS domain protein 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NPAS1 mRNA CTD PMID:36139627 NCBI chr 1:77,167,375...77,187,887
Ensembl chr 1:77,167,381...77,186,762
JBrowse link
G Npb neuropeptide B multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of NPB mRNA CTD PMID:36139627 NCBI chr10:105,883,992...105,887,689
Ensembl chr10:105,874,708...105,887,254
JBrowse link
G Npr3 natriuretic peptide receptor 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NPR3 mRNA CTD PMID:36139627 NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955
JBrowse link
G Nptx1 neuronal pentraxin 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NPTX1 mRNA CTD PMID:36139627 NCBI chr10:104,811,107...104,820,358
Ensembl chr10:104,811,403...104,820,367
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NR1D1 mRNA CTD PMID:36139627 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NR3C2 mRNA CTD PMID:36139627 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Nrep neuronal regeneration related protein multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NREP mRNA CTD PMID:36139627 NCBI chr18:25,017,069...25,046,564
Ensembl chr18:25,017,083...25,046,591
JBrowse link
G Nrp1 neuropilin 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of NRP1 mRNA CTD PMID:36139627 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
JBrowse link
G Nrp2 neuropilin 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NRP2 mRNA CTD PMID:36139627 NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958
JBrowse link
G Nt5e 5' nucleotidase, ecto multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NT5E mRNA CTD PMID:36139627 NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881
JBrowse link
G Ntsr1 neurotensin receptor 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NTSR1 mRNA CTD PMID:36139627 NCBI chr 3:167,606,215...167,656,377
Ensembl chr 3:167,606,215...167,656,377
JBrowse link
G Nyap1 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NYAP1 mRNA CTD PMID:36139627 NCBI chr12:18,956,192...18,967,624
Ensembl chr12:18,956,268...18,967,543
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of OAS1 mRNA CTD PMID:36139627 NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517
JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of OAS3 mRNA CTD PMID:36139627 NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of OASL mRNA CTD PMID:36139627 NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641
JBrowse link
G Obscn obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of OBSCN mRNA CTD PMID:36139627 NCBI chr10:43,774,113...43,919,718
Ensembl chr10:43,789,293...43,919,723
JBrowse link
G Onecut3 one cut homeobox 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ONECUT3 mRNA CTD PMID:36139627 NCBI chr 7:9,217,917...9,219,011
Ensembl chr 7:9,200,035...9,219,158
Ensembl chr 7:9,200,035...9,219,158
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of OSGIN1 mRNA CTD PMID:36139627 NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
JBrowse link
G P2rx6 purinergic receptor P2X 6 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of P2RX6 mRNA CTD PMID:36139627 NCBI chr11:83,439,922...83,450,449
Ensembl chr11:83,439,924...83,450,481
JBrowse link
G P3h2 prolyl 3-hydroxylase 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of P3H2 mRNA CTD PMID:36139627 NCBI chr11:74,634,267...74,775,422
Ensembl chr11:74,634,267...74,775,421
JBrowse link
G Pag1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PAG1 mRNA CTD PMID:36139627 NCBI chr 2:91,935,378...92,076,937
Ensembl chr 2:92,057,216...92,069,849
JBrowse link
G Paqr5 progestin and adipoQ receptor family member 5 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PAQR5 mRNA CTD PMID:36139627 NCBI chr 8:62,431,867...62,513,688
Ensembl chr 8:62,431,867...62,513,688
JBrowse link
G Paqr9 progestin and adipoQ receptor family member 9 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PAQR9 mRNA CTD PMID:36139627 NCBI chr 8:96,114,249...96,116,546 JBrowse link
G Pbld1 phenazine biosynthesis-like protein domain containing 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PBLD mRNA CTD PMID:36139627 NCBI chr20:25,551,274...25,566,543
Ensembl chr20:25,551,275...25,565,614
JBrowse link
G Pcdhb19 protocadherin beta 19 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PCDHB12 mRNA CTD PMID:36139627 NCBI chr18:29,203,188...29,207,632 JBrowse link
G Pde2a phosphodiesterase 2A multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PDE2A mRNA CTD PMID:36139627 NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434
JBrowse link
G Pdp2 pyruvate dehydrogenase phosphatase catalytic subunit 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PDP2 mRNA CTD PMID:36139627 NCBI chr19:386,408...394,068
Ensembl chr19:386,406...394,074
JBrowse link
G Per1 period circadian regulator 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PER1 mRNA CTD PMID:36139627 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
JBrowse link
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PFKFB4 mRNA CTD PMID:36139627 NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634
JBrowse link
G Pfn4 profilin family, member 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PFN4 mRNA CTD PMID:36139627 NCBI chr 6:27,786,619...27,796,710
Ensembl chr 6:27,786,619...27,796,710
JBrowse link
G Pgbd5 piggyBac transposable element derived 5 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PGBD5 mRNA CTD PMID:36139627 NCBI chr19:52,336,751...52,401,906
Ensembl chr19:52,336,751...52,402,397
JBrowse link
G Phlda2 pleckstrin homology-like domain, family A, member 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PHLDA2 mRNA CTD PMID:36139627 NCBI chr 1:198,696,897...198,699,292
Ensembl chr 1:198,696,897...198,697,836
JBrowse link
G Phospho1 phosphoethanolamine/phosphocholine phosphatase 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PHOSPHO1 mRNA CTD PMID:36139627 NCBI chr10:80,762,062...80,769,596
Ensembl chr10:80,760,792...80,770,342
JBrowse link
G Phtf1 putative homeodomain transcription factor 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PHTF1 mRNA CTD PMID:36139627 NCBI chr 2:191,470,849...191,537,399
Ensembl chr 2:191,473,130...191,512,078
JBrowse link
G Phyhip phytanoyl-CoA 2-hydroxylase interacting protein multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PHYHIP mRNA CTD PMID:36139627 NCBI chr15:45,533,974...45,545,223
Ensembl chr15:45,533,974...45,545,221
JBrowse link
G Piezo2 piezo-type mechanosensitive ion channel component 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PIEZO2 mRNA CTD PMID:36139627 NCBI chr18:56,468,449...56,844,984
Ensembl chr18:56,469,680...56,844,216
JBrowse link
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PIK3IP1 mRNA CTD PMID:36139627 NCBI chr14:78,203,539...78,216,616
Ensembl chr14:78,204,053...78,216,608
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PIK3R3 mRNA CTD PMID:36139627 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583
JBrowse link
G Piwil2 piwi-like RNA-mediated gene silencing 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PIWIL2 mRNA CTD PMID:36139627 NCBI chr15:45,431,402...45,498,034
Ensembl chr15:45,431,703...45,497,702
JBrowse link
G Pkd1l2 polycystin 1 like 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PKD1L2 mRNA CTD PMID:36139627 NCBI chr19:45,049,713...45,136,503
Ensembl chr19:45,049,719...45,135,532
JBrowse link
G Plac1 placenta enriched 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PLAC1 mRNA CTD PMID:36139627 NCBI chr  X:132,821,347...132,955,143
Ensembl chr  X:132,821,347...132,985,668
JBrowse link
G Plag1 PLAG1 zinc finger multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PLAG1 mRNA CTD PMID:36139627 NCBI chr 5:16,902,057...16,956,727
Ensembl chr 5:16,905,394...16,913,647
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PLAT mRNA CTD PMID:36139627 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PLAUR mRNA CTD PMID:36139627 NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595
JBrowse link
G Plcxd3 phosphatidylinositol-specific phospholipase C, X domain containing 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PLCXD3 mRNA CTD PMID:36139627 NCBI chr 2:53,567,022...53,746,384
Ensembl chr 2:53,567,022...53,746,384
JBrowse link
G Pld1 phospholipase D1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PLD1 mRNA CTD PMID:36139627 NCBI chr 2:110,849,205...111,047,692
Ensembl chr 2:110,893,608...111,047,692
JBrowse link
G Plek2 pleckstrin 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PLEK2 mRNA CTD PMID:36139627 NCBI chr 6:97,700,123...97,719,417
Ensembl chr 6:97,701,106...97,719,326
JBrowse link
G Plin1 perilipin 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PLIN1 mRNA CTD PMID:36139627 NCBI chr 1:133,664,294...133,676,854
Ensembl chr 1:133,664,892...133,676,828
JBrowse link
G Plin4 perilipin 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PLIN4 mRNA CTD PMID:36139627 NCBI chr 9:929,168...938,062
Ensembl chr 9:929,176...938,056
JBrowse link
G Plxna2 plexin A2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PLXNA2 mRNA CTD PMID:36139627 NCBI chr13:106,163,103...106,358,979
Ensembl chr13:106,163,103...106,358,979
JBrowse link
G Podxl podocalyxin-like multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PODXL mRNA CTD PMID:36139627 NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899
JBrowse link
G Pou2f2 POU class 2 homeobox 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of POU2F2 mRNA CTD PMID:36139627 NCBI chr 1:80,682,330...80,769,756
Ensembl chr 1:80,685,741...80,724,261
JBrowse link
G Pou2f3 POU class 2 homeobox 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of POU2F3 mRNA CTD PMID:36139627 NCBI chr 8:43,495,408...43,577,795
Ensembl chr 8:43,495,527...43,577,795
JBrowse link
G Pou6f1 POU class 6 homeobox 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of POU6F1 mRNA CTD PMID:36139627 NCBI chr 7:131,677,719...131,700,869
Ensembl chr 7:131,680,141...131,686,843
JBrowse link
G Ppfia3 PTPRF interacting protein alpha 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PPFIA3 mRNA CTD PMID:36139627 NCBI chr 1:95,817,110...95,845,950
Ensembl chr 1:95,817,110...95,845,798
JBrowse link
G Ppm1n protein phosphatase, Mg2+/Mn2+ dependent 1N multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PPM1N mRNA CTD PMID:36139627 NCBI chr 1:78,929,350...78,934,435
Ensembl chr 1:78,929,351...78,932,685
JBrowse link
G Ppp1r16b protein phosphatase 1, regulatory subunit 16B multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PPP1R16B mRNA CTD PMID:36139627 NCBI chr 3:147,323,652...147,419,658
Ensembl chr 3:147,324,126...147,418,937
JBrowse link
G Prag1 PEAK1 related kinase activating pseudokinase 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PRAG1 mRNA CTD PMID:36139627 NCBI chr16:56,087,885...56,141,153
Ensembl chr16:56,087,885...56,141,153
JBrowse link
G Prex1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PREX1 mRNA CTD PMID:36139627 NCBI chr 3:155,306,950...155,456,688
Ensembl chr 3:155,306,950...155,456,688
JBrowse link
G Prickle1 prickle planar cell polarity protein 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PRICKLE1 mRNA CTD PMID:36139627 NCBI chr 7:124,639,142...124,735,027
Ensembl chr 7:124,639,142...124,658,113
JBrowse link
G Prkg2 protein kinase cGMP-dependent 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PRKG2 mRNA CTD PMID:36139627 NCBI chr14:10,559,882...10,668,479
Ensembl chr14:10,559,882...10,666,888
JBrowse link
G Prnd prion like protein doppel multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PRND mRNA CTD PMID:36139627 NCBI chr 3:119,213,402...119,218,742
Ensembl chr 3:119,213,429...119,218,745
JBrowse link
G Prodh proline dehydrogenase multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PRODH mRNA CTD PMID:36139627 NCBI chr11:82,910,043...82,927,305
Ensembl chr11:82,910,137...82,927,305
JBrowse link
G Prodh2 proline dehydrogenase 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PRODH2 mRNA CTD PMID:36139627 NCBI chr 1:85,753,558...85,767,165
Ensembl chr 1:85,753,644...85,767,162
JBrowse link
G Prr5l proline rich 5 like multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PRR5L mRNA CTD PMID:36139627 NCBI chr 3:88,001,951...88,173,532
Ensembl chr 3:88,003,617...88,082,763
JBrowse link
G Prss22 serine protease 22 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PRSS22 mRNA CTD PMID:36139627 NCBI chr10:13,029,153...13,033,863
Ensembl chr10:13,029,153...13,033,863
JBrowse link
G Prss53 serine protease 53 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PRSS53 mRNA CTD PMID:36139627 NCBI chr 1:182,494,944...182,501,607
Ensembl chr 1:182,494,955...182,500,115
JBrowse link
G Prtn3 proteinase 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PRTN3 mRNA CTD PMID:36139627 NCBI chr 7:9,822,123...9,831,300
Ensembl chr 7:9,822,122...9,831,944
JBrowse link
G Psd3 pleckstrin and Sec7 domain containing 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PSD3 mRNA CTD PMID:36139627 NCBI chr16:21,465,643...22,035,846
Ensembl chr16:21,465,639...22,034,547
JBrowse link
G Psmb10 proteasome 20S subunit beta 10 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PSMB10 mRNA CTD PMID:36139627 NCBI chr19:33,830,958...33,833,442
Ensembl chr19:33,827,229...33,833,626
JBrowse link
G Psmb9 proteasome 20S subunit beta 9 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PSMB9 mRNA CTD PMID:36139627 NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512
JBrowse link
G Ptgir prostaglandin I2 receptor multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PTGIR mRNA CTD PMID:36139627 NCBI chr 1:77,579,596...77,581,979
Ensembl chr 1:77,579,596...77,581,979
JBrowse link
G Ptk6 protein tyrosine kinase 6 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PTK6 mRNA CTD PMID:36139627 NCBI chr 3:168,307,073...168,315,664
Ensembl chr 3:168,307,073...168,315,664
JBrowse link
G Pxmp2 peroxisomal membrane protein 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PXMP2 mRNA CTD PMID:36139627 NCBI chr12:46,394,051...46,404,561
Ensembl chr12:46,394,193...46,404,557
JBrowse link
G Pygb glycogen phosphorylase B multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PYGB mRNA CTD PMID:36139627 NCBI chr 3:139,611,724...139,658,521
Ensembl chr 3:139,611,749...139,663,553
JBrowse link
G Rab11fip4 RAB11 family interacting protein 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RAB11FIP4 mRNA CTD PMID:36139627 NCBI chr10:64,550,109...64,658,123
Ensembl chr10:64,550,177...64,654,759
JBrowse link
G Rab38 RAB38, member RAS oncogene family multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RAB38 mRNA CTD PMID:36139627 NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924
JBrowse link
G Rab39a RAB39A, member RAS oncogene family multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RAB39A mRNA CTD PMID:36139627 NCBI chr 8:54,088,744...54,105,756
Ensembl chr 8:54,088,129...54,106,483
JBrowse link
G Rab7b Rab7b, member RAS oncogene family multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RAB7B mRNA CTD PMID:36139627 NCBI chr13:43,121,168...43,147,581
Ensembl chr13:43,121,226...43,147,581
JBrowse link
G Rac2 Rac family small GTPase 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RAC2 mRNA CTD PMID:36139627 NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720
JBrowse link
G Rapgef5 Rap guanine nucleotide exchange factor 5 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RAPGEF5 mRNA CTD PMID:36139627 NCBI chr 6:138,445,127...138,679,943
Ensembl chr 6:138,437,991...138,679,936
JBrowse link
G Rasa4 RAS p21 protein activator 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RASA4B mRNA CTD PMID:36139627 NCBI chr12:20,552,805...20,580,177
Ensembl chr12:20,552,806...20,580,147
JBrowse link
G Rasl11a RAS-like family 11 member A multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of RASL11A mRNA CTD PMID:36139627 NCBI chr12:8,258,148...8,262,576
Ensembl chr12:8,258,159...8,262,576
JBrowse link
G Rassf9 Ras association domain family member 9 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RASSF9 mRNA CTD PMID:36139627 NCBI chr 7:37,599,720...37,631,553
Ensembl chr 7:37,599,720...37,635,245
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO trametinib results in decreased phosphorylation of RB1 protein CTD PMID:22733540 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Reep1 receptor accessory protein 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of REEP1 mRNA CTD PMID:36139627 NCBI chr 4:103,746,004...103,862,347
Ensembl chr 4:103,745,633...103,862,338
JBrowse link
G Rem2 RRAD and GEM like GTPase 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of REM2 mRNA CTD PMID:36139627 NCBI chr15:27,933,950...27,938,429
Ensembl chr15:27,933,950...27,938,429
JBrowse link
G RGD1562378 histone H4 variant H4-v.1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of H4C14 mRNA CTD PMID:36139627
G Rgmb repulsive guidance molecule BMP co-receptor b multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RGMB mRNA CTD PMID:36139627 NCBI chr 1:56,766,598...56,792,396
Ensembl chr 1:56,767,850...56,792,425
JBrowse link
G Ribc2 RIB43A domain with coiled-coils 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of RIBC2 mRNA CTD PMID:36139627 NCBI chr 7:116,242,863...116,257,868
Ensembl chr 7:116,242,863...116,257,863
JBrowse link
G Rimkla ribosomal modification protein rimK-like family member A multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RIMKLA mRNA CTD PMID:36139627 NCBI chr 5:133,072,179...133,098,840
Ensembl chr 5:133,073,960...133,098,792
JBrowse link
G Rnf182 ring finger protein 182 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RNF182 mRNA CTD PMID:36139627 NCBI chr17:21,026,110...21,081,760
Ensembl chr17:21,030,214...21,094,911
JBrowse link
G Rnf223 ring finger protein 223 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RNF223 mRNA CTD PMID:36139627 NCBI chr 5:166,720,408...166,726,236
Ensembl chr 5:166,724,984...166,725,751
JBrowse link
G Robo4 roundabout guidance receptor 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ROBO4 mRNA CTD PMID:36139627 NCBI chr 8:37,119,966...37,133,887
Ensembl chr 8:37,119,988...37,132,519
JBrowse link
G Ror2 receptor tyrosine kinase-like orphan receptor 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ROR2 mRNA CTD PMID:36139627 NCBI chr17:11,972,830...12,148,152
Ensembl chr17:11,972,830...12,148,152
JBrowse link
G Rora RAR-related orphan receptor A multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RORA mRNA CTD PMID:36139627 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO trametinib results in decreased phosphorylation of RPS6KB1 protein CTD PMID:22733540 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rragd Ras-related GTP binding D multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RRAGD mRNA CTD PMID:36139627 NCBI chr 5:47,373,902...47,409,369
Ensembl chr 5:47,373,463...47,409,356
JBrowse link
G Rspo1 R-spondin 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of RSPO1 mRNA CTD PMID:36139627 NCBI chr 5:137,251,629...137,273,273
Ensembl chr 5:137,251,659...137,272,933
JBrowse link
G RT1-Ha RT1 class II, locus Ha multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HLA-DPA1 mRNA CTD PMID:36139627 NCBI chr20:4,760,631...4,770,662
Ensembl chr20:4,760,118...4,770,244
JBrowse link
G Rtn2 reticulon 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RTN2 mRNA CTD PMID:36139627 NCBI chr 1:78,935,056...78,948,069
Ensembl chr 1:78,935,104...78,948,069
JBrowse link
G Rtp4 receptor (chemosensory) transporter protein 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of RTP4 mRNA CTD PMID:36139627 NCBI chr11:77,237,341...77,249,194
Ensembl chr11:77,238,216...77,335,437
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RUNX2 mRNA CTD PMID:36139627 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Rxfp4 relaxin family peptide/INSL5 receptor 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RXFP4 mRNA CTD PMID:36139627 NCBI chr 2:174,123,510...174,124,664 JBrowse link
G Ryr1 ryanodine receptor 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RYR1 mRNA CTD PMID:36139627 NCBI chr 1:84,292,578...84,423,799
Ensembl chr 1:84,292,578...84,423,812
JBrowse link
G S100a2 S100 calcium binding protein A2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of S100A2 mRNA CTD PMID:36139627 NCBI chr 2:176,075,060...176,078,782 JBrowse link
G Sall4 spalt-like transcription factor 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SALL4 mRNA CTD PMID:36139627 NCBI chr 3:157,474,067...157,491,055
Ensembl chr 3:157,474,642...157,490,822
JBrowse link
G Samd15 sterile alpha motif domain containing 15 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SAMD15 mRNA CTD PMID:36139627 NCBI chr 6:106,841,405...106,860,446
Ensembl chr 6:106,840,781...106,860,423
JBrowse link
G Samd9l1 sterile alpha motif domain containing 9 like 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SAMD9L mRNA CTD PMID:36139627 NCBI chr 4:31,362,054...31,376,412
Ensembl chr 4:31,361,669...31,376,415
JBrowse link
G Scarf1 scavenger receptor class F, member 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SCARF1 mRNA CTD PMID:36139627 NCBI chr10:60,359,213...60,371,516
Ensembl chr10:60,359,197...60,371,516
JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SCNN1B mRNA CTD PMID:36139627 NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451
JBrowse link
G Sdcbp2 syndecan binding protein 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SDCBP2 mRNA CTD PMID:36139627 NCBI chr 3:140,060,746...140,098,063
Ensembl chr 3:140,070,540...140,098,057
JBrowse link
G Sec14l2 SEC14-like lipid binding 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SEC14L2 mRNA CTD PMID:36139627 NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788
JBrowse link
G Sema3c semaphorin 3C multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SEMA3C mRNA CTD PMID:36139627 NCBI chr 4:17,583,212...17,747,234
Ensembl chr 4:17,583,212...17,746,534
JBrowse link
G Sema7a semaphorin 7A (John Milton Hagen blood group) multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SEMA7A mRNA CTD PMID:36139627 NCBI chr 8:58,348,448...58,370,536
Ensembl chr 8:58,348,448...58,370,536
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SERPINA3 mRNA CTD PMID:36139627 NCBI chr 6:123,323,632...123,331,166
Ensembl chr 6:123,323,629...123,332,433
JBrowse link
G Serpina5 serpin family A member 5 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SERPINA5 mRNA CTD PMID:36139627 NCBI chr 6:123,009,224...123,028,412
Ensembl chr 6:123,023,306...123,028,407
JBrowse link
G Serpinb8 serpin family B member 8 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SERPINB8 mRNA CTD PMID:36139627 NCBI chr13:23,626,945...23,650,270
Ensembl chr13:23,626,945...23,650,835
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SERPINE1 mRNA CTD PMID:36139627 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Serpine2 serpin family E member 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SERPINE2 mRNA CTD PMID:36139627 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
JBrowse link
G Serpini1 serpin family I member 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SERPINI1 mRNA CTD PMID:36139627 NCBI chr 2:160,346,403...160,433,135
Ensembl chr 2:160,346,758...160,433,135
JBrowse link
G Sfn stratifin multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SFN mRNA CTD PMID:36139627 Ensembl chr 5:145,826,201...145,831,314 JBrowse link
G Sfxn2 sideroflexin 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SFXN2 mRNA CTD PMID:36139627 NCBI chr 1:245,447,014...245,459,312
Ensembl chr 1:245,447,015...245,468,411
Ensembl chr 1:245,447,015...245,468,411
JBrowse link
G Sfxn3 sideroflexin 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SFXN3 mRNA CTD PMID:36139627 NCBI chr 1:243,907,958...243,917,065
Ensembl chr 1:243,907,751...243,917,073
JBrowse link
G Sh2d5 SH2 domain containing 5 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SH2D5 mRNA CTD PMID:36139627 NCBI chr 5:150,469,738...150,480,615
Ensembl chr 5:150,467,728...150,479,955
JBrowse link
G Sh3d21 SH3 domain containing 21 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SH3D21 mRNA CTD PMID:36139627 NCBI chr 5:138,429,180...138,444,540
Ensembl chr 5:138,429,180...138,444,407
JBrowse link
G Sh3tc2 SH3 domain and tetratricopeptide repeats 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SH3TC2 mRNA CTD PMID:36139627 NCBI chr18:55,416,383...55,477,419
Ensembl chr18:55,416,413...55,483,083
JBrowse link
G Shf Src homology 2 domain containing F multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SHF mRNA CTD PMID:36139627 NCBI chr 3:109,296,517...109,316,315
Ensembl chr 3:109,296,784...109,316,328
JBrowse link
G Siglec15 sialic acid binding Ig-like lectin 15 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SIGLEC15 mRNA CTD PMID:36139627 NCBI chr18:71,507,773...71,521,722
Ensembl chr18:71,505,399...71,521,881
JBrowse link
G Slc10a5 solute carrier family 10, member 5 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SLC10A5 mRNA CTD PMID:36139627 NCBI chr 2:91,457,540...91,458,844
Ensembl chr 2:91,444,454...91,489,651
JBrowse link
G Slc17a7 solute carrier family 17 member 7 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SLC17A7 mRNA CTD PMID:36139627 NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588
JBrowse link
G Slc2a3 solute carrier family 2 member 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SLC2A3 mRNA CTD PMID:36139627 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SLC47A2 mRNA CTD PMID:36139627 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Slc4a11 solute carrier family 4 member 11 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SLC4A11 mRNA CTD PMID:36139627 NCBI chr 3:117,900,223...117,912,787
Ensembl chr 3:117,900,223...117,912,674
JBrowse link
G Slc4a7 solute carrier family 4 member 7 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SLC4A7 mRNA CTD PMID:36139627 NCBI chr15:10,585,307...10,664,781
Ensembl chr15:10,588,979...10,664,781
JBrowse link
G Slc5a1 solute carrier family 5 member 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SLC5A1 mRNA CTD PMID:36139627 NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547
JBrowse link
G Slc6a9 solute carrier family 6 member 9 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SLC6A9 mRNA CTD PMID:36139627 NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
JBrowse link
G Slc9a3 solute carrier family 9 member A3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SLC9A3 mRNA CTD PMID:36139627 NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417
JBrowse link
G Slitrk3 SLIT and NTRK-like family, member 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SLITRK3 mRNA CTD PMID:36139627 NCBI chr 2:157,680,067...157,697,404
Ensembl chr 2:157,687,535...157,696,709
JBrowse link
G Smim5 small integral membrane protein 5 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SMIM5 mRNA CTD PMID:36139627 NCBI chr10:101,134,033...101,139,814
Ensembl chr10:101,134,033...101,139,813
JBrowse link
G Smoc2 SPARC related modular calcium binding 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SMOC2 mRNA CTD PMID:36139627 NCBI chr 1:55,262,472...55,391,804
Ensembl chr 1:55,262,530...55,391,693
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SMPD3 mRNA CTD PMID:36139627 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749
JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SNAI2 mRNA CTD PMID:36139627 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Snai3 snail family transcriptional repressor 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SNAI3 mRNA CTD PMID:36139627 NCBI chr19:50,516,771...50,529,295
Ensembl chr19:50,516,771...50,523,486
JBrowse link
G Socs2 suppressor of cytokine signaling 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SOCS2 mRNA CTD PMID:36139627 NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548
JBrowse link
G Spata18 spermatogenesis associated 18 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SPATA18 mRNA CTD PMID:36139627 NCBI chr14:34,531,931...34,558,671
Ensembl chr14:34,531,061...34,558,687
JBrowse link
G Spats2l spermatogenesis associated, serine-rich 2-like multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SPATS2L mRNA CTD PMID:36139627 NCBI chr 9:59,319,949...59,493,864
Ensembl chr 9:59,320,276...59,493,967
JBrowse link
G Spns3 sphingolipid transporter 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SPNS3 mRNA CTD PMID:36139627 NCBI chr10:57,114,247...57,169,056
Ensembl chr10:57,114,266...57,168,951
JBrowse link
G Spocd1 SPOC domain containing 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SPOCD1 mRNA CTD PMID:36139627 NCBI chr 5:142,288,822...142,297,113 JBrowse link
G Spon1 spondin 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SPON1 mRNA CTD PMID:36139627 NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226
JBrowse link
G Spsb1 splA/ryanodine receptor domain and SOCS box containing 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SPSB1 mRNA CTD PMID:36139627 NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468
JBrowse link
G Sptb spectrin, beta, erythrocytic multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SPTB mRNA CTD PMID:36139627 NCBI chr 6:95,310,342...95,437,221
Ensembl chr 6:95,310,326...95,437,118
JBrowse link
G Sptbn4 spectrin, beta, non-erythrocytic 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SPTBN4 mRNA CTD PMID:36139627 NCBI chr 1:82,650,750...82,738,345
Ensembl chr 1:82,650,751...82,737,228
JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO trametinib results in decreased expression of SQSTM1 protein CTD PMID:30339727 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the cleavage of SREBF1 protein] CTD PMID:29950559 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SRXN1 mRNA CTD PMID:36139627 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G St3gal1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ST3GAL1 mRNA CTD PMID:36139627 NCBI chr 7:98,845,270...98,913,409
Ensembl chr 7:98,845,270...98,913,236
JBrowse link
G Stambpl1 STAM binding protein-like 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of STAMBPL1 mRNA CTD PMID:36139627 NCBI chr 1:231,699,620...231,745,034
Ensembl chr 1:231,699,995...231,745,032
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation
multiple interactions
ISO trametinib results in increased phosphorylation of STAT3 protein
physapubescin B inhibits the reaction [trametinib results in increased phosphorylation of STAT3 protein]
CTD PMID:33035574 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stc1 stanniocalcin 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of STC1 mRNA CTD PMID:36139627 NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264
JBrowse link
G Stn1 STN1 subunit of CST complex multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of STN1 mRNA CTD PMID:36139627 NCBI chr 1:246,391,311...246,429,844
Ensembl chr 1:246,395,613...246,429,531
JBrowse link
G Stom stomatin multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of STOM mRNA CTD PMID:36139627 NCBI chr 3:18,645,058...18,667,343
Ensembl chr 3:18,644,378...18,667,354
JBrowse link
G Sulf2 sulfatase 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SULF2 mRNA CTD PMID:36139627 NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415
JBrowse link
G Sult2b1 sulfotransferase family 2B member 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SULT2B1 mRNA CTD PMID:36139627 NCBI chr 1:96,200,155...96,261,295
Ensembl chr 1:96,200,156...96,261,295
JBrowse link
G Sycp2 synaptonemal complex protein 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SYCP2 mRNA CTD PMID:36139627 NCBI chr 3:165,431,715...165,502,134
Ensembl chr 3:165,436,331...165,498,789
JBrowse link
G Sync syncoilin, intermediate filament protein multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SYNC mRNA CTD PMID:36139627 NCBI chr 5:141,631,837...141,656,184
Ensembl chr 5:141,632,367...141,688,659
JBrowse link
G Syne3 spectrin repeat containing, nuclear envelope family member 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SYNE3 mRNA CTD PMID:36139627 NCBI chr 6:123,872,895...123,964,773
Ensembl chr 6:123,873,174...123,953,409
JBrowse link
G Syt12 synaptotagmin 12 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SYT12 mRNA CTD PMID:36139627 NCBI chr 1:201,729,307...201,760,192
Ensembl chr 1:201,730,371...201,759,609
JBrowse link
G Syt5 synaptotagmin 5 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SYT5 mRNA CTD PMID:36139627 NCBI chr 1:69,277,351...69,285,071
Ensembl chr 1:69,277,351...69,285,067
JBrowse link
G Sytl2 synaptotagmin-like 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SYTL2 mRNA CTD PMID:36139627 NCBI chr 1:144,272,870...144,379,310
Ensembl chr 1:144,273,360...144,379,222
JBrowse link
G Tac3 tachykinin precursor 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TAC3 mRNA CTD PMID:36139627 NCBI chr 7:63,562,552...63,569,170
Ensembl chr 7:63,562,552...63,569,170
JBrowse link
G Tafa2 TAFA chemokine like family member 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TAFA2 mRNA CTD PMID:36139627 NCBI chr 7:58,942,598...59,418,640
Ensembl chr 7:58,942,610...59,417,299
JBrowse link
G Tapbpl TAP binding protein-like multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TAPBPL mRNA CTD PMID:36139627 NCBI chr 4:158,021,454...158,028,905 JBrowse link
G Tbx4 T-box transcription factor 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TBX4 mRNA CTD PMID:36139627 NCBI chr10:70,730,686...70,760,829
Ensembl chr10:70,731,163...70,760,825
JBrowse link
G Tcaf2 TRPM8 channel-associated factor 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TCAF2 mRNA CTD PMID:36139627
G Tchh trichohyalin multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TCHH mRNA CTD PMID:36139627 NCBI chr 2:179,105,246...179,112,014
Ensembl chr 2:179,109,609...179,110,985
Ensembl chr 2:179,109,609...179,110,985
JBrowse link
G Tex45 testis expressed 45 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TEX45 mRNA CTD PMID:36139627 NCBI chr12:1,520,983...1,538,127
Ensembl chr12:1,521,014...1,538,118
JBrowse link
G Tex9 testis expressed 9 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TEX9 mRNA CTD PMID:36139627 NCBI chr 8:73,168,519...73,213,935
Ensembl chr 8:73,177,810...73,214,261
JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TFPI2 mRNA CTD PMID:36139627 NCBI chr 4:31,981,786...31,986,707
Ensembl chr 4:31,982,178...31,986,600
JBrowse link
G Tfr2 transferrin receptor 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TFR2 mRNA CTD PMID:36139627 NCBI chr12:19,107,673...19,124,622
Ensembl chr12:19,107,673...19,124,591
JBrowse link
G Tjp3 tight junction protein 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TJP3 mRNA CTD PMID:36139627 NCBI chr 7:8,427,650...8,446,279
Ensembl chr 7:8,432,811...8,446,279
JBrowse link
G Tlcd1 TLC domain containing 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TLCD1 mRNA CTD PMID:36139627 NCBI chr10:63,074,469...63,076,502
Ensembl chr10:63,074,469...63,076,501
JBrowse link
G Tle6 TLE family member 6, subcortical maternal complex member multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TLE6 mRNA CTD PMID:36139627 NCBI chr 7:8,107,050...8,118,639
Ensembl chr 7:8,107,207...8,118,639
JBrowse link
G Tlr1 toll-like receptor 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TLR1 mRNA CTD PMID:36139627 NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TLR3 mRNA CTD PMID:36139627 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
JBrowse link
G Tlr6 toll-like receptor 6 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TLR6 mRNA CTD PMID:36139627 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685
JBrowse link
G Tm4sf19 transmembrane 4 L six family member 19 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TM4SF19 mRNA CTD PMID:36139627 NCBI chr11:68,372,945...68,386,192
Ensembl chr11:68,371,647...68,384,591
JBrowse link
G Tmc8 transmembrane channel-like 8 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TMC8 mRNA CTD PMID:36139627 NCBI chr10:103,000,038...103,010,601
Ensembl chr10:102,998,402...103,010,590
JBrowse link
G Tmem117 transmembrane protein 117 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TMEM117 mRNA CTD PMID:36139627 NCBI chr 7:125,757,591...126,219,692
Ensembl chr 7:125,757,591...126,219,690
JBrowse link
G Tmem144 transmembrane protein 144 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TMEM144 mRNA CTD PMID:36139627 NCBI chr 2:164,960,649...164,993,562
Ensembl chr 2:164,961,247...164,992,368
JBrowse link
G Tmem156 transmembrane protein 156 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TMEM156 mRNA CTD PMID:36139627 NCBI chr14:43,221,464...43,252,453
Ensembl chr14:43,223,381...43,252,449
JBrowse link
G Tmem158 transmembrane protein 158 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TMEM158 mRNA CTD PMID:36139627 NCBI chr 8:122,913,675...122,914,673
Ensembl chr 8:122,913,675...122,914,673
JBrowse link
G Tmem236 transmembrane protein 236 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TMEM236 mRNA CTD PMID:36139627 NCBI chr17:77,180,919...77,241,258
Ensembl chr17:77,188,163...77,238,671
JBrowse link
G Tmem25 transmembrane protein 25 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TMEM25 mRNA CTD PMID:36139627 NCBI chr 8:45,107,116...45,112,657
Ensembl chr 8:45,107,121...45,116,389
JBrowse link
G Tmem255b transmembrane protein 255B multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TMEM255B mRNA CTD PMID:36139627 NCBI chr16:76,079,840...76,108,179
Ensembl chr16:76,079,845...76,106,795
JBrowse link
G Tmem269 transmembrane protein 269 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TMEM269 mRNA CTD PMID:36139627 NCBI chr 5:132,817,324...132,836,360
Ensembl chr 5:132,817,324...132,829,977
JBrowse link
G Tmem270 transmembrane protein 270 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TMEM270 mRNA CTD PMID:36139627 NCBI chr12:21,793,631...21,798,723
Ensembl chr12:21,794,130...21,798,731
JBrowse link
G Tmem45a transmembrane protein 45A multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TMEM45A mRNA CTD PMID:36139627 NCBI chr11:43,713,309...43,799,526
Ensembl chr11:43,713,782...43,799,526
JBrowse link
G Tmem92 transmembrane protein 92 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TMEM92 mRNA CTD PMID:36139627 NCBI chr10:79,749,242...79,760,807 JBrowse link
G Tnfsf15 TNF superfamily member 15 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TNFSF15 mRNA CTD PMID:36139627 NCBI chr 5:77,140,099...77,156,142
Ensembl chr 5:77,139,878...77,156,228
JBrowse link
G Tnxb tenascin XB multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TNXB mRNA CTD PMID:36139627
G Tp53i3 tumor protein p53 inducible protein 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TP53I3 mRNA CTD PMID:36139627 NCBI chr 6:27,818,327...27,827,030 JBrowse link
G Tph1 tryptophan hydroxylase 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TPH1 mRNA CTD PMID:36139627 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
JBrowse link
G Trank1 tetratricopeptide repeat and ankyrin repeat containing 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TRANK1 mRNA CTD PMID:36139627 NCBI chr 8:111,275,973...111,355,491
Ensembl chr 8:111,276,354...111,355,092
JBrowse link
G Trib1 tribbles pseudokinase 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TRIB1 mRNA CTD PMID:36139627 NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731
JBrowse link
G Trib2 tribbles pseudokinase 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TRIB2 mRNA CTD PMID:36139627 NCBI chr 6:38,545,971...38,570,349
Ensembl chr 6:38,545,975...38,569,370
JBrowse link
G Trim29 tripartite motif-containing 29 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TRIM29 mRNA CTD PMID:36139627 NCBI chr 8:43,682,221...43,706,992
Ensembl chr 8:43,682,221...43,706,992
JBrowse link
G Trim63 tripartite motif containing 63 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TRIM63 mRNA CTD PMID:36139627 NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322
JBrowse link
G Trim9 tripartite motif-containing 9 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TRIM9 mRNA CTD PMID:36139627 NCBI chr 6:88,756,824...88,856,588
Ensembl chr 6:88,757,303...88,856,542
JBrowse link
G Trmt9b tRNA methyltransferase 9B (putative) multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TRMT9B mRNA CTD PMID:36139627 NCBI chr16:55,740,551...55,792,198
Ensembl chr16:55,743,018...55,792,144
JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TRPV2 mRNA CTD PMID:36139627 NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TSC22D3 mRNA CTD PMID:36139627 NCBI chr  X:104,217,898...104,277,935
Ensembl chr  X:104,217,925...104,276,861
JBrowse link
G Tsnaxip1 translin-associated factor X interacting protein 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TSNAXIP1 mRNA CTD PMID:36139627 NCBI chr19:33,716,834...33,734,824
Ensembl chr19:33,716,785...33,734,824
JBrowse link
G Ttc39a tetratricopeptide repeat domain 39A multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TTC39A mRNA CTD PMID:36139627 NCBI chr 5:124,165,102...124,204,973
Ensembl chr 5:124,151,760...124,204,973
JBrowse link
G Ttpa alpha tocopherol transfer protein multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TTPA mRNA CTD PMID:36139627 NCBI chr 5:33,497,537...33,518,936
Ensembl chr 5:33,497,137...33,518,073
JBrowse link
G Tuba1a tubulin, alpha 1A multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TUBA1A mRNA CTD PMID:36139627 NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186
JBrowse link
G Txk TXK tyrosine kinase multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TXK mRNA CTD PMID:36139627 NCBI chr14:35,463,369...35,519,448
Ensembl chr14:35,463,944...35,519,448
JBrowse link
G Uap1l1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of UAP1L1 mRNA CTD PMID:36139627 NCBI chr 3:8,172,335...8,180,505
Ensembl chr 3:8,173,216...8,180,443
JBrowse link
G Uba7 ubiquitin-like modifier activating enzyme 7 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of UBA7 mRNA CTD PMID:36139627 NCBI chr 8:108,665,289...108,674,099
Ensembl chr 8:108,665,292...108,674,099
JBrowse link
G Ufsp1 UFM1-specific peptidase 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of UFSP1 mRNA CTD PMID:36139627 Ensembl chr12:19,406,142...19,407,195 JBrowse link
G Uhrf2 ubiquitin like with PHD and ring finger domains 2 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of UHRF2 mRNA CTD PMID:36139627 NCBI chr 1:227,814,639...227,877,907
Ensembl chr 1:227,814,963...227,877,904
JBrowse link
G Upk1a uroplakin 1A multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of UPK1A mRNA CTD PMID:36139627 NCBI chr 1:85,859,671...85,870,670
Ensembl chr 1:85,859,671...85,870,354
JBrowse link
G Upk3b uroplakin 3B multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of UPK3B mRNA CTD PMID:36139627 NCBI chr12:20,629,491...20,638,193
Ensembl chr12:20,631,525...20,637,724
JBrowse link
G Ush1g USH1 protein network component sans multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of USH1G mRNA CTD PMID:36139627 NCBI chr10:100,559,721...100,563,590
Ensembl chr10:100,557,629...100,563,590
JBrowse link
G Vdr vitamin D receptor multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of VDR mRNA CTD PMID:36139627 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
G Veph1 ventricular zone expressed PH domain-containing 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of VEPH1 mRNA CTD PMID:36139627 NCBI chr 2:150,291,379...150,537,491
Ensembl chr 2:150,296,573...150,537,266
JBrowse link
G Vgf VGF nerve growth factor inducible multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of VGF mRNA CTD PMID:36139627 NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341
JBrowse link
G Vtn vitronectin multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of VTN mRNA CTD PMID:36139627 NCBI chr10:63,394,732...63,397,812
Ensembl chr10:63,394,719...63,397,810
JBrowse link
G Wasf3 WASP family member 3 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of WASF3 mRNA CTD PMID:36139627 NCBI chr12:8,563,805...8,660,799
Ensembl chr12:8,562,062...8,660,751
JBrowse link
G Wnt10b Wnt family member 10B multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of WNT10B mRNA CTD PMID:36139627 NCBI chr 7:129,922,088...129,927,892
Ensembl chr 7:129,922,088...129,927,892
JBrowse link
G Wnt11 Wnt family member 11 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of WNT11 mRNA CTD PMID:36139627 NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294
JBrowse link
G Wnt2b Wnt family member 2B multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of WNT2B mRNA CTD PMID:36139627 NCBI chr 2:192,454,226...192,468,599
Ensembl chr 2:192,453,824...192,470,308
JBrowse link
G Wnt4 Wnt family member 4 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of WNT4 mRNA CTD PMID:36139627 NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859
JBrowse link
G Wnt7b Wnt family member 7B multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of WNT7B mRNA CTD PMID:36139627 NCBI chr 7:116,634,817...116,679,089
Ensembl chr 7:116,634,814...116,679,581
JBrowse link
G Wnt8b Wnt family member 8B multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of WNT8B mRNA CTD PMID:36139627 NCBI chr 1:243,353,841...243,375,297
Ensembl chr 1:243,354,086...243,374,286
JBrowse link
G Xaf1 XIAP associated factor 1 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of XAF1 mRNA CTD PMID:36139627 NCBI chr10:56,917,284...56,929,791
Ensembl chr10:56,917,121...56,929,770
JBrowse link
G Zc3h6 zinc finger CCCH type containing 6 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ZC3H6 mRNA CTD PMID:36139627 NCBI chr 3:116,203,466...116,254,186
Ensembl chr 3:116,204,197...116,253,282
JBrowse link
G Zfp608 zinc finger protein 608 multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ZNF608 mRNA CTD PMID:36139627 NCBI chr18:48,304,873...48,412,846
Ensembl chr18:48,304,880...48,410,465
JBrowse link
G Zwint ZW10 interacting kinetochore protein multiple interactions ISO [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ZWINT mRNA CTD PMID:36139627 NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      biological role 19711
        antimicrobial agent 17880
          antiviral agent 10711
            anticoronaviral agent 9332
              trametinib 627
                trametinib dimethyl sulfoxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18798
                                    carbonyl compound 18798
                                      carboxylic acid 18518
                                        carboacyl group 17656
                                          univalent carboacyl group 17656
                                            carbamoyl group 17497
                                              carboxamide 17497
                                                acetamides 14633
                                                  trametinib 627
                                                    trametinib dimethyl sulfoxide 0
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