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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trametinib
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Accession:CHEBI:75998 term browser browse the term
Definition:A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment.
Synonyms:exact_synonym: N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide
 related_synonym: Formula=C26H23FIN5O4;   GSK 1120212;   InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34);   InChIKey=LIRYPHYGHXZJBZ-UHFFFAOYSA-N;   JTP 74057;   SMILES=CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O;   trametinibum
 xref: CAS:871700-17-3;   DrugBank:DB08911;   Drug_Central:4802;   KEGG:D10175;   LINCS:LSM-1143
 xref_mesh: MESH:C560077
 xref: PMID:21523318;   PMID:22245957;   PMID:23035153;   PMID:23237773;   PMID:23248257;   PMID:23290787;   PMID:23432625;   PMID:23438367;   PMID:23441129;   PMID:23533766;   PMID:23583440;   PMID:23587417;   PMID:23649971;   PMID:23658559;   PMID:23709751;   PMID:23807941;   PMID:23844038;   PMID:23846731;   PMID:23893461;   PMID:23971497;   PMID:23977666;   PMID:24055054;   Patent:WO2005121142;   Patent:WO2011038082;   Patent:WO2011038085;   Patent:WO2011047238;   Reaxys:12497153;   Wikipedia:Trametinib



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trametinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the expression of ACACA mRNA] CTD PMID:29950559 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acly ATP citrate lyase multiple interactions ISO trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the expression of ACLY mRNA] CTD PMID:29950559 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO trametinib results in increased phosphorylation of AKT1 protein
[omipalisib co-treated with trametinib] results in decreased phosphorylation of AKT1 protein
CTD PMID:22733540 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 multiple interactions ISO trametinib inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein] CTD PMID:25780039 NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression
ISO [trametinib co-treated with omipalisib] results in increased expression of BCL2L11 protein
trametinib results in increased expression of BCL2L11 protein
CTD PMID:22733540 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase multiple interactions ISO betulin affects the reaction [BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]]; BRAF protein affects the reaction [[APS-2-79 results in increased susceptibility to trametinib] which results in increased phosphorylation of MAPK1 protein]; BRAF protein affects the reaction [[APS-2-79 results in increased susceptibility to trametinib] which results in increased phosphorylation of MAPK3 protein]; BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]; fatostatin affects the reaction [BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the cleavage of SREBF1 protein]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the expression of ACACA mRNA]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the expression of ACLY mRNA]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the expression of FASN mRNA]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the phosphorylation of MAPK1 protein]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the phosphorylation of MAPK3 protein] CTD PMID:27556948 PMID:29950559 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP3 protein; trametinib promotes the reaction [physapubescin B results in increased expression of CASP3 protein modified form] CTD PMID:22733540 PMID:33035574 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions ISO [GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP7 protein CTD PMID:22733540 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp9 caspase 9 multiple interactions ISO trametinib promotes the reaction [physapubescin B results in increased expression of CASP9 protein modified form] CTD PMID:33035574 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO trametinib promotes the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA]; trametinib promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA] CTD PMID:25780039 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO trametinib promotes the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; trametinib promotes the reaction [Poly I-C results in increased expression of CXCL10 mRNA] CTD PMID:25780039 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the expression of FASN mRNA] CTD PMID:29950559 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Gna11 G protein subunit alpha 11 increases response to substance ISO GNA11 protein mutant form results in increased susceptibility to trametinib CTD PMID:22733540 NCBI chr 7:8,163,752...8,177,636
Ensembl chr 7:8,162,750...8,179,812
JBrowse link
G Gnaq G protein subunit alpha q multiple interactions
increases response to substance
ISO [GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP3 protein; [GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP7 protein; GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]
GNAQ protein mutant form results in increased susceptibility to trametinib
CTD PMID:22733540 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO trametinib promotes the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; trametinib promotes the reaction [Poly I-C results in increased expression of IFNB1 mRNA] CTD PMID:25780039 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO trametinib promotes the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein] CTD PMID:25780039 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [omipalisib co-treated with trametinib] results in increased phosphorylation of JUN protein; JUN results in decreased susceptibility to [omipalisib co-treated with trametinib] CTD PMID:22733540 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO trametinib affects the expression of and affects the lipidation of MAP1LC3B protein CTD PMID:30339727 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 decreases response to substance
multiple interactions
ISO MAP2K1 protein mutant form results in decreased susceptibility to trametinib
[MAP2K1 protein mutant form results in decreased susceptibility to trametinib] inhibits the reaction [trametinib results in decreased phosphorylation of MAPK1 protein]; [MAP2K1 protein mutant form results in decreased susceptibility to trametinib] inhibits the reaction [trametinib results in decreased phosphorylation of MAPK3 protein]
CTD PMID:29768711 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO [APS-2-79 results in increased susceptibility to trametinib] which results in increased phosphorylation of MAPK1 protein; [MAP2K1 protein mutant form results in decreased susceptibility to trametinib] inhibits the reaction [trametinib results in decreased phosphorylation of MAPK1 protein]; [omipalisib co-treated with trametinib] results in decreased phosphorylation of MAPK1 protein; BRAF protein affects the reaction [[APS-2-79 results in increased susceptibility to trametinib] which results in increased phosphorylation of MAPK1 protein]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the phosphorylation of MAPK1 protein]; trametinib inhibits the reaction [physapubescin B results in increased phosphorylation of MAPK1 protein]
trametinib inhibits the reaction [camostat results in increased phosphorylation of MAPK1 protein]; trametinib inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; trametinib inhibits the reaction [Poly I-C results in increased phosphorylation of MAPK1 protein]
CTD PMID:22733540 PMID:25104499 PMID:25780039 PMID:27556948 PMID:29768711 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO [APS-2-79 results in increased susceptibility to trametinib] which results in increased phosphorylation of MAPK3 protein; [MAP2K1 protein mutant form results in decreased susceptibility to trametinib] inhibits the reaction [trametinib results in decreased phosphorylation of MAPK3 protein]; [omipalisib co-treated with trametinib] results in decreased phosphorylation of MAPK3 protein; BRAF protein affects the reaction [[APS-2-79 results in increased susceptibility to trametinib] which results in increased phosphorylation of MAPK3 protein]; trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the phosphorylation of MAPK3 protein]; trametinib inhibits the reaction [physapubescin B results in increased phosphorylation of MAPK3 protein]
trametinib inhibits the reaction [camostat results in increased phosphorylation of MAPK3 protein]; trametinib inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; trametinib inhibits the reaction [Poly I-C results in increased phosphorylation of MAPK3 protein]
CTD PMID:22733540 PMID:25104499 PMID:25780039 PMID:27556948 PMID:29768711 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO trametinib results in decreased expression of MYC protein CTD PMID:22733540 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Ngfr nerve growth factor receptor increases expression
affects response to substance
ISO trametinib results in increased expression of NGFR protein
NGFR protein affects the susceptibility to trametinib
CTD PMID:30339727 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO trametinib results in decreased phosphorylation of RB1 protein CTD PMID:22733540 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO trametinib results in decreased phosphorylation of RPS6KB1 protein CTD PMID:22733540 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO trametinib results in decreased expression of SQSTM1 protein CTD PMID:30339727 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO trametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the cleavage of SREBF1 protein] CTD PMID:29950559 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation
multiple interactions
ISO trametinib results in increased phosphorylation of STAT3 protein
physapubescin B inhibits the reaction [trametinib results in increased phosphorylation of STAT3 protein]
CTD PMID:33035574 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link

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  CHEBI ontology 19812
    role 19763
      biological role 19763
        antimicrobial agent 17482
          antiviral agent 10310
            anticoronaviral agent 9018
              trametinib 28
                trametinib dimethyl sulfoxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    p-block element atom 19710
                      carbon group element atom 19631
                        carbon atom 19621
                          organic molecular entity 19621
                            organic group 18730
                              organic divalent group 18721
                                organodiyl group 18721
                                  carbonyl group 18670
                                    carbonyl compound 18670
                                      carboxylic acid 18367
                                        carboacyl group 17487
                                          univalent carboacyl group 17487
                                            carbamoyl group 17303
                                              carboxamide 17303
                                                acetamides 12420
                                                  trametinib 28
                                                    trametinib dimethyl sulfoxide 0
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