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Accession:CHEBI:75998 term browser browse the term
Definition:A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment.
Synonyms:exact_synonym: N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide
 related_synonym: Formula=C26H23FIN5O4;   GSK 1120212;   InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34);   InChIKey=LIRYPHYGHXZJBZ-UHFFFAOYSA-N;   JTP 74057;   SMILES=CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O;   trametinibum
 xref: CAS:871700-17-3 "ChemIDplus";   CAS:871700-17-3 "KEGG COMPOUND";   DrugBank:DB08911;   Drug_Central:4802 "DrugCentral";   KEGG:D10175;   LINCS:LSM-1143
 xref_mesh: MESH:C560077
 xref: PMID:21523318 "Europe PMC";   PMID:22245957 "Europe PMC";   PMID:23035153 "Europe PMC";   PMID:23237773 "Europe PMC";   PMID:23248257 "Europe PMC";   PMID:23290787 "Europe PMC";   PMID:23432625 "Europe PMC";   PMID:23438367 "Europe PMC";   PMID:23441129 "Europe PMC";   PMID:23533766 "Europe PMC";   PMID:23583440 "Europe PMC";   PMID:23587417 "Europe PMC";   PMID:23649971 "Europe PMC";   PMID:23658559 "Europe PMC";   PMID:23709751 "Europe PMC";   PMID:23807941 "Europe PMC";   PMID:23844038 "Europe PMC";   PMID:23846731 "Europe PMC";   PMID:23893461 "Europe PMC";   PMID:23971497 "Europe PMC";   PMID:23977666 "Europe PMC";   PMID:24055054 "Europe PMC";   Patent:WO2005121142;   Patent:WO2011038082;   Patent:WO2011038085;   Patent:WO2011047238;   Reaxys:12497153 "Reaxys";   Wikipedia:Trametinib

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trametinib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acaca acetyl-CoA carboxylase alpha JBrowse link 10 71,519,392 71,719,910 RGD:6480464
G Acly ATP citrate lyase JBrowse link 10 88,392,248 88,442,845 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:6480464
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Fasn fatty acid synthase JBrowse link 10 109,987,735 110,005,901 RGD:6480464
G Gna11 G protein subunit alpha 11 JBrowse link 7 11,033,400 11,047,284 RGD:6480464
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6480464
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      application 19232
        pharmaceutical 19094
          drug 19094
            antineoplastic agent 16568
              trametinib 17
                trametinib dimethyl sulfoxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic group 18340
                              organic divalent group 18330
                                organodiyl group 18330
                                  carbonyl group 18217
                                    carbonyl compound 18217
                                      carboxylic acid 17921
                                        carboacyl group 16944
                                          univalent carboacyl group 16944
                                            carbamoyl group 16623
                                              carboxamide 16623
                                                acetamides 11595
                                                  trametinib 17
                                                    trametinib dimethyl sulfoxide 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.