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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:teniposide
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Accession:CHEBI:75988 term browser browse the term
Definition:A furonaphthodioxole that is a synthetic derivative of podophyllotoxin with anti-tumour activity; causes single- and double-stranded breaks in DNA and DNA-protein cross-links and prevents repair by topoisomerase II binding.
Synonyms:exact_synonym: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-(2-thienylmethylene)-beta-D-glucopyranoside
 related_synonym: 4'-Demethylepipodophyllotoxin 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside);   4'-Demethylepipodophyllotoxin-beta-D-thenylidene glucoside;   Formula=C32H32O13S;   HSDB 6546;   InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9,16,21,23-24,26-29,31-35H,10-12H2,1-2H3/t16-,21+,23+,24-,26+,27+,28+,29+,31?,32-/m0/s1;   InChIKey=NRUKOCRGYNPUPR-PSZSYXFXSA-N;   NSC-122819;   SMILES=COc1cc(cc(OC)c1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3COC(O[C@H]3[C@H](O)[C@H]2O)c2cccs2)c2cc3OCOc3cc12;   VM-26;   Vumon;   teniposido;   teniposidum
 alt_id: CHEBI:9917
 xref: CAS:29767-20-2;   DrugBank:DB00444;   HMDB:HMDB0014587;   KEGG:C11153;   KEGG:D02698
 xref_mesh: MESH:D013713
 xref: PDBeChem:9TP;   PMID:21430063;   PMID:21821840;   PMID:22644709;   PMID:22846410;   PMID:23266449;   PMID:23466610;   PMID:23679827;   PMID:23838380;   Reaxys:1417328;   Wikipedia:Teniposide


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teniposide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance ISO ABCC1 results in decreased susceptibility to Teniposide CTD PMID:8968083 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Ar androgen receptor multiple interactions ISO Teniposide binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Teniposide results in increased expression of CDKN1A mRNA; Teniposide results in increased expression of CDKN1A protein CTD PMID:25914138 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases methylation ISO CYP3A5 protein results in decreased methylation of Teniposide CTD PMID:8114683 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Teniposide binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Teniposide binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases response to substance ISO FGF2 protein results in decreased susceptibility to Teniposide CTD PMID:20221717 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Teniposide inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Mir135b microRNA 135b decreases response to substance ISO MIR135B mRNA results in decreased susceptibility to Teniposide CTD PMID:27570640 NCBI chr13:48,976,986...48,977,082
Ensembl chr13:48,976,986...48,977,082
JBrowse link
G Mir196b microRNA 196b decreases response to substance ISO MIR196B mRNA results in decreased susceptibility to Teniposide CTD PMID:27570640 NCBI chr 4:82,199,056...82,199,140
Ensembl chr 4:82,199,056...82,199,140
JBrowse link
G Mttp microsomal triglyceride transfer protein decreases expression
multiple interactions
ISO Teniposide results in decreased expression of MTTP mRNA
Teniposide promotes the reaction [CETP protein results in decreased expression of MTTP mRNA]
CTD PMID:25914138 NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Teniposide results in decreased expression of MYC mRNA; Teniposide results in decreased expression of MYC protein CTD PMID:11585056 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions
affects localization
affects response to substance
ISO NR1H2 mutant form inhibits the reaction [Teniposide results in increased expression of CETP mRNA]; Teniposide promotes the reaction [NR1H2 protein results in increased expression of CETP mRNA]
Teniposide affects the localization of NR1H2 protein
NR1H2 protein affects the susceptibility to Teniposide
CTD PMID:25914138 NCBI chr 1:100,554,577...100,559,896
Ensembl chr 1:100,554,544...100,559,942
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions
increases expression
affects response to substance
ISO NR1H3 mutant form inhibits the reaction [Teniposide results in increased expression of CETP mRNA]; Teniposide promotes the reaction [NR1H3 protein results in increased expression of CETP mRNA]; Teniposide results in increased expression of and affects the localization of NR1H3 protein
Teniposide results in increased expression of NR1H3 mRNA
NR1H3 protein affects the susceptibility to Teniposide
CTD PMID:25914138 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 decreases expression ISO Teniposide results in decreased expression of NRIP1 mRNA; Teniposide results in decreased expression of NRIP1 protein CTD PMID:25914138 NCBI chr11:14,658,225...14,742,478
Ensembl chr11:14,658,225...14,741,563
JBrowse link
G Odc1 ornithine decarboxylase 1 decreases expression ISO Teniposide results in decreased expression of ODC1 protein CTD PMID:11585056 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Teniposide binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO Teniposide promotes the reaction [RXRA protein results in increased expression of CETP mRNA]; Tretinoin promotes the reaction [Teniposide promotes the reaction [RXRA protein results in increased expression of CETP mRNA]] CTD PMID:25914138 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO Teniposide inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue] CTD PMID:30863990 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Teniposide binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Teniposide binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO TOP2A results in decreased susceptibility to [Cisplatin co-treated with Teniposide] CTD PMID:11325482 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        epitope 6835
          beta-D-glucose 1603
            beta-D-glucoside 1411
              teniposide 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            heteroorganic entity 19148
                              organochalcogen compound 18856
                                organooxygen compound 18778
                                  carbohydrates and carbohydrate derivatives 12180
                                    carbohydrate 12180
                                      monosaccharide 4023
                                        aldose 2537
                                          aldohexose 2184
                                            glucose 2146
                                              D-glucose 2146
                                                D-glucopyranose 1712
                                                  beta-D-glucose 1603
                                                    beta-D-glucoside 1411
                                                      teniposide 22
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