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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nitroprusside
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Accession:CHEBI:7596 term browser browse the term
Definition:An iron coordination entity that has formula C5FeN6O.
Synonyms:exact_synonym: pentacyanidonitrosylferrate(2-);   pentacyanidonitrosylferrate(III)
 related_synonym: Formula=C5FeN6O;   InChI=1S/5CN.Fe.NO/c5*1-2;;1-2/q;;;;;2*-1;   InChIKey=ASPOIVQEUUCDQT-UHFFFAOYSA-N;   Nitroferricyanide;   SMILES=O=N[Fe--](C#N)(C#N)(C#N)(C#N)C#N;   [Fe(CN)5(NO)](2-)
 xref: CAS:15078-28-1;   DrugBank:DB00325;   KEGG:C07269
 xref_mesh: MESH:D009599
 xref: MolBase:329



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nitroprusside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco2 aconitase 2 multiple interactions
decreases activity
ISO Aluminum promotes the reaction [Nitroprusside results in decreased activity of ACO2 protein] CTD PMID:12470706 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
JBrowse link
G Adm adrenomedullin decreases expression EXP Nitroprusside results in decreased expression of ADM mRNA CTD PMID:12899678 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Agt angiotensinogen decreases response to substance ISO AGT protein results in decreased susceptibility to Nitroprusside CTD PMID:18174886 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO AIFM1 protein inhibits the reaction [Nitroprusside results in decreased reduction of Glutathione]; AIFM1 protein promotes the reaction [Nitroprusside results in decreased reduction of Adenine Nucleotides] CTD PMID:15316071 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
[Nitroprusside results in increased expression of ITGB3 protein] which results in increased phosphorylation of and results in increased activity of AKT1 protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]; olaparib promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]; PARP1 protein affects the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]; veliparib promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cilomilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; Cilomilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]; Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]; Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]
CTD PMID:18276108 PMID:21332719 PMID:30296409 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alad aminolevulinate dehydratase decreases activity
multiple interactions
ISO Nitroprusside results in decreased activity of ALAD protein
Quinolones inhibits the reaction [Nitroprusside results in decreased activity of ALAD protein]
CTD PMID:29317251 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases secretion
ISO APP protein promotes the reaction [Nitroprusside results in decreased activity of CHAT protein]
Nitroprusside results in decreased secretion of APP protein alternative form
CTD PMID:10691295 PMID:16724269 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
affects localization
EXP
ISO
FGF2 protein inhibits the reaction [Nitroprusside results in increased expression of BAX protein]; IGF1 protein inhibits the reaction [Nitroprusside results in increased expression of BAX protein]
[Nitroprusside results in increased abundance of Nitric Oxide] which affects the localization of BAX protein; SB 203580 inhibits the reaction [[Nitroprusside results in increased abundance of Nitric Oxide] which affects the localization of BAX protein]
Nitroprusside results in increased expression of BAX; Nitroprusside results in increased expression of BAX protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Nitroprusside affects the localization of BAX protein]]; Nitroprusside results in increased expression of and affects the localization of BAX protein; triciribine inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Nitroprusside affects the localization of BAX protein]]; Ursodeoxycholic Acid inhibits the reaction [Nitroprusside results in increased expression of and affects the localization of BAX protein]
CTD PMID:10203697 PMID:15961378 PMID:22178905 PMID:22878015 PMID:23665936 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
Nitroprusside results in decreased expression of BCL2; Nitroprusside results in decreased expression of BCL2 protein
[Nitroprusside results in increased nitrosation of and results in decreased ubiquitination of and results in decreased degradation of BCL2 protein] which results in decreased susceptibility to Chromates
FGF2 protein inhibits the reaction [Nitroprusside results in decreased expression of BCL2 protein]; IGF1 protein inhibits the reaction [Nitroprusside results in decreased expression of BCL2 protein]
CTD PMID:10203697 PMID:15708893 PMID:16980304 PMID:23665936 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
EXP MAPK3 protein affects the susceptibility to [Nitroprusside results in decreased expression of BCL2L1 mRNA]; MAPK8 protein affects the susceptibility to [Nitroprusside results in decreased expression of BCL2L1 mRNA]
Nitroprusside results in decreased expression of BCL2L1 mRNA; Nitroprusside results in decreased expression of BCL2L1 protein
CTD PMID:20132804 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bdkrb2 bradykinin receptor B2 affects response to substance ISO BDKRB2 affects the susceptibility to Nitroprusside CTD PMID:10614985 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression
multiple interactions
EXP Nitroprusside results in decreased expression of BID protein modified form
Cilostazol inhibits the reaction [Nitroprusside results in decreased expression of BID protein modified form]; Cilostazol inhibits the reaction [Nitroprusside results in increased cleavage of and results in increased localization of BID protein]; Nitroprusside results in increased cleavage of and results in increased localization of BID protein
CTD PMID:18311796 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nitroprusside results in decreased expression of BIRC5 protein]; 6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine promotes the reaction [Nitroprusside results in decreased expression of BIRC5 mRNA]; NSC 663284 promotes the reaction [Nitroprusside results in decreased expression of BIRC5 mRNA]
Nitroprusside results in decreased expression of BIRC5 mRNA; Nitroprusside results in decreased expression of BIRC5 protein
CTD PMID:14988404 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions
increases secretion
increases response to substance
EXP Flurbiprofen inhibits the reaction [CALCA protein results in increased susceptibility to Nitroprusside]; Indomethacin inhibits the reaction [CALCA protein results in increased susceptibility to Nitroprusside]
Nitroprusside results in increased secretion of CALCA protein
CTD PMID:8581270 PMID:18809208 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Cartpt CART prepropeptide multiple interactions EXP Nitroprusside affects the cleavage of and affects the expression of CARTPT protein CTD PMID:12588509 NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
increases activity
multiple interactions
ISO
EXP
Nitroprusside results in increased expression of CASP3 mRNA
Nitroprusside results in increased cleavage of CASP3 protein
Nitroprusside results in increased expression of CASP3 protein modified form
Nitroprusside results in increased activity of CASP3 protein
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitroprusside results in increased cleavage of CASP3 protein]; [Nitroprusside results in increased abundance of Nitric Oxide] which results in increased activity of CASP3 protein; MIR1A-2 mRNA affects the reaction [Nitroprusside results in increased activity of CASP3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [Bortezomib results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased activity of CASP3 protein]; U 0126 inhibits the reaction [[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased activity of CASP3 protein]
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitroprusside results in increased cleavage of CASP3 protein]; epigallocatechin gallate inhibits the reaction [Nitroprusside binds to and results in increased activity of CASP3 protein]; Nitroprusside binds to and results in increased activity of CASP3 protein; Nitroprusside inhibits the reaction [Deferoxamine results in increased activity of CASP3 protein]; Nitroprusside inhibits the reaction [MIR135B mRNA inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein]]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [Bortezomib results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Ursodeoxycholic Acid inhibits the reaction [Nitroprusside results in increased activity of CASP3 protein]
cilostazol inhibits the reaction [Nitroprusside results in increased activity of CASP3 protein]
CTD PMID:15708893 PMID:16374551 PMID:18311796 PMID:20559625 PMID:22178905 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases expression
multiple interactions
increases activity
ISO
EXP
Nitroprusside results in increased expression of CASP7 mRNA
Ursodeoxycholic Acid inhibits the reaction [Nitroprusside results in increased activity of CASP7 protein]
cilostazol inhibits the reaction [Nitroprusside results in increased activity of CASP7 protein]
CTD PMID:15708893 PMID:18311796 PMID:22178905 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
EXP
ISO
Nitroprusside results in increased activity of CASP8 protein
[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased activity of CASP8 protein
Nitroprusside inhibits the reaction [Deferoxamine results in increased activity of CASP8 protein]
cilostazol inhibits the reaction [Nitroprusside results in increased activity of CASP8 protein]
CTD PMID:16374551 PMID:18311796 PMID:22878015 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 decreases activity
multiple interactions
increases activity
ISO Nitroprusside results in decreased activity of CASP9 protein
[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased activity of CASP9 protein
epigallocatechin gallate inhibits the reaction [Nitroprusside binds to and results in increased activity of CASP9 protein]; Nitroprusside binds to and results in increased activity of CASP9 protein; Ursodeoxycholic Acid inhibits the reaction [Nitroprusside results in increased activity of CASP9 protein]
CTD PMID:22178905 PMID:22543296 PMID:22878015 PMID:23665936 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase increases activity
multiple interactions
decreases activity
EXP
ISO
Nitroprusside results in increased activity of CAT protein
Quinolones inhibits the reaction [Nitroprusside results in decreased activity of CAT protein]
CTD PMID:20559625 PMID:29317251 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cav1 caveolin 1 multiple interactions
increases expression
ISO Nitroprusside results in decreased ubiquitination of and results in decreased degradation of CAV1 protein; Nitroprusside results in increased metabolism of and results in increased stability of CAV1 protein
Nitroprusside results in increased expression of CAV1 protein
CTD PMID:19706615 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [Nitroprusside co-treated with TNF co-treated with IFNG] results in increased expression of CCL2 mRNA CTD PMID:15153526 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccn4 cellular communication network factor 4 increases expression ISO Nitroprusside results in increased expression of CCN4 mRNA; Nitroprusside results in increased expression of CCN4 protein CTD PMID:19238344 NCBI chr 7:98,645,238...98,677,253
Ensembl chr 7:98,645,182...98,677,248
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases phosphorylation ISO Nitroprusside results in decreased phosphorylation of CDK1 protein CTD PMID:14988404 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression
multiple interactions
ISO Nitroprusside results in increased expression of CEBPB protein alternative form
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitroprusside results in increased expression of CEBPB protein alternative form]
CTD PMID:30482226 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Chat choline O-acetyltransferase multiple interactions
decreases activity
ISO APP protein promotes the reaction [Nitroprusside results in decreased activity of CHAT protein] CTD PMID:16724269 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions
increases phosphorylation
ISO [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of CHUK protein]] which results in decreased localization of NFKB1 protein; Bee Venoms inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]; Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of and results in increased activity of CHUK protein]; Nitroprusside results in increased phosphorylation of and results in increased activity of CHUK protein
[Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of CHUK protein]] which results in decreased localization of NFKB1 protein; Bee Venoms inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]]; Glutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]]; Hydrogen Peroxide inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]]; Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]; Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of and results in increased activity of CHUK protein]; Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of CHUK protein]; Nitroprusside results in increased phosphorylation of and results in increased activity of CHUK protein
CTD PMID:17067557 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Col1a2 collagen type I alpha 2 chain decreases expression ISO Nitroprusside results in decreased expression of COL1A2 mRNA CTD PMID:22543296 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 affects response to substance ISO CPS1 gene SNP affects the susceptibility to Nitroprusside CTD PMID:14718356 NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cilomilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]; Cilomilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]; Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]; Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein] CTD PMID:18276108 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases secretion
EXP beta-Endorphin inhibits the reaction [Nitroprusside results in increased secretion of CRH protein]; Corticosterone affects the reaction [Nitroprusside results in increased secretion of CRH protein]; Dynorphins inhibits the reaction [Nitroprusside results in increased secretion of CRH protein]; Nitroprusside results in increased expression of and results in increased secretion of CRH protein; Yohimbine inhibits the reaction [Nitroprusside results in increased expression of and results in increased secretion of CRH protein] CTD PMID:3015567 PMID:3031743 PMID:3497798 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO Nitroprusside results in increased expression of DDIT3 protein
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitroprusside results in increased expression of DDIT3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; Nitroprusside promotes the reaction [Bortezomib results in increased expression of DDIT3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased expression of DDIT3 protein]
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitroprusside results in increased expression of DDIT3 protein]; Nitroprusside inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; Nitroprusside inhibits the reaction [Bortezomib results in increased expression of DDIT3 protein]; Nitroprusside inhibits the reaction [Chloroquine results in increased expression of DDIT3 protein]
CTD PMID:30482226 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Nitroprusside inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]; Nitroprusside inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]; Nitroprusside inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:16023617 PMID:16389725 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Edn3 endothelin 3 multiple interactions
decreases expression
EXP Nitroprusside inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]
Nitroprusside results in decreased expression of EDN3 protein
CTD PMID:7982458 PMID:16023617 NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP Nitroprusside inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]; Nitroprusside inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein] CTD PMID:16023617 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 multiple interactions
decreases expression
EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in decreased expression of ENPP1 protein]; 3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine promotes the reaction [Nitroprusside results in decreased expression of ENPP1 protein] CTD PMID:21414308 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
JBrowse link
G Epo erythropoietin multiple interactions ISO Nitroprusside inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA] CTD PMID:11286986 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Nitroprusside]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Nitroprusside] CTD PMID:17158209 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
decreases response to substance
EXP
ISO
FGF2 protein inhibits the reaction [Nitroprusside results in decreased expression of BCL2 protein]; FGF2 protein inhibits the reaction [Nitroprusside results in increased expression of BAX protein]
FGF2 protein results in decreased susceptibility to Nitroprusside
CTD PMID:10203697 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
affects expression
multiple interactions
ISO
EXP
Nitroprusside results in increased expression of FOS protein
Nitroprusside affects the expression of FOS protein
Nitroprusside results in increased expression of FOS mRNA; Nitroprusside results in increased expression of FOS protein
[Nitroprusside co-treated with Urethane co-treated with Chloralose] results in increased expression of FOS protein; [Nitroprusside co-treated with Urethane] affects the expression of FOS protein
CTD PMID:7844257 PMID:8294911 PMID:8698450 PMID:8750937 PMID:11588591 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions ISO Zinc Sulfate promotes the reaction [Nitroprusside results in increased expression of G6PD mRNA] CTD PMID:17018880 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression EXP Nitroprusside results in decreased expression of GNAI2 protein CTD PMID:16962941 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Gnai3 G protein subunit alpha i3 decreases expression EXP Nitroprusside results in decreased expression of GNAI3 protein CTD PMID:16962941 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
JBrowse link
G Gosr1 golgi SNAP receptor complex member 1 multiple interactions ISO GOSR1 protein affects the reaction [Deferoxamine inhibits the reaction [Nitroprusside results in decreased phosphorylation of MAPK1 protein]]; GOSR1 protein affects the reaction [Deferoxamine inhibits the reaction [Nitroprusside results in decreased phosphorylation of MAPK3 protein]]; GOSR1 protein affects the reaction [Nitroprusside results in decreased expression of NFE2L2 protein]; MAPK3 protein affects the reaction [GOSR1 protein affects the reaction [Nitroprusside results in decreased expression of NFE2L2 protein]] CTD PMID:31066958 NCBI chr10:61,570,499...61,607,287
Ensembl chr10:61,450,494...61,607,177
Ensembl chr10:61,450,494...61,607,177
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 affects response to substance ISO GRK3 mutant form affects the susceptibility to Nitroprusside CTD PMID:10198406 NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP
ISO
Nitroprusside results in decreased phosphorylation of and results in increased activity of GSK3B protein CTD PMID:29353218 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 3-(2-(4-chlorophenylsulfanyl)phenyl)-N-(4-dimethylaminobutyl)acrylamide promotes the reaction [Nitroprusside results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole promotes the reaction [Nitroprusside results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Nitroprusside promotes the reaction [3-(2-(2,2-dimethylpropylsulfanyl)pyridin-3-yl)-N-(3-hydroxycyclohexyl)acrylamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Nitroprusside results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:12495780 PMID:17050951 NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 3-(2-(4-chlorophenylsulfanyl)phenyl)-N-(4-dimethylaminobutyl)acrylamide promotes the reaction [Nitroprusside results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole promotes the reaction [Nitroprusside results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Nitroprusside promotes the reaction [3-(2-(2,2-dimethylpropylsulfanyl)pyridin-3-yl)-N-(3-hydroxycyclohexyl)acrylamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Nitroprusside results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:12495780 PMID:17050951 NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases activity
multiple interactions
decreases expression
ISO Nitroprusside results in decreased activity of HIF1A protein
Nitroprusside inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; Nitroprusside inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
Nitroprusside results in decreased expression of HIF1A mRNA; Nitroprusside results in decreased expression of HIF1A protein
CTD PMID:11286986 PMID:15465035 PMID:28624453 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
increases expression
ISO
EXP
[linsidomine co-treated with Nitroprusside] results in increased expression of HMOX1 mRNA; [Nitroprusside results in increased abundance of nitrosonium ion] which results in increased expression of HMOX1 mRNA; Dactinomycin inhibits the reaction [Nitroprusside results in increased expression of HMOX1 mRNA]; IFNG protein inhibits the reaction [Nitroprusside results in increased expression of HMOX1 mRNA]; Nitroprusside promotes the reaction [S-Nitrosoglutathione results in increased expression of HMOX1 mRNA]; S-Nitrosoglutathione promotes the reaction [Nitroprusside results in increased expression of HMOX1 mRNA]
Nitroprusside inhibits the reaction [sulforaphane results in increased expression of HMOX1 protein]
Nitroprusside results in decreased expression of HMOX1 protein
Nitroprusside results in increased expression of HMOX1 mRNA; Nitroprusside results in increased expression of HMOX1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nitroprusside results in increased expression of HMOX1 protein]; Cilostazol inhibits the reaction [Nitroprusside results in decreased expression of HMOX1 protein]; Deferoxamine inhibits the reaction [Nitroprusside results in increased expression of HMOX1 protein]; KT 5720 inhibits the reaction [Nitroprusside results in increased expression of HMOX1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Nitroprusside results in increased expression of HMOX1 protein]; Nitroprusside inhibits the reaction [sulforaphane results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Nitroprusside results in increased expression of HMOX1 protein]
CTD PMID:8764571 PMID:10349844 PMID:10423162 PMID:12393473 PMID:16439612 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like multiple interactions ISO [Nitroprusside results in increased abundance of nitrosonium ion] which results in decreased expression of HNRNPDL mRNA CTD PMID:12393473 NCBI chr14:9,558,079...9,563,654
Ensembl chr14:9,557,425...9,562,506
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like multiple interactions ISO [Nitroprusside results in increased abundance of nitrosonium ion] which results in decreased expression of HSPA1L mRNA CTD PMID:12393473 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO Nitroprusside inhibits the reaction [Glucose deficiency results in decreased expression of HSPD1 protein] CTD PMID:17855661 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Ibsp integrin-binding sialoprotein multiple interactions
increases expression
ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in increased expression of IBSP mRNA] CTD PMID:22543296 NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693
JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions
ISO Nitroprusside results in decreased expression of IFNG mRNA
IFNG protein inhibits the reaction [Nitroprusside results in increased expression of HMOX1 mRNA]; Nitroprusside inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Nitroprusside inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]
[Nitroprusside co-treated with TNF co-treated with IFNG] results in increased expression of CCL2 mRNA; [Nitroprusside co-treated with TNF co-treated with IFNG] results in increased expression of NFKBIA mRNA; [Nitroprusside co-treated with TNF co-treated with IFNG] results in increased expression of TLR2 mRNA; [Nitroprusside co-treated with TNF co-treated with IFNG] results in increased expression of TNF mRNA
CTD PMID:9201699 PMID:10349844 PMID:11076874 PMID:15153526 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 decreases response to substance
multiple interactions
ISO
EXP
IGF1 protein results in decreased susceptibility to Nitroprusside
IGF1 protein inhibits the reaction [Nitroprusside results in decreased expression of BCL2 protein]; IGF1 protein inhibits the reaction [Nitroprusside results in increased expression of BAX protein]
CTD PMID:10203697 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions
increases activity
ISO Bee Venoms inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]; Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]
Bee Venoms inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]; Glutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]; Hydrogen Peroxide inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]; Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]
CTD PMID:17067557 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Nitroprusside inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Nitroprusside inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Nitroprusside inhibits the reaction [MIR135B mRNA inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL1B protein]] CTD PMID:11076874 PMID:28484287 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 decreases expression
increases expression
multiple interactions
ISO Nitroprusside results in decreased expression of IL4 mRNA
Nitroprusside results in increased expression of IL4 mRNA
Cyclosporine inhibits the reaction [Nitroprusside results in increased expression of IL4 mRNA]
CTD PMID:9201699 PMID:16533816 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO [Nitroprusside results in increased expression of ITGB3 protein] which results in increased phosphorylation of and results in increased activity of AKT1 protein; [Nitroprusside results in increased expression of ITGB3 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Nitroprusside results in increased expression of ITGB3 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:21332719 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects localization EXP Nitroprusside affects the localization of JUN protein CTD PMID:20132804 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Nitroprusside results in increased expression of JUNB mRNA CTD PMID:8294911 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 affects activity EXP Nitroprusside affects the activity of KCNJ2 protein CTD PMID:14993195 NCBI chr10:96,060,849...96,071,401
Ensembl chr10:96,060,821...96,071,445
JBrowse link
G Kng2 kininogen 2 decreases activity EXP Nitroprusside results in decreased activity of KNG1 CTD PMID:1334751 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO [MAOB protein co-treated with MAOA protein] affects the susceptibility to Nitroprusside CTD PMID:11834493 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Maob monoamine oxidase B multiple interactions ISO [MAOB protein co-treated with MAOA protein] affects the susceptibility to Nitroprusside CTD PMID:11834493 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
decreases expression
increases phosphorylation
multiple interactions
ISO
EXP
Nitroprusside results in decreased phosphorylation of MAPK1 protein
Nitroprusside results in decreased expression of MAPK1 protein modified form
Nitroprusside results in increased phosphorylation of MAPK1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Nitroprusside results in increased phosphorylation of MAPK1 protein]; Nitroprusside inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]
[Nitroprusside results in increased expression of ITGB3 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; Deferoxamine inhibits the reaction [Nitroprusside results in decreased phosphorylation of MAPK1 protein]; GOSR1 protein affects the reaction [Deferoxamine inhibits the reaction [Nitroprusside results in decreased phosphorylation of MAPK1 protein]]
CTD PMID:15486966 PMID:16389725 PMID:16439612 PMID:20132804 PMID:21332719 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
decreases expression
affects response to substance
increases phosphorylation
multiple interactions
ISO
EXP
Nitroprusside results in decreased phosphorylation of MAPK3 protein
Nitroprusside results in decreased expression of MAPK3 protein modified form
MAPK3 protein affects the susceptibility to Nitroprusside
Nitroprusside results in increased phosphorylation of MAPK3 protein
[Nitroprusside results in increased expression of ITGB3 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; Deferoxamine inhibits the reaction [Nitroprusside results in decreased phosphorylation of MAPK3 protein]; GOSR1 protein affects the reaction [Deferoxamine inhibits the reaction [Nitroprusside results in decreased phosphorylation of MAPK3 protein]]; MAPK3 protein affects the reaction [GOSR1 protein affects the reaction [Nitroprusside results in decreased expression of NFE2L2 protein]]
MAPK3 protein affects the susceptibility to [Nitroprusside results in decreased expression of BCL2L1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Nitroprusside results in increased phosphorylation of MAPK3 protein]; Nitroprusside inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:15486966 PMID:16389725 PMID:16439612 PMID:20132804 PMID:21332719 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression
affects response to substance
multiple interactions
EXP Nitroprusside results in decreased expression of MAPK8 protein modified form
MAPK8 protein affects the susceptibility to Nitroprusside
MAPK8 protein affects the susceptibility to [Nitroprusside results in decreased expression of BCL2L1 mRNA]
CTD PMID:20132804 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases expression EXP Nitroprusside results in decreased expression of MAPK9 protein modified form CTD PMID:20132804 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO Nitroprusside inhibits the reaction [Deferoxamine results in increased cleavage of MCL1 protein] CTD PMID:16374551 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mir1 microRNA 1 multiple interactions
increases expression
ISO MIR1A-2 mRNA affects the reaction [Nitroprusside results in increased activity of CASP3 protein]
Nitroprusside results in increased expression of MIR1A-2 mRNA
CTD PMID:25678843 NCBI chr18:1,887,537...1,887,623 JBrowse link
G Mir135b microRNA 135b multiple interactions ISO Nitroprusside inhibits the reaction [MIR135B mRNA inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein]]; Nitroprusside inhibits the reaction [MIR135B mRNA inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL1B protein]]; Nitroprusside inhibits the reaction [MIR135B mRNA inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]] CTD PMID:28484287 NCBI chr13:43,638,857...43,638,953
Ensembl chr13:43,638,857...43,638,953
JBrowse link
G Mt1 metallothionein 1 increases expression
multiple interactions
ISO Nitroprusside results in increased expression of MT1A mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nitroprusside results in increased expression of MT1A mRNA]; Zinc Sulfate promotes the reaction [Nitroprusside results in increased expression of MT1A mRNA]
CTD PMID:17018880 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mt2A metallothionein 2A multiple interactions
increases expression
ISO [Nitroprusside results in increased abundance of nitrosonium ion] which results in increased expression of MT2A mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nitroprusside results in increased expression of MT2A mRNA]; Zinc Sulfate promotes the reaction [Nitroprusside results in increased expression of MT2A mRNA] CTD PMID:12393473 PMID:17018880 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions
increases expression
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nitroprusside results in increased expression of MTF1 mRNA]; Nitroprusside promotes the reaction [Zinc Sulfate results in increased expression of MTF1 mRNA] CTD PMID:17018880 NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase decreases activity EXP Nitroprusside results in decreased activity of MTR protein CTD PMID:9108260 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Nitroprusside results in decreased expression of MYC mRNA CTD PMID:7798212 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression
ISO
EXP
Nitroprusside inhibits the reaction [sulforaphane results in increased expression of NFE2L2 protein]
Nitroprusside results in decreased expression of NFE2L2 protein
Deferoxamine inhibits the reaction [Nitroprusside results in decreased expression of NFE2L2 protein]; GOSR1 protein affects the reaction [Nitroprusside results in decreased expression of NFE2L2 protein]; MAPK3 protein affects the reaction [GOSR1 protein affects the reaction [Nitroprusside results in decreased expression of NFE2L2 protein]]
CTD PMID:29353218 PMID:31066958 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases localization
increases activity
ISO [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of CHUK protein]] which results in decreased localization of NFKB1 protein; [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]] which results in decreased localization of NFKB1 protein; Bee Venoms inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]; Melitten inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]]
Nitroprusside results in increased activity of NFKB1 protein
CTD PMID:17067557 PMID:18507870 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases phosphorylation
ISO [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]] which results in decreased localization of NFKB1 protein; [Nitroprusside co-treated with TNF co-treated with IFNG] results in increased expression of NFKBIA mRNA; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]]; Glutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]]; Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]
[Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]] which results in decreased localization of NFKB1 protein; Bee Venoms inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]; Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]]
CTD PMID:15153526 PMID:17067557 PMID:18507870 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO Nitroprusside inhibits the reaction [Glucose deficiency results in decreased expression of NOS1 protein] CTD PMID:17855661 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
increases expression
decreases activity
ISO [Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; Bee Venoms inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Melitten inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Nitroprusside inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Nitroprusside inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]
Nitroprusside results in decreased expression of NOS2 mRNA
[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; Bee Venoms inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Melitten inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Nitroprusside inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Nitroprusside]; Plant Extracts inhibits the reaction [Nitroprusside results in increased expression of NOS2 mRNA]; Plant Extracts inhibits the reaction [Nitroprusside results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]
Nitroprusside results in increased expression of NOS2 mRNA; Nitroprusside results in increased expression of NOS2 protein
Nitroprusside results in decreased activity of NOS2 protein
CTD PMID:11076874 PMID:11498454 PMID:17067557 PMID:18507870 PMID:25829766 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Nitroprusside inhibits the reaction [Glucose deficiency results in decreased expression of NOS3 protein] CTD PMID:17855661 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nppb natriuretic peptide B decreases expression ISO Nitroprusside results in decreased expression of NPPB protein CTD PMID:20339970 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
decreases expression
EXP
ISO
Nitroprusside inhibits the reaction [sulforaphane results in increased expression of NQO1 protein]
Nitroprusside results in decreased expression of NQO1 protein
CTD PMID:29353218 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO PARP1 protein affects the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein] CTD PMID:30296409 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Plg plasminogen decreases response to substance EXP PLG protein results in decreased susceptibility to Nitroprusside CTD PMID:9710261 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases secretion
EXP Corticosterone inhibits the reaction [Nitroprusside results in increased secretion of POMC protein]; Nitroprusside inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]; nonylphenol inhibits the reaction [Nitroprusside inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]] CTD PMID:3015567 PMID:20837582 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO Nitroprusside inhibits the reaction [Glucose deficiency results in decreased expression of PPARGC1A mRNA] CTD PMID:17855661 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prnp prion protein multiple interactions ISO [Nitroprusside results in increased abundance of nitrosonium ion] which results in increased expression of PRNP mRNA CTD PMID:12393473 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO [Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; Bee Venoms inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Melitten inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Nitroprusside inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]
[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; Bee Venoms inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Melitten inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Nitroprusside inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 mRNA]; Nitroprusside inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]
CTD PMID:16874658 PMID:17067557 PMID:18507870 PMID:28624453 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ramp2 receptor activity modifying protein 2 increases expression EXP Nitroprusside results in increased expression of RAMP2 mRNA CTD PMID:12899678 NCBI chr10:86,187,366...86,190,692 JBrowse link
G Rasd1 ras related dexamethasone induced 1 multiple interactions EXP Nitroprusside results in increased nitrosation of and results in increased activity of RASD1 protein CTD PMID:16908409 NCBI chr10:44,766,451...44,775,773
Ensembl chr10:44,766,455...44,768,186
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases localization
increases activity
ISO Bee Venoms inhibits the reaction [Nitroprusside results in increased localization of RELA protein]; Melitten inhibits the reaction [Nitroprusside results in increased localization of RELA protein]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Nitroprusside results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased localization of RELA protein]]
Nitroprusside results in increased activity of RELA protein
CTD PMID:17067557 PMID:18507870 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ren renin multiple interactions
increases activity
ISO
EXP
[Halothane co-treated with Nitroprusside] results in increased activity of REN protein; bunitrolol inhibits the reaction [Nitroprusside results in increased activity of REN protein]; esmolol inhibits the reaction [Nitroprusside results in increased activity of REN protein]; Nitroprusside promotes the reaction [Anesthetics, Combined results in increased activity of REN protein]; Propranolol affects the reaction [Nitroprusside promotes the reaction [Anesthetics, Combined results in increased activity of REN protein]]; Propranolol inhibits the reaction [Nitroprusside results in increased activity of REN protein]
Nitroprusside affects the reaction [Sodium affects the activity of REN protein]
CTD PMID:453612 PMID:1867428 PMID:2413294 PMID:2569849 PMID:3152422 More... NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Retn resistin decreases expression ISO Nitroprusside results in decreased expression of RETN mRNA CTD PMID:18369347 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
JBrowse link
G S100b S100 calcium binding protein B increases secretion
multiple interactions
EXP Nitroprusside results in increased secretion of S100B protein
resveratrol inhibits the reaction [Nitroprusside results in increased secretion of S100B protein]
CTD PMID:23284918 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Nitroprusside results in increased expression of and results in increased activity of SIRT1 protein CTD PMID:18204789 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions ISO [Nitroprusside results in increased abundance of nitrosonium ion] which results in decreased expression of SLC11A2 mRNA CTD PMID:12393473 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
JBrowse link
G Slc30a1 solute carrier family 30 member 1 multiple interactions
increases expression
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nitroprusside results in increased expression of SLC30A1 mRNA]; Zinc Sulfate promotes the reaction [Nitroprusside results in increased expression of SLC30A1 mRNA] CTD PMID:17018880 NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO 1,10-phenanthroline inhibits the reaction [[Hydrogen Peroxide co-treated with Nitroprusside] results in decreased expression of SOD1 protein]; [Hydrogen Peroxide co-treated with Nitroprusside] results in decreased expression of SOD1 protein; Acetylcysteine inhibits the reaction [[Hydrogen Peroxide co-treated with Nitroprusside] results in decreased expression of SOD1 protein] CTD PMID:20674559 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases response to substance
ISO 1,10-phenanthroline inhibits the reaction [[Hydrogen Peroxide co-treated with Nitroprusside] results in increased expression of SOD2 protein]; [Hydrogen Peroxide co-treated with Nitroprusside] results in increased expression of SOD2 protein; Acetylcysteine inhibits the reaction [[Hydrogen Peroxide co-treated with Nitroprusside] results in increased expression of SOD2 protein]
SOD2 protein results in increased susceptibility to Nitroprusside
CTD PMID:10511315 PMID:20674559 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
increases expression
ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in increased expression of SPP1 mRNA] CTD PMID:22543296 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases cleavage
multiple interactions
ISO Nitroprusside results in increased cleavage of SPTAN1 protein
rosiglitazone inhibits the reaction [Nitroprusside results in increased cleavage of SPTAN1 protein]
CTD PMID:19226370 NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046
JBrowse link
G Tacr1 tachykinin receptor 1 increases response to substance EXP TACR1 protein results in increased susceptibility to Nitroprusside CTD PMID:16982039 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO [Nitroprusside results in increased abundance of nitrosonium ion] which results in decreased expression of TFRC mRNA CTD PMID:12393473 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases expression
EXP [Nitroprusside co-treated with Urethane co-treated with Chloralose] results in increased expression of TH protein; Nitroprusside inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]; Nitroprusside inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]
Nitroprusside results in increased expression of TH protein
CTD PMID:12088752 PMID:16023617 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO [Nitroprusside co-treated with TNF co-treated with IFNG] results in increased expression of TLR2 mRNA CTD PMID:15153526 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tnf tumor necrosis factor decreases response to substance
multiple interactions
EXP
ISO
TNF protein results in decreased susceptibility to Nitroprusside
[Nitroprusside co-treated with TNF co-treated with IFNG] results in increased expression of CCL2 mRNA; [Nitroprusside co-treated with TNF co-treated with IFNG] results in increased expression of NFKBIA mRNA; [Nitroprusside co-treated with TNF co-treated with IFNG] results in increased expression of TLR2 mRNA; [Nitroprusside co-treated with TNF co-treated with IFNG] results in increased expression of TNF mRNA
Nitroprusside inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Nitroprusside inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Nitroprusside inhibits the reaction [MIR135B mRNA inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]]
CTD PMID:9710261 PMID:11076874 PMID:15153526 PMID:28484287 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases phosphorylation
increases expression
EXP
ISO
cilostazol inhibits the reaction [Nitroprusside results in increased phosphorylation of TP53 protein]
Nitroprusside results in increased expression of TP53 protein
CTD PMID:15979383 PMID:18311796 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions
increases expression
ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitroprusside results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [Bortezomib results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased expression of TRIB3 protein] CTD PMID:30482226 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO Nitroprusside promotes the reaction [anandamide binds to and results in increased activity of TRPV1 protein] CTD PMID:11278420 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Nitroprusside inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA] CTD PMID:11286986 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP [Xanthine co-treated with XDH protein] inhibits the reaction [Nitroprusside results in increased abundance of Cyclic GMP] CTD PMID:17339839 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      molecular entity 19799
        transition element molecular entity 16549
          transition element coordination entity 11158
            iron coordination entity 372
              nitroprusside 115
                sodium nitroprusside + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  metal atom 17430
                    transition element atom 16845
                      d-block element atom 16836
                        iron group element atom 876
                          iron atom 854
                            iron molecular entity 854
                              iron coordination entity 372
                                nitroprusside 115
                                  sodium nitroprusside + 0
paths to the root