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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:vadimezan
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Accession:CHEBI:75934 term browser browse the term
Definition:A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 5,6-dimethyl-9-oxoxanthen-4-yl group.
Synonyms:exact_synonym: (5,6-dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid
 related_synonym: (5,6-dimethyl-9-oxoxanthen-4-yl)acetic acid;   5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid;   5,6-Dimethylxanthenone-4-acetic acid;   5,6-Dimethylxanthenoneacetic acid;   5,6-MeXAA;   AS-1404;   Dimethyloxoxanthene acetic acid;   Formula=C17H14O4;   InChI=1S/C17H14O4/c1-9-6-7-13-15(20)12-5-3-4-11(8-14(18)19)17(12)21-16(13)10(9)2/h3-7H,8H2,1-2H3,(H,18,19);   InChIKey=XGOYIMQSIKSOBS-UHFFFAOYSA-N;   NSC 640488;   SMILES=Cc1ccc2c(oc3c(CC(O)=O)cccc3c2=O)c1C;   vadimezanum
 xref: CAS:117570-53-3
 xref_mesh: MESH:C066668
 xref: PDBeChem:1YE;   PMID:20050824;   PMID:20072732;   PMID:20118240;   PMID:20460477;   PMID:21205086;   PMID:21321262;   PMID:21575001;   PMID:21588382;   PMID:21680264;   PMID:21709202;   PMID:21819972;   PMID:21870897;   PMID:22142330;   PMID:22695475;   PMID:23481183;   PMID:23481185;   Patent:NZ576925;   Reaxys:4262852;   Wikipedia:Vadimezan


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vadimezan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) affects export
affects transport		 EXP ABCC1 protein affects the export of vadimezan metabolite
ABCC1 protein affects the transport of vadimezan analog		 CTD PMID:15282097 PMID:15784341 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 affects transport
affects export		 EXP ABCC2 protein affects the transport of vadimezan analog
ABCC2 protein affects the export of vadimezan metabolite		 CTD PMID:15282097 PMID:15784341 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of CCL2 mRNA]]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of CCL2 protein]] CTD PMID:37046119 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions
increases oxidation		 EXP Acridines analog inhibits the reaction [CYP1A2 protein results in increased oxidation of vadimezan] CTD PMID:16120190 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of GPT protein]] CTD PMID:37046119 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G IFNB1 interferon beta 1 increases expression ISO vadimezan results in increased expression of IFNB1 mRNA CTD PMID:36958387 NCBI chr 9:21,077,104...21,077,942
Ensembl chr 9:21,077,104...21,077,942 		JBrowse link
G IL1A interleukin 1 alpha increases expression ISO vadimezan results in increased expression of IL1A protein CTD PMID:16944150 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL6 interleukin 6 increases expression
multiple interactions		 ISO vadimezan results in increased expression of IL6 protein
vadimezan results in increased expression of IL6 mRNA
vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of IL6 mRNA]]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of IL6 protein]]		 CTD PMID:16944150 PMID:36958387 PMID:37046119 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IRF3 interferon regulatory factor 3 increases phosphorylation ISO vadimezan results in increased phosphorylation of IRF3 protein CTD PMID:36958387 NCBI chr19:49,659,572...49,665,857
Ensembl chr19:49,659,569...49,665,875 		JBrowse link
G P2RX1 purinergic receptor P2X 1 multiple interactions ISO [vadimezan affects the reaction [P2RX1 protein affects the susceptibility to Acetaminophen]] which affects the phosphorylation of RELA protein; [vadimezan affects the reaction [P2RX1 protein affects the susceptibility to Acetaminophen]] which affects the phosphorylation of STING1 protein; [vadimezan affects the reaction [P2RX1 protein affects the susceptibility to Acetaminophen]] which affects the phosphorylation of TBK1 protein; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of CCL2 mRNA]]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of CCL2 protein]]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of GPT protein]]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of IL6 mRNA]]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of IL6 protein]]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of TNF mRNA]]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of TNF protein]]; vadimezan affects the reaction [P2RX1 protein affects the susceptibility to Acetaminophen] CTD PMID:37046119 NCBI chr17:3,896,592...3,916,465
Ensembl chr17:3,896,592...3,916,476 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO [vadimezan affects the reaction [P2RX1 protein affects the susceptibility to Acetaminophen]] which affects the phosphorylation of RELA protein CTD PMID:37046119 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G STING1 stimulator of interferon response cGAMP interactor 1 multiple interactions ISO [vadimezan affects the reaction [P2RX1 protein affects the susceptibility to Acetaminophen]] which affects the phosphorylation of STING1 protein CTD PMID:37046119 NCBI chr 5:139,475,533...139,482,758
Ensembl chr 5:139,475,533...139,482,935 		JBrowse link
G TBK1 TANK binding kinase 1 multiple interactions ISO [vadimezan affects the reaction [P2RX1 protein affects the susceptibility to Acetaminophen]] which affects the phosphorylation of TBK1 protein CTD PMID:37046119 NCBI chr12:64,452,120...64,502,114
Ensembl chr12:64,452,090...64,502,114 		JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression		 ISO TNF protein affects the reaction [vadimezan affects the metabolism of Thalidomide]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of TNF mRNA]]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of TNF protein]]
vadimezan results in increased expression of TNF mRNA
vadimezan results in increased expression of TNF protein		 CTD PMID:15060740 PMID:16944150 PMID:36958387 PMID:37046119 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G VEGFA vascular endothelial growth factor A increases expression ISO vadimezan results in increased expression of VEGFA protein CTD PMID:16944150 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      application 25172
        pharmaceutical 24558
          drug 24544
            antineoplastic agent 20859
              vadimezan 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            organic molecule 25222
                              organic cyclic compound 24274
                                organic heterocyclic compound 22328
                                  oxacycle 19986
                                    dibenzopyran 288
                                      xanthenes 282
                                        xanthones 212
                                          vadimezan 15
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