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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:vadimezan
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Accession:CHEBI:75934 term browser browse the term
Definition:A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 5,6-dimethyl-9-oxoxanthen-4-yl group.
Synonyms:exact_synonym: (5,6-dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid
 related_synonym: (5,6-dimethyl-9-oxoxanthen-4-yl)acetic acid;   5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid;   5,6-Dimethylxanthenone-4-acetic acid;   5,6-Dimethylxanthenoneacetic acid;   5,6-MeXAA;   AS 1404;   Dimethyloxoxanthene acetic acid;   Formula=C17H14O4;   InChI=1S/C17H14O4/c1-9-6-7-13-15(20)12-5-3-4-11(8-14(18)19)17(12)21-16(13)10(9)2/h3-7H,8H2,1-2H3,(H,18,19);   InChIKey=XGOYIMQSIKSOBS-UHFFFAOYSA-N;   NSC 640488;   SMILES=Cc1ccc2c(oc3c(CC(O)=O)cccc3c2=O)c1C;   vadimezanum
 xref: CAS:117570-53-3
 xref_mesh: MESH:C066668
 xref: PDBeChem:1YE;   PMID:20050824;   PMID:20072732;   PMID:20118240;   PMID:20460477;   PMID:21205086;   PMID:21321262;   PMID:21575001;   PMID:21588382;   PMID:21680264;   PMID:21709202;   PMID:21819972;   PMID:21870897;   PMID:22142330;   PMID:22695475;   PMID:23481183;   PMID:23481185;   Patent:NZ576925;   Reaxys:4262852;   Wikipedia:Vadimezan


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vadimezan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects export
affects transport
ISO ABCC1 protein affects the export of vadimezan metabolite
ABCC1 protein affects the transport of vadimezan analog
CTD PMID:15282097 PMID:15784341 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects transport
affects export
ISO ABCC2 protein affects the transport of vadimezan analog
ABCC2 protein affects the export of vadimezan metabolite
CTD PMID:15282097 PMID:15784341 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases oxidation
ISO Acridines analog inhibits the reaction [CYP1A2 protein results in increased oxidation of vadimezan] CTD PMID:16120190 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Il1a interleukin 1 alpha increases expression EXP vadimezan results in increased expression of IL1A protein CTD PMID:16944150 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il6 interleukin 6 increases expression EXP vadimezan results in increased expression of IL6 protein CTD PMID:16944150 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
TNF protein affects the reaction [vadimezan affects the metabolism of Thalidomide]
vadimezan results in increased expression of TNF protein
CTD PMID:15060740 PMID:16944150 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression EXP vadimezan results in increased expression of VEGFA protein CTD PMID:16944150 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

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  CHEBI ontology 19812
    role 19761
      application 19471
        pharmaceutical 19319
          drug 19319
            antineoplastic agent 17316
              vadimezan 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      ketone 16924
                                        cyclic ketone 15393
                                          xanthones 175
                                            vadimezan 7
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