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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:vadimezan
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Accession:CHEBI:75934 term browser browse the term
Definition:A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 5,6-dimethyl-9-oxoxanthen-4-yl group.
Synonyms:exact_synonym: (5,6-dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid
 related_synonym: (5,6-dimethyl-9-oxoxanthen-4-yl)acetic acid;   5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid;   5,6-Dimethylxanthenone-4-acetic acid;   5,6-Dimethylxanthenoneacetic acid;   5,6-MeXAA;   AS 1404;   Dimethyloxoxanthene acetic acid;   Formula=C17H14O4;   InChI=1S/C17H14O4/c1-9-6-7-13-15(20)12-5-3-4-11(8-14(18)19)17(12)21-16(13)10(9)2/h3-7H,8H2,1-2H3,(H,18,19);   InChIKey=XGOYIMQSIKSOBS-UHFFFAOYSA-N;   NSC 640488;   SMILES=Cc1ccc2c(oc3c(CC(O)=O)cccc3c2=O)c1C;   vadimezanum
 xref: CAS:117570-53-3
 xref_mesh: MESH:C066668
 xref: PDBeChem:1YE;   PMID:20050824;   PMID:20072732;   PMID:20118240;   PMID:20460477;   PMID:21205086;   PMID:21321262;   PMID:21575001;   PMID:21588382;   PMID:21680264;   PMID:21709202;   PMID:21819972;   PMID:21870897;   PMID:22142330;   PMID:22695475;   PMID:23481183;   PMID:23481185;   Patent:NZ576925;   Reaxys:4262852;   Wikipedia:Vadimezan


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vadimezan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects export
affects transport
ISO ABCC1 protein affects the export of vadimezan metabolite
ABCC1 protein affects the transport of vadimezan analog
CTD PMID:15282097, PMID:15784341 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects transport
affects export
ISO ABCC2 protein affects the transport of vadimezan analog
ABCC2 protein affects the export of vadimezan metabolite
CTD PMID:15282097, PMID:15784341 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases oxidation
ISO Acridines analog inhibits the reaction [CYP1A2 protein results in increased oxidation of vadimezan] CTD PMID:16120190 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Il1a interleukin 1 alpha increases expression EXP vadimezan results in increased expression of IL1A protein CTD PMID:16944150 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il6 interleukin 6 increases expression EXP vadimezan results in increased expression of IL6 protein CTD PMID:16944150 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
TNF protein affects the reaction [vadimezan affects the metabolism of Thalidomide]
vadimezan results in increased expression of TNF protein
CTD PMID:15060740, PMID:16944150 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression EXP vadimezan results in increased expression of VEGFA protein CTD PMID:16944150 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            antineoplastic agent 16985
              vadimezan 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      ketone 16144
                                        cyclic ketone 13813
                                          xanthones 167
                                            vadimezan 7
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