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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:amfenac
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Accession:CHEBI:75915 term browser browse the term
Definition:An oxo monocarboxylic acid that is benzophenone in which one of the phenyl groups is substituted by an amino group and a carboxymethyl group at position 2 and 3, respectively. The corresponding carboxamide, nepafenac, is a prodrug of amfenac and is used for the treatment of pain and inflammation following cataract surgery.
Synonyms:exact_synonym: (2-amino-3-benzoylphenyl)acetic acid
 related_synonym: (2-Amino-3-benzoylphenyl)essigsaeure;   2-amino-3-benzoylbenzeneacetic acid;   Formula=C15H13NO3;   InChI=1S/C15H13NO3/c16-14-11(9-13(17)18)7-4-8-12(14)15(19)10-5-2-1-3-6-10/h1-8H,9,16H2,(H,17,18);   InChIKey=SOYCMDCMZDHQFP-UHFFFAOYSA-N;   SMILES=Nc1c(CC(O)=O)cccc1C(=O)c1ccccc1;   amfenaco;   amfenacum
 xref: CAS:51579-82-9;   Drug_Central:154;   KEGG:D07443;   PMID:10850857;   PMID:19897019;   PMID:3540874;   PMID:8320556;   Patent:DE2324768;   Patent:US4045576;   Reaxys:2381781;   Wikipedia:Amfenac
 cyclic_relationship: is_conjugate_acid_of CHEBI:75917



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bromfenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 decreases activity ISO bromfenac results in decreased activity of ABCB11 protein CTD PMID:22646477 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 decreases activity ISO bromfenac results in decreased activity of ABCC2 protein CTD PMID:22646477 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression ISO bromfenac results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression ISO bromfenac results in increased expression of CXCL8 mRNA CTD PMID:32816093 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of bromfenac metabolite CTD PMID:31815452 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases hydroxylation ISO CYP2C8 protein results in increased hydroxylation of bromfenac CTD PMID:31815452 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 increases hydroxylation ISO CYP2C19 protein results in increased hydroxylation of bromfenac CTD PMID:31815452 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions
increases hydroxylation
ISO Acetylcysteine affects the reaction [CYP2C9 protein results in increased hydroxylation of bromfenac]; Glutathione affects the reaction [CYP2C9 protein results in increased hydroxylation of bromfenac] CTD PMID:31815452 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
JBrowse link
G Ereg epiregulin increases expression ISO bromfenac results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO bromfenac results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Il1b interleukin 1 beta increases expression ISO bromfenac results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Met met proto-oncogene increases expression ISO bromfenac results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO bromfenac results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 decreases expression ISO bromfenac results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO bromfenac results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 2:164,195,990...164,231,086
Ensembl chr 2:164,195,990...164,231,015
JBrowse link
G Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 increases metabolic processing
multiple interactions
ISO UGT2B7 protein results in increased metabolism of bromfenac
Mefenamic Acid inhibits the reaction [UGT2B7 protein results in increased metabolism of bromfenac]
CTD PMID:31815452 NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22188
    role 22173
      application 21755
        anti-inflammatory agent 17219
          anti-inflammatory drug 15224
            non-steroidal anti-inflammatory drug 14434
              amfenac 16
                bromfenac 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 22188
    subatomic particle 22180
      composite particle 22180
        hadron 22180
          baryon 22180
            nucleon 22180
              atomic nucleus 22180
                atom 22180
                  main group element atom 22114
                    main group molecular entity 22114
                      s-block molecular entity 21706
                        hydrogen molecular entity 21622
                          hydrides 20748
                            inorganic hydride 18678
                              pnictogen hydride 18658
                                nitrogen hydride 18537
                                  azane 18445
                                    ammonia 18444
                                      organic amino compound 18444
                                        aromatic amine 15740
                                          anilines 14581
                                            substituted aniline 14212
                                              amfenac 16
                                                bromfenac 16
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