CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: amfenac
Accession: CHEBI:75915
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Definition: An oxo monocarboxylic acid that is benzophenone in which one of the phenyl groups is substituted by an amino group and a carboxymethyl group at position 2 and 3, respectively. The corresponding carboxamide, nepafenac, is a prodrug of amfenac and is used for the treatment of pain and inflammation following cataract surgery.
Synonyms: exact_synonym: (2-amino-3-benzoylphenyl)acetic acid
related_synonym: (2-Amino-3-benzoylphenyl)essigsaeure; 2-amino-3-benzoylbenzeneacetic acid; Formula=C15H13NO3; InChI=1S/C15H13NO3/c16-14-11(9-13(17)18)7-4-8-12(14)15(19)10-5-2-1-3-6-10/h1-8H,9,16H2,(H,17,18); InChIKey=SOYCMDCMZDHQFP-UHFFFAOYSA-N; SMILES=Nc1c(CC(O)=O)cccc1C(=O)c1ccccc1; amfenaco; amfenacum
xref: CAS:51579-82-9; Drug_Central:154; KEGG:D07443; PMID:10850857; PMID:19897019; PMID:3540874; PMID:8320556; Patent:DE2324768; Patent:US4045576; Reaxys:2381781; Wikipedia:Amfenac
cyclic_relationship: is_conjugate_acid_of CHEBI:75917
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Abcb11
ATP-binding cassette, sub-family B member 11
decreases activity
ISO
bromfenac results in decreased activity of ABCB11 protein
CTD
PMID:22646477
NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
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Abcc2
ATP-binding cassette, sub-family member 2
decreases activity
ISO
bromfenac results in decreased activity of ABCC2 protein
CTD
PMID:22646477
NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
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Bmp6
bone morphogenetic protein 6
increases expression
ISO
bromfenac results in increased expression of BMP6 mRNA
CTD
PMID:32816093
NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278
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Cxcl15
C-X-C motif chemokine ligand 15
increases expression
ISO
bromfenac results in increased expression of CXCL8 mRNA
CTD
PMID:32816093
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases metabolic processing
ISO
CYP1A2 protein results in increased metabolism of bromfenac metabolite
CTD
PMID:31815452
NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
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Cyp2c29
cytochrome P450, family 2, subfamily c, polypeptide 29
increases hydroxylation
ISO
CYP2C8 protein results in increased hydroxylation of bromfenac
CTD
PMID:31815452
NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157
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Cyp2c38
cytochrome P450, family 2, subfamily c, polypeptide 38
increases hydroxylation
ISO
CYP2C19 protein results in increased hydroxylation of bromfenac
CTD
PMID:31815452
NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
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Cyp2c65
cytochrome P450, family 2, subfamily c, polypeptide 65
multiple interactions increases hydroxylation
ISO
Acetylcysteine affects the reaction [CYP2C9 protein results in increased hydroxylation of bromfenac]; Glutathione affects the reaction [CYP2C9 protein results in increased hydroxylation of bromfenac]
CTD
PMID:31815452
NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
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Ereg
epiregulin
increases expression
ISO
bromfenac results in increased expression of EREG mRNA
CTD
PMID:32816093
NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505
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Il1a
interleukin 1 alpha
increases expression
ISO
bromfenac results in increased expression of IL1A mRNA
CTD
PMID:32816093
NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
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Il1b
interleukin 1 beta
increases expression
ISO
bromfenac results in increased expression of IL1B mRNA
CTD
PMID:32816093
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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Met
met proto-oncogene
increases expression
ISO
bromfenac results in increased expression of MET mRNA
CTD
PMID:32816093
NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
bromfenac results in increased expression of PTGS2 mRNA
CTD
PMID:32816093
NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
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Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
decreases expression
ISO
bromfenac results in decreased expression of SLC7A11 mRNA
CTD
PMID:32816093
NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
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Slpi
secretory leukocyte peptidase inhibitor
increases expression
ISO
bromfenac results in increased expression of SLPI mRNA
CTD
PMID:32816093
NCBI chr 2:164,195,990...164,231,086
Ensembl chr 2:164,195,990...164,231,015
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Ugt2b34
UDP glucuronosyltransferase 2 family, polypeptide B34
increases metabolic processing multiple interactions
ISO
UGT2B7 protein results in increased metabolism of bromfenac Mefenamic Acid inhibits the reaction [UGT2B7 protein results in increased metabolism of bromfenac]
CTD
PMID:31815452
NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796
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