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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:amfenac
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Accession:CHEBI:75915 term browser browse the term
Definition:An oxo monocarboxylic acid that is benzophenone in which one of the phenyl groups is substituted by an amino group and a carboxymethyl group at position 2 and 3, respectively. The corresponding carboxamide, nepafenac, is a prodrug of amfenac and is used for the treatment of pain and inflammation following cataract surgery.
Synonyms:exact_synonym: (2-amino-3-benzoylphenyl)acetic acid
 related_synonym: (2-Amino-3-benzoylphenyl)essigsaeure;   2-amino-3-benzoylbenzeneacetic acid;   Formula=C15H13NO3;   InChI=1S/C15H13NO3/c16-14-11(9-13(17)18)7-4-8-12(14)15(19)10-5-2-1-3-6-10/h1-8H,9,16H2,(H,17,18);   InChIKey=SOYCMDCMZDHQFP-UHFFFAOYSA-N;   SMILES=Nc1c(CC(O)=O)cccc1C(=O)c1ccccc1;   amfenaco;   amfenacum
 xref: CAS:51579-82-9;   Drug_Central:154;   KEGG:D07443;   PMID:10850857;   PMID:19897019;   PMID:3540874;   PMID:8320556;   Patent:DE2324768;   Patent:US4045576;   Reaxys:2381781;   Wikipedia:Amfenac
 cyclic_relationship: is_conjugate_acid_of CHEBI:75917


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bromfenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO bromfenac results in decreased activity of ABCB11 protein CTD PMID:22646477 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity ISO bromfenac results in decreased activity of ABCC2 protein CTD PMID:22646477 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of bromfenac metabolite CTD PMID:31815452 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases hydroxylation ISO CYP2C19 protein results in increased hydroxylation of bromfenac CTD PMID:31815452 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases hydroxylation ISO CYP2C8 protein results in increased hydroxylation of bromfenac CTD PMID:31815452 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases metabolic processing
multiple interactions
ISO UGT2B7 protein results in increased metabolism of bromfenac
Mefenamic Acid inhibits the reaction [UGT2B7 protein results in increased metabolism of bromfenac]
CTD PMID:31815452 NCBI chr14:22,597,103...22,619,968 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        anti-inflammatory agent 14965
          anti-inflammatory drug 13624
            non-steroidal anti-inflammatory drug 12708
              amfenac 6
                bromfenac 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            inorganic hydride 17430
                              pnictogen hydride 17402
                                nitrogen hydride 17243
                                  azane 16960
                                    ammonia 16959
                                      organic amino compound 16958
                                        aromatic amine 13634
                                          anilines 12341
                                            substituted aniline 11837
                                              amfenac 6
                                                bromfenac 6
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