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Accession:CHEBI:75915 term browser browse the term
Definition:An oxo monocarboxylic acid that is benzophenone in which one of the phenyl groups is substituted by an amino group and a carboxymethyl group at position 2 and 3, respectively. The corresponding carboxamide, nepafenac, is a prodrug of amfenac and is used for the treatment of pain and inflammation following cataract surgery.
Synonyms:exact_synonym: (2-amino-3-benzoylphenyl)acetic acid
 related_synonym: (2-Amino-3-benzoylphenyl)essigsaeure;   2-amino-3-benzoylbenzeneacetic acid;   Formula=C15H13NO3;   InChI=1S/C15H13NO3/c16-14-11(9-13(17)18)7-4-8-12(14)15(19)10-5-2-1-3-6-10/h1-8H,9,16H2,(H,17,18);   InChIKey=SOYCMDCMZDHQFP-UHFFFAOYSA-N;   SMILES=Nc1c(CC(O)=O)cccc1C(=O)c1ccccc1;   amfenaco;   amfenacum
 xref: CAS:51579-82-9 "ChemIDplus";   Drug_Central:154 "DrugCentral";   KEGG:D07443;   PMID:10850857 "Europe PMC";   PMID:19897019 "Europe PMC";   PMID:3540874 "Europe PMC";   PMID:8320556 "Europe PMC";   Patent:DE2324768;   Patent:US4045576;   Reaxys:2381781 "Reaxys";   Wikipedia:Amfenac
 cyclic_relationship: is_conjugate_acid_of CHEBI:75917

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bromfenac term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP binding cassette subfamily B member 11 JBrowse link 3 55,480,024 55,587,946 RGD:6480464
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      application 19220
        anti-inflammatory agent 14905
          anti-inflammatory drug 13591
            non-steroidal anti-inflammatory drug 12671
              amfenac 2
                bromfenac 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    main group molecular entity 19531
                      s-block molecular entity 19314
                        hydrogen molecular entity 19303
                          hydrides 18231
                            inorganic hydride 17095
                              pnictogen hydride 17053
                                nitrogen hydride 16874
                                  azane 16551
                                    ammonia 16548
                                      organic amino compound 16547
                                        aromatic amine 13576
                                          anilines 12299
                                            substituted aniline 11795
                                              amfenac 2
                                                bromfenac 2
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.