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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nitrendipine
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Accession:CHEBI:7582 term browser browse the term
Definition:A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.
Synonyms:exact_synonym: ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
 related_synonym: 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester;   BAY e 5009;   Bayotensin;   Baypress;   Bylotensin;   Deiten;   Formula=C18H20N2O6;   InChI=1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3;   InChIKey=PVHUJELLJLJGLN-UHFFFAOYSA-N;   Nidrel;   SMILES=CCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC;   nitrendipino;   nitrendipinum
 xref: CAS:39562-70-4;   DrugBank:DB01054;   Drug_Central:1947;   HMDB:HMDB0015187;   KEGG:C07713;   KEGG:D00629;   LINCS:LSM-1246
 xref_mesh: MESH:D009568
 xref: PMID:1725797;   PMID:1790544;   PMID:20398559;   PMID:21811924;   PMID:23648675;   PMID:6085389;   Patent:CN101416954;   Patent:DE2117571;   Patent:US3799934;   Reaxys:498823;   Wikipedia:Nitrendipine


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nitrendipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Nitrendipine results in decreased activity of ABCB11 protein
Nitrendipine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:20829430, PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Agtr1a angiotensin II receptor, type 1a affects response to substance ISO AGTR1 gene SNP affects the susceptibility to Nitrendipine CTD PMID:8952600 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Ar androgen receptor decreases activity ISO Nitrendipine results in decreased activity of AR protein CTD PMID:25257666 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Nitrendipine promotes the reaction [Gentamicins results in increased expression of BAX protein] CTD PMID:19698708 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Nitrendipine promotes the reaction [Gentamicins results in decreased expression of BCL2 protein] CTD PMID:19698708 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Nitrendipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of CALCA protein] CTD PMID:2470235 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Cck cholecystokinin multiple interactions ISO Nitrendipine inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein] CTD PMID:25787141 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Nitrendipine results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Gast gastrin multiple interactions ISO Nitrendipine inhibits the reaction [Colforsin results in increased secretion of GAST protein]; Nitrendipine inhibits the reaction [Terbutaline results in increased secretion of GAST protein] CTD PMID:9277405 NCBI chr10:88,245,532...88,248,485
Ensembl chr10:88,245,532...88,248,484
JBrowse link
G Gcg glucagon multiple interactions ISO Nitrendipine inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form] CTD PMID:25787141 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Nitrendipine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Nitrendipine inhibits the reaction [bisphenol A results in increased expression of IL4 protein]; Nitrendipine inhibits the reaction [nonylphenol results in increased expression of IL4 protein] CTD PMID:12709020 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases activity
ISO Nitrendipine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]
Nitrendipine results in increased activity of NR1H4 protein
CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Ren renin increases activity ISO Nitrendipine results in increased activity of REN protein CTD PMID:2869952, PMID:6734029 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        fuel 10797
          methanol 3062
            methyl ester 3051
              nitrendipine 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      chalcogen 19362
                        oxygen atom 19323
                          oxygen molecular entity 19323
                            hydroxides 19068
                              organic hydroxy compound 18634
                                alcohol 14987
                                  primary alcohol 13886
                                    ethanols 8108
                                      ethanol 8108
                                        ethyl ester 3174
                                          nitrendipine 14
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