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ONTOLOGY REPORT - ANNOTATIONS


Term:nitrazepam
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Accession:CHEBI:7581 term browser browse the term
Definition:A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one which is substituted at positions 5 and 7 by phenyl and nitro groups, respectively. It is used as a hypnotic for the short-term management of insomnia and for the treatment of epileptic spasms in infants (West's syndrome).
Synonyms:related_synonym: 1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one;   7-nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one;   Apodorm;   Atempol;   Benzalin;   Calsmin;   Dormicum;   Eatan;   Eunoctin;   Formula=C15H11N3O3;   Gerson;   Hipnax;   Hipsal;   Ibrovek;   Imeson;   Imesont;   InChI=1S/C15H11N3O3/c19-14-9-16-15(10-4-2-1-3-5-10)12-8-11(18(20)21)6-7-13(12)17-14/h1-8H,9H2,(H,17,19);   InChIKey=KJONHKAYOJNZEC-UHFFFAOYSA-N;   Mogadon;   N-desmethylnimetazepam;   Nelbon;   Nelmat;   Neozepam;   Neuchlonic;   Nitrados;   Paxisyn;   Pelson;   Persopit;   Radedorm;   Relact;   Remnos;   Ro 4-5360;   Ro 5-3059;   SMILES=[O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3)c2c1;   Somitran;   Sonebon;   Sonnolin;   Surem;   Trazenin;   Unisomnia;   nitrazepamum
 xref: CAS:146-22-5 "ChemIDplus";   CAS:146-22-5 "KEGG COMPOUND";   CAS:146-22-5 "NIST Chemistry WebBook";   DrugBank:DB01595;   Drug_Central:1945 "DrugCentral";   HMDB:HMDB0015534;   KEGG:C07487;   KEGG:D00531;   LINCS:LSM-5681
 xref_mesh: MESH:D009567
 xref: PMID:10030438 "Europe PMC";   PMID:15637997 "Europe PMC";   PMID:18603831 "Europe PMC";   PMID:19557123 "Europe PMC";   PMID:23085494 "Europe PMC";   PMID:23245766 "Europe PMC";   PMID:331868 "Europe PMC";   PMID:578380 "Europe PMC";   PMID:6143468 "Europe PMC";   PMID:6926838 "Europe PMC";   PMID:6988458 "Europe PMC";   PMID:7037262 "Europe PMC";   Patent:US3121076;   Reaxys:757185 "Reaxys";   Wikipedia:Nitrazepam


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nitrazepam term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1c1 aldo-keto reductase family 1, member C1 JBrowse link 17 69,441,253 69,460,334 RGD:6480464
G Akr1c2 aldo-keto reductase family 1, member C2 JBrowse link 17 69,388,337 69,435,160 RGD:6480464
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
nimetazepam term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      biological role 19596
        biophysical role 12118
          membrane transport modulator 11882
            GABA modulator 4634
              nitrazepam 7
                nimetazepam 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic molecule 19327
                              organic cyclic compound 19076
                                organic heterocyclic compound 18151
                                  organonitrogen heterocyclic compound 16960
                                    benzodiazepine 527
                                      1,4-benzodiazepinone 107
                                        nitrazepam 7
                                          nimetazepam 3
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