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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nitrazepam
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Accession:CHEBI:7581 term browser browse the term
Definition:A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one which is substituted at positions 5 and 7 by phenyl and nitro groups, respectively. It is used as a hypnotic for the short-term management of insomnia and for the treatment of epileptic spasms in infants (West's syndrome).
Synonyms:related_synonym: 1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one;   7-nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one;   Apodorm;   Atempol;   Benzalin;   Calsmin;   Dormicum;   Eatan;   Eunoctin;   Formula=C15H11N3O3;   Gerson;   Hipnax;   Hipsal;   Ibrovek;   Imeson;   Imesont;   InChI=1S/C15H11N3O3/c19-14-9-16-15(10-4-2-1-3-5-10)12-8-11(18(20)21)6-7-13(12)17-14/h1-8H,9H2,(H,17,19);   InChIKey=KJONHKAYOJNZEC-UHFFFAOYSA-N;   Mogadon;   N-desmethylnimetazepam;   Nelbon;   Nelmat;   Neozepam;   Neuchlonic;   Nitrados;   Paxisyn;   Pelson;   Persopit;   Radedorm;   Relact;   Remnos;   Ro 4-5360;   Ro 5-3059;   SMILES=[O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3)c2c1;   Somitran;   Sonebon;   Sonnolin;   Surem;   Trazenin;   Unisomnia;   nitrazepamum
 xref: CAS:146-22-5;   DrugBank:DB01595;   Drug_Central:1945;   HMDB:HMDB0015534;   KEGG:C07487;   KEGG:D00531;   LINCS:LSM-5681
 xref_mesh: MESH:D009567
 xref: PMID:10030438;   PMID:15637997;   PMID:18603831;   PMID:19557123;   PMID:23085494;   PMID:23245766;   PMID:331868;   PMID:578380;   PMID:6143468;   PMID:6926838;   PMID:6988458;   PMID:7037262;   Patent:US3121076;   Reaxys:757185;   Wikipedia:Nitrazepam


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nitrazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Nitrazepam results in decreased activity of AKR1C4 protein CTD PMID:11995921 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Nitrazepam results in decreased activity of AKR1C2 protein CTD PMID:11995921 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Nitrazepam results in decreased activity of AKR1C3 protein CTD PMID:11995921 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Casp3 caspase 3 multiple interactions ISO CYP3A4 protein affects the reaction [Nitrazepam results in increased activity of CASP3 protein] CTD PMID:19005028 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO CYP3A4 protein affects the reaction [Nitrazepam results in increased activity of CASP7 protein] CTD PMID:19005028 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Nitrazepam binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
nimetazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP3 protein] CTD PMID:19005028 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP7 protein] CTD PMID:19005028 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO nimetazepam inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biophysical role 12642
          membrane transport modulator 12441
            GABA modulator 4655
              nitrazepam 7
                nimetazepam 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organonitrogen heterocyclic compound 17485
                                    benzodiazepine 542
                                      1,4-benzodiazepinone 116
                                        nitrazepam 7
                                          nimetazepam 3
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