prokaryotic metabolite - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	prokaryotic metabolite	go back to main search page
Accession:	CHEBI:75787	browse the term
Definition:	Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea.
Synonyms:	related_synonym:	prokaryotic metabolites

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Rat (18567) Mouse (19213) Human (21589) Chinchilla (0) Bonobo (0) Dog (396) Squirrel (0) Pig (371) Green Monkey (2) Naked Mole-rat (0) All
Genes (396)

1,2-dihexadecanoyl-sn-glycero-3-phosphocholine

term browser

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Object Name

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Evidence

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PubMed Reference(s)

RGD Reference(s)

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G

phospholipase C gamma 1

decreases activity
multiple interactions

1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein
dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]

NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714

1,4-dithiothreitol

term browser

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Object Name

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PubMed Reference(s)

RGD Reference(s)

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G

heat shock protein family A (Hsp70) member 5

increases expression

Dithiothreitol metabolite results in increased expression of HSPA5 protein

NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257

1-stearoyl-2-arachidonoylphosphatidic acid

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G

phospholipase C gamma 1

increases activity

1-stearoyl-2-arachidonoylphosphatidic acid results in increased activity of PLCG1 protein

NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714

2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile

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PubMed Reference(s)

RGD Reference(s)

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G

ATP binding cassette subfamily B member 1

multiple interactions

[Verapamil results in decreased activity of ABCB1 protein] which affects the transport of Digoxin

NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727

3',5'-cyclic AMP

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Object Name

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PubMed Reference(s)

RGD Reference(s)

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G

purinergic receptor P2Y2

multiple interactions

[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP]

NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059

3'-CMP

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RGD Reference(s)

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G

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

multiple interactions

[delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate

NCBI chr 6:17,910,141...17,914,573
Ensembl chr 6:17,910,192...17,914,653

3-isobutyl-1-methyl-7H-xanthine

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PubMed Reference(s)

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G

CF transmembrane conductance regulator

multiple interactions

[1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of CFTR protein

NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977

4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide

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G

potassium voltage-gated channel subfamily H member 2

multiple interactions

Cisapride binds to and results in decreased activity of KCNH2 protein

NCBI chr16:15,009,031...15,041,786
Ensembl chr16:15,009,031...15,041,504

5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid

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PubMed Reference(s)

RGD Reference(s)

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G

purinergic receptor P2Y2

multiple interactions

pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP]

NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059

7,9-dihydro-1H-purine-2,6,8(3H)-trione

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G

ATPase H+ transporting V0 subunit d1

increases expression

Uric Acid results in increased expression of ATP6V0D1 protein

NCBI chr 5:81,926,589...81,965,959
Ensembl chr 5:81,926,612...81,965,526

G

DnaJ heat shock protein family (Hsp40) member C3

increases expression

Uric Acid results in increased expression of DNAJC3 protein

NCBI chr22:46,323,263...46,402,240
Ensembl chr22:46,307,905...46,398,625

G

eukaryotic translation elongation factor 2

decreases expression

Uric Acid results in decreased expression of EEF2 protein

NCBI chr20:55,577,413...55,586,422
Ensembl chr20:55,522,213...55,586,126

G

ezrin

increases expression

Uric Acid results in increased expression of EZR protein

NCBI chr 1:48,160,206...48,210,036
Ensembl chr 1:48,160,206...48,210,036

G

heterogeneous nuclear ribonucleoprotein A2/B1

increases expression

Uric Acid results in increased expression of HNRNPA2B1 protein

NCBI chr14:39,498,805...39,509,034
Ensembl chr14:39,500,897...39,508,952

G

heat shock protein 90 alpha family class A member 1

increases expression

Uric Acid results in increased expression of HSP90AA1 protein

NCBI chr 8:70,091,203...70,096,107
Ensembl chr 8:70,092,217...70,095,243

G

heat shock protein family A (Hsp70) member 5

increases expression

Uric Acid results in increased expression of HSPA5 protein

NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257

G

heat shock protein family D (Hsp60) member 1

decreases expression

Uric Acid results in decreased expression of HSPD1 protein

NCBI chr37:7,010,421...7,025,912

G

inner membrane mitochondrial protein

increases expression

Uric Acid results in increased expression of IMMT protein

NCBI chr17:38,927,508...38,964,522
Ensembl chr17:38,927,531...38,967,004

G

ATP synthase subunit d, mitochondrial-like

increases expression

Uric Acid results in increased expression of ATP5PD protein

NCBI chr 7:66,856,651...66,857,162

G

malate dehydrogenase 2

decreases expression

Uric Acid results in decreased expression of MDH2 protein

NCBI chr 6:7,389,266...7,405,311

G

NSF attachment protein alpha

decreases expression

Uric Acid results in decreased expression of NAPA protein

NCBI chr 1:108,510,920...108,533,317
Ensembl chr 1:108,510,931...108,532,881

G

ornithine aminotransferase

increases expression

Uric Acid results in increased expression of OAT protein

NCBI chr28:33,763,661...33,788,817
Ensembl chr28:33,758,473...33,788,759

G

pyruvate carboxylase

decreases expression

Uric Acid results in decreased expression of PC protein

NCBI chr18:50,406,994...50,507,677
Ensembl chr18:50,412,272...50,507,669

G

RAB11A, member RAS oncogene family

decreases expression

Uric Acid results in decreased expression of RAB11A protein

NCBI chr30:30,200,831...30,218,412
Ensembl chr30:30,200,831...30,218,411

G

SUMO1 activating enzyme subunit 1

decreases expression

Uric Acid results in decreased expression of SAE1 protein

NCBI chr 1:108,757,543...108,864,763
Ensembl chr 1:108,749,061...108,859,797

G

solute carrier family 25 member 12

decreases expression

Uric Acid results in decreased expression of SLC25A12 protein

NCBI chr36:16,185,011...16,391,080
Ensembl chr36:16,185,649...16,483,016

G

solute carrier family 2 member 9

increases transport

SLC2A9 protein results in increased transport of Uric Acid

NCBI chr 3:69,394,304...69,588,462
Ensembl chr 3:69,394,152...69,595,802

8-(4-chlorophenylthio)-cAMP

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PubMed Reference(s)

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G

CF transmembrane conductance regulator

multiple interactions

[1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of CFTR protein

NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977

acetylcholine

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G

potassium inwardly rectifying channel subfamily J member 3

multiple interactions

Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]

NCBI chr36:1,354,686...1,496,397
Ensembl chr36:1,354,678...1,493,766

G

potassium inwardly rectifying channel subfamily J member 6

multiple interactions

Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]

NCBI chr31:32,752,585...33,010,999
Ensembl chr31:32,755,899...32,934,478

G

mitogen-activated protein kinase 14

multiple interactions

Acetylcholine results in increased phosphorylation of and results in increased activity of MAPK14 protein

NCBI chr12:5,145,647...5,221,558
Ensembl chr12:5,146,037...5,220,603

acyclovir

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PubMed Reference(s)

RGD Reference(s)

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G

arginine vasopressin

decreases activity

Acyclovir results in decreased activity of AVP protein

NCBI chr24:18,183,057...18,184,827
Ensembl chr24:18,183,057...18,184,883

amlodipine

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G

renin

increases expression

Amlodipine results in increased expression of REN protein

NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012

amphotericin B

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PubMed Reference(s)

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G

interleukin 6

multiple interactions
increases expression

N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein]

NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519

G

protein kinase cAMP-activated catalytic subunit beta

multiple interactions
increases expression

N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of PRKACG protein]

NCBI chr 6:63,615,445...63,729,386
Ensembl chr 6:63,618,323...63,730,146

G

renin

decreases secretion

Amphotericin B results in decreased secretion of REN protein

NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012

G

tumor necrosis factor

increases expression

Amphotericin B results in increased expression of TNF protein

NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425

atenolol

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PubMed Reference(s)

RGD Reference(s)

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G

renin

multiple interactions

Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]

NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012

atropine

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PubMed Reference(s)

RGD Reference(s)

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G

acetylcholinesterase

multiple interactions

[Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein]

NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702

G

secretin

multiple interactions

Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates]

benazepril

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PubMed Reference(s)

RGD Reference(s)

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G

desmin

decreases expression

benazepril results in decreased expression of DES mRNA

NCBI chr37:25,933,525...25,939,910
Ensembl chr37:25,933,455...25,940,985

Butyrylcholine

term browser

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PubMed Reference(s)

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G

butyrylcholinesterase

increases hydrolysis
multiple interactions

BCHE protein results in increased hydrolysis of butyrylcholine
Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]

PMID:4631366 PMID:4985882

NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583

butyrylthiocholine

term browser

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Object Name

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PubMed Reference(s)

RGD Reference(s)

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G

butyrylcholinesterase

increases hydrolysis

BCHE protein results in increased hydrolysis of Butyrylthiocholine

NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583

capsaicin

term browser

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PubMed Reference(s)

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G

5-hydroxytryptamine receptor 1B

multiple interactions

HTR1B protein promotes the reaction [donitriptan results in decreased susceptibility to Capsaicin]

NCBI chr12:38,659,088...38,659,546

G

transient receptor potential cation channel subfamily V member 1

multiple interactions
increases activity

JYL 1421 inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]

NCBI chr 9:47,404,987...47,443,871
Ensembl chr 9:47,404,972...47,431,926

carmustine

term browser

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PubMed Reference(s)

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G

O-6-methylguanine-DNA methyltransferase

decreases response to substance
multiple interactions

MGMT protein mutant form results in decreased susceptibility to Carmustine; MGMT protein results in decreased susceptibility to Carmustine
MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]

PMID:14617759 PMID:15053863

NCBI chr28:38,204,611...38,427,482
Ensembl chr28:38,204,610...38,427,380

Ceronapril

term browser

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PubMed Reference(s)

RGD Reference(s)

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G

angiotensin I converting enzyme

decreases activity

ceronapril results in decreased activity of ACE protein

NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358

ceruletide

term browser

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G

secretin

multiple interactions

[Ceruletide co-treated with SCT protein] results in increased abundance of Bicarbonates

cilazapril monohydrate

term browser

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G

angiotensinogen

decreases expression

Cilazapril results in decreased expression of AGT protein

NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880

G

renin

increases activity

Cilazapril results in increased activity of REN protein

NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012

cilostazol

term browser

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PubMed Reference(s)

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G

MYC proto-oncogene, bHLH transcription factor

decreases expression

Cilostazol results in decreased expression of MYC mRNA

NCBI chr13:25,200,772...25,205,309
Ensembl chr13:25,200,577...25,205,309

cimetidine

term browser

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PubMed Reference(s)

RGD Reference(s)

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G

solute carrier family 22 member 2

decreases activity

Cimetidine results in decreased activity of SLC22A2 protein

NCBI chr 1:49,327,621...49,348,435
Ensembl chr 1:49,327,296...49,348,435

cisapride

term browser

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Object Name

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PubMed Reference(s)

RGD Reference(s)

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G

potassium voltage-gated channel subfamily H member 2

multiple interactions

Cisapride binds to and results in decreased activity of KCNH2 protein

NCBI chr16:15,009,031...15,041,786
Ensembl chr16:15,009,031...15,041,504

clofibrate

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Object Name

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G

acetyl-CoA acyltransferase 2

increases expression

Clofibrate results in increased expression of ACAA2 mRNA

NCBI chr 7:79,028,636...79,057,720

G

acyl-CoA dehydrogenase very long chain

increases expression

Clofibrate results in increased expression of ACADVL protein

NCBI chr 5:32,189,191...32,194,255
Ensembl chr 5:32,186,502...32,327,990

G

alanine--glyoxylate and serine--pyruvate aminotransferase

decreases expression

Clofibrate results in decreased expression of AGXT protein

NCBI chr25:50,968,291...50,976,089

G

adenosylhomocysteinase

decreases expression

Clofibrate results in decreased expression of AHCY protein

NCBI chr24:23,410,553...23,423,494
Ensembl chr24:23,411,140...23,419,767

G

argininosuccinate lyase

increases expression

Clofibrate results in increased expression of ASL protein

NCBI chr 6:768,522...779,144
Ensembl chr 6:730,358...779,424

G

argininosuccinate synthase 1

decreases expression

Clofibrate results in decreased expression of ASS1 protein

NCBI chr 9:53,425,228...53,478,007
Ensembl chr 9:53,425,448...53,477,904

G

carbamoyl-phosphate synthase 1

increases expression

Clofibrate results in increased expression of CPS1 protein

NCBI chr37:18,308,164...18,428,487
Ensembl chr37:18,143,986...18,427,697

G

carnitine palmitoyltransferase 2

increases expression

Clofibrate results in increased expression of CPT2 mRNA

NCBI chr 5:55,718,209...55,786,175
Ensembl chr 5:55,718,510...55,744,809

G

cytochrome P450 family 1 subfamily A member 2

decreases expression

Clofibrate results in decreased expression of CYP1A2 mRNA

NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135

G

cytochrome P450 family 2 subfamily A polypeptide 13

decreases expression

Clofibrate results in decreased expression of CYP2A13 mRNA

NCBI chr 1:112,932,246...112,938,248
Ensembl chr 1:112,931,985...112,938,350

G

cytochrome P450 2B11

decreases expression

Clofibrate results in decreased expression of CYP2B6 mRNA

NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293

G

cytochrome P450 2C21

decreases expression

Clofibrate results in decreased expression of CYP2C18 mRNA

NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587

G

cytochrome P450 family 2 subfamily E member 1

increases expression

Clofibrate results in increased expression of CYP2E1 protein

NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754

G

cytochrome P-450 3A12

decreases expression

Clofibrate results in decreased expression of CYP3A12 mRNA

G

cytochrome P450 3A26

decreases expression

Clofibrate results in decreased expression of CYP3A26 mRNA

NCBI chr 6:9,777,663...9,815,345
Ensembl chr 6:9,777,659...9,869,352

G

cytochrome P450, family 4, subfamily A, polypeptide 11

increases expression

Clofibrate results in increased expression of CYP4A11 mRNA

NCBI chr15:13,663,337...13,676,350
Ensembl chr15:13,604,130...13,676,344

G

dihydrolipoamide S-succinyltransferase

increases expression

Clofibrate results in increased expression of DLST protein

NCBI chr 8:48,003,730...48,025,001
Ensembl chr 8:48,002,211...48,024,999

G

enoyl-CoA hydratase, short chain 1

increases expression

Clofibrate results in increased expression of ECHS1 protein

NCBI chr28:40,939,856...40,947,694
Ensembl chr28:40,939,961...40,946,167

G

GDP dissociation inhibitor 1

increases expression

Clofibrate results in increased expression of GDI1 protein

NCBI chr X:122,141,633...122,146,724
Ensembl chr X:122,141,566...122,146,824

G

glutathione S-transferase alpha 4

decreases expression

Clofibrate results in decreased expression of GSTA4 mRNA

NCBI chr12:20,426,724...20,443,200
Ensembl chr12:20,426,726...20,443,200

G

glutathione S-transferase kappa 1

decreases expression

Clofibrate results in decreased expression of GSTK1 mRNA

NCBI chr16:6,411,678...6,416,135

G

glutathione S-transferase omega 1

decreases expression

Clofibrate results in decreased expression of GSTO1 mRNA

NCBI chr28:16,569,421...16,579,239
Ensembl chr28:16,569,066...16,619,880

G

hydroxyacyl-CoA dehydrogenase

increases expression

Clofibrate results in increased expression of HADH mRNA

NCBI chr32:28,460,445...28,506,141
Ensembl chr32:28,460,193...28,531,280

G

heat shock protein family D (Hsp60) member 1

increases expression

Clofibrate results in increased expression of HSPD1 protein

NCBI chr37:7,010,421...7,025,912

G

keratin 1

increases expression

Clofibrate results in increased expression of KRT1 protein

NCBI chr27:2,422,150...2,427,160

G

keratin 18

decreases expression

Clofibrate results in decreased expression of KRT18 protein

NCBI chr27:2,189,269...2,193,368
Ensembl chr27:2,189,269...2,193,368

G

glutathione S-transferase A2

decreases expression

Clofibrate results in decreased expression of GSTA3 mRNA; Clofibrate results in decreased expression of GSTA3 protein

NCBI chr12:20,349,133...20,365,023

G

glutathione S-transferase Mu 1

decreases expression

Clofibrate results in decreased expression of GSTM1 mRNA

NCBI chr 6:42,201,697...42,207,886

G

microsomal glutathione S-transferase 1

increases expression

Clofibrate results in increased expression of MGST1 mRNA

NCBI chr27:30,370,588...30,391,898
Ensembl chr27:30,370,594...30,391,778

G

pyruvate carboxylase

increases expression

Clofibrate results in increased expression of PC protein

NCBI chr18:50,406,994...50,507,677
Ensembl chr18:50,412,272...50,507,669

G

phosphoenolpyruvate carboxykinase 2, mitochondrial

increases expression

Clofibrate results in increased expression of PCK2 protein

NCBI chr 8:4,099,016...4,107,870
Ensembl chr 8:4,098,671...4,107,865

G

peroxiredoxin 6

decreases expression

Clofibrate results in decreased expression of PRDX6 protein

NCBI chr 7:25,663,238...25,675,855
Ensembl chr 7:25,663,579...25,675,754

G

selenium binding protein 1

decreases expression

Clofibrate results in decreased expression of SELENBP1 protein

NCBI chr17:60,410,727...60,418,770
Ensembl chr17:60,410,734...60,418,704

G

serine hydroxymethyltransferase 1

decreases expression

Clofibrate results in decreased expression of SHMT1 protein

NCBI chr 5:41,221,531...41,248,653
Ensembl chr 5:41,221,562...41,253,166

G

UDP-glucose pyrophosphorylase 2

decreases expression

Clofibrate results in decreased expression of UGP2 protein

NCBI chr10:63,532,366...63,598,362
Ensembl chr10:63,533,171...63,597,452

G

ubiquinol-cytochrome c reductase core protein 1

increases expression

Clofibrate results in increased expression of UQCRC1 protein

NCBI chr20:40,507,767...40,515,854
Ensembl chr20:40,506,907...40,520,110

G

urocanate hydratase 1

decreases expression

Clofibrate results in decreased expression of UROC1 protein

NCBI chr20:676,624...717,109
Ensembl chr20:678,073...717,141

colforsin daropate hydrochloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

insulin

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK1 protein; [Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK3 protein

NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122

G

mitogen-activated protein kinase 1

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; [Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK1 protein

NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998

G

mitogen-activated protein kinase 3

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK3 protein

NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425

G

nuclear receptor subfamily 1 group I member 2

increases activity

Colforsin results in increased activity of NR1I2 protein

NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347

copper atom

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amyloid beta precursor protein

increases expression

Copper results in increased expression of APP protein

NCBI chr31:21,351,207...21,614,466
Ensembl chr31:21,351,207...21,614,337

G

copper metabolism domain containing 1

increases abundance
decreases export

COMMD1 gene mutant form results in increased abundance of Copper
COMMD1 gene mutant form results in decreased export of Copper

PMID:20433422 PMID:22879914

NCBI chr10:61,886,281...62,059,610
Ensembl chr10:61,886,281...62,059,591

copper(0)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amyloid beta precursor protein

increases expression

Copper results in increased expression of APP protein

NCBI chr31:21,351,207...21,614,466
Ensembl chr31:21,351,207...21,614,337

G

copper metabolism domain containing 1

increases abundance
decreases export

COMMD1 gene mutant form results in increased abundance of Copper
COMMD1 gene mutant form results in decreased export of Copper

PMID:20433422 PMID:22879914

NCBI chr10:61,886,281...62,059,610
Ensembl chr10:61,886,281...62,059,591

corticotropin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

insulin

increases abundance

INS protein results in increased abundance of Adrenocorticotropic Hormone

NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122

cytidine 5'-monophosphate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

multiple interactions

[delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate

NCBI chr 6:17,910,141...17,914,573
Ensembl chr 6:17,910,192...17,914,653

D-glucitol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

mitogen-activated protein kinase 1

increases phosphorylation

Sorbitol results in increased phosphorylation of MAPK1 protein

NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998

G

mitogen-activated protein kinase 3

increases phosphorylation

Sorbitol results in increased phosphorylation of MAPK3 protein

NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425

D-mannitol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

claudin 4

increases expression

Mannitol results in increased expression of CLDN4 protein

NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145

desferrioxamine B

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensinogen

multiple interactions

Deferoxamine inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin]

NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880

diclofenac

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 2C41

affects metabolic processing
increases hydroxylation

CYP2C9 protein affects the metabolism of Diclofenac
CYP2C19 protein results in increased hydroxylation of Diclofenac

PMID:15677349 PMID:15801540

G

prostaglandin-endoperoxide synthase 1

decreases activity

Diclofenac results in decreased activity of PTGS1 protein alternative form

NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819

dihexadecanoyl phosphatidic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

phospholipase C gamma 1

multiple interactions
increases activity

dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]
dipalmitoylphosphatidic acid results in increased activity of PLCG1 protein

NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714

dimyristoyl phosphatidic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

phospholipase C gamma 1

increases activity

dimyristoylphosphatidic acid results in increased activity of PLCG1 protein

NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714

dioleoyl phosphatidic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

phospholipase C gamma 1

increases activity

dioleoylphosphatidic acid results in increased activity of PLCG1 protein

NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714

doxorubicin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

increases expression
affects response to substance
multiple interactions

Doxorubicin results in increased expression of ABCB1 protein
ABCB1 protein affects the susceptibility to Doxorubicin
valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]; valspodar inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]

PMID:15492788 PMID:24975508 PMID:28093773

NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727

G

hepatocyte growth factor

decreases response to substance

HGF protein results in decreased susceptibility to Doxorubicin

NCBI chr18:21,329,688...21,410,257
Ensembl chr18:21,332,817...21,410,263

G

troponin T2, cardiac type

affects expression

Doxorubicin affects the expression of TNNT2 protein

NCBI chr 7:1,598,306...1,620,531
Ensembl chr 7:1,598,306...1,613,741

G

vasoactive intestinal peptide

decreases expression

Doxorubicin results in decreased expression of VIP protein

NCBI chr 1:42,941,655...42,950,160
Ensembl chr 1:42,941,224...42,950,700

G

X-linked inhibitor of apoptosis

affects response to substance

XIAP affects the susceptibility to Doxorubicin

NCBI chr X:95,300,234...95,356,103
Ensembl chr X:95,331,827...95,351,582

DPDPE

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier organic anion transporter family member 1B2

increases transport

SLCO1B3 protein results in increased transport of Enkephalin, D-Penicillamine (2,5)-

NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989

emodepside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

affects response to substance

ABCB1 protein affects the susceptibility to emodepside

NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727

enalapril

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

multiple interactions

[Ranolazine co-treated with Enalapril] affects the expression of ATP2A2 protein

NCBI chr26:8,148,181...8,209,392
Ensembl chr26:8,148,236...8,209,388

G

early growth response 1

multiple interactions

[Ranolazine co-treated with Enalapril] affects the expression of EGR1 protein

NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575

G

GATA binding protein 4

multiple interactions

[Ranolazine co-treated with Enalapril] affects the expression of GATA4 protein

NCBI chr25:26,126,172...26,211,474
Ensembl chr25:26,127,853...26,182,989

G

potassium voltage-gated channel subfamily D member 3

decreases expression

Enalapril results in decreased expression of KCND3 mRNA

NCBI chr17:63,470,829...63,668,354
Ensembl chr17:63,470,415...63,668,035

G

NGFI-A binding protein 1

multiple interactions

[Ranolazine co-treated with Enalapril] affects the expression of NAB1 protein

NCBI chr37:1,207,619...1,243,546
Ensembl chr37:1,207,638...1,241,610

G

nitric oxide synthase 3

multiple interactions
increases expression

FR 173657 inhibits the reaction [Enalapril results in increased expression of NOS3 mRNA]

NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277

G

natriuretic peptide A

decreases expression
multiple interactions

Enalapril results in decreased expression of NPPA protein
FR 173657 inhibits the reaction [Enalapril results in decreased expression of NPPA protein]

NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385

G

renin

increases activity
multiple interactions

Enalapril results in increased activity of REN protein
[Enalapril co-treated with FR 173657] results in increased activity of REN protein

NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012

G

solute carrier family 8 member A1

multiple interactions

[Ranolazine co-treated with Enalapril] affects the expression of SLC8A1 protein

NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700

eplerenone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

multiple interactions

Eplerenone binds to and results in decreased activity of AR protein

NCBI chr24:34,713,390...34,731,461
NCBI chr X:51,969,785...52,167,450
Ensembl chr X:51,969,785...52,151,912

etoposide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

decreases response to substance

ABCC1 protein results in decreased susceptibility to Etoposide

NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331

felodipine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nuclear receptor subfamily 1 group I member 2

increases activity

Felodipine results in increased activity of NR1I2 protein

NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347

fenfluramine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

endothelin 1

increases activity

Fenfluramine results in increased activity of EDN1 protein

NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383

flufenamic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

copine 6

decreases activity

Flufenamic Acid results in decreased activity of DHRS4 protein

NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744

ganglioside GM1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

G protein subunit alpha q

multiple interactions

G(M1) Ganglioside inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]

NCBI chr 1:80,733,530...80,928,065
Ensembl chr 1:80,715,366...80,928,065

G

hexosaminidase subunit beta

multiple interactions

G(M1) Ganglioside inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; G(M1) Ganglioside inhibits the reaction [Melitten results in increased secretion of HEXB protein]; G(M1) Ganglioside inhibits the reaction [Wasp Venoms results in increased secretion of HEXB protein]

PMID:21334356 PMID:21671308

NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417

glutathione

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

claudin 4

multiple interactions

Glutathione inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]

NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145

G

mitogen-activated protein kinase 1

multiple interactions

Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]

NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998

G

mitogen-activated protein kinase 3

multiple interactions

Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]

NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425

G

mitogen-activated protein kinase 8

multiple interactions

Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]

NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401

G

mitogen-activated protein kinase 9

multiple interactions

Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]

NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119

glyburide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CF transmembrane conductance regulator

decreases activity

Glyburide results in decreased activity of CFTR protein

NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977

hydrogen peroxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

claudin 4

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; U 0126 inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]

NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145

G

mitogen-activated protein kinase 1

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]

NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998

G

mitogen-activated protein kinase 3

increases phosphorylation
multiple interactions

Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]

NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425

G

mitogen-activated protein kinase 8

increases phosphorylation
multiple interactions

Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]

NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401

G

mitogen-activated protein kinase 9

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]

NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119

G

superoxide dismutase 2

multiple interactions
decreases activity

Dihydrotestosterone promotes the reaction [Hydrogen Peroxide results in decreased activity of SOD2 protein]

NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706

hydrogencarbonate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

secretin

increases abundance
multiple interactions

SCT protein results in increased abundance of Bicarbonates
[Ceruletide co-treated with SCT protein] results in increased abundance of Bicarbonates; Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates]

indometacin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hexosaminidase subunit beta

multiple interactions

Indomethacin promotes the reaction [mastoparan results in increased secretion of HEXB protein]

NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417

G

prostaglandin-endoperoxide synthase 1

decreases activity

Indomethacin results in decreased activity of PTGS1 protein alternative form

NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819

iprodione

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

[iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein

NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444

G

cytochrome P450 family 1 subfamily A member 1

multiple interactions

[iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein

NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866

iron atom

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ceruloplasmin

multiple interactions
increases export

[CP protein co-treated with TF protein] results in increased export of Iron; CP protein promotes the reaction [TF protein binds to Iron]
CP protein results in increased export of Iron

NCBI chr23:43,969,297...44,033,226
Ensembl chr23:43,969,435...44,030,369

G

serotransferrin

multiple interactions
increases export

[CP protein co-treated with TF protein] results in increased export of Iron; CP protein promotes the reaction [TF protein binds to Iron]
TF protein results in increased export of Iron

NCBI chr23:30,658,250...30,683,816
Ensembl chr23:30,595,704...30,683,845

iron(0)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ceruloplasmin

multiple interactions
increases export

[CP protein co-treated with TF protein] results in increased export of Iron; CP protein promotes the reaction [TF protein binds to Iron]
CP protein results in increased export of Iron

NCBI chr23:43,969,297...44,033,226
Ensembl chr23:43,969,435...44,030,369

G

serotransferrin

multiple interactions
increases export

[CP protein co-treated with TF protein] results in increased export of Iron; CP protein promotes the reaction [TF protein binds to Iron]
TF protein results in increased export of Iron

NCBI chr23:30,658,250...30,683,816
Ensembl chr23:30,595,704...30,683,845

ivermectin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

affects abundance
increases response to substance
multiple interactions

ABCB1 protein affects the abundance of Ivermectin
ABCB1 gene mutant form results in increased susceptibility to Ivermectin; ABCB1 mutant form results in increased susceptibility to Ivermectin; ABCB1 protein mutant form results in increased susceptibility to Ivermectin
ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of ALB mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of DAO mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of EBF3 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GABRQ mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GLRA1 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of KLK6 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of MAB21L2 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC10A4 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC18A2 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of TTR mRNA]

PMID:20595473 PMID:22834856 PMID:22924731 PMID:23186803 PMID:25419811

NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727

G

albumin

multiple interactions

ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of ALB mRNA]

NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709

G

D-amino acid oxidase

multiple interactions

ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of DAO mRNA]

NCBI chr26:18,032,663...18,057,277
Ensembl chr26:18,033,392...18,057,238

G

EBF transcription factor 3

multiple interactions

ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of EBF3 mRNA]

NCBI chr28:38,489,635...38,601,800
Ensembl chr28:38,491,047...38,602,022

G

gamma-aminobutyric acid type A receptor subunit theta

multiple interactions

ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GABRQ mRNA]

NCBI chr X:120,607,815...120,630,251
Ensembl chr X:120,607,686...120,628,343

G

glycine receptor alpha 1

multiple interactions

ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GLRA1 mRNA]

NCBI chr 4:57,443,094...57,541,494
Ensembl chr 4:57,443,999...57,528,376

G

kallikrein related peptidase 6

multiple interactions

ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of KLK6 mRNA]

NCBI chr 1:105,902,147...105,907,585

G

mab-21 like 2

multiple interactions

ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of MAB21L2 mRNA]

NCBI chr15:48,538,912...48,541,651
Ensembl chr15:48,539,955...48,541,034

G

solute carrier family 10 member 4

multiple interactions

ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC10A4 mRNA]

NCBI chr13:44,293,956...44,299,529
Ensembl chr13:44,277,094...44,299,732

G

solute carrier family 18 member A2

multiple interactions

ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC18A2 mRNA]

NCBI chr28:27,731,709...27,809,341
Ensembl chr28:27,731,004...27,767,993

G

transthyretin

multiple interactions

ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of TTR mRNA]

NCBI chr 7:57,940,354...57,947,084
Ensembl chr 7:57,914,381...57,947,058

L-1,4-dithiothreitol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

heat shock protein family A (Hsp70) member 5

increases expression

Dithiothreitol metabolite results in increased expression of HSPA5 protein

NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257

lead(II) chloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

endothelin 1

increases secretion

lead chloride results in increased secretion of EDN1 protein

NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383

G

endothelin 2

increases secretion

lead chloride results in increased secretion of EDN2 protein

NCBI chr15:1,647,966...1,654,272
Ensembl chr15:1,648,077...1,654,272

loperamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

affects response to substance
increases export

ABCB1 protein affects the susceptibility to Loperamide
ABCB1 protein results in increased export of Loperamide

PMID:25660379 PMID:28093773

NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727

loratadine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases activity

Loratadine results in increased activity of CASP3 protein

NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505

masitinib

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 5

increases expression

masitinib results in increased expression of ABCA5 mRNA

NCBI chr 9:15,708,070...15,781,100
Ensembl chr 9:15,420,835...15,783,045

G

abhydrolase domain containing 14A

increases expression

masitinib results in increased expression of ABHD14A mRNA

NCBI chr20:37,738,500...37,744,689

G

actin binding transcription modulator

decreases expression

masitinib results in decreased expression of ABITRAM mRNA

NCBI chr11:64,094,653...64,100,078
Ensembl chr11:64,094,721...64,109,421

G

actin binding LIM protein 1

increases expression

masitinib results in increased expression of ABLIM1 mRNA

NCBI chr28:25,260,323...25,543,369
Ensembl chr28:25,260,873...25,545,304

G

acetyl-CoA acetyltransferase 2

decreases expression

masitinib results in decreased expression of ACAT2 mRNA

NCBI chr 1:49,011,665...49,029,368
Ensembl chr 1:49,011,706...49,029,327

G

acyl-CoA synthetase medium chain family member 3

increases expression

masitinib results in increased expression of ACSM3 mRNA

NCBI chr 6:24,558,010...24,594,326
Ensembl chr 6:24,558,142...24,582,728

G

actin like 7A

increases expression

masitinib results in increased expression of ACTL7A mRNA

NCBI chr11:64,031,305...64,033,908
Ensembl chr11:64,032,358...64,033,788

G

actin related protein 2

decreases expression

masitinib results in decreased expression of ACTR2 protein

NCBI chr10:64,696,068...64,733,027
Ensembl chr10:64,696,111...64,730,553

G

ADP-ribosylarginine hydrolase

increases expression

masitinib results in increased expression of ADPRH mRNA

NCBI chr33:23,218,633...23,226,844
Ensembl chr33:23,218,101...23,224,667

G

aspartylglucosaminidase

increases expression

masitinib results in increased expression of AGA mRNA

NCBI chr16:52,314,860...52,324,879
Ensembl chr16:52,314,535...52,324,894

G

argonaute RISC catalytic component 2

decreases expression

masitinib results in decreased expression of AGO2 mRNA

NCBI chr13:35,169,243...35,230,252
Ensembl chr13:35,180,912...35,268,577

G

agrin

increases expression

masitinib results in increased expression of AGRN mRNA

NCBI chr 5:56,239,621...56,273,679
Ensembl chr 5:56,239,701...56,272,745

G

androgen induced 1

increases expression

masitinib results in increased expression of AIG1 mRNA

NCBI chr 1:34,643,994...34,884,445
Ensembl chr 1:34,643,764...34,884,119

G

5'-aminolevulinate synthase 2

increases expression

masitinib results in increased expression of ALAS2 mRNA

NCBI chr X:46,703,477...46,731,767
Ensembl chr X:46,703,477...46,723,529

G

aldehyde dehydrogenase 5 family member A1

decreases expression

masitinib results in decreased expression of ALDH5A1 mRNA

NCBI chr35:22,560,005...22,590,996
Ensembl chr35:22,560,008...22,587,875

G

antagonist of mitotic exit network 1 homolog

increases expression

masitinib results in increased expression of AMN1 mRNA

NCBI chr27:17,044,301...17,100,444
Ensembl chr27:17,044,309...17,361,570

G

ankyrin repeat domain containing 26

increases expression

masitinib results in increased expression of ANKRD26 mRNA

NCBI chr 2:6,230,466...6,402,360

G

acidic nuclear phosphoprotein 32 family member E

decreases expression

masitinib results in decreased expression of ANP32E mRNA

NCBI chr17:59,460,864...59,482,467
Ensembl chr17:59,462,766...59,477,936

G

annexin A1

increases expression

masitinib results in increased expression of ANXA1 protein

NCBI chr 1:84,744,159...84,763,011
Ensembl chr 1:84,744,163...84,763,011

G

annexin A6

increases expression

masitinib results in increased expression of ANXA6 protein

NCBI chr 4:58,091,186...58,140,102
Ensembl chr 4:58,091,251...58,139,372

G

armadillo repeat containing 12

increases expression

masitinib results in increased expression of ARMC12 mRNA

NCBI chr12:4,868,831...4,879,801
Ensembl chr12:4,869,774...4,879,793

G

activating signal cointegrator 1 complex subunit 1

decreases expression

masitinib results in decreased expression of ASCC1 mRNA

NCBI chr 4:22,779,644...22,876,434
Ensembl chr 4:22,779,781...22,874,215

G

beta-1,4-galactosyltransferase 7

increases expression

masitinib results in increased expression of B4GALT7 mRNA

NCBI chr11:3,497,860...3,507,513
Ensembl chr11:3,498,153...3,505,034

G

baculoviral IAP repeat containing 5

decreases expression

masitinib results in decreased expression of BIRC5 mRNA

NCBI chr 9:2,930,308...2,959,307

G

BTB domain containing 3

decreases expression

masitinib results in decreased expression of BTBD3 mRNA

NCBI chr24:10,478,635...10,512,773
Ensembl chr24:10,479,900...10,512,185

G

carbonic anhydrase 2

decreases expression

masitinib results in decreased expression of CA2 mRNA

NCBI chr29:31,959,225...31,975,309
Ensembl chr29:31,935,172...31,980,579

G

calcium/calmodulin dependent protein kinase II gamma

increases expression

masitinib results in increased expression of CAMK2G mRNA

NCBI chr 4:24,244,063...24,299,362
Ensembl chr 4:24,245,960...24,299,357

G

capping actin protein, gelsolin like

increases expression

masitinib results in increased expression of CAPG protein

NCBI chr17:39,619,429...39,640,944
Ensembl chr17:39,619,248...39,640,942

G

chaperonin containing TCP1 subunit 2

decreases expression

masitinib results in decreased expression of CCT2 protein

NCBI chr10:11,560,287...11,586,559
Ensembl chr10:11,560,396...11,578,433

G

CD5 molecule like

increases expression

masitinib results in increased expression of CD5L mRNA

NCBI chr 7:40,516,190...40,526,528
Ensembl chr 7:40,516,190...40,526,528

G

cytidine and dCMP deaminase domain containing 1

increases expression

masitinib results in increased expression of CDADC1 mRNA

NCBI chr22:2,443,459...2,489,147
Ensembl chr22:2,436,206...2,489,016

G

cyclin dependent kinase inhibitor 1A

increases expression

masitinib results in increased expression of CDKN1A mRNA

NCBI chr12:5,746,898...5,755,103
Ensembl chr12:5,745,852...5,892,281

G

cytokine induced apoptosis inhibitor 1

decreases expression

masitinib results in decreased expression of CIAPIN1 mRNA

NCBI chr 2:58,977,592...58,992,785
Ensembl chr 2:58,977,676...58,992,581

G

cold inducible RNA binding protein

increases expression

masitinib results in increased expression of CIRBP mRNA

NCBI chr20:57,521,609...57,526,526
Ensembl chr20:57,519,119...57,526,435

G

C-type lectin domain family 2 member B

decreases expression

masitinib results in decreased expression of CLEC2B mRNA

NCBI chr27:36,088,754...36,143,581
Ensembl chr27:36,120,134...36,143,040

G

CKLF like MARVEL transmembrane domain containing 7

increases expression

masitinib results in increased expression of CMTM7 mRNA

NCBI chr23:12,317,636...12,382,836
Ensembl chr23:12,328,303...12,382,837

G

coronin 1A

increases expression

masitinib results in increased expression of CORO1A protein

NCBI chr 6:18,161,850...18,167,915
Ensembl chr 6:18,160,601...18,167,818

G

copine 1

increases expression

masitinib results in increased expression of CPNE1 mRNA

NCBI chr24:24,554,636...24,589,748
Ensembl chr24:24,554,636...24,589,731

G

copine 6

increases expression

masitinib results in increased expression of DHRS4 mRNA

NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744

G

cathepsin K

increases expression

masitinib results in increased expression of CTSK mRNA

NCBI chr17:59,928,725...59,938,293
Ensembl chr17:59,929,287...59,938,507

G

MHC class I DLA-12

increases expression

masitinib results in increased expression of DLA-12 mRNA

NCBI chr12:933,321...936,671
Ensembl chr12:932,613...987,561

G

MHC class I DLA-64

increases expression

masitinib results in increased expression of DLA-64 mRNA

NCBI chr12:983,573...986,969

G

DLG associated protein 1

decreases expression

masitinib results in decreased expression of DLGAP1 mRNA

NCBI chr 7:70,082,563...70,949,116
Ensembl chr 7:70,081,885...70,406,213

G

DLG associated protein 5

decreases expression

masitinib results in decreased expression of DLGAP5 mRNA

NCBI chr 8:30,998,806...31,038,614
Ensembl chr 8:30,994,402...31,036,540

G

deleted in primary ciliary dyskinesia homolog

decreases expression

masitinib results in decreased expression of DPCD mRNA

NCBI chr28:14,201,302...14,219,121
Ensembl chr28:14,201,351...14,219,121

G

dihydropyrimidinase like 3

decreases expression

masitinib results in decreased expression of DPYSL3 mRNA

NCBI chr 2:41,687,725...41,809,402
Ensembl chr 2:41,690,845...41,802,376

G

EBP like

increases expression

masitinib results in increased expression of EBPL mRNA

NCBI chr22:2,116,588...2,137,935
Ensembl chr22:2,116,131...2,182,633

G

ER degradation enhancing alpha-mannosidase like protein 2

increases expression

masitinib results in increased expression of EDEM2 mRNA

NCBI chr24:24,137,228...24,165,995
Ensembl chr24:24,137,228...24,165,968

G

eukaryotic translation initiation factor 3 subunit A

decreases expression

masitinib results in decreased expression of EIF3A protein

NCBI chr28:29,290,668...29,326,851
Ensembl chr28:29,291,422...29,326,701

G

eukaryotic translation initiation factor 4A1

decreases expression

masitinib results in decreased expression of EIF4A1 protein

NCBI chr 5:32,495,606...32,500,805
Ensembl chr 5:32,484,572...32,500,805

G

eukaryotic translation initiation factor 5A2

decreases expression

masitinib results in decreased expression of EIF5A2 mRNA

NCBI chr34:35,309,812...35,322,382
Ensembl chr34:35,314,172...35,322,392

G

epididymal sperm binding protein 1

increases expression

masitinib results in increased expression of ELSPBP1 mRNA

NCBI chr 1:108,159,609...108,187,224
Ensembl chr 1:108,159,611...108,188,076

G

electron transfer flavoprotein dehydrogenase

decreases expression

masitinib results in decreased expression of ETFDH mRNA

NCBI chr15:55,752,170...55,781,118
Ensembl chr15:55,752,200...55,792,105

G

gamma-glutamyltransferase 1

increases expression

masitinib results in increased expression of GGT1 mRNA

NCBI chr26:28,301,455...28,315,029

G

gastrokine 1

increases expression

masitinib results in increased expression of GKN1 mRNA

NCBI chr10:67,788,329...67,793,445
Ensembl chr10:67,788,110...67,793,589

G

glia maturation factor beta

decreases expression

masitinib results in decreased expression of GMFB mRNA

NCBI chr 8:30,394,020...30,408,408
Ensembl chr 8:30,359,499...30,408,357

G

glutathione S-transferase alpha 4

increases expression

masitinib results in increased expression of GSTA4 mRNA

NCBI chr12:20,426,724...20,443,200
Ensembl chr12:20,426,726...20,443,200

G

glucoside xylosyltransferase 1

decreases expression

masitinib results in decreased expression of GXYLT1 mRNA

NCBI chr27:11,754,609...11,810,245
Ensembl chr27:11,765,072...11,807,787

G

heme binding protein 2

decreases expression

masitinib results in decreased expression of HEBP2 mRNA

NCBI chr 1:30,716,395...30,724,814
Ensembl chr 1:30,716,606...30,724,613

G

homocysteine inducible ER protein with ubiquitin like domain 1

increases expression

masitinib results in increased expression of HERPUD1 mRNA

NCBI chr 2:59,388,492...59,400,028
Ensembl chr 2:59,388,494...59,400,003

G

heat shock protein 90 beta family member 1

increases expression

masitinib results in increased expression of HSP90B1 protein

NCBI chr15:42,456,793...42,474,122
Ensembl chr15:42,456,764...42,579,311

G

5-hydroxytryptamine receptor 2B

increases expression

masitinib results in increased expression of HTR2B mRNA

NCBI chr25:43,042,306...43,056,361
Ensembl chr25:43,042,173...43,056,612

G

hyaluronidase 3

increases expression

masitinib results in increased expression of HYAL3 mRNA

NCBI chr20:39,041,940...39,047,388
Ensembl chr20:39,042,070...39,047,365

G

insulin like growth factor binding protein 7

increases expression

masitinib results in increased expression of IGFBP7 mRNA

NCBI chr13:49,138,406...49,207,235
Ensembl chr13:49,138,402...49,207,394

G

interleukin 13

increases expression

masitinib results in increased expression of IL13 mRNA

NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388

G

inner mitochondrial membrane peptidase subunit 2

increases expression

masitinib results in increased expression of IMMP2L mRNA

NCBI chr14:50,487,679...51,336,906

G

iroquois homeobox 6

increases expression

masitinib results in increased expression of IRX6 protein

NCBI chr 2:60,630,688...60,636,285
Ensembl chr 2:60,630,447...60,636,416

G

integrin subunit alpha 6

decreases expression

masitinib results in decreased expression of ITGA6 mRNA

NCBI chr36:16,777,363...16,858,725
Ensembl chr36:16,776,863...16,855,449

G

junction adhesion molecule like

decreases expression

masitinib results in decreased expression of JAML mRNA

NCBI chr 5:15,485,378...15,513,457
Ensembl chr 5:15,476,582...15,513,075

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

masitinib results in increased expression of JUN mRNA

NCBI chr 5:50,966,698...50,968,939

G

potassium channel tetramerization domain containing 19

increases expression

masitinib results in increased expression of KCTD19 mRNA

NCBI chr 5:82,060,946...82,093,248
Ensembl chr 5:82,061,449...82,093,246

G

kelch like family member 5

increases expression

masitinib results in increased expression of KLHL5 mRNA

NCBI chr 3:73,258,925...73,347,262
Ensembl chr 3:73,262,895...73,344,879

G

ladybird homeobox 2

increases expression

masitinib results in increased expression of LBX2 mRNA

NCBI chr17:48,641,630...48,643,411
Ensembl chr17:48,641,674...48,643,239

G

lin-7 homolog C, crumbs cell polarity complex component

decreases expression

masitinib results in decreased expression of LIN7C mRNA

NCBI chr21:48,061,446...48,071,458
Ensembl chr21:48,064,929...48,071,429

G

heat shock 70 kDa protein 1-like

increases expression

masitinib results in increased expression of HSPA1L mRNA

NCBI chr12:1,281,164...1,285,010
Ensembl chr12:1,281,472...1,285,440

G

GPN-loop GTPase 1

decreases expression

masitinib results in decreased expression of GPN1 mRNA

NCBI chr17:21,654,516...21,678,435
Ensembl chr17:21,545,673...21,673,157

G

phytanoyl-CoA hydroxylase-like

increases expression

masitinib results in increased expression of PHYH mRNA

NCBI chr 2:23,185,901...23,206,719
Ensembl chr 2:23,185,782...23,253,497

G

hemoglobin subunit beta-like

increases expression

masitinib results in increased expression of HBG1 mRNA

NCBI chr21:28,187,535...28,188,991

G

LON peptidase N-terminal domain and ring finger 1

increases expression

masitinib results in increased expression of LONRF1 mRNA

NCBI chr16:36,220,324...36,256,896
Ensembl chr16:36,221,156...36,256,897

G

LDL receptor related protein 1

increases expression

masitinib results in increased expression of LRP1 mRNA

NCBI chr10:1,260,256...1,341,705
Ensembl chr10:1,260,719...1,352,271

G

LDL receptor related protein 8

decreases expression

masitinib results in decreased expression of LRP8 mRNA

NCBI chr 5:55,604,878...55,684,666
Ensembl chr 5:55,604,878...55,699,736

G

LYR motif containing 1

increases expression

masitinib results in increased expression of LYRM1 mRNA

NCBI chr 6:24,428,461...24,460,291
Ensembl chr 6:24,441,307...24,460,331

G

MAGE family member F1

decreases expression

masitinib results in decreased expression of MAGEF1 mRNA

NCBI chr34:17,543,381...17,545,089
Ensembl chr34:17,543,906...17,544,868

G

MOB kinase activator 1B

decreases expression

masitinib results in decreased expression of MOB1B mRNA

NCBI chr13:60,145,168...60,197,916
Ensembl chr13:60,145,366...60,195,463

G

multiple PDZ domain crumbs cell polarity complex component

increases expression

masitinib results in increased expression of MPDZ mRNA

NCBI chr11:33,691,434...33,826,500
Ensembl chr11:33,692,296...33,826,437

G

myozenin 1

increases expression

masitinib results in increased expression of MYOZ1 mRNA

NCBI chr 4:24,158,532...24,165,416
Ensembl chr 4:24,158,720...24,165,392

G

NSF attachment protein gamma

decreases expression

masitinib results in decreased expression of NAPG mRNA

NCBI chr 7:76,403,561...76,424,994
Ensembl chr 7:76,403,595...76,423,170

G

NADH:ubiquinone oxidoreductase core subunit S1

decreases expression

masitinib results in decreased expression of NDUFS1 mRNA

NCBI chr37:14,680,908...14,713,838
Ensembl chr37:14,683,083...14,713,754

G

NFKB inhibitor alpha

increases expression

masitinib results in increased expression of NFKBIA mRNA

NCBI chr 8:14,100,203...14,103,453
Ensembl chr 8:14,100,671...14,103,433

G

NRAS proto-oncogene, GTPase

decreases expression

masitinib results in decreased expression of NRAS mRNA

NCBI chr17:52,411,733...52,418,788
Ensembl chr17:52,411,733...52,418,788

G

neuronal vesicle trafficking associated 1

decreases expression

masitinib results in decreased expression of NSG1 mRNA

NCBI chr 3:69,805,646...69,831,200
Ensembl chr 3:69,805,592...69,831,194

G

neurotrophic receptor tyrosine kinase 1

increases expression

masitinib results in increased expression of NTRK1 mRNA

NCBI chr 7:41,140,931...41,159,326
Ensembl chr 7:41,140,879...41,159,288

G

OCA2 melanosomal transmembrane protein

decreases expression

masitinib results in decreased expression of OCA2 mRNA

NCBI chr 3:32,361,825...32,713,631
Ensembl chr 3:32,361,517...32,713,572

G

O-linked N-acetylglucosamine (GlcNAc) transferase

increases expression

masitinib results in increased expression of OGT mRNA

NCBI chr X:55,821,227...55,857,597
Ensembl chr X:55,821,234...55,855,502

G

3-oxoacid CoA-transferase 1

increases expression

masitinib results in increased expression of OXCT1 protein

NCBI chr 4:67,709,846...67,841,737
Ensembl chr 4:67,527,531...67,841,518

G

poly(ADP-ribose) polymerase family member 14

increases expression

masitinib results in increased expression of PARP14 mRNA

NCBI chr33:25,763,282...25,798,284
Ensembl chr33:25,763,255...25,798,198

G

pericentriolar material 1

increases expression

masitinib results in increased expression of PCM1 mRNA

NCBI chr16:41,212,733...41,291,654
Ensembl chr16:41,214,417...41,291,376

G

procollagen C-endopeptidase enhancer 2

decreases expression

masitinib results in decreased expression of PCOLCE2 mRNA

NCBI chr23:38,424,408...38,486,800
Ensembl chr23:38,426,216...38,487,252

G

phosphodiesterase 6H

increases expression

masitinib results in increased expression of PDE6H mRNA

NCBI chr27:31,640,731...31,664,494
Ensembl chr27:31,640,737...31,664,401

G

pyruvate dehydrogenase E1 subunit alpha 1

decreases expression

masitinib results in decreased expression of PDHA1 mRNA

NCBI chr X:15,338,364...15,354,011
Ensembl chr X:15,338,202...15,387,458

G

protein disulfide isomerase family A member 3

increases expression

masitinib results in increased expression of PDIA3 protein

NCBI chr30:10,487,926...10,513,437
Ensembl chr30:10,487,921...10,513,397

G

phosphatidylethanolamine binding protein 4

increases expression

masitinib results in increased expression of PEBP4 mRNA

NCBI chr25:34,329,160...34,574,086
Ensembl chr25:34,317,421...34,574,066

G

platelet and endothelial cell adhesion molecule 1

increases expression

masitinib results in increased expression of PECAM1 mRNA

NCBI chr 9:12,166,124...12,219,553
Ensembl chr 9:12,166,775...12,219,778

G

PHD finger protein 10

increases expression

masitinib results in increased expression of PHF10 mRNA

NCBI chr12:71,955,354...71,998,283
Ensembl chr12:71,787,082...71,998,243

G

protein O-mannosyltransferase 1

decreases expression

masitinib results in decreased expression of POMT1 mRNA

NCBI chr 9:52,615,349...52,631,538
Ensembl chr 9:52,615,655...52,630,836

G

cytochrome p450 oxidoreductase

increases expression

masitinib results in increased expression of POR mRNA

NCBI chr 6:7,247,780...7,316,282
Ensembl chr 6:7,263,574...7,316,297

G

inorganic pyrophosphatase 1

decreases expression

masitinib results in decreased expression of PPA1 protein

NCBI chr 4:21,145,547...21,189,985
Ensembl chr 4:21,145,547...21,182,748

G

phosphoribosyl pyrophosphate synthetase 2

decreases expression

masitinib results in decreased expression of PRPS2 mRNA

NCBI chr X:9,281,686...9,326,551
Ensembl chr X:9,281,730...9,418,289

G

proteasome 20S subunit beta 9

increases expression

masitinib results in increased expression of PSMB9 mRNA

NCBI chr12:2,432,287...2,438,920
Ensembl chr12:2,432,505...2,438,069

G

proteasome 26S subunit, non-ATPase 6

decreases expression

masitinib results in decreased expression of PSMD6 protein

NCBI chr20:27,206,801...27,220,059

G

proteasome 26S subunit, non-ATPase 9

decreases expression

masitinib results in decreased expression of PSMD9 mRNA

NCBI chr26:7,376,154...7,400,655
Ensembl chr26:7,377,413...7,400,573

G

parathyroid hormone

increases expression

masitinib results in increased expression of PTH mRNA

NCBI chr21:36,417,062...36,419,967
Ensembl chr21:36,417,058...36,419,967

G

2-phosphoxylose phosphatase 1

decreases expression

masitinib results in decreased expression of ACPL2 mRNA

NCBI chr23:37,145,065...37,197,808
Ensembl chr23:37,145,086...37,196,427

G

R3H domain containing 2

increases expression

masitinib results in increased expression of R3HDM2 mRNA

NCBI chr10:1,377,664...1,504,008
Ensembl chr10:1,370,350...1,504,017

G

RAB44, member RAS oncogene family

increases expression

masitinib results in increased expression of RAB44 mRNA

NCBI chr12:5,769,056...5,804,963
Ensembl chr12:5,770,882...5,804,949

G

RAS guanyl releasing protein 2

increases expression

masitinib results in increased expression of RASGRP2 mRNA

NCBI chr18:52,412,331...52,426,910
Ensembl chr18:52,412,367...52,426,916

G

regulator of calcineurin 1

increases expression

masitinib results in increased expression of RCAN1 mRNA

NCBI chr31:29,908,046...30,002,412
Ensembl chr31:29,909,388...30,002,418

G

regulator of G protein signaling 13

decreases expression

masitinib results in decreased expression of RGS13 mRNA

NCBI chr38:6,291,146...6,316,662
Ensembl chr38:6,291,182...6,315,198

G

secretion associated Ras related GTPase 1B

decreases expression

masitinib results in decreased expression of SAR1A mRNA

NCBI chr11:22,713,459...22,743,190
Ensembl chr11:22,717,942...22,743,124

G

stearoyl-CoA desaturase

decreases expression

masitinib results in decreased expression of SCD mRNA

NCBI chr28:13,112,741...13,129,129
Ensembl chr28:13,113,006...13,125,801

G

selenium binding protein 1

increases expression

masitinib results in increased expression of SELENBP1 protein

NCBI chr17:60,410,727...60,418,770
Ensembl chr17:60,410,734...60,418,704

G

serpin family E member 2

increases expression

masitinib results in increased expression of SERPINE2 mRNA

NCBI chr37:29,699,551...29,750,151
Ensembl chr37:29,700,024...29,724,228

G

SFT2 domain containing 2

decreases expression

masitinib results in decreased expression of SFT2D2 mRNA

NCBI chr 7:30,258,748...30,281,371

G

Src like adaptor

increases expression

masitinib results in increased expression of SLA mRNA

NCBI chr13:29,503,304...29,590,679
Ensembl chr13:29,504,867...29,569,773

G

solute carrier family 25 member 12

decreases expression

masitinib results in decreased expression of SLC25A12 mRNA

NCBI chr36:16,185,011...16,391,080
Ensembl chr36:16,185,649...16,483,016

G

structural maintenance of chromosomes 5

decreases expression

masitinib results in decreased expression of SMC5 mRNA

NCBI chr 1:87,192,988...87,285,678
Ensembl chr 1:87,194,867...87,285,606

G

serine racemase

increases expression

masitinib results in increased expression of SRR mRNA

G

stimulator of interferon response cGAMP interactor 1

increases expression

masitinib results in increased expression of TMEM173 mRNA

NCBI chr 2:34,783,947...34,792,204
Ensembl chr 2:34,784,232...34,789,072

G

storkhead box 1

increases expression

masitinib results in increased expression of STOX1 mRNA

NCBI chr 4:20,013,893...20,065,480
Ensembl chr 4:20,014,007...20,060,394

G

syntaxin 16

increases expression

masitinib results in increased expression of STX16 mRNA

NCBI chr24:43,425,719...43,451,828
Ensembl chr24:43,426,470...43,449,077

G

serine/threonine/tyrosine interacting like 1

increases expression

masitinib results in increased expression of STYXL1 mRNA

NCBI chr 6:7,323,911...7,389,878
Ensembl chr 6:7,316,477...7,389,842

G

TAR DNA binding protein

decreases expression

masitinib results in decreased expression of TARDBP protein

NCBI chr 2:84,987,752...84,998,136
Ensembl chr 2:84,989,952...84,998,593

G

TBC1 domain family member 14

decreases expression

masitinib results in decreased expression of TBC1D14 mRNA

NCBI chr 3:58,992,743...59,097,581
Ensembl chr 3:58,926,237...59,097,621

G

transcobalamin 2

increases expression

masitinib results in increased expression of TCN2 mRNA

NCBI chr26:23,693,664...23,710,342
Ensembl chr26:23,693,773...23,709,832

G

t-complex 1

decreases expression

masitinib results in decreased expression of TCP1 protein

NCBI chr 1:49,029,260...49,038,023
Ensembl chr 1:49,029,282...49,038,020

G

TEA domain transcription factor 4

increases expression

masitinib results in increased expression of TEAD4 mRNA

NCBI chr27:41,744,100...41,783,223
Ensembl chr27:41,748,871...41,803,556

G

thymocyte selection associated family member 2

decreases expression

masitinib results in decreased expression of THEMIS2 mRNA

NCBI chr 2:72,465,719...72,501,962
Ensembl chr 2:72,464,026...72,502,928

G

TM2 domain containing 2

increases expression

masitinib results in increased expression of TM2D2 mRNA

NCBI chr16:26,551,563...26,557,554
Ensembl chr16:26,551,628...26,556,285

G

transmembrane protein 108

increases expression

masitinib results in increased expression of TMEM108 mRNA

NCBI chr23:29,992,038...30,331,791
Ensembl chr23:29,992,021...30,396,840

G

transmembrane protein 260

increases expression

masitinib results in increased expression of TMEM260 mRNA

NCBI chr 8:32,238,992...32,309,320
Ensembl chr 8:32,238,988...32,306,317

G

TNF superfamily member 10

increases expression

masitinib results in increased expression of TNFSF10 mRNA

NCBI chr34:36,719,249...36,734,989
Ensembl chr34:36,670,849...36,735,060

G

transportin 1

decreases expression

masitinib results in decreased expression of TNPO1 mRNA

NCBI chr 2:55,795,737...55,859,366
Ensembl chr 2:55,799,907...55,851,213

G

tensin 1

decreases expression

masitinib results in decreased expression of TNS1 mRNA

NCBI chr37:24,578,855...24,776,153
Ensembl chr37:24,581,806...24,808,049

G

thymocyte selection associated high mobility group box

increases expression

masitinib results in increased expression of TOX mRNA

NCBI chr29:9,542,471...9,841,759
Ensembl chr29:9,544,561...9,842,034

G

thyroid stimulating hormone subunit beta

increases expression

masitinib results in increased expression of TSHB mRNA

NCBI chr17:52,659,137...52,685,388
Ensembl chr17:52,681,357...52,685,390

G

tetraspanin 2

increases expression

masitinib results in increased expression of TSPAN2 mRNA

NCBI chr17:52,692,744...52,749,048
Ensembl chr17:52,694,603...52,744,276

G

tetratricopeptide repeat domain 38

increases expression

masitinib results in increased expression of TTC38 protein

NCBI chr10:19,887,285...19,910,347
Ensembl chr10:19,773,373...19,910,683

G

TTL family tubulin polyglutamylase complex subunit L1

decreases expression

masitinib results in decreased expression of TTLL1 mRNA

NCBI chr10:22,456,150...22,492,375
Ensembl chr10:22,456,146...22,488,505

G

ubiquitin C-terminal hydrolase L3

increases expression

masitinib results in increased expression of UCHL3 protein

NCBI chr22:29,348,962...29,397,944
Ensembl chr22:29,348,706...29,407,965

G

ubiquinol-cytochrome c reductase complex assembly factor 1

decreases expression

masitinib results in decreased expression of UQCC mRNA

NCBI chr24:24,285,147...24,381,819
Ensembl chr24:24,286,320...24,381,699

G

uroporphyrinogen decarboxylase

increases expression

masitinib results in increased expression of UROD protein

NCBI chr15:15,313,808...15,317,130
Ensembl chr15:15,312,674...15,320,010

G

uroporphyrinogen III synthase

increases expression

masitinib results in increased expression of UROS mRNA

NCBI chr28:34,952,074...34,983,532
Ensembl chr28:34,948,003...34,983,532

G

valosin containing protein lysine methyltransferase

decreases expression

masitinib results in decreased expression of VCPKMT mRNA

NCBI chr 8:26,611,333...26,636,700
Ensembl chr 8:26,625,677...26,636,316

G

WAPL cohesin release factor

decreases expression

masitinib results in decreased expression of WAPAL mRNA

NCBI chr 4:34,219,644...34,297,456
Ensembl chr 4:34,219,645...34,302,839

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta

increases expression

masitinib results in increased expression of YWHAZ protein

NCBI chr13:2,729,404...2,764,422

G

zinc finger protein 23

increases expression

masitinib results in increased expression of ZNF23 mRNA

NCBI chr 5:77,246,374...77,260,761
Ensembl chr 5:77,246,667...77,260,350

mastoparan

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

G protein subunit alpha q

multiple interactions

G(M1) Ganglioside inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]; ganglioside, GD1a inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]; mastoparan results in increased activity of and affects the localization of GNAQ protein

NCBI chr 1:80,733,530...80,928,065
Ensembl chr 1:80,715,366...80,928,065

G

hexosaminidase subunit beta

multiple interactions
increases secretion

G(M1) Ganglioside inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; ganglioside, GD1a inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; Indomethacin promotes the reaction [mastoparan results in increased secretion of HEXB protein]; methyl-beta-cyclodextrin promotes the reaction [mastoparan results in increased secretion of HEXB protein]; Pertussis Toxin inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; Quinacrine promotes the reaction [mastoparan results in increased secretion of HEXB protein]; YM-254890 inhibits the reaction [mastoparan results in increased secretion of HEXB protein]

NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417

melittin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hexosaminidase subunit beta

multiple interactions
increases secretion

G(M1) Ganglioside inhibits the reaction [Melitten results in increased secretion of HEXB protein]; sialogangliosides inhibits the reaction [Melitten results in increased secretion of HEXB protein]; trisialoganglioside GT1 inhibits the reaction [Melitten results in increased secretion of HEXB protein]

NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417

milbemycin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

increases response to substance
multiple interactions

ABCB1 gene mutant form results in increased susceptibility to moxidectin; ABCB1 mutant form results in increased susceptibility to moxidectin
ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of ALB mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of DAO mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of EBF3 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of GABRQ mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of GLRA1 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of KLK6 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of MAB21L2 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of SLC10A4 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of SLC18A2 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of TTR mRNA]

PMID:23186803 PMID:25419811

NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727

G

albumin

multiple interactions

ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of ALB mRNA]

NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709

G

D-amino acid oxidase

multiple interactions

ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of DAO mRNA]

NCBI chr26:18,032,663...18,057,277
Ensembl chr26:18,033,392...18,057,238

G

EBF transcription factor 3

multiple interactions

ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of EBF3 mRNA]

NCBI chr28:38,489,635...38,601,800
Ensembl chr28:38,491,047...38,602,022

G

gamma-aminobutyric acid type A receptor subunit theta

multiple interactions

ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of GABRQ mRNA]

NCBI chr X:120,607,815...120,630,251
Ensembl chr X:120,607,686...120,628,343

G

glycine receptor alpha 1

multiple interactions

ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of GLRA1 mRNA]

NCBI chr 4:57,443,094...57,541,494
Ensembl chr 4:57,443,999...57,528,376

G

kallikrein related peptidase 6

multiple interactions

ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of KLK6 mRNA]

NCBI chr 1:105,902,147...105,907,585

G

mab-21 like 2

multiple interactions

ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of MAB21L2 mRNA]

NCBI chr15:48,538,912...48,541,651
Ensembl chr15:48,539,955...48,541,034

G

solute carrier family 10 member 4

multiple interactions

ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of SLC10A4 mRNA]

NCBI chr13:44,293,956...44,299,529
Ensembl chr13:44,277,094...44,299,732

G

solute carrier family 18 member A2

multiple interactions

ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of SLC18A2 mRNA]

NCBI chr28:27,731,709...27,809,341
Ensembl chr28:27,731,004...27,767,993

G

transthyretin

multiple interactions

ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of TTR mRNA]

NCBI chr 7:57,940,354...57,947,084
Ensembl chr 7:57,914,381...57,947,058

mocetinostat

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

A-kinase anchoring protein 12

increases expression

mocetinostat results in increased expression of AKAP12 mRNA

NCBI chr 1:41,614,893...41,712,350
Ensembl chr 1:41,614,714...41,709,798

G

ankyrin 1

decreases expression

mocetinostat results in decreased expression of ANK1 mRNA

NCBI chr16:23,858,299...23,966,181
Ensembl chr16:23,766,193...23,964,226

G

ankyrin 3

increases expression

mocetinostat results in increased expression of ANK3 mRNA

NCBI chr 4:12,166,275...12,827,175
Ensembl chr 4:12,167,550...12,827,037

G

adaptor related protein complex 2 subunit mu 1

decreases expression

mocetinostat results in decreased expression of AP2M1 mRNA

NCBI chr34:17,071,199...17,080,445
Ensembl chr34:17,071,235...17,080,445

G

adaptor related protein complex 2 subunit sigma 1

decreases expression

mocetinostat results in decreased expression of AP2S1 mRNA

NCBI chr 1:109,094,098...109,105,233
Ensembl chr 1:109,082,221...109,105,230

G

adaptor related protein complex 3 subunit sigma 1

increases expression

mocetinostat results in increased expression of AP3S1 mRNA

NCBI chr11:5,543,140...5,611,322
Ensembl chr11:5,543,222...5,610,930

G

ADP ribosylation factor 4

increases expression

mocetinostat results in increased expression of ARF4 mRNA

NCBI chr20:32,849,725...32,871,127
Ensembl chr20:32,849,757...32,870,721

G

autophagy related 4D cysteine peptidase

decreases expression

mocetinostat results in decreased expression of ATG4D mRNA

NCBI chr20:50,618,458...50,623,703
Ensembl chr20:50,618,459...50,624,179

G

autophagy related 7

decreases expression

mocetinostat results in decreased expression of ATG7 mRNA

NCBI chr20:6,916,354...7,154,849
Ensembl chr20:6,916,515...7,154,800

G

ATPase Na+/K+ transporting subunit alpha 1

increases expression

mocetinostat results in increased expression of ATP1A1 mRNA

NCBI chr17:53,828,482...53,847,043
Ensembl chr17:53,813,976...53,847,167

G

B cell receptor associated protein 29

increases expression

mocetinostat results in increased expression of BCAP29 mRNA

NCBI chr18:12,969,594...13,021,948
Ensembl chr18:12,970,411...13,022,022

G

biogenesis of lysosomal organelles complex 1 subunit 1

decreases expression

mocetinostat results in decreased expression of BLOC1S1 mRNA

NCBI chr10:116,993...120,244

G

BCL2 interacting protein 1

decreases expression

mocetinostat results in decreased expression of BNIP1 mRNA

NCBI chr 4:39,255,685...39,303,485
Ensembl chr 4:39,289,776...39,303,430

G

calcium voltage-gated channel auxiliary subunit beta 3

increases expression

mocetinostat results in increased expression of CACNB3 mRNA

NCBI chr27:5,705,587...5,714,620
Ensembl chr27:5,706,064...5,717,647

G

calcium/calmodulin dependent protein kinase ID

increases expression

mocetinostat results in increased expression of CAMK1D mRNA

NCBI chr 2:23,680,395...24,113,922
Ensembl chr 2:23,685,672...24,114,084

G

calcium/calmodulin dependent serine protein kinase

increases expression

mocetinostat results in increased expression of CASK mRNA

NCBI chr X:35,939,117...36,296,438
Ensembl chr X:35,940,647...36,297,014

G

caveolin 1

increases expression

mocetinostat results in increased expression of CAV1 mRNA

NCBI chr14:55,458,934...55,494,563
Ensembl chr14:55,461,048...55,492,935

G

chibby 1, beta catenin antagonist

decreases expression

mocetinostat results in decreased expression of CBY1 mRNA

NCBI chr10:26,125,064...26,134,693
Ensembl chr10:26,125,189...26,128,285

G

charged multivesicular body protein 4B

decreases expression

mocetinostat results in decreased expression of CHMP4B mRNA

NCBI chr24:22,995,677...23,050,084
Ensembl chr24:22,995,672...23,049,287

G

charged multivesicular body protein 5

decreases expression

mocetinostat results in decreased expression of CHMP5 mRNA

NCBI chr11:50,363,488...50,376,081

G

charged multivesicular body protein 6

decreases expression

mocetinostat results in decreased expression of CHMP6 mRNA

NCBI chr 9:997,951...1,001,659
Ensembl chr 9:998,653...1,002,538

G

clathrin heavy chain like 1

increases expression

mocetinostat results in increased expression of CLTCL1 mRNA

NCBI chr26:29,907,235...30,002,136
Ensembl chr26:29,906,278...30,002,128

G

COPI coat complex subunit beta 1

increases expression

mocetinostat results in increased expression of COPB1 mRNA

NCBI chr21:37,186,380...37,224,549
Ensembl chr21:37,186,424...37,224,519

G

COPI coat complex subunit beta 2

decreases expression

mocetinostat results in decreased expression of COPB2 mRNA

NCBI chr23:35,536,520...35,604,708
Ensembl chr23:35,536,615...35,566,569

G

COPI coat complex subunit gamma 1

decreases expression

mocetinostat results in decreased expression of COPG1 mRNA

NCBI chr20:2,832,150...2,860,356
Ensembl chr20:2,832,198...2,860,320

G

derlin 2

decreases expression

mocetinostat results in decreased expression of DERL2 mRNA

NCBI chr 5:31,319,660...31,330,846
Ensembl chr 5:31,319,717...31,330,841

G

dynamin 1 like

decreases expression

mocetinostat results in decreased expression of DNM1L mRNA

NCBI chr27:16,161,855...16,211,983
Ensembl chr27:16,163,357...16,211,957

G

glycosylphosphatidylinositol anchor attachment 1

decreases expression

mocetinostat results in decreased expression of GPAA1 mRNA

NCBI chr13:37,577,162...37,580,346
Ensembl chr13:37,576,354...37,580,345

G

HPS4 biogenesis of lysosomal organelles complex 3 subunit 2

decreases expression

mocetinostat results in decreased expression of HPS4 mRNA

NCBI chr26:20,131,658...20,157,532
Ensembl chr26:19,933,281...20,157,058

G

histidine rich calcium binding protein

decreases expression

mocetinostat results in decreased expression of HRC mRNA

NCBI chr 1:107,304,718...107,308,741
Ensembl chr 1:107,304,924...107,308,740

G

potassium two pore domain channel subfamily K member 1

increases expression

mocetinostat results in increased expression of KCNK1 mRNA

NCBI chr 4:6,117,406...6,139,390
Ensembl chr 4:6,118,373...6,122,093

G

potassium calcium-activated channel subfamily M regulatory beta subunit 4

increases expression

mocetinostat results in increased expression of KCNMB4 mRNA

NCBI chr10:12,211,372...12,251,739

G

potassium voltage-gated channel modifier subfamily S member 3

increases expression

mocetinostat results in increased expression of KCNS3 mRNA

NCBI chr17:13,297,242...13,338,319
Ensembl chr17:13,336,374...13,337,849

G

kinesin family member 5A

increases expression

mocetinostat results in increased expression of KIF5A mRNA

NCBI chr10:1,637,007...1,666,790
Ensembl chr10:1,636,932...1,664,767

G

kinesin family member 5B

decreases expression

mocetinostat results in decreased expression of KIF5B mRNA

NCBI chr 2:14,835,906...14,880,896
Ensembl chr 2:14,835,901...14,878,251

G

kinesin family member 5C

increases expression

mocetinostat results in increased expression of KIF5C mRNA

NCBI chr19:50,535,622...50,684,485
Ensembl chr19:50,535,456...50,668,738

G

late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

decreases expression

mocetinostat results in decreased expression of LAMTOR1 mRNA

NCBI chr21:25,981,170...25,986,942
Ensembl chr21:25,981,254...25,996,432

G

late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

decreases expression

mocetinostat results in decreased expression of LAMTOR2 mRNA

NCBI chr 7:41,760,632...41,764,926
Ensembl chr 7:41,760,638...41,763,299

G

tubulin beta-2B chain

increases expression

mocetinostat results in increased expression of TUBB2B mRNA

NCBI chr35:3,494,982...3,498,274
Ensembl chr35:3,495,277...3,498,248

G

mal, T cell differentiation protein 2

increases expression

mocetinostat results in increased expression of MAL2 mRNA

NCBI chr13:18,404,979...18,422,076
Ensembl chr13:18,406,633...18,420,469

G

microtubule associated monooxygenase, calponin and LIM domain containing 1

increases expression

mocetinostat results in increased expression of MICAL1 mRNA

NCBI chr12:66,350,459...66,358,391
Ensembl chr12:66,350,427...66,360,615

G

myopalladin

decreases expression

mocetinostat results in decreased expression of MYPN mRNA

NCBI chr 4:19,364,146...19,468,827
Ensembl chr 4:19,381,416...19,465,995

G

peroxisomal biogenesis factor 19

decreases expression

mocetinostat results in decreased expression of PEX19 mRNA

NCBI chr38:21,939,054...21,945,281
Ensembl chr38:21,939,018...21,944,602

G

DNA polymerase epsilon 2, accessory subunit

increases expression

mocetinostat results in increased expression of DNAAF2 mRNA

NCBI chr 8:26,264,220...26,295,089
Ensembl chr 8:26,251,160...26,295,317

G

protein phosphatase 3 catalytic subunit alpha

increases expression

mocetinostat results in increased expression of PPP3CA mRNA

NCBI chr32:22,688,141...22,996,693
Ensembl chr32:22,688,143...22,996,688

G

RAB27A, member RAS oncogene family

increases expression

mocetinostat results in increased expression of RAB27A mRNA

NCBI chr30:20,633,576...20,706,240
Ensembl chr30:20,635,400...20,690,521

G

RAB31, member RAS oncogene family

increases expression

mocetinostat results in increased expression of RAB31 mRNA

NCBI chr 7:75,678,896...75,807,716
Ensembl chr 7:75,678,908...75,817,426

G

RAB3A interacting protein

increases expression

mocetinostat results in increased expression of RAB3IP mRNA

NCBI chr10:11,673,749...11,714,282
Ensembl chr10:11,673,777...11,714,281

G

Rab9 effector protein with kelch motifs

increases expression

mocetinostat results in increased expression of RABEPK mRNA

NCBI chr 9:57,857,269...57,877,333
Ensembl chr 9:57,857,269...57,883,761

G

secretory carrier membrane protein 3

decreases expression

mocetinostat results in decreased expression of SCAMP3 mRNA

NCBI chr 7:42,294,764...42,299,097

G

sodium voltage-gated channel alpha subunit 10

increases expression

mocetinostat results in increased expression of SCN10A mRNA

NCBI chr23:8,420,468...8,527,414
Ensembl chr23:8,420,472...8,527,383

G

syndecan binding protein

increases expression

mocetinostat results in increased expression of SDCBP mRNA

NCBI chr29:9,331,876...9,370,489

G

SEC24 homolog B, COPII coat complex component

increases expression

mocetinostat results in increased expression of SEC24B mRNA

NCBI chr32:29,671,702...29,766,628
Ensembl chr32:29,671,738...29,772,192

G

SEC24 homolog D, COPII coat complex component

increases expression

mocetinostat results in increased expression of SEC24D mRNA

NCBI chr32:37,690,158...37,795,762
Ensembl chr32:37,690,399...37,924,252

G

SEC63 homolog, protein translocation regulator

increases expression

mocetinostat results in increased expression of SEC63 mRNA

NCBI chr12:64,983,442...65,028,573

G

SFT2 domain containing 1

decreases expression

mocetinostat results in decreased expression of SFT2D1 mRNA

NCBI chr 1:54,335,832...54,354,199
Ensembl chr 1:54,336,005...54,354,137

G

smoothelin

decreases expression

mocetinostat results in decreased expression of SMTN mRNA

NCBI chr26:24,085,356...24,108,005
Ensembl chr26:24,085,382...24,108,540

G

synaptosome associated protein 23

increases expression

mocetinostat results in increased expression of SNAP23 mRNA

NCBI chr30:9,453,931...9,493,506
Ensembl chr30:9,456,084...9,492,329

G

SNAP associated protein

decreases expression

mocetinostat results in decreased expression of SNAPIN mRNA

NCBI chr 7:43,410,554...43,411,929
Ensembl chr 7:43,410,998...43,412,323

G

sorting nexin 15

decreases expression

mocetinostat results in decreased expression of SNX15 mRNA

NCBI chr18:52,152,562...52,165,081
Ensembl chr18:52,152,561...52,165,048

G

sorting nexin 16

increases expression

mocetinostat results in increased expression of SNX16 mRNA

NCBI chr29:28,882,768...28,922,713
Ensembl chr29:28,884,426...28,920,797

G

sorting nexin 17

decreases expression

mocetinostat results in decreased expression of SNX17 mRNA

NCBI chr17:21,326,496...21,332,170
Ensembl chr17:21,326,503...21,331,857

G

sorting nexin 24

increases expression

mocetinostat results in increased expression of SNX24 mRNA

NCBI chr11:12,776,934...12,869,304
Ensembl chr11:12,708,712...12,888,165

G

sorting nexin 7

increases expression

mocetinostat results in increased expression of SNX7 mRNA

NCBI chr 6:51,004,307...51,388,283
Ensembl chr 6:51,025,203...51,094,539

G

spectrin beta, non-erythrocytic 1

increases expression

mocetinostat results in increased expression of SPTBN1 mRNA

NCBI chr10:55,429,989...55,571,917
Ensembl chr10:55,429,940...55,571,916

G

signal transducing adaptor molecule 2

decreases expression

mocetinostat results in decreased expression of STAM2 mRNA

NCBI chr19:53,213,904...53,256,711
Ensembl chr19:53,216,274...53,256,756
Ensembl chr19:53,216,274...53,256,756

G

stonin 1

increases expression

mocetinostat results in increased expression of STON1 mRNA

NCBI chr10:50,421,635...50,470,302
Ensembl chr10:50,436,715...50,467,878

G

syntaxin 4

decreases expression

mocetinostat results in decreased expression of STX4 mRNA

NCBI chr 6:17,184,044...17,189,481
Ensembl chr 6:17,184,399...17,189,370

G

synaptotagmin like 1

increases expression

mocetinostat results in increased expression of SYTL1 mRNA

NCBI chr 2:72,916,445...72,925,219
Ensembl chr 2:72,916,445...72,925,147

G

synaptotagmin like 4

increases expression

mocetinostat results in increased expression of SYTL4 mRNA

NCBI chr X:74,537,937...74,617,580
Ensembl chr X:74,539,183...74,565,753

G

transferrin receptor

decreases expression

mocetinostat results in decreased expression of TFRC mRNA

NCBI chr33:29,206,024...29,237,221
Ensembl chr33:29,208,609...29,238,242

G

transmembrane p24 trafficking protein 1

decreases expression

mocetinostat results in decreased expression of TMED1 mRNA

NCBI chr20:50,395,862...50,399,118
Ensembl chr20:50,396,005...50,407,535

G

transmembrane p24 trafficking protein 2

decreases expression

mocetinostat results in decreased expression of TMED2 mRNA

NCBI chr26:6,039,046...6,047,490
Ensembl chr26:6,039,405...6,047,459

G

tripartite motif containing 54

decreases expression

mocetinostat results in decreased expression of TRIM54 mRNA

NCBI chr17:21,257,660...21,278,410
Ensembl chr17:21,257,706...21,278,274

G

tumor susceptibility 101

decreases expression

mocetinostat results in decreased expression of TSG101 mRNA

NCBI chr21:40,910,870...40,952,922
Ensembl chr21:40,910,874...40,952,808

G

titin

decreases expression

mocetinostat results in decreased expression of TTN mRNA

NCBI chr36:22,146,870...22,417,858
Ensembl chr36:22,147,824...22,417,826

G

tubulin alpha 4a

decreases expression

mocetinostat results in decreased expression of TUBA4A mRNA

NCBI chr37:25,799,075...25,803,257
Ensembl chr37:25,796,107...25,802,892

G

tubulin, gamma 1

decreases expression

mocetinostat results in decreased expression of TUBG1 mRNA

NCBI chr 9:20,358,683...20,363,455
Ensembl chr 9:20,322,253...20,363,455

G

USO1 vesicle transport factor

decreases expression

mocetinostat results in decreased expression of USO1 mRNA

NCBI chr32:305,895...395,113
Ensembl chr32:305,935...394,896

G

vacuolar protein sorting 13 homolog B

decreases expression

mocetinostat results in decreased expression of VPS13B mRNA

NCBI chr13:1,101,226...1,834,933
Ensembl chr13:1,101,610...1,871,225

G

VPS16 core subunit of CORVET and HOPS complexes

decreases expression

mocetinostat results in decreased expression of VPS16 mRNA

NCBI chr24:18,401,440...18,424,605
Ensembl chr24:18,399,572...18,424,510

G

VPS26, retromer complex component A

decreases expression

mocetinostat results in decreased expression of VPS26A mRNA

NCBI chr 4:20,265,120...20,296,125
Ensembl chr 4:20,264,905...20,294,674

G

VPS29 retromer complex component

decreases expression

mocetinostat results in decreased expression of VPS29 mRNA

NCBI chr26:8,301,699...8,309,364
Ensembl chr26:8,301,699...8,309,364

G

VPS33A core subunit of CORVET and HOPS complexes

decreases expression

mocetinostat results in decreased expression of VPS33A mRNA

NCBI chr26:7,090,669...7,119,913

G

VPS33B late endosome and lysosome associated

decreases expression

mocetinostat results in decreased expression of VPS33B mRNA

NCBI chr 3:53,220,199...53,239,738
Ensembl chr 3:53,220,194...53,239,732

G

VPS35 retromer complex component

decreases expression

mocetinostat results in decreased expression of VPS35 mRNA

NCBI chr15:8,428,073...8,454,601
Ensembl chr15:8,428,172...8,454,049

G

VPS41 subunit of HOPS complex

decreases expression

mocetinostat results in decreased expression of VPS41 mRNA

NCBI chr18:10,788,846...10,956,207
Ensembl chr18:10,788,891...10,955,645

G

VPS52 subunit of GARP complex

decreases expression

mocetinostat results in decreased expression of VPS52 mRNA

NCBI chr12:2,697,508...2,712,831
Ensembl chr12:2,697,508...2,712,831

G

VPS54 subunit of GARP complex

increases expression

mocetinostat results in increased expression of VPS54 mRNA

NCBI chr10:63,598,373...63,676,753
Ensembl chr10:63,599,229...63,676,747

G

vesicle transport through interaction with t-SNAREs 1B

decreases expression

mocetinostat results in decreased expression of VTI1B mRNA

NCBI chr 8:41,619,365...41,650,389
Ensembl chr29:19,153,616...19,154,245
Ensembl chr 8:19,153,616...19,154,245

N-acetyl-L-cysteine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

claudin 4

multiple interactions

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]

NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145

G

mitogen-activated protein kinase 1

multiple interactions

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]

NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998

G

mitogen-activated protein kinase 3

multiple interactions

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]

NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425

G

mitogen-activated protein kinase 8

multiple interactions

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]

NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401

G

mitogen-activated protein kinase 9

multiple interactions

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]

NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119

nicotinamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

peroxisome proliferator activated receptor gamma

increases expression
multiple interactions

Niacinamide results in increased expression of PPARG protein
Resveratrol inhibits the reaction [Niacinamide results in increased expression of PPARG protein]

NCBI chr20:6,134,618...6,265,481
Ensembl chr20:6,050,357...6,207,981

G

RUNX family transcription factor 2

increases acetylation
multiple interactions
decreases expression

Niacinamide results in increased acetylation of RUNX2 protein
Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide results in increased acetylation of RUNX2 protein]

NCBI chr12:13,723,535...13,842,565
Ensembl chr12:13,628,539...13,840,785
Ensembl chr12:13,628,539...13,840,785

G

sirtuin 1

decreases expression
multiple interactions

Niacinamide results in decreased expression of SIRT1 protein
Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of SIRT1 protein]

NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279

nitric oxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

kininogen 1

increases activity

Nitric Oxide deficiency results in increased activity of KNG1 protein modified form

NCBI chr34:19,288,629...19,318,096
Ensembl chr34:19,287,109...19,318,081

G

WT1 transcription factor

multiple interactions

[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased expression of WT1 mRNA

NCBI chr18:35,099,660...35,148,767
Ensembl chr18:35,103,934...35,148,000

nitroglycerin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

renin

decreases activity

Nitroglycerin results in decreased activity of REN protein

NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012

nitroprusside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

proopiomelanocortin

increases expression

Nitroprusside results in increased expression of POMC protein

NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440

G

renin

increases activity

Nitroprusside results in increased activity of REN protein

PMID:2434793 PMID:6399253

NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012

G

WT1 transcription factor

multiple interactions

[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased expression of WT1 mRNA

NCBI chr18:35,099,660...35,148,767
Ensembl chr18:35,103,934...35,148,000

NS-398

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

prostaglandin-endoperoxide synthase 2

decreases expression

N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of PTGS2 mRNA; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of PTGS2 protein

PMID:12857884 PMID:15198222

NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903

G

RELA proto-oncogene, NF-kB subunit

decreases localization

N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased localization of RELA protein

NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875

ochratoxin A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

multiple interactions
increases expression

CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of ACTA2 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]
ochratoxin A results in increased expression of ACTA2 mRNA; ochratoxin A results in increased expression of ACTA2 protein

NCBI chr26:38,700,434...38,714,915
Ensembl chr26:38,700,480...38,711,753

G

B9 domain containing 2

increases expression
multiple interactions

ochratoxin A results in increased expression of TGFB1 mRNA; ochratoxin A results in increased expression of TGFB1 protein
CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of TGFB1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]

NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885

G

gasdermin D

multiple interactions
increases expression

CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of GSDMD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]
ochratoxin A results in increased expression of GSDMD mRNA; ochratoxin A results in increased expression of GSDMD protein

NCBI chr13:37,221,219...37,226,912
Ensembl chr13:37,193,022...37,228,360

G

interleukin 18

multiple interactions
increases expression

CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of IL18 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA]

NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348

G

interleukin 1 beta

multiple interactions
increases expression

CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of IL1B mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of IL1B protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]
ochratoxin A results in increased expression of IL1B mRNA; ochratoxin A results in increased expression of IL1B protein

NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458

G

interleukin 6

increases secretion
increases expression

ochratoxin A results in increased secretion of IL6 protein
ochratoxin A results in increased expression of IL6 mRNA

NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519

G

NLR family pyrin domain containing 3

multiple interactions
increases expression

N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of NLRP3 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of CASP1 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of VIM protein]
ochratoxin A results in increased expression of NLRP3 mRNA; ochratoxin A results in increased expression of NLRP3 protein

NCBI chr 8:251,776...313,290
Ensembl chr 8:253,407...313,059

G

PYD and CARD domain containing

increases expression
multiple interactions

ochratoxin A results in increased expression of PYCARD mRNA; ochratoxin A results in increased expression of PYCARD protein
N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of PYCARD mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of PYCARD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD protein]

NCBI chr 6:17,049,352...17,051,348
Ensembl chr 6:17,049,705...17,051,240

G

tumor necrosis factor

increases secretion
increases expression

ochratoxin A results in increased secretion of TNF protein
ochratoxin A results in increased expression of TNF mRNA

NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425

G

vimentin

multiple interactions
increases expression

CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of VIM protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of VIM protein]
ochratoxin A results in increased expression of VIM mRNA; ochratoxin A results in increased expression of VIM protein

NCBI chr 2:19,671,316...19,679,367
Ensembl chr 2:19,671,316...19,679,466

p-cresol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 2C41

affects metabolic processing

CYP2C11 protein affects the metabolism of 4-cresol

G

cytochrome P450 family 2 subfamily E member 1

affects metabolic processing

CYP2E1 protein affects the metabolism of 4-cresol

NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754

paracetamol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

prostaglandin-endoperoxide synthase 1

decreases activity

Acetaminophen results in decreased activity of PTGS1 protein alternative form

NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819

G

UDP glucuronosyltransferase 1 family, polypeptide A6

increases glucuronidation

UGT1A6 protein results in increased glucuronidation of Acetaminophen

NCBI chr25:45,081,655...45,161,584
Ensembl chr25:45,032,130...45,160,941

phalloidin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tight junction protein 1

multiple interactions

Phalloidine inhibits the reaction [Calcium Oxalate results in decreased expression of TJP1 protein]

NCBI chr 3:38,997,122...39,076,617
Ensembl chr 3:38,997,076...39,241,574

phenacetin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 1 subfamily A member 2

affects metabolic processing

CYP1A2 protein affects the metabolism of Phenacetin

NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135

G

prostaglandin-endoperoxide synthase 1

decreases activity

Phenacetin results in decreased activity of PTGS1 protein alternative form

NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819

phenylglyoxylic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

copine 6

increases reduction

DHRS4 protein results in increased reduction of phenylglyoxylic acid

NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744

phosphatidylinositol 3-phosphate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; [Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; [Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]

NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141

prochloraz

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

[2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz; [prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz

NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444

G

cytochrome P450 family 1 subfamily A member 1

multiple interactions

[prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein

NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866

rac-lactic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

secretin

decreases abundance

SCT protein results in decreased abundance of Lactic Acid

ranolazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

affects expression
multiple interactions

Ranolazine affects the expression of ATP2A2 protein
[Ranolazine co-treated with Enalapril] affects the expression of ATP2A2 protein; [Ranolazine co-treated with Metoprolol] affects the expression of ATP2A2 protein

NCBI chr26:8,148,181...8,209,392
Ensembl chr26:8,148,236...8,209,388

G

early growth response 1

multiple interactions
affects expression

[Ranolazine co-treated with Enalapril] affects the expression of EGR1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of EGR1 protein
Ranolazine affects the expression of EGR1 protein

NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575

G

GATA binding protein 4

affects expression
multiple interactions

Ranolazine affects the expression of GATA4 protein
[Ranolazine co-treated with Enalapril] affects the expression of GATA4 protein; [Ranolazine co-treated with Metoprolol] affects the expression of GATA4 protein

NCBI chr25:26,126,172...26,211,474
Ensembl chr25:26,127,853...26,182,989

G

NGFI-A binding protein 1

affects expression
multiple interactions

Ranolazine affects the expression of NAB1 protein
[Ranolazine co-treated with Enalapril] affects the expression of NAB1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of NAB1 protein

NCBI chr37:1,207,619...1,243,546
Ensembl chr37:1,207,638...1,241,610

G

solute carrier family 8 member A1

affects expression
multiple interactions

Ranolazine affects the expression of SLC8A1 protein
[Ranolazine co-treated with Enalapril] affects the expression of SLC8A1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of SLC8A1 protein

NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700

rhodamine 123

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

increases export

ABCB1 protein results in increased export of Rhodamine 123

NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727

rifampicin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

increases expression

Rifampin results in increased expression of ABCB1 mRNA; Rifampin results in increased expression of ABCB1 protein

NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727

G

nuclear receptor subfamily 1 group I member 2

increases activity

Rifampin results in increased activity of NR1I2 protein

NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347

ritonavir

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

multiple interactions

allicin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; Quercetin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]

NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727

G

nuclear receptor subfamily 1 group I member 2

increases activity

Ritonavir results in increased activity of NR1I2 protein

NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347

salicylamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

[salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Tetrachlorodibenzodioxin

NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444

saquinavir

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

affects transport

ABCC2 protein affects the transport of Saquinavir

NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740

SDZ PSC 833

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

multiple interactions

valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]; valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Vincristine]; valspodar inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]

PMID:15492788 PMID:24975508

NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727

silodosin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 1A

multiple interactions

silodosin binds to and results in decreased activity of ADRA1A protein; silodosin inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]

NCBI chr25:30,690,959...30,801,484
Ensembl chr25:30,693,571...30,801,486

simvastatin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nitric oxide synthase 3

increases expression
decreases expression

Simvastatin results in increased expression of NOS3 protein
Simvastatin results in decreased expression of NOS3 mRNA

NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277

sincalide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier organic anion transporter family member 1B2

increases transport

SLCO1B3 protein results in increased transport of Sincalide

NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989

sodium chloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

claudin 4

increases expression
multiple interactions

Sodium Chloride results in increased expression of CLDN4 protein
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]

NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Sodium Chloride results in increased expression of JUN protein
pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]; U 0126 inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]

NCBI chr 5:50,966,698...50,968,939

G

mitogen-activated protein kinase 1

increases phosphorylation
multiple interactions

Sodium Chloride results in increased phosphorylation of MAPK1 protein
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]

NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998

G

mitogen-activated protein kinase 3

increases phosphorylation
multiple interactions

Sodium Chloride results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]

NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]

NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401

G

mitogen-activated protein kinase 9

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]

NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119

G

superoxide dismutase 2

increases expression

Sodium Chloride results in increased expression of SOD2 protein

NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706

G

Sp1 transcription factor

multiple interactions
increases expression

pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein]; Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]; U 0126 inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; U 0126 inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein]

NCBI chr27:1,802,587...1,861,187
Ensembl chr27:1,805,184...1,847,226

SR 144528

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cannabinoid receptor 2

multiple interactions

SR 144528 binds to and results in decreased activity of CNR2 protein

NCBI chr 2:75,640,636...75,662,000
Ensembl chr 2:75,658,999...75,660,126

succimer

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutathione-disulfide reductase

multiple interactions

[monoisoamyl-2,3-dimercaptosuccinate co-treated with Succimer] inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]

NCBI chr16:33,633,949...33,680,411
Ensembl chr16:33,633,968...33,679,752

succinylcholine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

butyrylcholinesterase

increases hydrolysis
multiple interactions

BCHE protein results in increased hydrolysis of Succinylcholine
Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]

NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583

taurocholic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier organic anion transporter family member 1B2

increases transport

SLCO1B3 protein results in increased transport of Taurocholic Acid

NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989

thapsigargin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

heat shock protein family A (Hsp70) member 5

increases expression

Thapsigargin results in increased expression of HSPA5 protein

NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257

troleandomycin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nuclear receptor subfamily 1 group I member 2

increases activity

Troleandomycin results in increased activity of NR1I2 protein

NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347

tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions

[Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein]

NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702

G

secretin

multiple interactions

Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates]

tunicamycin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

heat shock protein 90 beta family member 1

increases expression

Tunicamycin results in increased expression of HSP90B1 protein

NCBI chr15:42,456,793...42,474,122
Ensembl chr15:42,456,764...42,579,311

G

heat shock protein family A (Hsp70) member 5

increases expression

Tunicamycin results in increased expression of HSPA5 protein

NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257

urea

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

claudin 4

increases expression

Urea results in increased expression of CLDN4 protein

NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145

G

superoxide dismutase 2

increases expression

Urea results in increased expression of SOD2 protein

NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706

UTP

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

purinergic receptor P2Y2

multiple interactions
increases activity

[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid; [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP]

NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059

vasopressin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

insulin

multiple interactions

INS protein promotes the reaction [Sodium results in increased abundance of Vasopressins]

NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122

verapamil

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

multiple interactions

[Verapamil results in decreased activity of ABCB1 protein] which affects the transport of Digoxin

NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727

vincristine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

increases export
multiple interactions
affects response to substance

ABCB1 protein results in increased export of Vincristine
valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Vincristine]

PMID:24975508 PMID:28093773

NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727

G

ATP binding cassette subfamily C member 1

decreases response to substance

ABCC1 protein results in decreased susceptibility to Vincristine

NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331

vorinostat

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calsequestrin 1

decreases expression

Vorinostat results in decreased expression of CASQ1 mRNA

NCBI chr38:22,012,060...22,020,430
Ensembl chr38:22,011,060...22,020,383

G

heat shock protein 70

decreases expression

Vorinostat results in decreased expression of HSP70 mRNA

NCBI chr12:1,285,282...1,287,670

G

TNNI3 interacting kinase

decreases expression

Vorinostat results in decreased expression of TNNI3K mRNA

NCBI chr 6:71,825,853...72,107,832
Ensembl chr 6:71,815,734...72,119,476

YM-254890

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hexosaminidase subunit beta

multiple interactions

YM-254890 inhibits the reaction [mastoparan results in increased secretion of HEXB protein]

NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417

yohimbine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

multiple interactions

Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein]

NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141

G

protein kinase C zeta

multiple interactions

Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]

NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664

zileuton

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arachidonate 5-lipoxygenase

decreases activity

zileuton results in decreased activity of ALOX5 protein

NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	499
role	499
biological role	499
biochemical role	459
metabolite	450
prokaryotic metabolite	396
archaeal metabolite +	0
bacterial metabolite +	396

paths to the root