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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nisoldipine
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Accession:CHEBI:7577 term browser browse the term
Definition:A racemate consisting of equimolar amounts of (R)- and (S)-nisoldipine. A calcium channel blocker, it is used in the treatment of hypertension and angina pectoris.
Synonyms:exact_synonym: rac-methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
 related_synonym: (+-)-isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate;   1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-methylpropyl ester;   Baymycard;   Sular;   Syscor;   Zadipina;   nisoldipino;   nisoldipinum
 xref: CAS:63675-72-9;   DrugBank:DB00401;   HMDB:HMDB0014545;   KEGG:C07699;   KEGG:D00618
 xref_mesh: MESH:D015737
 xref: PMID:23841582;   PMID:2667729;   PMID:3154674;   PMID:8150600;   PMID:8429113;   PMID:8592476;   Patent:DE2549568;   Patent:US4154839;   Reaxys:454188;   Wikipedia:Nisoldipine



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nisoldipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Nisoldipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:11895100 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Ar androgen receptor decreases activity ISO Nisoldipine results in decreased activity of AR protein CTD PMID:25257666 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Nisoldipine results in decreased activity of CYP1A2 protein CTD PMID:10805063 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Nisoldipine results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Edn1 endothelin 1 decreases expression ISO Nisoldipine results in decreased expression of EDN1 protein CTD PMID:8742913 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO Nisoldipine results in decreased activity of ESR1 protein CTD PMID:25257666 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Nisoldipine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
decreases activity
increases activity
ISO Nisoldipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
Nisoldipine results in decreased activity of NR1H4 protein
Nisoldipine results in increased activity of NR1H4 protein
CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    chemical entity 19916
      chemical substance 14422
        mixture 13739
          racemate 12113
            nisoldipine 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      chalcogen 19612
                        oxygen atom 19586
                          oxygen molecular entity 19586
                            hydroxides 19389
                              organic hydroxy compound 19003
                                alcohol 15559
                                  aliphatic alcohol 11860
                                    alkyl alcohol 11768
                                      methanol 3963
                                        methyl ester 3910
                                          methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 8
                                            (R)-nisoldipine 8
                                              nisoldipine 8
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