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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nimodipine
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Accession:CHEBI:7575 term browser browse the term
Definition:A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Synonyms:exact_synonym: 2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
 related_synonym: 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester;   BAY e 9736;   Formula=C21H26N2O7;   InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3;   InChIKey=UIAGMCDKSXEBJQ-UHFFFAOYSA-N;   Nimotop;   Periplum;   SMILES=COCCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC(C)C;   isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate;   isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate;   nimodipino;   nimodipinum
 xref: CAS:66085-59-4;   DrugBank:DB00393;   Drug_Central:1937;   KEGG:C07267;   KEGG:D00438;   LINCS:LSM-1659
 xref_mesh: MESH:D009553
 xref: PMID:12137606;   PMID:16180362;   PMID:17110283;   PMID:21869451;   PMID:22262041;   PMID:22300914;   PMID:8519001;   Patent:DE2117571;   Patent:US3799934;   Reaxys:459792;   Wikipedia:Nimodipine


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nimodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions EXP Nimodipine inhibits the reaction [APP protein results in increased uptake of Calcium] CTD PMID:12383957 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Ar androgen receptor decreases activity ISO Nimodipine results in decreased activity of AR protein CTD PMID:25257666 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Nimodipine results in increased expression of BAX protein CTD PMID:17490525 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Nimodipine results in decreased expression of BCL2 protein CTD PMID:17490525 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO [alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in decreased expression of BDNF protein] CTD PMID:30776390 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions ISO Nimodipine inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein] CTD PMID:27095094 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Nimodipine inhibits the reaction [Potassium results in increased secretion of CALCA protein] CTD PMID:18178321 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Palmitic Acid promotes the reaction [Nimodipine results in increased activity of CASP3 protein]
[alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]; Nimodipine inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]
CTD PMID:22700542, PMID:30776390 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Palmitic Acid promotes the reaction [Nimodipine results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Cat catalase multiple interactions EXP Nimodipine inhibits the reaction [Pilocarpine results in increased expression of CAT protein] CTD PMID:16115668 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide multiple interactions ISO Nimodipine inhibits the reaction [cypermethrin results in increased expression of CGA mRNA] CTD PMID:28731686 NCBI chr 5:50,362,491...50,393,368
Ensembl chr 5:50,381,244...50,393,367
JBrowse link
G Clu clusterin multiple interactions ISO Nimodipine inhibits the reaction [Cadmium results in increased expression of CLU protein]; Nimodipine inhibits the reaction [Zinc results in increased expression of CLU protein] CTD PMID:19288494 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of COL1A1 protein] CTD PMID:27095094 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in decreased phosphorylation of CREB1 protein]; Nimodipine inhibits the reaction [Dibutyl Phthalate results in decreased phosphorylation of CREB1 protein] CTD PMID:30776390 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO Nimodipine inhibits the reaction [cypermethrin results in increased expression of CYP11A1 mRNA] CTD PMID:28731686 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Dbh dopamine beta-hydroxylase multiple interactions EXP Nimodipine inhibits the reaction [Dichlorvos results in increased activity of DBH protein] CTD PMID:12186780 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP Nimodipine inhibits the reaction [Dichlorvos results in decreased activity of DRD2 protein] CTD PMID:12186780 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Nimodipine inhibits the reaction [Zinc results in increased expression of EGR1 protein] CTD PMID:10428039 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP
ISO
Nimodipine affects the reaction [Haloperidol results in increased expression of FOS protein]
Nimodipine results in increased expression of FOS mRNA
CTD PMID:12730611, PMID:17913375 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Nimodipine inhibits the reaction [cypermethrin results in increased expression of FSHB mRNA]; Nimodipine inhibits the reaction [cypermethrin results in increased secretion of FSHB protein] CTD PMID:28731686 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of FTH1 protein] CTD PMID:27095094 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions ISO Nimodipine promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA] CTD PMID:27095094 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Nimodipine inhibits the reaction [4-OH-2',3,3',4',5'-pentachlorobiphenyl results in increased expression of JUN protein] CTD PMID:16300829 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions EXP Nimodipine inhibits the reaction [KCNH2 protein affects the abundance of Calcium] CTD PMID:11040061 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO Nimodipine inhibits the reaction [cypermethrin results in increased expression of LHB mRNA]; Nimodipine inhibits the reaction [cypermethrin results in increased secretion of LHB protein] CTD PMID:28731686 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions EXP Nimodipine inhibits the reaction [Dichlorvos results in increased phosphorylation of MAP2 protein] CTD PMID:16635102 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Nimodipine co-treated with alpha-Tocopherol] inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK1 protein]; Nimodipine inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:29149324, PMID:30776390 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Nimodipine co-treated with alpha-Tocopherol] inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK3 protein]; Nimodipine inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:29149324, PMID:30776390 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions EXP Nimodipine promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein] CTD PMID:27095094 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Nimodipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nppc natriuretic peptide C multiple interactions EXP Nimodipine inhibits the reaction [NPPC protein results in increased uptake of Calcium] CTD PMID:18222015 NCBI chr 9:93,731,436...93,735,636
Ensembl chr 9:93,731,436...93,735,636
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
decreases activity
increases activity
ISO Nimodipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; Nimodipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
Nimodipine results in decreased activity of NR1H4 protein
Nimodipine results in increased activity of NR1H4 protein
CTD PMID:25257666, PMID:27773686 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Nimodipine results in increased activity of NR1I2 protein CTD PMID:21068194, PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Nimodipine inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of RAF1 protein] CTD PMID:29149324 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions ISO Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein] CTD PMID:27095094 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Nimodipine inhibits the reaction [cypermethrin results in increased expression of STAR mRNA] CTD PMID:28731686 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Nimodipine inhibits the reaction [Dichlorvos results in increased activity of TH protein] CTD PMID:12186780 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP Nimodipine inhibits the reaction [ferrous sulfate results in increased expression of TIMP1 protein] CTD PMID:27095094 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in increased expression of TNF protein] CTD PMID:30776390 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

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  CHEBI ontology 19770
    role 19718
      application 19363
        solvent 16419
          2-methoxyethanol 336
            2-methoxyethyl ester 45
              nimodipine 39
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19550
                        carbon atom 19539
                          organic molecular entity 19539
                            organic group 18488
                              organic divalent group 18481
                                organodiyl group 18481
                                  carbonyl group 18384
                                    carbonyl compound 18384
                                      carboxylic ester 14061
                                        2-methoxyethyl ester 45
                                          nimodipine 39
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.