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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nilutamide
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Accession:CHEBI:7573 term browser browse the term
Definition:An imidazolidinone that has formula C12H10F3N3O4.
Synonyms:exact_synonym: 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione
 related_synonym: 5,5-Dimethyl-3-(alpha,alpha,alpha-trifluoro-4-nitro-m-tolyl)hydantoin;   Formula=C12H10F3N3O4;   InChI=1S/C12H10F3N3O4/c1-11(2)9(19)17(10(20)16-11)6-3-4-8(18(21)22)7(5-6)12(13,14)15/h3-5H,1-2H3,(H,16,20);   InChIKey=XWXYUMMDTVBTOU-UHFFFAOYSA-N;   Nilandron;   SMILES=CC1(C)NC(=O)N(C1=O)c1ccc(c(c1)C(F)(F)F)[N+]([O-])=O;   nilutamida;   nilutamidum
 xref: Beilstein:841906;   CAS:63612-50-0;   DrugBank:DB00665;   Drug_Central:1933;   KEGG:C08164;   KEGG:D00965;   LINCS:LSM-2513
 xref_mesh: MESH:C021277
 xref: Patent:DE2649925;   Patent:US4097578;   Wikipedia:Nilutamide

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nilutamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases expression ISO nilutamide results in increased expression of AKT1 protein CTD PMID:16616092 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Ar androgen receptor affects binding
increases response to substance
decreases activity
multiple interactions		 ISO nilutamide binds to AR protein
AR protein mutant form results in increased susceptibility to nilutamide
nilutamide results in decreased activity of AR protein
[AR protein mutant form results in increased susceptibility to nilutamide] which results in increased activity of AR protein mutant form; nilutamide analog binds to and affects the localization of AR protein; nilutamide binds to and results in decreased activity of AR protein; nilutamide inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; nilutamide inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; nilutamide inhibits the reaction [Metribolone results in increased activity of AR protein]; nilutamide inhibits the reaction [mibolerone affects the localization of AR protein]		 CTD PMID:15509168, PMID:16125883, PMID:16857237, PMID:18324785, PMID:18973785, PMID:21543282, PMID:27473015 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO nilutamide results in decreased expression of CDKN1B protein CTD PMID:16616092 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP nilutamide inhibits the reaction [Dihydrotestosterone results in decreased activity of GAPDH protein] CTD PMID:10650946 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962 		JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions ISO nilutamide inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA] CTD PMID:16496412 NCBI chr 6:41,932,941...42,002,770
Ensembl chr 6:41,932,244...42,002,819 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions EXP nilutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of IGF1R protein] CTD PMID:10650946 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        pharmaceutical 19301
          drug 19301
            antineoplastic agent 17001
              nilutamide 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            organic hydride 18269
                              organic fundamental parent 18269
                                hydrocarbon 17988
                                  halohydrocarbon 13956
                                    haloalkane 11674
                                      fluoroalkane 7118
                                        fluoromethanes 6335
                                          tetrafluoromethane 6335
                                            trifluoromethyl group 6335
                                              (trifluoromethyl)benzenes 6335
                                                nilutamide 6
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