The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol in which both stereocentres have R-configuration; the (R,R)-enantiomer of the racemic opioid analgesic tramadol, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer.
Tramadol affects the activity of CASP3 protein Vitamin E inhibits the reaction [Tramadol results in increased expression of CASP3 protein] Tramadol results in decreased activity of CASP3 protein
Tramadol results in decreased expression of CAT mRNA; Tramadol results in decreased expression of CAT protein Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]
Tramadol results in decreased expression of CKB mRNA Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]
Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]
CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol CYP2D6 protein affects the methylation of Tramadol [CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol CYP2D6 protein results in decreased methylation of Tramadol CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol CYP2D6 gene mutant form results in increased susceptibility to Tramadol CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol
Tramadol results in increased activity of HTR2A protein Tramadol results in increased expression of HTR2A mRNA Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]
Tramadol binds to OPRD1 protein [Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin
Tramadol binds to OPRK1 protein [Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin
Tramadol binds to OPRM1 protein [Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin
Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]
Tramadol results in decreased expression of SOD1 mRNA; Tramadol results in decreased expression of SOD1 protein Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA] Tramadol results in decreased expression of SOD2 mRNA
Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein]
[Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of TNF protein]
Ethanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein]
Tramadol affects the activity of CASP3 protein Tramadol results in decreased activity of CASP3 protein Vitamin E inhibits the reaction [Tramadol results in increased expression of CASP3 protein]
Tramadol results in decreased expression of CAT mRNA; Tramadol results in decreased expression of CAT protein Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]
Tramadol results in decreased expression of CKB mRNA Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]
Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]
CYP2D6 gene mutant form results in increased susceptibility to Tramadol CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol [CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol CYP2D6 protein results in decreased methylation of Tramadol CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol CYP2D6 protein affects the methylation of Tramadol
Tramadol results in increased activity of GPT protein Tramadol results in increased expression of GPT protein Vitamin E inhibits the reaction [Tramadol results in increased expression of GPT protein]
Tramadol binds to OPRD1 protein [Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin
[Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin
[Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin
Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]
Tramadol results in decreased expression of SOD1 mRNA; Tramadol results in decreased expression of SOD1 protein Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA] Tramadol results in decreased expression of SOD2 mRNA
Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein]
[Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of TNF protein]
Tramadol results in increased expression of TNNI3 protein Ethanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein]