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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions decreases activity |
ISO |
Nifedipine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Nifedipine results in decreased activity of ABCB11 protein |
CTD |
PMID:24014644 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression |
ISO |
Nifedipine results in increased expression of ABCB1 protein |
CTD |
PMID:8632764 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
increases expression |
EXP |
Nifedipine results in increased expression of ABCC2 mRNA |
CTD |
PMID:12206135 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
increases activity multiple interactions increases expression |
ISO |
Nifedipine results in increased activity of ABCC3 protein [Nifedipine results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA Nifedipine results in increased expression of ABCC3 mRNA |
CTD |
PMID:14570758 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases expression multiple interactions |
ISO |
Nifedipine results in decreased expression of AKT1 protein modified form 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]; [Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of AKT1 protein; Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]; Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]] |
CTD |
PMID:20530298 PMID:20562903 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Apoa1 |
apolipoprotein A1 |
increases expression |
ISO |
Nifedipine results in increased expression of APOA1 |
CTD |
PMID:1928808 |
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NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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G |
Apoa2 |
apolipoprotein A2 |
increases expression |
ISO |
Nifedipine results in increased expression of APOA2 |
CTD |
PMID:1928808 |
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NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
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G |
Avp |
arginine vasopressin |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [AVP protein results in increased import of and results in increased abundance of Calcium] |
CTD |
PMID:14711191 |
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NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP ISO |
Nifedipine inhibits the reaction [Gentamicins results in increased expression of BAX protein] Nifedipine inhibits the reaction [DMD gene mutant form results in increased expression of BAX mRNA] |
CTD |
PMID:19698708 PMID:24349043 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO EXP |
Nifedipine results in decreased expression of BCL2 Nifedipine results in increased expression of and affects the localization of BCL2 protein Nifedipine inhibits the reaction [Gentamicins results in decreased expression of BCL2 protein] |
CTD |
PMID:10075388 PMID:10695937 PMID:19698708 |
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NCBI chr13:22,689,783...22,853,920
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BDNF protein] |
CTD |
PMID:11279263 |
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NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Cacna1c |
calcium voltage-gated channel subunit alpha1 C |
affects response to substance multiple interactions |
ISO |
CACNA1C protein affects the susceptibility to Nifedipine Nifedipine inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:18441296 PMID:20128810 |
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NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
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G |
Camk2a |
calcium/calmodulin-dependent protein kinase II alpha |
multiple interactions |
EXP ISO |
Nifedipine inhibits the reaction [FPL 64176 promotes the reaction [CAMK2A protein binds to DRD3 protein]] Nifedipine inhibits the reaction [Cocaine results in increased expression of and results in increased phosphorylation of CAMK2A protein] |
CTD |
PMID:19217379 PMID:28194001 |
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NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]]; Nifedipine inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein] |
CTD |
PMID:24995437 PMID:26923100 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Clu |
clusterin |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [methoxyacetic acid results in increased expression of and results in increased secretion of CLU protein] |
CTD |
PMID:14656996 |
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NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
EXP ISO |
Nifedipine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein] Nifedipine inhibits the reaction [Potassium Chloride results in increased phosphorylation of CREB1 protein] Nifedipine inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:20128810 PMID:21113126 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Csn2 |
casein beta |
decreases expression multiple interactions |
ISO |
Nifedipine results in decreased expression of CSN2 mRNA Nifedipine promotes the reaction [Cadmium results in decreased expression of CSN2 mRNA] |
CTD |
PMID:21167921 |
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NCBI chr14:20,322,581...20,329,818
Ensembl chr14:20,322,581...20,329,817
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity |
ISO |
Nifedipine results in decreased activity of CYP1A1 protein |
CTD |
PMID:18420780 PMID:33814510 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity multiple interactions |
ISO EXP |
Nifedipine results in decreased activity of CYP1A2 protein Nifedipine inhibits the reaction [CYP1A2 protein results in increased metabolism of 3-cyano-7-ethoxycoumarin] |
CTD |
PMID:10805063 PMID:18420780 PMID:19858067 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
Nifedipine results in decreased activity of CYP1B1 protein |
CTD |
PMID:18420780 PMID:33814510 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
decreases activity |
ISO |
Nifedipine results in decreased activity of CYP2B10 protein |
CTD |
PMID:18420780 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
multiple interactions |
EXP |
Nifedipine promotes the reaction [Cyclosporine results in increased expression of CYP2C11 protein] |
CTD |
PMID:28899749 |
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NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
decreases activity |
ISO |
Nifedipine results in decreased activity of CYP2C8 protein Nifedipine results in decreased activity of CYP2C29 protein |
CTD |
PMID:15601807 PMID:18420780 |
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
decreases activity |
ISO |
Nifedipine results in decreased activity of CYP2D6 protein |
CTD |
PMID:18420780 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity |
ISO |
Nifedipine results in decreased activity of CYP2E1 protein |
CTD |
PMID:18420780 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp2j4 |
cytochrome P450, family 2, subfamily j, polypeptide 4 |
decreases activity |
ISO |
Nifedipine results in decreased activity of CYP2J2 protein |
CTD |
PMID:30965050 |
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NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions increases oxidation increases hydroxylation affects oxidation increases expression increases metabolic processing affects metabolic processing |
EXP ISO |
[SOD2 co-treated with CYP3A4] affects the susceptibility to Nifedipine; Nifedipine inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline] CYP3A4 protein results in increased oxidation of Nifedipine CYP3A4 protein results in increased hydroxylation of Nifedipine CYP3A4 protein affects the oxidation of Nifedipine Nifedipine results in increased expression of CYP3A4 mRNA; Nifedipine results in increased expression of CYP3A4 protein 6',7'-dihydroxybergamottin inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine]; [Nifedipine binds to CYP3A4 promoter] which results in decreased expression of CYP3A4 mRNA; [Nifedipine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA]]; Cimetidine inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine]; Nifedipine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine]; YM 758 inhibits the reaction [CYP3A4 protein results in increased metabolism of Nifedipine] CYP3A4 protein affects the metabolism of Nifedipine |
CTD |
PMID:2271712 PMID:12851153 PMID:15286053 PMID:15618748 PMID:15634941 PMID:15784650 PMID:15937564 PMID:16712844 PMID:16837568 PMID:17041008 PMID:17954527 PMID:18846481 PMID:19230594 PMID:19299527 PMID:19501153 PMID:19858067 PMID:20863320 PMID:22524704 PMID:23146034 PMID:25069801 More...
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NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
increases expression |
EXP |
Nifedipine results in increased expression of CYP3A23-3A1 mRNA |
CTD |
PMID:16125621 |
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NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of DDIT3 mRNA]; Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of DDIT3 protein] |
CTD |
PMID:22226148 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Dmd |
dystrophin |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [DMD gene mutant form results in increased abundance of Calcium]; Nifedipine inhibits the reaction [DMD gene mutant form results in increased expression of BAX mRNA]; Nifedipine inhibits the reaction [DMD gene mutant form results in increased expression of NOS2 mRNA]; Nifedipine inhibits the reaction [DMD gene mutant form results in increased secretion of Adenosine Triphosphate] |
CTD |
PMID:24349043 |
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NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]] |
CTD |
PMID:11124974 |
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NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
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G |
Drd3 |
dopamine receptor D3 |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [FPL 64176 promotes the reaction [CAMK2A protein binds to DRD3 protein]] |
CTD |
PMID:19217379 |
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NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
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G |
Edn1 |
endothelin 1 |
decreases activity increases activity multiple interactions |
EXP |
Nifedipine results in decreased activity of EDN1 protein Nifedipine results in increased activity of EDN1 protein Nifedipine inhibits the reaction [Isoproterenol results in increased activity of EDN1 promoter] |
CTD |
PMID:7528292 PMID:11435416 PMID:12628492 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 mRNA]; Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 protein] |
CTD |
PMID:22226148 |
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NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Elk1 |
ETS transcription factor ELK1 |
multiple interactions |
EXP |
Nifedipine affects the reaction [Haloperidol results in increased phosphorylation of ELK1 protein] |
CTD |
PMID:17913375 |
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NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713
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G |
Esr1 |
estrogen receptor 1 |
increases activity |
ISO |
Nifedipine results in increased activity of ESR1 protein |
CTD |
PMID:25257666 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Fgf2 |
fibroblast growth factor 2 |
affects response to substance multiple interactions |
ISO |
Nifedipine affects the susceptibility to FGF2 protein Nifedipine inhibits the reaction [FGF2 protein results in increased expression of FOS mRNA] |
CTD |
PMID:15141722 PMID:16188231 |
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NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Fgf7 |
fibroblast growth factor 7 |
increases secretion increases expression |
ISO |
Nifedipine results in increased secretion of FGF7 protein Nifedipine results in increased expression of FGF7 mRNA |
CTD |
PMID:11023675 |
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NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions decreases expression |
ISO EXP |
Nifedipine inhibits the reaction [FGF2 protein results in increased expression of FOS mRNA] Nifedipine results in decreased expression of FOS protein [Nifedipine co-treated with omega-Conotoxin GVIA co-treated with omega-Agatoxin IVA] inhibits the reaction [Potassium Chloride affects the expression of FOS mRNA]; Nifedipine affects the reaction [Haloperidol results in increased expression of FOS protein]; Nifedipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS protein]; Nifedipine inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; Nifedipine inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein] |
CTD |
PMID:7534335 PMID:16188231 PMID:17913375 PMID:20211981 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Gfap |
glial fibrillary acidic protein |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [diphenylditelluride results in decreased phosphorylation of GFAP protein] |
CTD |
PMID:21863293 |
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NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Gria1 |
glutamate ionotropic receptor AMPA type subunit 1 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [Cocaine results in increased expression of and results in increased phosphorylation of GRIA1 protein] |
CTD |
PMID:28194001 |
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NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] |
CTD |
PMID:23769903 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Hdac4 |
histone deacetylase 4 |
affects localization |
EXP |
Nifedipine affects the localization of HDAC4 protein |
CTD |
PMID:20559781 |
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NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
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G |
Hgf |
hepatocyte growth factor |
increases expression |
ISO |
Nifedipine results in increased expression of HGF protein |
CTD |
PMID:15071489 |
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NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
Nifedipine results in increased expression of HMOX1 protein |
CTD |
PMID:21525764 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hnmt |
histamine N-methyltransferase |
decreases activity |
EXP |
Nifedipine results in decreased activity of HNMT protein |
CTD |
PMID:2408645 |
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NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012
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G |
Hsf1 |
heat shock transcription factor 1 |
increases activity |
ISO |
Nifedipine results in increased activity of HSF1 protein |
CTD |
PMID:34170685 |
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NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of HSPA5 mRNA]; Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of HSPA5 protein] |
CTD |
PMID:22226148 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Igf1 |
insulin-like growth factor 1 |
decreases response to substance |
ISO |
Nifedipine results in decreased susceptibility to IGF1 protein |
CTD |
PMID:16485066 |
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NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Igf2 |
insulin-like growth factor 2 |
decreases response to substance |
ISO |
Nifedipine results in decreased susceptibility to IGF2 protein |
CTD |
PMID:16485066 |
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NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
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G |
Il1b |
interleukin 1 beta |
increases expression |
ISO |
Nifedipine results in increased expression of IL1B mRNA |
CTD |
PMID:28138970 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Kcna1 |
potassium voltage-gated channel subfamily A member 1 |
multiple interactions |
EXP |
[Nifedipine co-treated with omega-Conotoxin GVIA co-treated with omega-Agatoxin IVA] promotes the reaction [Potassium Chloride results in increased expression of KCNA1 mRNA] |
CTD |
PMID:20211981 |
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NCBI chr 4:159,464,223...159,472,905
Ensembl chr 4:159,464,188...159,472,682
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G |
Kcna3 |
potassium voltage-gated channel subfamily A member 3 |
decreases activity |
ISO |
Nifedipine results in decreased activity of KCNA3 protein |
CTD |
PMID:17638537 |
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NCBI chr 2:194,632,360...194,633,937
Ensembl chr 2:194,632,196...194,650,138
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G |
Kcnc3 |
potassium voltage-gated channel subfamily C member 3 |
multiple interactions |
EXP |
[Nifedipine co-treated with omega-Conotoxin GVIA co-treated with omega-Agatoxin IVA] inhibits the reaction [Potassium Chloride results in increased expression of KCNC3 mRNA] |
CTD |
PMID:20211981 |
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NCBI chr 1:95,080,960...95,095,165
Ensembl chr 1:95,080,960...95,095,160
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK1 protein] Nifedipine affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK1 protein] |
CTD |
PMID:15086530 PMID:25045119 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK3 protein] Nifedipine affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK3 protein] |
CTD |
PMID:15086530 PMID:25045119 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
Nifedipine results in decreased expression of and results in decreased activity of MMP9 protein |
CTD |
PMID:18204791 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Myc |
MYC proto-oncogene, bHLH transcription factor |
increases expression |
ISO |
Nifedipine results in increased expression of MYC protein |
CTD |
PMID:10695937 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Myh10 |
myosin heavy chain 10 |
decreases expression |
ISO EXP |
Nifedipine results in decreased expression of MYH10 protein |
CTD |
PMID:20530298 |
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NCBI chr10:53,393,901...53,525,174
Ensembl chr10:53,394,389...53,525,165
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Myh11 |
myosin heavy chain 11 |
increases expression |
ISO EXP |
Nifedipine results in increased expression of MYH11 protein |
CTD |
PMID:20530298 |
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NCBI chr10:743,364...838,459
Ensembl chr10:743,685...838,459
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Myh7 |
myosin heavy chain 7 |
decreases response to substance |
ISO |
MYH7 gene mutant form results in decreased susceptibility to Nifedipine |
CTD |
PMID:29741611 |
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NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
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Myl9 |
myosin light chain 9 |
decreases phosphorylation |
EXP |
Nifedipine results in decreased phosphorylation of MYL9 protein |
CTD |
PMID:17272349 |
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NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
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Nampt |
nicotinamide phosphoribosyltransferase |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [Glucose results in increased secretion of NAMPT protein] |
CTD |
PMID:23536823 |
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NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
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G |
Nefl |
neurofilament light chain |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFL protein] |
CTD |
PMID:21863293 |
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NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
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G |
Nefm |
neurofilament medium chain |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFM protein] |
CTD |
PMID:21863293 |
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NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
affects localization |
ISO |
Nifedipine affects the localization of NFE2L2 protein |
CTD |
PMID:21525764 |
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NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased degradation of NFKBIA protein] |
CTD |
PMID:23583884 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Ngf |
nerve growth factor |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [NGF protein results in increased uptake of Calcium] |
CTD |
PMID:1374475 |
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NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] Nifedipine inhibits the reaction [DMD gene mutant form results in increased expression of NOS2 mRNA] |
CTD |
PMID:11245857 PMID:24349043 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; [Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein; Nifedipine inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]; Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 mRNA]; Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]; Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]; Nifedipine promotes the reaction [Simvastatin inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]]; Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 mRNA]]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]]; wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]] |
CTD |
PMID:20562903 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Nppa |
natriuretic peptide A |
decreases expression |
ISO |
Nifedipine results in decreased expression of NPPA mRNA |
CTD |
PMID:20559781 |
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NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Nppb |
natriuretic peptide B |
multiple interactions |
EXP |
[Losartan co-treated with Nifedipine] results in decreased expression of NPPB mRNA |
CTD |
PMID:17666919 |
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NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
multiple interactions decreases activity |
ISO |
Nifedipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] Nifedipine results in decreased activity of NR1H4 protein |
CTD |
PMID:25257666 |
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NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
[Nifedipine results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; [Nifedipine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA]]; Nifedipine binds to and results in increased activity of NR1I2 protein; NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA] |
CTD |
PMID:14570758 PMID:17041008 PMID:21291553 PMID:25069801 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Olr1 |
oxidized low density lipoprotein receptor 1 |
decreases expression |
ISO |
Nifedipine results in decreased expression of OLR1 mRNA |
CTD |
PMID:12072588 |
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NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
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Pdcd4 |
programmed cell death 4 |
decreases expression |
ISO |
Nifedipine results in decreased expression of PDCD4 mRNA |
CTD |
PMID:21873647 |
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NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
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Pla2g4a |
phospholipase A2 group IVA |
multiple interactions |
ISO EXP |
[Nifedipine co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA] |
CTD |
PMID:18938131 PMID:19162293 PMID:23583884 |
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NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
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G |
Prl |
prolactin |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [bisphenol A results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [Coumestrol results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [Dieldrin results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [Endosulfan results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [Estradiol results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [nonylphenol results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [o,p'-DDT results in increased secretion of PRL protein] |
CTD |
PMID:15811834 PMID:17174995 |
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NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO EXP |
[Nifedipine co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] arachidonyltrifluoromethane promotes the reaction [Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] |
CTD |
PMID:18388244 PMID:18938131 PMID:19063610 PMID:23583884 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and affects the localization of RELA protein] |
CTD |
PMID:23583884 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Ren |
renin |
multiple interactions increases activity increases expression |
ISO |
[Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein; Angiotensin-Converting Enzyme Inhibitors promotes the reaction [Nifedipine results in increased activity of REN protein]; Nifedipine promotes the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein] Nifedipine results in increased expression of REN protein |
CTD |
PMID:3142437 PMID:3313686 PMID:3326920 PMID:6184561 PMID:6354932 |
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NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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RT1-Bb |
RT1 class II, locus Bb |
affects expression |
ISO |
Nifedipine affects the expression of HLA-DQB1 mRNA |
CTD |
PMID:25811541 |
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NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
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G |
Scn5a |
sodium voltage-gated channel alpha subunit 5 |
decreases activity |
EXP |
Nifedipine results in decreased activity of SCN5A protein |
CTD |
PMID:16331678 PMID:17978865 |
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NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
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G |
Serpinb2 |
serpin family B member 2 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA] |
CTD |
PMID:18388244 |
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NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408
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G |
Slc1a2 |
solute carrier family 1 member 2 |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC1A2 protein] |
CTD |
PMID:26988466 |
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NCBI chr 3:89,005,129...89,126,498
Ensembl chr 3:89,005,129...89,126,498
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G |
Slc22a1 |
solute carrier family 22 member 1 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:21641380 |
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NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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G |
Slc22a3 |
solute carrier family 22 member 3 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:21641380 |
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NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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Slc22a4 |
solute carrier family 22 member 4 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] |
CTD |
PMID:21641380 |
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NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720
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G |
Slc22a5 |
solute carrier family 22 member 5 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] |
CTD |
PMID:21641380 |
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NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
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G |
Slc23a2 |
solute carrier family 23 member 2 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [Calcium results in increased expression of SLC23A2 mRNA]; Nifedipine inhibits the reaction [Phosphates results in increased expression of SLC23A2 mRNA] |
CTD |
PMID:12788230 |
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NCBI chr 3:119,302,651...119,395,289
Ensembl chr 3:119,302,666...119,460,343
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions affects response to substance increases expression |
EXP ISO |
[SOD2 co-treated with CYP3A4] affects the susceptibility to Nifedipine SOD2 protein affects the susceptibility to Nifedipine Nifedipine results in increased expression of SOD2 mRNA; Nifedipine results in increased expression of SOD2 protein |
CTD |
PMID:18327084 PMID:19501153 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Spp1 |
secreted phosphoprotein 1 |
multiple interactions |
ISO |
Nifedipine inhibits the reaction [Calcium results in increased expression of SPP1 mRNA]; Nifedipine inhibits the reaction [Phosphates results in increased expression of SPP1 mRNA] |
CTD |
PMID:12788230 |
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NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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G |
Star |
steroidogenic acute regulatory protein |
multiple interactions |
EXP ISO |
Nifedipine inhibits the reaction [Oxygen deficiency results in decreased expression of STAR mRNA]; Nifedipine inhibits the reaction [Oxygen deficiency results in decreased expression of STAR protein] Nifedipine promotes the reaction [Cyclic AMP results in increased expression of STAR mRNA] |
CTD |
PMID:19822634 PMID:22226148 |
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NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
[Losartan co-treated with Nifedipine] results in decreased expression of TGFB1 mRNA |
CTD |
PMID:17666919 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TNF mRNA]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of TNF protein] |
CTD |
PMID:23583884 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfaip3 |
TNF alpha induced protein 3 |
decreases expression |
ISO |
Nifedipine results in decreased expression of TNFAIP3 mRNA |
CTD |
PMID:21873647 |
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NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
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G |
Tp53 |
tumor protein p53 |
increases activity |
ISO |
Nifedipine results in increased activity of TP53 protein |
CTD |
PMID:12082016 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tpd52 |
tumor protein D52 |
increases expression |
ISO |
Nifedipine results in increased expression of TPD52 mRNA |
CTD |
PMID:21873647 |
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NCBI chr 2:92,735,246...92,816,079
Ensembl chr 2:92,735,620...92,816,622
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
[Nifedipine co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA] arachidonyltrifluoromethane promotes the reaction [Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]] |
CTD |
PMID:18388244 PMID:18938131 PMID:19063610 PMID:19162293 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Vim |
vimentin |
multiple interactions |
EXP |
Nifedipine inhibits the reaction [diphenylditelluride results in decreased phosphorylation of VIM protein] |
CTD |
PMID:21863293 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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