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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nifedipine
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Accession:CHEBI:7565 term browser browse the term
Definition:A dihydropyridine that has formula C17H18N2O6.
Synonyms:exact_synonym: dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
 related_synonym: 4-(2'-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethylester;   Adalat;   Adapine;   Coracten;   Formula=C17H18N2O6;   InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3;   InChIKey=HYIMSNHJOBLJNT-UHFFFAOYSA-N;   Nifecard;   Nifecor;   Nifedipres;   Procardia;   SMILES=COC(=O)C1=C(C)NC(C)=C(C1c1ccccc1[N+]([O-])=O)C(=O)OC;   nifedipino;   nifedipinum
 xref: Beilstein:497773;   CAS:21829-25-4;   DrugBank:DB01115;   Drug_Central:1922;   KEGG:C07266;   KEGG:D00437;   LINCS:LSM-4176
 xref_mesh: MESH:D009543
 xref: Wikipedia:Nifedipine


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nifedipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Nifedipine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Nifedipine results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Nifedipine results in increased expression of ABCB1 protein CTD PMID:8632764 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP Nifedipine results in increased expression of ABCC2 mRNA CTD PMID:12206135 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases activity
multiple interactions
increases expression
ISO Nifedipine results in increased activity of ABCC3 protein
[Nifedipine results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA
Nifedipine results in increased expression of ABCC3 mRNA
CTD PMID:14570758 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression
multiple interactions
ISO Nifedipine results in decreased expression of AKT1 protein modified form
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]; [Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of AKT1 protein; Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]; Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]
CTD PMID:20530298, PMID:20562903 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apoa1 apolipoprotein A1 increases expression ISO Nifedipine results in increased expression of APOA1 CTD PMID:1928808 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoa2 apolipoprotein A2 increases expression ISO Nifedipine results in increased expression of APOA2 CTD PMID:1928808 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802
JBrowse link
G Avp arginine vasopressin multiple interactions EXP Nifedipine inhibits the reaction [AVP protein results in increased import of and results in increased abundance of Calcium] CTD PMID:14711191 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
Nifedipine inhibits the reaction [Gentamicins results in increased expression of BAX protein]
Nifedipine inhibits the reaction [DMD gene mutant form results in increased expression of BAX mRNA]
CTD PMID:19698708, PMID:24349043 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
Nifedipine results in decreased expression of BCL2
Nifedipine results in increased expression of and affects the localization of BCL2 protein
Nifedipine inhibits the reaction [Gentamicins results in decreased expression of BCL2 protein]
CTD PMID:10075388, PMID:10695937, PMID:19698708 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Nifedipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BDNF protein] CTD PMID:11279263 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C affects response to substance
multiple interactions
ISO CACNA1C protein affects the susceptibility to Nifedipine
Nifedipine inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein]
CTD PMID:18441296, PMID:20128810 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP
ISO
Nifedipine inhibits the reaction [FPL 64176 promotes the reaction [CAMK2A protein binds to DRD3 protein]]
Nifedipine inhibits the reaction [Cocaine results in increased expression of and results in increased phosphorylation of CAMK2A protein]
CTD PMID:19217379, PMID:28194001 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Nifedipine inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]]; Nifedipine inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein] CTD PMID:24995437, PMID:26923100 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Clu clusterin multiple interactions EXP Nifedipine inhibits the reaction [methoxyacetic acid results in increased expression of and results in increased secretion of CLU protein] CTD PMID:14656996 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP
ISO
Nifedipine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]
Nifedipine inhibits the reaction [Potassium Chloride results in increased phosphorylation of CREB1 protein]
Nifedipine inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein]
CTD PMID:20128810, PMID:21113126 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Csn2 casein beta decreases expression
multiple interactions
ISO Nifedipine results in decreased expression of CSN2 mRNA
Nifedipine promotes the reaction [Cadmium results in decreased expression of CSN2 mRNA]
CTD PMID:21167921 NCBI chr14:21,972,274...21,979,511
Ensembl chr14:21,972,274...21,979,510
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Nifedipine results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
multiple interactions
ISO
EXP
Nifedipine results in decreased activity of CYP1A2 protein
Nifedipine inhibits the reaction [CYP1A2 protein results in increased metabolism of 3-cyano-7-ethoxycoumarin]
CTD PMID:10805063, PMID:18420780, PMID:19858067 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Nifedipine results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity ISO Nifedipine results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP Nifedipine promotes the reaction [Cyclosporine results in increased expression of CYP2C11 protein] CTD PMID:28899749 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Nifedipine results in decreased activity of CYP2C8 protein
Nifedipine results in decreased activity of CYP2C29 protein
CTD PMID:15601807, PMID:18420780 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Nifedipine results in decreased activity of CYP2D6 protein CTD PMID:18420780 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Nifedipine results in decreased activity of CYP2E1 protein CTD PMID:18420780 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Nifedipine results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP [SOD2 co-treated with CYP3A4] affects the susceptibility to Nifedipine; Nifedipine inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline] CTD PMID:19501153, PMID:19858067 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Nifedipine results in increased expression of CYP3A23-3A1 mRNA CTD PMID:16125621 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of DDIT3 mRNA]; Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of DDIT3 protein] CTD PMID:22226148 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dmd dystrophin multiple interactions ISO Nifedipine inhibits the reaction [DMD gene mutant form results in increased abundance of Calcium]; Nifedipine inhibits the reaction [DMD gene mutant form results in increased expression of BAX mRNA]; Nifedipine inhibits the reaction [DMD gene mutant form results in increased expression of NOS2 mRNA]; Nifedipine inhibits the reaction [DMD gene mutant form results in increased secretion of Adenosine Triphosphate] CTD PMID:24349043 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP Nifedipine inhibits the reaction [DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]] CTD PMID:11124974 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 multiple interactions EXP Nifedipine inhibits the reaction [FPL 64176 promotes the reaction [CAMK2A protein binds to DRD3 protein]] CTD PMID:19217379 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Edn1 endothelin 1 decreases activity
increases activity
multiple interactions
EXP Nifedipine results in decreased activity of EDN1 protein
Nifedipine results in increased activity of EDN1 protein
Nifedipine inhibits the reaction [Isoproterenol results in increased activity of EDN1 promoter]
CTD PMID:7528292, PMID:11435416, PMID:12628492 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 mRNA]; Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 protein] CTD PMID:22226148 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions EXP Nifedipine affects the reaction [Haloperidol results in increased phosphorylation of ELK1 protein] CTD PMID:17913375 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO Nifedipine results in increased activity of ESR1 protein CTD PMID:25257666 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fgf2 fibroblast growth factor 2 affects response to substance
multiple interactions
ISO Nifedipine affects the susceptibility to FGF2 protein
Nifedipine inhibits the reaction [FGF2 protein results in increased expression of FOS mRNA]
CTD PMID:15141722, PMID:16188231 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgf7 fibroblast growth factor 7 increases secretion
increases expression
ISO Nifedipine results in increased secretion of FGF7 protein
Nifedipine results in increased expression of FGF7 mRNA
CTD PMID:11023675 NCBI chr 3:118,315,859...118,368,464
Ensembl chr 3:118,317,761...118,366,872
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO
EXP
Nifedipine inhibits the reaction [FGF2 protein results in increased expression of FOS mRNA]
Nifedipine results in decreased expression of FOS protein
[Nifedipine co-treated with omega-Conotoxin GVIA co-treated with omega-Agatoxin IVA] inhibits the reaction [Potassium Chloride affects the expression of FOS mRNA]; Nifedipine affects the reaction [Haloperidol results in increased expression of FOS protein]; Nifedipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS protein]; Nifedipine inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; Nifedipine inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein]
CTD PMID:7534335, PMID:16188231, PMID:17913375, PMID:20211981 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Nifedipine inhibits the reaction [diphenylditelluride results in decreased phosphorylation of GFAP protein] CTD PMID:21863293 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions ISO Nifedipine inhibits the reaction [Cocaine results in increased expression of and results in increased phosphorylation of GRIA1 protein] CTD PMID:28194001 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Nifedipine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hdac4 histone deacetylase 4 affects localization EXP Nifedipine affects the localization of HDAC4 protein CTD PMID:20559781 NCBI chr 9:99,052,945...99,299,715
Ensembl chr 9:99,057,089...99,299,715
JBrowse link
G Hgf hepatocyte growth factor increases expression ISO Nifedipine results in increased expression of HGF protein CTD PMID:15071489 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Nifedipine results in increased expression of HMOX1 protein CTD PMID:21525764 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnmt histamine N-methyltransferase decreases activity EXP Nifedipine results in decreased activity of HNMT protein CTD PMID:2408645 NCBI chr 3:905,111...937,038
Ensembl chr 3:904,765...937,102
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of HSPA5 mRNA]; Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of HSPA5 protein] CTD PMID:22226148 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Igf1 insulin-like growth factor 1 decreases response to substance ISO Nifedipine results in decreased susceptibility to IGF1 protein CTD PMID:16485066 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf2 insulin-like growth factor 2 decreases response to substance ISO Nifedipine results in decreased susceptibility to IGF2 protein CTD PMID:16485066 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Nifedipine results in increased expression of IL1B mRNA CTD PMID:28138970 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Kcna1 potassium voltage-gated channel subfamily A member 1 multiple interactions EXP [Nifedipine co-treated with omega-Conotoxin GVIA co-treated with omega-Agatoxin IVA] promotes the reaction [Potassium Chloride results in increased expression of KCNA1 mRNA] CTD PMID:20211981 NCBI chr 4:159,190,781...159,192,526
Ensembl chr 4:159,190,804...159,192,526
JBrowse link
G Kcna3 potassium voltage-gated channel subfamily A member 3 decreases activity ISO Nifedipine results in decreased activity of KCNA3 protein CTD PMID:17638537 NCBI chr 2:209,766,767...209,768,344
Ensembl chr 2:209,766,512...209,769,711
JBrowse link
G Kcnc3 potassium voltage-gated channel subfamily C member 3 multiple interactions EXP [Nifedipine co-treated with omega-Conotoxin GVIA co-treated with omega-Agatoxin IVA] inhibits the reaction [Potassium Chloride results in increased expression of KCNC3 mRNA] CTD PMID:20211981 NCBI chr 1:100,593,453...100,607,874
Ensembl chr 1:100,593,680...100,607,874
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Nifedipine inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK1 protein]
Nifedipine affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK1 protein]
CTD PMID:15086530, PMID:25045119 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Nifedipine inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK3 protein]
Nifedipine affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK3 protein]
CTD PMID:15086530, PMID:25045119 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Nifedipine results in decreased expression of and results in decreased activity of MMP9 protein CTD PMID:18204791 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Nifedipine results in increased expression of MYC protein CTD PMID:10695937 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myh10 myosin heavy chain 10 decreases expression ISO
EXP
Nifedipine results in decreased expression of MYH10 protein CTD PMID:20530298 NCBI chr10:55,274,910...55,406,738
Ensembl chr10:55,275,411...55,406,732
JBrowse link
G Myh11 myosin heavy chain 11 increases expression ISO
EXP
Nifedipine results in increased expression of MYH11 protein CTD PMID:20530298 NCBI chr10:764,421...859,184
Ensembl chr10:764,421...859,184
JBrowse link
G Myh7 myosin heavy chain 7 decreases response to substance ISO MYH7 gene mutant form results in decreased susceptibility to Nifedipine CTD PMID:29741611 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Myl9 myosin light chain 9 decreases phosphorylation EXP Nifedipine results in decreased phosphorylation of MYL9 protein CTD PMID:17272349 NCBI chr 3:152,857,573...152,863,961
Ensembl chr 3:152,857,592...152,863,960
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions ISO Nifedipine inhibits the reaction [Glucose results in increased secretion of NAMPT protein] CTD PMID:23536823 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Nefl neurofilament light multiple interactions EXP Nifedipine inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFL protein] CTD PMID:21863293 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
JBrowse link
G Nefm neurofilament medium multiple interactions EXP Nifedipine inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFM protein] CTD PMID:21863293 NCBI chr15:44,855,307...44,860,604
Ensembl chr15:44,855,310...44,860,604
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization ISO Nifedipine affects the localization of NFE2L2 protein CTD PMID:21525764 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:23583884 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Nifedipine inhibits the reaction [NGF protein results in increased uptake of Calcium] CTD PMID:1374475 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Nifedipine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Nifedipine inhibits the reaction [DMD gene mutant form results in increased expression of NOS2 mRNA]
CTD PMID:11245857, PMID:24349043 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; [Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein; Nifedipine inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]; Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 mRNA]; Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]; Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]; Nifedipine promotes the reaction [Simvastatin inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]]; Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 mRNA]]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]]; wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]] CTD PMID:20562903 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nppa natriuretic peptide A decreases expression ISO Nifedipine results in decreased expression of NPPA mRNA CTD PMID:20559781 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP [Losartan co-treated with Nifedipine] results in decreased expression of NPPB mRNA CTD PMID:17666919 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
decreases activity
ISO Nifedipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
Nifedipine results in decreased activity of NR1H4 protein
CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Nifedipine results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; [Nifedipine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA]]; Nifedipine binds to and results in increased activity of NR1I2 protein; NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA] CTD PMID:14570758, PMID:17041008, PMID:21291553, PMID:25069801 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 decreases expression ISO Nifedipine results in decreased expression of OLR1 mRNA CTD PMID:12072588 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Pdcd4 programmed cell death 4 decreases expression ISO Nifedipine results in decreased expression of PDCD4 mRNA CTD PMID:21873647 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO
EXP
[Nifedipine co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA] CTD PMID:18938131, PMID:19162293, PMID:23583884 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Prl prolactin multiple interactions EXP Nifedipine inhibits the reaction [bisphenol A results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [Coumestrol results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [Dieldrin results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [Endosulfan results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [Estradiol results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [nonylphenol results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [o,p'-DDT results in increased secretion of PRL protein] CTD PMID:15811834, PMID:17174995 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
[Nifedipine co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]
arachidonyltrifluoromethane promotes the reaction [Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]
CTD PMID:18388244, PMID:18938131, PMID:19063610, PMID:23583884 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and affects the localization of RELA protein] CTD PMID:23583884 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin multiple interactions
increases activity
increases expression
ISO [Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein; Angiotensin-Converting Enzyme Inhibitors promotes the reaction [Nifedipine results in increased activity of REN protein]; Nifedipine promotes the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein]
Nifedipine results in increased expression of REN protein
CTD PMID:3142437, PMID:3313686, PMID:3326920, PMID:6184561, PMID:6354932 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Nifedipine affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity EXP Nifedipine results in decreased activity of SCN5A protein CTD PMID:16331678, PMID:17978865 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Serpinb2 serpin family B member 2 multiple interactions ISO Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA] CTD PMID:18388244 NCBI chr13:27,449,907...27,463,015
Ensembl chr13:27,449,934...27,463,010
JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions EXP Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC1A2 protein] CTD PMID:26988466 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Nifedipine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Nifedipine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO Nifedipine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] CTD PMID:21641380 NCBI chr10:39,334,972...39,373,508 JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Nifedipine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:21641380 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slc23a2 solute carrier family 23 member 2 multiple interactions ISO Nifedipine inhibits the reaction [Calcium results in increased expression of SLC23A2 mRNA]; Nifedipine inhibits the reaction [Phosphates results in increased expression of SLC23A2 mRNA] CTD PMID:12788230 NCBI chr 3:124,632,491...124,842,225
Ensembl chr 3:124,632,492...124,724,252
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
affects response to substance
increases expression
EXP
ISO
[SOD2 co-treated with CYP3A4] affects the susceptibility to Nifedipine
SOD2 protein affects the susceptibility to Nifedipine
Nifedipine results in increased expression of SOD2 mRNA; Nifedipine results in increased expression of SOD2 protein
CTD PMID:18327084, PMID:19501153 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO Nifedipine inhibits the reaction [Calcium results in increased expression of SPP1 mRNA]; Nifedipine inhibits the reaction [Phosphates results in increased expression of SPP1 mRNA] CTD PMID:12788230 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP
ISO
Nifedipine inhibits the reaction [Oxygen deficiency results in decreased expression of STAR mRNA]; Nifedipine inhibits the reaction [Oxygen deficiency results in decreased expression of STAR protein]
Nifedipine promotes the reaction [Cyclic AMP results in increased expression of STAR mRNA]
CTD PMID:19822634, PMID:22226148 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Losartan co-treated with Nifedipine] results in decreased expression of TGFB1 mRNA CTD PMID:17666919 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TNF mRNA]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of TNF protein] CTD PMID:23583884 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 decreases expression ISO Nifedipine results in decreased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tp53 tumor protein p53 increases activity ISO Nifedipine results in increased activity of TP53 protein CTD PMID:12082016 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpd52 tumor protein D52 increases expression ISO Nifedipine results in increased expression of TPD52 mRNA CTD PMID:21873647 NCBI chr 2:94,959,732...95,041,277
Ensembl chr 2:95,008,311...95,040,514
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [Nifedipine co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]
arachidonyltrifluoromethane promotes the reaction [Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]]
CTD PMID:18388244, PMID:18938131, PMID:19063610, PMID:19162293 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin multiple interactions EXP Nifedipine inhibits the reaction [diphenylditelluride results in decreased phosphorylation of VIM protein] CTD PMID:21863293 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        fuel 10797
          methanol 3062
            methyl ester 3051
              nifedipine 99
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      chalcogen 19362
                        oxygen atom 19323
                          oxygen molecular entity 19323
                            hydroxides 19068
                              organic hydroxy compound 18634
                                alcohol 14987
                                  aliphatic alcohol 11105
                                    alkyl alcohol 11059
                                      methanol 3062
                                        methyl ester 3051
                                          nifedipine 99
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.