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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Gly-His-Lys
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Accession:CHEBI:75430 term browser browse the term
Definition:A tripeptide composed of glycine, L-histidine and L-lysine residues joined in sequence.
Synonyms:exact_synonym: glycyl-L-histidyl-L-lysine
 related_synonym: Formula=C14H24N6O4;   GHK;   Gly-L-His-L-Lys;   Glycyl-histidyl-lysine;   InChI=1S/C14H24N6O4/c15-4-2-1-3-10(14(23)24)20-13(22)11(19-12(21)6-16)5-9-7-17-8-18-9/h7-8,10-11H,1-6,15-16H2,(H,17,18)(H,19,21)(H,20,22)(H,23,24)/t10-,11-/m0/s1;   InChIKey=MVORZMQFXBLMHM-QWRGUYRKSA-N;   SMILES=NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN)C(O)=O;   glycylhistidyllysine;   liver cell growth factor
 xref: CAS:49557-75-7;   CBA:545731
 xref_mesh: MESH:C020905
 xref: PMID:18644225;   PMID:20143136;   PMID:21457130;   PMID:21780203;   PMID:21898044;   PMID:22666519;   PMID:22937864;   PMID:22999295;   PMID:23019153;   PMID:23285694;   PMID:23744835;   Reaxys:965283



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Gly-His-Lys term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 multiple interactions ISO glycyl-histidyl-lysine inhibits the reaction [TNF protein results in increased secretion of IL6 protein] CTD PMID:23285694 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP [glycyl-histidyl-lysine co-treated with Copper] results in increased expression of MMP2 mRNA; [glycyl-histidyl-lysine co-treated with Copper] results in increased secretion of MMP2 protein CTD PMID:11045606 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [glycyl-histidyl-lysine co-treated with Copper] results in increased secretion of TIMP1 protein CTD PMID:11045606 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP [glycyl-histidyl-lysine co-treated with Copper] results in increased secretion of TIMP2 protein CTD PMID:11045606 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO glycyl-histidyl-lysine inhibits the reaction [TNF protein results in increased secretion of IL6 protein] CTD PMID:23285694 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19908
    role 19883
      biological role 19881
        biochemical role 19571
          metabolite 19556
            Gly-His-Lys 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19908
    subatomic particle 19906
      composite particle 19906
        hadron 19906
          baryon 19906
            nucleon 19906
              atomic nucleus 19906
                atom 19906
                  main group element atom 19853
                    p-block element atom 19853
                      carbon group element atom 19799
                        carbon atom 19794
                          organic molecular entity 19794
                            organic group 18960
                              organic divalent group 18941
                                organodiyl group 18941
                                  carbonyl group 18893
                                    carbonyl compound 18893
                                      carboxylic acid 18614
                                        carboacyl group 17709
                                          univalent carboacyl group 17709
                                            carbamoyl group 17556
                                              carboxamide 17556
                                                peptide 9570
                                                  oligopeptide 1324
                                                    tripeptide 970
                                                      Gly-His-Lys 5
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