CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: Gly-His-Lys
Accession: CHEBI:75430
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Definition: A tripeptide composed of glycine, L-histidine and L-lysine residues joined in sequence.
Synonyms: exact_synonym: glycyl-L-histidyl-L-lysine
related_synonym: Formula=C14H24N6O4; GHK; Gly-L-His-L-Lys; Glycyl-histidyl-lysine; InChI=1S/C14H24N6O4/c15-4-2-1-3-10(14(23)24)20-13(22)11(19-12(21)6-16)5-9-7-17-8-18-9/h7-8,10-11H,1-6,15-16H2,(H,17,18)(H,19,21)(H,20,22)(H,23,24)/t10-,11-/m0/s1; InChIKey=MVORZMQFXBLMHM-QWRGUYRKSA-N; SMILES=NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN)C(O)=O; glycylhistidyllysine; liver cell growth factor
xref: CAS:49557-75-7; CBA:545731
xref_mesh: MESH:C020905
xref: PMID:18644225; PMID:20143136; PMID:21457130; PMID:21780203; PMID:21898044; PMID:22666519; PMID:22937864; PMID:22999295; PMID:23019153; PMID:23285694; PMID:23744835; Reaxys:965283
G
Il6
interleukin 6
multiple interactions
ISO
glycyl-histidyl-lysine inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
CTD
PMID:23285694
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Mmp2
matrix metallopeptidase 2
multiple interactions
EXP
[glycyl-histidyl-lysine co-treated with Copper] results in increased expression of MMP2 mRNA; [glycyl-histidyl-lysine co-treated with Copper] results in increased secretion of MMP2 protein
CTD
PMID:11045606
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
G
Timp1
TIMP metallopeptidase inhibitor 1
multiple interactions
EXP
[glycyl-histidyl-lysine co-treated with Copper] results in increased secretion of TIMP1 protein
CTD
PMID:11045606
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
G
Timp2
TIMP metallopeptidase inhibitor 2
multiple interactions
EXP
[glycyl-histidyl-lysine co-treated with Copper] results in increased secretion of TIMP2 protein
CTD
PMID:11045606
NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
G
Tnf
tumor necrosis factor
multiple interactions
ISO
glycyl-histidyl-lysine inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
CTD
PMID:23285694
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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