Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dibenzoylmethane
go back to main search page
Accession:CHEBI:75417 term browser browse the term
Definition:A beta-diketone that is acetylacetone (acac) in which both methyl groups have been replaced by phenyl groups. It is a minor constituent of the root extract of licorice (Glycyrrhiza glabra) and exhibits antimutagenic and anticancer effects.
Synonyms:exact_synonym: 1,3-diphenylpropane-1,3-dione
 related_synonym: 1,3-Diphenyl-1,3-propanedione;   2-Benzoylacetophenone;   DBM;   Formula=C15H12O2;   InChI=1S/C15H12O2/c16-14(12-7-3-1-4-8-12)11-15(17)13-9-5-2-6-10-13/h1-10H,11H2;   InChIKey=NZZIMKJIVMHWJC-UHFFFAOYSA-N;   Phenyl phenacyl ketone;   SMILES=O=C(CC(=O)c1ccccc1)c1ccccc1;   omega-Benzoylacetophenone
 xref: CAS:120-46-7;   LINCS:LSM-2003
 xref_mesh: MESH:C061481
 xref: PMID:12122651;   PMID:19706764;   PMID:21162108;   PMID:21341276;   PMID:21523861;   PMID:23586238;   Reaxys:514910;   Wikipedia:Dibenzoylmethane


show annotations for term's descendants           Sort by:
 
dibenzoylmethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO dibenzoylmethane results in increased expression of ABCG2 protein CTD PMID:17077187 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO dibenzoylmethane results in decreased phosphorylation of AKT1 protein
[dibenzoylmethane co-treated with sulforaphane] results in decreased phosphorylation of AKT1 protein
CTD PMID:17942926 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases expression
ISO ODC1 protein inhibits the reaction [dibenzoylmethane results in increased expression of BAD protein] CTD PMID:21523861 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO dibenzoylmethane results in increased expression of BAX protein CTD PMID:17942926 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO dibenzoylmethane inhibits the reaction [ESR1 protein binds to BCL2 enhancer]; dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of BCL2 mRNA] CTD PMID:16051634 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp9 caspase 9 multiple interactions ISO ODC1 protein inhibits the reaction [dibenzoylmethane results in increased activity of CASP9 protein] CTD PMID:21523861 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cbr3 carbonyl reductase 3 increases expression
multiple interactions
ISO dibenzoylmethane results in increased expression of CBR3 mRNA
[sulforaphane co-treated with dibenzoylmethane] results in increased expression of CBR3 mRNA
CTD PMID:17942926 NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO dibenzoylmethane results in decreased expression of CCND1 protein CTD PMID:17942926 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO dibenzoylmethane results in decreased expression of CDKN1A protein CTD PMID:17942926 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Clu clusterin decreases expression
multiple interactions
ISO dibenzoylmethane results in decreased expression of CLU mRNA
[sulforaphane co-treated with dibenzoylmethane] results in decreased expression of CLU mRNA
CTD PMID:17942926 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Ephx1 epoxide hydrolase 1 increases activity
multiple interactions
increases expression
ISO dibenzoylmethane results in increased activity of EPHX1 protein
[sulforaphane co-treated with dibenzoylmethane] results in increased expression of EPHX1 mRNA
dibenzoylmethane results in increased expression of EPHX1 mRNA
CTD PMID:3621371 PMID:17942926 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO dibenzoylmethane inhibits the reaction [ESR1 protein binds to BCL2 enhancer]; dibenzoylmethane inhibits the reaction [ESR1 protein binds to MYC enhancer]; dibenzoylmethane inhibits the reaction [ESR1 protein binds to TERT enhancer] CTD PMID:16051634 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO dibenzoylmethane results in increased expression of GCLC mRNA
[sulforaphane co-treated with dibenzoylmethane] results in increased expression of GCLC mRNA
CTD PMID:17942926 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression
multiple interactions
ISO dibenzoylmethane results in increased expression of GSTM1 mRNA
[sulforaphane co-treated with dibenzoylmethane] results in increased expression of GSTM1 mRNA
CTD PMID:17942926 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions
increases expression
ISO [sulforaphane co-treated with dibenzoylmethane] results in increased expression of GSTM3 mRNA
dibenzoylmethane results in increased expression of GSTM3 mRNA
CTD PMID:17942926 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of HRAS mRNA] CTD PMID:16051634 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO dibenzoylmethane inhibits the reaction [ESR1 protein binds to MYC enhancer] CTD PMID:16051634 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
decreases response to substance
ISO ODC1 protein inhibits the reaction [dibenzoylmethane results in increased abundance of Reactive Oxygen Species]; ODC1 protein inhibits the reaction [dibenzoylmethane results in increased activity of CASP9 protein]; ODC1 protein inhibits the reaction [dibenzoylmethane results in increased expression of BAD protein]
ODC1 protein results in decreased susceptibility to dibenzoylmethane
CTD PMID:21523861 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions ISO [sulforaphane co-treated with dibenzoylmethane] results in increased expression of PTGR1 mRNA CTD PMID:17942926 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO dibenzoylmethane results in decreased expression of PTGS2 protein CTD PMID:17942926 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO dibenzoylmethane inhibits the reaction [ESR1 protein binds to TERT enhancer]; dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of TERT mRNA] CTD PMID:16051634 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19757
      biological role 19757
        antimutagen 79
          dibenzoylmethane 21
            2,4,4',6-tetrahydroxydibenzoylmethane 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic group 18725
                              organic divalent group 18716
                                organodiyl group 18716
                                  carbonyl group 18664
                                    carbonyl compound 18664
                                      ketone 16925
                                        diketone 1185
                                          beta-diketone 896
                                            dibenzoylmethane 21
                                              2,4,4',6-tetrahydroxydibenzoylmethane 0
paths to the root