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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dibenzoylmethane
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Accession:CHEBI:75417 term browser browse the term
Definition:A beta-diketone that is acetylacetone (acac) in which both methyl groups have been replaced by phenyl groups. It is a minor constituent of the root extract of licorice (Glycyrrhiza glabra) and exhibits antimutagenic and anticancer effects.
Synonyms:exact_synonym: 1,3-diphenylpropane-1,3-dione
 related_synonym: 1,3-Diphenyl-1,3-propanedione;   2-Benzoylacetophenone;   DBM;   Formula=C15H12O2;   InChI=1S/C15H12O2/c16-14(12-7-3-1-4-8-12)11-15(17)13-9-5-2-6-10-13/h1-10H,11H2;   InChIKey=NZZIMKJIVMHWJC-UHFFFAOYSA-N;   Phenyl phenacyl ketone;   SMILES=O=C(CC(=O)c1ccccc1)c1ccccc1;   omega-benzoylacetophenone
 xref: CAS:120-46-7;   LINCS:LSM-2003
 xref_mesh: MESH:C061481
 xref: PMID:12122651;   PMID:19706764;   PMID:21162108;   PMID:21341276;   PMID:21523861;   PMID:23586238;   Reaxys:514910;   Wikipedia:Dibenzoylmethane


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dibenzoylmethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO dibenzoylmethane results in increased expression of ABCG2 protein CTD PMID:17077187 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO dibenzoylmethane results in decreased phosphorylation of AKT1 protein
[dibenzoylmethane co-treated with sulforafan] results in decreased phosphorylation of AKT1 protein
CTD PMID:17942926 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases expression
ISO ODC1 protein inhibits the reaction [dibenzoylmethane results in increased expression of BAD protein] CTD PMID:21523861 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO dibenzoylmethane results in increased expression of BAX protein CTD PMID:17942926 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO dibenzoylmethane inhibits the reaction [ESR1 protein binds to BCL2 enhancer]; dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of BCL2 mRNA] CTD PMID:16051634 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp9 caspase 9 multiple interactions ISO ODC1 protein inhibits the reaction [dibenzoylmethane results in increased activity of CASP9 protein] CTD PMID:21523861 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cbr3 carbonyl reductase 3 increases expression
multiple interactions
ISO dibenzoylmethane results in increased expression of CBR3 mRNA
[sulforafan co-treated with dibenzoylmethane] results in increased expression of CBR3 mRNA
CTD PMID:17942926 NCBI chr11:33,909,417...33,917,674
Ensembl chr11:33,909,439...33,917,674
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO dibenzoylmethane results in decreased expression of CCND1 protein CTD PMID:17942926 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO dibenzoylmethane results in decreased expression of CDKN1A protein CTD PMID:17942926 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Clu clusterin decreases expression
multiple interactions
ISO dibenzoylmethane results in decreased expression of CLU mRNA
[sulforafan co-treated with dibenzoylmethane] results in decreased expression of CLU mRNA
CTD PMID:17942926 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Ephx1 epoxide hydrolase 1 increases activity
multiple interactions
increases expression
ISO dibenzoylmethane results in increased activity of EPHX1 protein
[sulforafan co-treated with dibenzoylmethane] results in increased expression of EPHX1 mRNA
dibenzoylmethane results in increased expression of EPHX1 mRNA
CTD PMID:3621371, PMID:17942926 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO dibenzoylmethane inhibits the reaction [ESR1 protein binds to BCL2 enhancer]; dibenzoylmethane inhibits the reaction [ESR1 protein binds to MYC enhancer]; dibenzoylmethane inhibits the reaction [ESR1 protein binds to TERT enhancer] CTD PMID:16051634 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO dibenzoylmethane results in increased expression of GCLC mRNA
[sulforafan co-treated with dibenzoylmethane] results in increased expression of GCLC mRNA
CTD PMID:17942926 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression
multiple interactions
ISO dibenzoylmethane results in increased expression of GSTM1 mRNA
[sulforafan co-treated with dibenzoylmethane] results in increased expression of GSTM1 mRNA
CTD PMID:17942926 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions
increases expression
ISO [sulforafan co-treated with dibenzoylmethane] results in increased expression of GSTM3 mRNA
dibenzoylmethane results in increased expression of GSTM3 mRNA
CTD PMID:17942926 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of HRAS mRNA] CTD PMID:16051634 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO dibenzoylmethane inhibits the reaction [ESR1 protein binds to MYC enhancer] CTD PMID:16051634 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
decreases response to substance
ISO ODC1 protein inhibits the reaction [dibenzoylmethane results in increased abundance of Reactive Oxygen Species]; ODC1 protein inhibits the reaction [dibenzoylmethane results in increased activity of CASP9 protein]; ODC1 protein inhibits the reaction [dibenzoylmethane results in increased expression of BAD protein]
ODC1 protein results in decreased susceptibility to dibenzoylmethane
CTD PMID:21523861 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions ISO [sulforafan co-treated with dibenzoylmethane] results in increased expression of PTGR1 mRNA CTD PMID:17942926 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO dibenzoylmethane results in decreased expression of PTGS2 protein CTD PMID:17942926 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO dibenzoylmethane inhibits the reaction [ESR1 protein binds to TERT enhancer]; dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of TERT mRNA] CTD PMID:16051634 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimutagen 79
          dibenzoylmethane 21
            2,4,4',6-tetrahydroxydibenzoylmethane 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      ketone 16144
                                        diketone 1163
                                          beta-diketone 878
                                            dibenzoylmethane 21
                                              2,4,4',6-tetrahydroxydibenzoylmethane 0
paths to the root

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