Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulindac sulfide
go back to main search page
Accession:CHEBI:75408 term browser browse the term
Definition:An aryl sulfide that is a metabolite of sulindac. A non-steroidal anti-inflammatory drug, which also has anticancer activity.
Synonyms:exact_synonym: {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfanyl)benzylidene]-1H-inden-3-yl}acetic acid
 related_synonym: Formula=C20H17FO2S;   InChI=1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-;   InChIKey=LFWHFZJPXXOYNR-MFOYZWKCSA-N;   SMILES=CSc1ccc(cc1)\\C=C1\\C(C)=C(CC(O)=O)c2cc(F)ccc12
 xref: CAS:49627-27-2;   HMDB:HMDB0060614
 xref_mesh: MESH:C025462
 xref: PDBeChem:SFI;   PMID:21458423;   PMID:21991341;   PMID:23202471;   PMID:23280445;   PMID:23443799;   Patent:JP2005247807;   Patent:NZ336035;   Reaxys:2950058


show annotations for term's descendants           Sort by:
 
sulindac sulfide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO sulindac sulfide results in increased expression of ABCG2 mRNA CTD PMID:16184548 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Actn1 actinin, alpha 1 decreases expression ISO sulindac sulfide results in decreased expression of ACTN1 mRNA CTD PMID:16184548 NCBI chr 6:103,376,557...103,470,497
Ensembl chr 6:103,375,799...103,470,555
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 decreases expression ISO sulindac sulfide results in decreased expression of ADAM9 mRNA CTD PMID:16184548 NCBI chr16:71,810,377...71,887,926
Ensembl chr16:71,810,377...71,887,926
JBrowse link
G Adm adrenomedullin increases expression ISO sulindac sulfide results in increased expression of ADM mRNA CTD PMID:16184548 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Adra2c adrenoceptor alpha 2C decreases expression ISO sulindac sulfide results in decreased expression of ADRA2C mRNA CTD PMID:12734198 NCBI chr14:80,730,307...80,732,010
Ensembl chr14:80,730,307...80,732,010
JBrowse link
G Ahr aryl hydrocarbon receptor increases localization ISO sulindac sulfide results in increased localization of AHR protein CTD PMID:17985343 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akap12 A-kinase anchoring protein 12 increases expression ISO sulindac sulfide results in increased expression of AKAP12 mRNA CTD PMID:12734198 NCBI chr 1:40,816,130...40,906,582
Ensembl chr 1:40,816,107...40,906,581
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression ISO sulindac sulfide results in decreased expression of ALDOC mRNA CTD PMID:16184548 NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126
JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression ISO sulindac sulfide results in increased expression of ALOX15 protein CTD PMID:16166323 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link
G Anxa5 annexin A5 increases expression ISO sulindac sulfide results in increased expression of ANXA5 protein CTD PMID:18678619 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO sulindac sulfide inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein] CTD PMID:19013290 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G App amyloid beta precursor protein multiple interactions
affects cleavage
ISO
EXP
[sulindac sulfide results in decreased activity of PSEN1 protein] which affects the cleavage of APP protein; PSEN1 protein affects the reaction [sulindac sulfide affects the cleavage of APP protein]; PSEN1 protein mutant form promotes the reaction [sulindac sulfide affects the cleavage of APP protein]; sulindac sulfide affects the cleavage of and affects the localization of APP protein; sulindac sulfide affects the reaction [PSEN1 protein affects the cleavage of APP protein]
sulindac sulfide inhibits the reaction [APP protein results in increased uptake of Calcium]
CTD PMID:11700559, PMID:12637581, PMID:12777371, PMID:12805356, PMID:14690522, PMID:15274632, PMID:17573346, PMID:17962197, PMID:18359496, PMID:18426795, PMID:18648507 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Ar androgen receptor multiple interactions ISO AR protein affects the reaction [sulindac sulfide results in decreased expression of KLK3 protein]; sulindac sulfide results in decreased expression of and results in decreased activity of AR protein CTD PMID:14581372 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Areg amphiregulin increases expression ISO sulindac sulfide results in increased expression of AREG mRNA CTD PMID:16184548 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Arl6ip1 ADP-ribosylation factor like GTPase 6 interacting protein 1 decreases expression ISO sulindac sulfide results in decreased expression of ARL6IP1 mRNA CTD PMID:12734198 NCBI chr 1:187,770,160...187,779,675
Ensembl chr 1:187,770,160...187,779,675
JBrowse link
G Arpc1b actin related protein 2/3 complex, subunit 1B decreases expression ISO sulindac sulfide results in decreased expression of ARPC1B mRNA CTD PMID:12734198 NCBI chr12:11,252,300...11,265,849
Ensembl chr12:11,252,296...11,265,865
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 decreases expression ISO sulindac sulfide results in decreased expression of ASAH1 mRNA CTD PMID:16184548 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836
JBrowse link
G Atf3 activating transcription factor 3 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sulindac sulfide results in increased expression of ATF3 mRNA]; [sulindac sulfide results in increased phosphorylation of MAPK1 protein] which results in increased expression of ATF3 protein; [sulindac sulfide results in increased phosphorylation of MAPK3 protein] which results in increased expression of ATF3 protein; EGR1 protein promotes the reaction [sulindac sulfide results in increased expression of ATF3 mRNA]; MAP2K1 protein promotes the reaction [sulindac sulfide results in increased expression of ATF3 mRNA]
sulindac sulfide results in increased expression of ATF3 mRNA; sulindac sulfide results in increased expression of ATF3 protein
CTD PMID:12734198, PMID:15897233, PMID:16079301, PMID:16184548, PMID:21554132, PMID:24440808 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 increases expression ISO sulindac sulfide results in increased expression of ATP6V0A1 mRNA CTD PMID:16184548 NCBI chr10:88,914,264...88,967,736
Ensembl chr10:88,914,276...88,967,748
JBrowse link
G Aurka aurora kinase A decreases expression ISO sulindac sulfide results in decreased expression of AURKA mRNA CTD PMID:12734198 NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210
JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression
increases localization
multiple interactions
ISO sulindac sulfide results in decreased expression of BAD protein
sulindac sulfide results in increased localization of BAD protein
[sulindac sulfide results in decreased expression of YWHAE protein] which results in increased localization of BAD protein; sulindac sulfide promotes the reaction [BAD protein binds to YWHAE protein]
CTD PMID:17409426, PMID:18678619 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases response to substance EXP BAK1 results in increased susceptibility to sulindac sulfide CTD PMID:18349538 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression
affects response to substance
ISO BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]]; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]]; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein]]
sulindac sulfide results in increased expression of BAX mRNA
sulindac sulfide results in decreased expression of BAX protein
BAX protein affects the susceptibility to sulindac sulfide
CTD PMID:12203115, PMID:16886631 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcam basal cell adhesion molecule (Lutheran blood group) decreases expression ISO sulindac sulfide results in decreased expression of BCAM mRNA CTD PMID:12734198 NCBI chr 1:80,674,463...80,689,122
Ensembl chr 1:80,674,444...80,689,171
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member decreases phosphorylation ISO sulindac sulfide results in decreased phosphorylation of BCAR1 protein CTD PMID:10741720 NCBI chr19:43,932,543...43,967,452
Ensembl chr19:43,932,554...43,955,783
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO sulindac sulfide results in decreased expression of BCL2 protein CTD PMID:18678619 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO sulindac sulfide results in decreased expression of BCL2L1 protein CTD PMID:11912124 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression
increases cleavage
ISO sulindac sulfide results in decreased expression of BID protein
sulindac sulfide results in increased cleavage of BID protein
CTD PMID:12203115, PMID:16886631 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO sulindac sulfide results in increased expression of BIRC3 mRNA CTD PMID:16184548 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B decreases expression ISO sulindac sulfide results in decreased expression of BUB1B mRNA CTD PMID:16184548 NCBI chr 3:110,367,949...110,420,471
Ensembl chr 3:110,367,939...110,420,458
JBrowse link
G Cacng3 calcium voltage-gated channel auxiliary subunit gamma 3 increases expression ISO sulindac sulfide results in increased expression of CACNG3 mRNA CTD PMID:16184548 NCBI chr 1:192,613,766...192,708,371
Ensembl chr 1:192,613,372...192,709,078
JBrowse link
G Casp3 caspase 3 increases activity
increases expression
multiple interactions
ISO sulindac sulfide results in increased activity of CASP3 protein
sulindac sulfide results in increased expression of CASP3 mRNA
[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]]; MAP2K1 protein inhibits the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP3 protein]; sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein]; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]
CTD PMID:11051267, PMID:12203115, PMID:12414664, PMID:14555707, PMID:15548677, PMID:16886631, PMID:20371263 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO [sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein] CTD PMID:20371263 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP8 protein]; sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:11559570, PMID:12203115, PMID:12414664, PMID:16886631 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein]]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP9 protein]; sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein] CTD PMID:12203115, PMID:12414664 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 increases expression ISO sulindac sulfide results in increased expression of CCAR1 mRNA CTD PMID:12734198 NCBI chr20:32,373,443...32,416,044
Ensembl chr20:32,373,443...32,416,044
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression
increases expression
ISO sulindac sulfide results in decreased expression of CCN2 mRNA
sulindac sulfide results in increased expression of CCN2 mRNA
CTD PMID:12734198, PMID:16184548 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO sulindac sulfide inhibits the reaction [CTNNB1 protein results in increased expression of CCND1 protein]
sulindac sulfide results in decreased expression of CCND1 mRNA; sulindac sulfide results in decreased expression of CCND1 protein
CTD PMID:14710233, PMID:15188006, PMID:15767558 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd4 Cd4 molecule increases expression ISO sulindac sulfide results in increased expression of CD4 mRNA CTD PMID:12734198 NCBI chr 4:157,381,862...157,408,357
Ensembl chr 4:157,383,052...157,408,176
JBrowse link
G Cd46 CD46 molecule decreases expression ISO sulindac sulfide results in decreased expression of CD46 mRNA CTD PMID:16184548 NCBI chr13:113,786,525...113,818,741
Ensembl chr13:113,787,349...113,817,995
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO sulindac sulfide results in increased expression of and results in increased activity of CDH1 protein CTD PMID:12391285 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh17 cadherin 17 decreases expression ISO sulindac sulfide results in decreased expression of CDH17 mRNA CTD PMID:16184548 NCBI chr 5:25,354,187...25,443,675
Ensembl chr 5:25,391,115...25,443,718
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
affects activity
increases expression
ISO PPARD protein inhibits the reaction [sulindac sulfide results in increased expression of CDKN1A mRNA]; PPARG protein promotes the reaction [sulindac sulfide results in increased expression of CDKN1A mRNA]
sulindac sulfide affects the activity of CDKN1A protein
sulindac sulfide results in increased expression of CDKN1A mRNA; sulindac sulfide results in increased expression of CDKN1A protein
CTD PMID:15694660, PMID:15767558, PMID:16091736, PMID:16184548 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO sulindac sulfide results in increased expression of CEBPB mRNA; sulindac sulfide results in increased expression of CEBPB protein CTD PMID:12734198, PMID:16184548 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO sulindac sulfide results in decreased expression of CFLAR protein CTD PMID:11912124 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Clp1 cleavage factor polyribonucleotide kinase subunit 1 decreases expression ISO sulindac sulfide results in decreased expression of CLP1 mRNA CTD PMID:12734198 NCBI chr 3:72,125,269...72,137,122
Ensembl chr 3:72,125,273...72,128,973
JBrowse link
G Cryab crystallin, alpha B increases expression ISO sulindac sulfide results in increased expression of CRYAB mRNA CTD PMID:16184548 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of CTNNB1 protein]; sulindac sulfide affects the localization of and results in decreased expression of CTNNB1 protein; sulindac sulfide inhibits the reaction [CTNNB1 protein results in increased expression of CCND1 protein]; sulindac sulfide inhibits the reaction [CTNNB1 protein results in increased expression of MET protein]; sulindac sulfide results in decreased expression of and results in decreased localization of CTNNB1 protein CTD PMID:14555707, PMID:14710233, PMID:15188006 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctsc cathepsin C decreases expression ISO sulindac sulfide results in decreased expression of CTSC mRNA CTD PMID:16184548 NCBI chr 1:151,918,514...151,949,979
Ensembl chr 1:151,918,571...151,949,983
JBrowse link
G Cyb5b cytochrome b5 type B decreases expression ISO sulindac sulfide results in decreased expression of CYB5B mRNA CTD PMID:12734198 NCBI chr19:39,357,814...39,391,680
Ensembl chr19:39,357,791...39,393,189
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO sulindac sulfide results in increased expression of CYP1A1 mRNA CTD PMID:12734198, PMID:16184548, PMID:17985343 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO sulindac sulfide results in increased expression of CYP1A2 mRNA CTD PMID:17985343 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO sulindac sulfide results in increased expression of CYP1B1 mRNA CTD PMID:12734198, PMID:17985343 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Dcbld2 discoidin, CUB and LCCL domain containing 2 increases expression ISO sulindac sulfide results in increased expression of DCBLD2 mRNA CTD PMID:12734198 NCBI chr11:44,237,814...44,292,884
Ensembl chr11:44,241,111...44,292,884
JBrowse link
G Ddx11 DEAD/H-box helicase 11 decreases expression ISO sulindac sulfide results in decreased expression of DDX11 mRNA CTD PMID:16184548 NCBI chr 9:114,113,642...114,133,908
Ensembl chr 9:114,111,580...114,132,492
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO sulindac sulfide results in decreased expression of DHCR24 mRNA CTD PMID:16184548 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression ISO sulindac sulfide results in decreased expression of DHCR7 mRNA CTD PMID:16184548 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904
JBrowse link
G Dynll1 dynein light chain LC8-type 1 decreases expression ISO sulindac sulfide results in decreased expression of DYNLL1 mRNA CTD PMID:12734198 NCBI chr12:47,074,200...47,076,573
Ensembl chr12:47,074,200...47,076,572
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
increases ubiquitination
increases phosphorylation
decreases phosphorylation
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [sulindac sulfide results in decreased expression of EGFR protein]
sulindac sulfide results in increased ubiquitination of EGFR protein
sulindac sulfide results in increased phosphorylation of EGFR protein
sulindac sulfide results in decreased phosphorylation of EGFR protein
CTD PMID:20332299 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO EGR1 protein affects the reaction [sulindac sulfide results in increased expression of THBS1 mRNA]; EGR1 protein promotes the reaction [sulindac sulfide results in increased expression of ATF3 mRNA]; EGR1 protein promotes the reaction [sulindac sulfide results in increased expression of GDF15 mRNA]; ELK1 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK1 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK3 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; U 0126 inhibits the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]
sulindac sulfide results in increased expression of EGR1 mRNA; sulindac sulfide results in increased expression of EGR1 protein
CTD PMID:15509713, PMID:16079301, PMID:16227405, PMID:17599376 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; ELK1 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK1 protein promotes the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; MAPK3 protein promotes the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; sulindac sulfide results in increased phosphorylation of and affects the activity of ELK1 protein; U 0126 inhibits the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein] CTD PMID:17599376 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of ERBB2 protein] CTD PMID:20332299 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of ERBB3 protein] CTD PMID:20332299 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 affects cleavage ISO sulindac sulfide affects the cleavage of ERBB4 protein CTD PMID:12777371 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644
JBrowse link
G Esd esterase D increases expression ISO sulindac sulfide results in increased expression of ESD mRNA CTD PMID:12734198 NCBI chr15:56,756,848...56,776,348
Ensembl chr15:56,756,661...56,776,348
JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO sulindac sulfide results in decreased expression of ESR1 mRNA; sulindac sulfide results in decreased expression of ESR1 protein CTD PMID:16740773 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Etfb electron transfer flavoprotein subunit beta decreases expression ISO sulindac sulfide results in decreased expression of ETFB mRNA CTD PMID:16184548 NCBI chr 1:98,472,776...98,486,940
Ensembl chr 1:98,472,745...98,486,976
JBrowse link
G Etnppl ethanolamine-phosphate phospho-lyase increases expression ISO sulindac sulfide results in increased expression of ETNPPL mRNA CTD PMID:12734198 NCBI chr 2:235,738,377...235,760,351
Ensembl chr 2:235,738,416...235,760,352
JBrowse link
G Fabp1 fatty acid binding protein 1 multiple interactions
increases expression
ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [sulindac sulfide analog results in increased expression of FABP1 protein]; PPARG protein affects the reaction [sulindac sulfide analog results in increased expression of FABP1 protein] CTD PMID:17602619, PMID:18665581 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
increases expression
ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [sulindac sulfide analog results in increased expression of FABP4 protein]; PPARG protein affects the reaction [sulindac sulfide analog results in increased expression of FABP4 protein] CTD PMID:17602619, PMID:18665581 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fcgrt Fc fragment of IgG receptor and transporter decreases expression ISO sulindac sulfide results in decreased expression of FCGRT mRNA CTD PMID:16184548 NCBI chr 1:101,086,872...101,096,159
Ensembl chr 1:101,086,877...101,095,594
JBrowse link
G Fdps farnesyl diphosphate synthase decreases expression ISO sulindac sulfide results in decreased expression of FDPS mRNA CTD PMID:16184548 NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 decreases expression ISO sulindac sulfide results in decreased expression of FGFR4 mRNA CTD PMID:16184548 NCBI chr17:9,990,072...10,004,339
Ensembl chr17:9,990,078...10,004,321
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 affects metabolic processing
increases metabolic processing
ISO FMO3 gene polymorphism affects the metabolism of sulindac sulfide
FMO3 protein results in increased metabolism of sulindac sulfide
CTD PMID:17142560, PMID:17559352 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963
JBrowse link
G Foxm1 forkhead box M1 decreases expression ISO sulindac sulfide results in decreased expression of FOXM1 mRNA CTD PMID:16184548 NCBI chr 4:161,685,236...161,697,633
Ensembl chr 4:161,685,258...161,696,305
JBrowse link
G Gal3st4 galactose-3-O-sulfotransferase 4 decreases expression ISO sulindac sulfide results in decreased expression of GAL3ST4 mRNA CTD PMID:16184548 NCBI chr12:19,583,110...19,592,444
Ensembl chr12:19,583,110...19,592,000
JBrowse link
G Gars glycyl-tRNA synthetase increases expression ISO sulindac sulfide results in increased expression of GARS1 mRNA CTD PMID:12734198 NCBI chr 4:85,235,122...85,276,085
Ensembl chr 4:85,235,172...85,276,044
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions
increases expression
ISO EGR1 protein promotes the reaction [sulindac sulfide results in increased expression of GDF15 mRNA]
sulindac sulfide results in increased expression of GDF15 mRNA; sulindac sulfide results in increased expression of GDF15 protein
CTD PMID:11895857, PMID:11925476, PMID:12734198, PMID:15180942, PMID:15509713, PMID:15555568, PMID:15767558, PMID:18076062 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gk glycerol kinase increases expression ISO sulindac sulfide results in increased expression of GK mRNA CTD PMID:16184548 NCBI chr  X:54,227,291...54,303,897
Ensembl chr  X:54,227,397...54,303,864
JBrowse link
G Glcci1 glucocorticoid induced 1 increases expression ISO sulindac sulfide results in increased expression of GLCCI1 mRNA CTD PMID:16184548 NCBI chr 4:34,282,625...34,612,709
Ensembl chr 4:34,282,625...34,614,438
JBrowse link
G Grn granulin precursor decreases expression ISO sulindac sulfide results in decreased expression of GRN mRNA CTD PMID:16184548 NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO sulindac sulfide binds to and results in decreased activity of GSTP1 protein CTD PMID:15300575 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO sulindac sulfide results in decreased expression of HDAC1 mRNA CTD PMID:16184548 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hgf hepatocyte growth factor decreases expression ISO sulindac sulfide results in decreased expression of HGF mRNA CTD PMID:10807402 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hm13 histocompatibility minor 13 affects binding
multiple interactions
ISO sulindac sulfide binds to HM13 protein
sulindac sulfide inhibits the reaction [L 685458 binds to HM13 protein]
CTD PMID:17932033 NCBI chr 3:148,150,695...148,189,623
Ensembl chr 3:148,150,698...148,189,623
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO sulindac sulfide results in decreased expression of HSD3B1 mRNA CTD PMID:16184548
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO sulindac sulfide results in increased expression of HSPA1B mRNA CTD PMID:16184548 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Icam2 intercellular adhesion molecule 2 increases expression ISO sulindac sulfide results in increased expression of ICAM2 mRNA CTD PMID:16184548 NCBI chr10:94,569,889...94,581,218
Ensembl chr10:94,569,890...94,576,512
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression ISO sulindac sulfide results in decreased expression of ID1 mRNA; sulindac sulfide results in decreased expression of ID1 protein CTD PMID:16184548, PMID:21554132 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 decreases expression ISO sulindac sulfide results in decreased expression of IFITM3 mRNA CTD PMID:16184548 NCBI chr 1:213,810,712...213,811,821
Ensembl chr 1:213,810,696...213,811,901
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO sulindac sulfide results in increased expression of IFRD1 mRNA CTD PMID:12734198 NCBI chr 6:60,132,025...60,151,354
Ensembl chr 6:60,132,024...60,151,420
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases activity ISO sulindac sulfide results in decreased activity of IKBKB protein CTD PMID:11912124 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 decreases expression ISO sulindac sulfide results in decreased expression of IL13RA1 mRNA CTD PMID:16184548 NCBI chr  X:122,724,081...122,783,801
Ensembl chr  X:122,724,129...122,781,479
JBrowse link
G Il1r1 interleukin 1 receptor type 1 increases expression ISO sulindac sulfide results in increased expression of IL1R1 mRNA CTD PMID:16184548 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Ilf3 interleukin enhancer binding factor 3 decreases expression ISO sulindac sulfide results in decreased expression of ILF3 mRNA CTD PMID:16184548 NCBI chr 8:22,402,877...22,440,984
Ensembl chr 8:22,402,890...22,440,885
JBrowse link
G Insig1 insulin induced gene 1 decreases expression ISO sulindac sulfide results in decreased expression of INSIG1 mRNA CTD PMID:12734198 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 increases expression ISO sulindac sulfide results in increased expression of ISG20 mRNA CTD PMID:16184548 NCBI chr 1:140,602,553...140,608,892
Ensembl chr 1:140,601,791...140,608,946
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression ISO sulindac sulfide results in decreased expression of ITPR1 mRNA CTD PMID:15767558 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
JBrowse link
G Jag2 jagged canonical Notch ligand 2 increases expression ISO sulindac sulfide results in increased expression of JAG2 mRNA CTD PMID:16184548 NCBI chr 6:137,711,144...137,733,331
Ensembl chr 6:137,711,155...137,733,026
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO sulindac sulfide results in increased expression of JUN mRNA CTD PMID:16704987 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kalrn kalirin, RhoGEF kinase decreases expression ISO sulindac sulfide results in decreased expression of KALRN mRNA CTD PMID:16184548 NCBI chr11:69,484,293...70,025,682
Ensembl chr11:69,484,293...70,025,633
JBrowse link
G Klhl21 kelch-like family member 21 increases expression ISO sulindac sulfide results in increased expression of KLHL21 mRNA CTD PMID:16184548 NCBI chr 5:169,181,418...169,190,073
Ensembl chr 5:169,181,418...169,190,073
JBrowse link
G Krt14 keratin 14 increases expression ISO sulindac sulfide results in increased expression of KRT14 mRNA CTD PMID:16184548 NCBI chr10:88,118,029...88,122,233
Ensembl chr10:88,055,823...88,122,233
JBrowse link
G Krt16 keratin 16 increases expression ISO sulindac sulfide results in increased expression of KRT16 mRNA CTD PMID:16184548 NCBI chr10:88,149,210...88,152,167
Ensembl chr10:88,149,345...88,152,064
JBrowse link
G Krt17 keratin 17 increases expression ISO sulindac sulfide results in increased expression of KRT17 mRNA CTD PMID:16184548 NCBI chr10:88,158,993...88,163,712
Ensembl chr10:88,118,001...88,163,723
JBrowse link
G Krt19 keratin 19 decreases expression ISO sulindac sulfide results in decreased expression of KRT19 mRNA CTD PMID:12734198 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
JBrowse link
G Krt5 keratin 5 decreases expression ISO sulindac sulfide results in decreased expression of KRT5 mRNA CTD PMID:12734198 NCBI chr 7:143,320,142...143,324,536
Ensembl chr 7:143,316,920...143,453,546
JBrowse link
G Lamc1 laminin subunit gamma 1 increases expression
decreases expression
ISO sulindac sulfide results in increased expression of LAMC1 mRNA
sulindac sulfide results in decreased expression of LAMC1 protein
CTD PMID:15561105, PMID:16184548 NCBI chr13:70,656,727...70,783,515
Ensembl chr13:70,658,707...70,783,515
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 decreases expression ISO sulindac sulfide results in decreased expression of LAMP1 mRNA CTD PMID:16184548 NCBI chr16:81,689,576...81,714,341
Ensembl chr16:81,689,335...81,714,419
JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO sulindac sulfide results in decreased expression of LDHA mRNA CTD PMID:12734198 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Ldlr low density lipoprotein receptor decreases expression ISO sulindac sulfide results in decreased expression of LDLR mRNA CTD PMID:16184548 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 decreases expression ISO sulindac sulfide results in decreased expression of MAD2L1 mRNA; sulindac sulfide results in decreased expression of MAD2L1 protein CTD PMID:12734198 NCBI chr 4:97,530,993...97,543,179
Ensembl chr 4:97,531,083...97,537,086
JBrowse link
G Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 increases expression ISO sulindac sulfide results in increased expression of MAGI1 mRNA CTD PMID:12734198 NCBI chr 4:125,684,816...126,300,013
Ensembl chr 4:125,687,307...125,958,112
JBrowse link
G Mal mal, T-cell differentiation protein decreases expression ISO sulindac sulfide results in decreased expression of MAL mRNA CTD PMID:16184548 NCBI chr 3:120,209,647...120,233,655
Ensembl chr 3:120,209,647...120,233,655
JBrowse link
G Man2b2 mannosidase, alpha, class 2B, member 2 increases expression ISO sulindac sulfide results in increased expression of MAN2B2 mRNA CTD PMID:12734198 NCBI chr14:78,939,959...78,964,961
Ensembl chr14:78,939,903...78,964,961
JBrowse link
G Manf mesencephalic astrocyte-derived neurotrophic factor increases expression ISO sulindac sulfide results in increased expression of MANF mRNA CTD PMID:16184548 NCBI chr 8:115,623,175...115,626,408
Ensembl chr 8:115,623,178...115,626,380
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO MAP2K1 protein inhibits the reaction [sulindac sulfide results in decreased phosphorylation of MAPK1 protein]; MAP2K1 protein inhibits the reaction [sulindac sulfide results in decreased phosphorylation of MAPK3 protein]; MAP2K1 protein inhibits the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]; MAP2K1 protein promotes the reaction [sulindac sulfide results in increased expression of ATF3 mRNA] CTD PMID:15548677, PMID:16079301 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 decreases expression ISO sulindac sulfide results in decreased expression of MAP3K1 mRNA CTD PMID:12734198 NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation
ISO [sulindac sulfide results in increased phosphorylation of MAPK1 protein] which results in increased expression of ATF3 protein; [sulindac sulfide results in increased phosphorylation of MAPK1 protein] which results in increased expression of THBS1 protein; MAP2K1 protein inhibits the reaction [sulindac sulfide results in decreased phosphorylation of MAPK1 protein]; MAPK1 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK1 protein promotes the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; sulindac sulfide results in increased phosphorylation of and affects the activity of MAPK1 protein CTD PMID:15548677, PMID:16079301, PMID:17599376, PMID:18261746 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk10 mitogen activated protein kinase 10 increases expression ISO sulindac sulfide results in increased expression of MAPK10 mRNA CTD PMID:12734198 NCBI chr14:8,079,955...8,371,508
Ensembl chr14:8,080,275...8,368,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
decreases phosphorylation
ISO [sulindac sulfide results in increased phosphorylation of MAPK3 protein] which results in increased expression of ATF3 protein; [sulindac sulfide results in increased phosphorylation of MAPK3 protein] which results in increased expression of THBS1 protein; MAP2K1 protein inhibits the reaction [sulindac sulfide results in decreased phosphorylation of MAPK3 protein]; MAPK3 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK3 protein promotes the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; sulindac sulfide results in increased phosphorylation of and affects the activity of MAPK3 protein CTD PMID:15548677, PMID:16079301, PMID:17599376, PMID:18261746 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO sulindac sulfide results in increased activity of MAPK8 protein CTD PMID:11051267 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mars2 methionyl-tRNA synthetase 2, mitochondrial increases expression ISO sulindac sulfide results in increased expression of MARS2 mRNA CTD PMID:16184548 NCBI chr 9:64,434,814...64,437,730
Ensembl chr 9:64,434,904...64,436,664
Ensembl chr 9:64,434,904...64,436,664
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO sulindac sulfide results in decreased expression of MCM2 mRNA CTD PMID:16184548 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions ISO sulindac sulfide inhibits the reaction [CTNNB1 protein results in increased expression of MET protein] CTD PMID:14710233 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases expression
increases expression
ISO sulindac sulfide results in decreased expression of MMP1 mRNA
sulindac sulfide results in increased expression of MMP1 mRNA
CTD PMID:15767558, PMID:16184548 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp10 matrix metallopeptidase 10 increases expression ISO sulindac sulfide results in increased expression of MMP10 mRNA CTD PMID:16184548 NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243
JBrowse link
G Mras muscle RAS oncogene homolog increases expression ISO sulindac sulfide results in increased expression of MRAS mRNA CTD PMID:16184548 NCBI chr 8:107,629,028...107,656,851
Ensembl chr 8:107,629,028...107,681,512
JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases expression ISO sulindac sulfide results in decreased expression of MSMO1 mRNA CTD PMID:12734198 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
JBrowse link
G Msx1 msh homeobox 1 decreases expression ISO sulindac sulfide results in decreased expression of MSX1 mRNA; sulindac sulfide results in decreased expression of MSX1 protein CTD PMID:12734198 NCBI chr14:77,712,262...77,716,061
Ensembl chr14:77,712,240...77,716,059
JBrowse link
G Mtfr1 mitochondrial fission regulator 1 increases expression ISO sulindac sulfide results in increased expression of MTFR1 mRNA CTD PMID:16184548 NCBI chr 2:104,005,696...104,040,914
Ensembl chr 2:104,020,955...104,039,198
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase increases expression ISO sulindac sulfide results in increased expression of MTHFD2 mRNA CTD PMID:12734198 NCBI chr 4:115,004,433...115,015,965
Ensembl chr 4:115,004,448...115,015,965
JBrowse link
G Muc1 mucin 1, cell surface associated decreases expression ISO sulindac sulfide results in decreased expression of MUC1 mRNA CTD PMID:16184548 NCBI chr 2:188,543,137...188,547,874
Ensembl chr 2:188,543,137...188,547,874
JBrowse link
G Mx2 MX dynamin like GTPase 2 decreases expression ISO sulindac sulfide results in decreased expression of MX1 mRNA CTD PMID:16184548 NCBI chr11:38,035,306...38,066,185
Ensembl chr11:38,035,450...38,059,950
JBrowse link
G Myh10 myosin heavy chain 10 increases expression ISO sulindac sulfide results in increased expression of MYH10 mRNA CTD PMID:12734198 NCBI chr10:55,274,910...55,406,738
Ensembl chr10:55,275,411...55,406,732
JBrowse link
G Ncapd3 non-SMC condensin II complex, subunit D3 decreases expression ISO sulindac sulfide results in decreased expression of NCAPD3 mRNA CTD PMID:16184548 NCBI chr 8:28,075,629...28,145,024
Ensembl chr 8:28,075,551...28,144,741
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases activity ISO sulindac sulfide results in decreased activity of NFKB1 protein CTD PMID:12085227 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation ISO sulindac sulfide results in decreased phosphorylation of NFKBIA protein CTD PMID:12085227 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Niban1 niban apoptosis regulator 1 increases expression ISO sulindac sulfide results in increased expression of NIBAN1 mRNA CTD PMID:12734198 NCBI chr13:68,949,665...69,101,600
Ensembl chr13:68,949,665...69,101,588
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
ISO sulindac sulfide results in increased activity of NQO1 protein
sulindac sulfide results in increased expression of NQO1 mRNA
CTD PMID:17985343 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nup133 nucleoporin 133 increases expression ISO sulindac sulfide results in increased expression of NUP133 mRNA CTD PMID:12734198 NCBI chr19:56,681,965...56,731,404
Ensembl chr19:56,681,979...56,731,372
JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression ISO sulindac sulfide results in increased expression of ODC1 mRNA CTD PMID:16184548 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
decreases expression
increases cleavage
ISO GW0742 promotes the reaction [sulindac sulfide results in increased cleavage of PARP1 protein]
sulindac sulfide results in decreased expression of PARP1 mRNA
CTD PMID:12663503, PMID:16184548, PMID:16886631, PMID:18678619, PMID:21400612 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pawr pro-apoptotic WT1 regulator increases expression ISO sulindac sulfide results in increased expression of PAWR mRNA CTD PMID:10833474 NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 decreases expression ISO sulindac sulfide results in decreased expression of PCSK9 mRNA CTD PMID:16184548 NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726
JBrowse link
G Pgam1 phosphoglycerate mutase 1 decreases expression ISO sulindac sulfide results in decreased expression of PGAM1 mRNA CTD PMID:12734198 NCBI chr 1:261,158,204...261,165,814
Ensembl chr 1:261,158,261...261,165,808
JBrowse link
G Pgr progesterone receptor decreases expression ISO sulindac sulfide results in decreased expression of PGR mRNA; sulindac sulfide results in decreased expression of PGR protein CTD PMID:16740773 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression ISO sulindac sulfide results in decreased expression of PKM mRNA CTD PMID:16184548 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO sulindac sulfide results in decreased expression of PLAU mRNA CTD PMID:15767558 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO sulindac sulfide results in increased expression of PMAIP1 mRNA CTD PMID:16184548 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Pold3 DNA polymerase delta 3, accessory subunit decreases expression ISO sulindac sulfide results in decreased expression of POLD3 mRNA CTD PMID:16184548 NCBI chr 1:165,085,142...165,122,385
Ensembl chr 1:165,083,622...165,123,455
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO sulindac sulfide results in increased expression of PPARA mRNA CTD PMID:11948457 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions
increases expression
decreases activity
decreases expression
ISO PPARD protein affects the reaction [sulindac sulfide results in decreased expression of YWHAE protein]; PPARD protein inhibits the reaction [sulindac sulfide results in increased expression of CDKN1A mRNA]; sulindac sulfide binds to and results in decreased activity of PPARD protein
sulindac sulfide results in increased expression of PPARD mRNA; sulindac sulfide results in increased expression of PPARD protein
sulindac sulfide results in decreased activity of PPARD protein
sulindac sulfide results in decreased expression of PPARD mRNA; sulindac sulfide results in decreased expression of PPARD protein
CTD PMID:10555149, PMID:11948457, PMID:16091736, PMID:17409426, PMID:18678619, PMID:21400612 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
increases activity
affects binding
ISO [sulindac sulfide results in increased activity of PPARG protein] which results in increased expression of PTGS2 protein; PPARG protein affects the reaction [sulindac sulfide analog results in increased expression of FABP1 protein]; PPARG protein affects the reaction [sulindac sulfide analog results in increased expression of FABP4 protein]; PPARG protein promotes the reaction [sulindac sulfide results in increased expression of CDKN1A mRNA]; sulindac sulfide analog binds to and results in increased activity of PPARG protein; sulindac sulfide analog inhibits the reaction [troglitazone binds to PPARG protein]; sulindac sulfide binds to and results in increased activity of PPARG protein
sulindac sulfide results in increased expression of PPARG mRNA
sulindac sulfide analog binds to PPARG protein
CTD PMID:10866999, PMID:11948457, PMID:16091736, PMID:17602619, PMID:18665581 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha decreases expression ISO sulindac sulfide results in decreased expression of PPP2R1A mRNA CTD PMID:12734198 NCBI chr 1:60,717,386...60,736,629
Ensembl chr 1:60,717,386...60,736,609
JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 decreases expression ISO sulindac sulfide results in decreased expression of PPT1 mRNA CTD PMID:16184548 NCBI chr 5:140,538,260...140,558,163
Ensembl chr 5:140,538,260...140,558,162
JBrowse link
G Prep prolyl endopeptidase increases expression ISO sulindac sulfide results in increased expression of PREP mRNA CTD PMID:12734198 NCBI chr20:50,172,618...50,269,992
Ensembl chr20:50,172,618...50,269,992
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha increases expression ISO sulindac sulfide results in increased expression of PRKACA mRNA CTD PMID:16184548 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Prkcsh protein kinase C substrate 80K-H decreases expression ISO sulindac sulfide results in decreased expression of PRKCSH mRNA CTD PMID:16184548 NCBI chr 8:23,014,802...23,026,507
Ensembl chr 8:23,014,956...23,026,503
JBrowse link
G Prrx1 paired related homeobox 1 decreases expression ISO sulindac sulfide results in decreased expression of PRRX1 mRNA CTD PMID:16184548 NCBI chr13:81,147,038...81,215,559
Ensembl chr13:81,147,348...81,214,546
JBrowse link
G Prss23 serine protease 23 decreases expression ISO sulindac sulfide results in decreased expression of PRSS23 mRNA CTD PMID:12734198 NCBI chr 1:153,732,528...153,742,111
Ensembl chr 1:153,732,532...153,752,541
JBrowse link
G Psen1 presenilin 1 decreases response to substance
decreases activity
multiple interactions
ISO PSEN1 gene mutant form results in decreased susceptibility to sulindac sulfide
sulindac sulfide results in decreased activity of PSEN1 protein
[sulindac sulfide results in decreased activity of PSEN1 protein] which affects the cleavage of APP protein; PSEN1 protein affects the reaction [sulindac sulfide affects the cleavage of APP protein]; PSEN1 protein mutant form promotes the reaction [sulindac sulfide affects the cleavage of APP protein]; sulindac sulfide affects the reaction [PSEN1 protein affects the cleavage of APP protein]
CTD PMID:12805356, PMID:17573346, PMID:17962197 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 decreases expression ISO sulindac sulfide results in decreased expression of PSMC2 mRNA CTD PMID:16184548 NCBI chr 4:9,867,132...9,881,383
Ensembl chr 4:9,867,101...9,881,484
JBrowse link
G Ptgdr2 prostaglandin D2 receptor 2 affects binding
multiple interactions
ISO sulindac sulfide binds to PTGDR2 protein
[sulindac sulfide binds to PTGDR2 protein] which results in decreased abundance of Cyclic AMP; sulindac sulfide inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]
CTD PMID:15563582 NCBI chr 1:226,976,455...226,995,641
Ensembl chr 1:226,993,250...226,994,849
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO sulindac sulfide results in decreased activity of PTGS1 protein CTD PMID:11245490 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
decreases activity
increases response to substance
ISO [sulindac sulfide results in increased activity of PPARG protein] which results in increased expression of PTGS2 protein; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP3 protein]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP8 protein]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP9 protein]; sulindac sulfide inhibits the reaction [PTGS2 protein results in decreased expression of TNFRSF10B mRNA]; sulindac sulfide inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
sulindac sulfide results in increased expression of PTGS2 mRNA; sulindac sulfide results in increased expression of PTGS2 protein
sulindac sulfide results in decreased activity of PTGS2 protein
PTGS2 protein results in increased susceptibility to sulindac sulfide
CTD PMID:10485483, PMID:10866999, PMID:11245490, PMID:11948457, PMID:12208739, PMID:12414664 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO sulindac sulfide results in decreased phosphorylation of PTK2 protein CTD PMID:10741720 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F decreases expression ISO sulindac sulfide results in decreased expression of PTPRF mRNA CTD PMID:16184548 NCBI chr 5:137,036,936...137,112,930
Ensembl chr 5:137,036,935...137,112,927
JBrowse link
G Pvt1 Pvt1 oncogene increases expression ISO sulindac sulfide results in increased expression of PVT1 mRNA CTD PMID:12734198 NCBI chr 7:102,648,394...102,871,316 JBrowse link
G Ranbp1 RAN binding protein 1 increases expression ISO sulindac sulfide results in increased expression of RANBP1 mRNA CTD PMID:12734198 NCBI chr11:86,890,585...86,898,818
Ensembl chr11:86,890,585...86,898,818
JBrowse link
G Rap1gap Rap1 GTPase-activating protein increases expression ISO sulindac sulfide results in increased expression of RAP1GAP mRNA CTD PMID:12734198 NCBI chr 5:156,008,868...156,074,350
Ensembl chr 5:156,026,911...156,074,395
JBrowse link
G Rb1 RB transcriptional corepressor 1 affects activity ISO sulindac sulfide affects the activity of RB1 protein CTD PMID:15694660 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Recql4 RecQ like helicase 4 decreases expression ISO sulindac sulfide results in decreased expression of RECQL4 mRNA CTD PMID:16184548 NCBI chr 7:117,765,892...117,773,128
Ensembl chr 7:117,763,783...117,773,134
JBrowse link
G Reg1a regenerating family member 1 alpha decreases expression ISO sulindac sulfide results in decreased expression of REG1A mRNA CTD PMID:16184548 NCBI chr 4:109,497,962...109,500,626
Ensembl chr 4:109,497,962...109,501,082
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases activity ISO sulindac sulfide results in decreased activity of RELA protein CTD PMID:11912124, PMID:12085227 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rere arginine-glutamic acid dipeptide repeats decreases expression ISO sulindac sulfide results in decreased expression of RERE mRNA CTD PMID:12734198 NCBI chr 5:167,330,966...167,664,506
Ensembl chr 5:167,331,035...167,664,505
JBrowse link
G Rgs16 regulator of G-protein signaling 16 increases expression ISO sulindac sulfide results in increased expression of RGS16 mRNA CTD PMID:16184548 NCBI chr13:71,163,411...71,185,147
Ensembl chr13:71,179,910...71,185,216
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO [sulindac sulfide results in increased activity of RHOA protein] which results in increased expression of THBS1 protein; RHOA protein promotes the reaction [sulindac sulfide results in increased expression of THBS1 protein] CTD PMID:18261746 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO sulindac sulfide results in decreased expression of RRM2 mRNA CTD PMID:12734198 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G Rrs1 ribosome biogenesis regulator 1 homolog increases expression ISO sulindac sulfide results in increased expression of RRS1 mRNA CTD PMID:12734198 NCBI chr 5:9,430,710...9,432,343
Ensembl chr 5:9,430,728...9,432,343
JBrowse link
G Serpinb5 serpin family B member 5 decreases expression ISO sulindac sulfide results in decreased expression of SERPINB5 mRNA CTD PMID:15897233 NCBI chr13:26,903,052...26,923,250
Ensembl chr13:26,903,052...26,923,250
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO sulindac sulfide results in increased expression of SERPINE1 mRNA CTD PMID:15897233 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Skp2 S-phase kinase associated protein 2 decreases expression ISO sulindac sulfide results in decreased expression of SKP2 mRNA CTD PMID:16184548 NCBI chr 2:58,506,146...58,534,211
Ensembl chr 2:58,506,151...58,534,211
JBrowse link
G Slc25a1 solute carrier family 25 member 1 decreases expression ISO sulindac sulfide results in decreased expression of SLC25A1 mRNA CTD PMID:16184548 NCBI chr11:87,204,248...87,207,265
Ensembl chr11:87,204,175...87,207,264
JBrowse link
G Slc25a45 solute carrier family 25, member 45 increases expression ISO sulindac sulfide results in increased expression of SLC25A45 mRNA CTD PMID:12734198 NCBI chr 1:221,236,817...221,244,564
Ensembl chr 1:221,236,773...221,244,563
JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO sulindac sulfide results in increased expression of SLC3A2 mRNA CTD PMID:16184548 NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
JBrowse link
G Sprr1b small proline-rich protein 1B increases expression ISO sulindac sulfide results in increased expression of SPRR1B mRNA CTD PMID:16184548 NCBI chr 2:192,622,972...192,624,848
Ensembl chr 2:192,623,244...192,623,681
JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 decreases expression ISO sulindac sulfide results in decreased expression of SPTBN1 mRNA CTD PMID:12734198 NCBI chr14:114,517,839...114,700,199
Ensembl chr14:114,518,816...114,692,764
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO sulindac sulfide results in increased expression of SQSTM1 mRNA CTD PMID:16184548 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 decreases expression ISO sulindac sulfide results in decreased expression of SREBF2 mRNA CTD PMID:16184548 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression
ISO sulindac sulfide results in decreased expression of and results in decreased phosphorylation of STAT3 protein
sulindac sulfide results in decreased expression of STAT3 mRNA
CTD PMID:17566705 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO sulindac sulfide results in increased expression of STC2 mRNA CTD PMID:12734198 NCBI chr10:16,542,909...16,552,675
Ensembl chr10:16,542,882...16,553,295
JBrowse link
G Stk17b serine/threonine kinase 17b increases expression ISO sulindac sulfide results in increased expression of STK17B mRNA CTD PMID:16184548 NCBI chr 9:60,399,261...60,430,081
Ensembl chr 9:60,399,261...60,430,081
JBrowse link
G Syde1 synapse defective Rho GTPase homolog 1 increases expression ISO sulindac sulfide results in increased expression of SYDE1 mRNA CTD PMID:12734198 NCBI chr 7:14,037,646...14,043,632
Ensembl chr 7:14,037,620...14,043,779
JBrowse link
G Tfap2b transcription factor AP-2 beta increases expression ISO sulindac sulfide results in increased expression of TFAP2B mRNA CTD PMID:16184548 NCBI chr 9:25,410,669...25,440,568
Ensembl chr 9:25,410,669...25,440,411
JBrowse link
G Tff3 trefoil factor 3 decreases expression ISO sulindac sulfide results in decreased expression of TFF3 mRNA CTD PMID:16184548 NCBI chr20:9,850,800...9,855,481
Ensembl chr20:9,850,803...9,855,481
JBrowse link
G Thbs1 thrombospondin 1 multiple interactions
increases expression
ISO [sulindac sulfide results in increased activity of RHOA protein] which results in increased expression of THBS1 protein; [sulindac sulfide results in increased phosphorylation of MAPK1 protein] which results in increased expression of THBS1 protein; [sulindac sulfide results in increased phosphorylation of MAPK3 protein] which results in increased expression of THBS1 protein; EGR1 protein affects the reaction [sulindac sulfide results in increased expression of THBS1 mRNA]; RHOA protein promotes the reaction [sulindac sulfide results in increased expression of THBS1 protein]; U 0126 inhibits the reaction [sulindac sulfide results in increased expression of THBS1 mRNA]; U 0126 inhibits the reaction [sulindac sulfide results in increased expression of THBS1 protein]
sulindac sulfide results in increased expression of THBS1 mRNA; sulindac sulfide results in increased expression of THBS1 protein
CTD PMID:16227405, PMID:18261746 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Tk1 thymidine kinase 1 decreases expression ISO sulindac sulfide results in decreased expression of TK1 mRNA CTD PMID:16184548 NCBI chr10:106,817,556...106,828,888
Ensembl chr10:106,817,601...106,828,884
JBrowse link
G Tmpo thymopoietin decreases expression ISO sulindac sulfide results in decreased expression of TMPO mRNA CTD PMID:16184548 NCBI chr 7:31,847,412...31,872,416
Ensembl chr 7:31,847,410...31,872,423
JBrowse link
G Tmsb4x thymosin beta 4, X-linked decreases expression ISO sulindac sulfide results in decreased expression of TMSB4X mRNA CTD PMID:15292456 NCBI chr  X:28,593,405...28,617,267
Ensembl chr  X:28,593,405...28,595,395
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein; [sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein; sulindac sulfide inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein]; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein] CTD PMID:10866999, PMID:20371263 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO sulindac sulfide results in increased expression of TNFRSF10A mRNA; sulindac sulfide results in increased expression of TNFRSF10A protein CTD PMID:15180942 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]]; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]]; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein]]; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein] CTD PMID:12203115 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO sulindac sulfide results in decreased expression of TP53 protein CTD PMID:9192825 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trip4 thyroid hormone receptor interactor 4 increases expression ISO sulindac sulfide results in increased expression of TRIP4 mRNA CTD PMID:16184548 NCBI chr 8:71,369,121...71,533,281
Ensembl chr 8:71,371,370...71,533,459
JBrowse link
G Tspan8 tetraspanin 8 decreases expression ISO sulindac sulfide results in decreased expression of TSPAN8 mRNA CTD PMID:16184548 NCBI chr 7:58,814,805...58,847,564
Ensembl chr 7:58,814,805...58,847,563
JBrowse link
G Tuba4a tubulin, alpha 4A decreases expression ISO sulindac sulfide results in decreased expression of TUBA4A mRNA CTD PMID:12734198 NCBI chr 9:82,415,599...82,419,918
Ensembl chr 9:82,415,605...82,419,288
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO sulindac sulfide results in increased expression of TXNRD1 mRNA CTD PMID:16184548 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Uba7 ubiquitin-like modifier activating enzyme 7 decreases expression ISO sulindac sulfide results in decreased expression of UBA7 mRNA CTD PMID:16184548 NCBI chr 8:116,754,178...116,766,765
Ensembl chr 8:116,754,178...116,764,126
JBrowse link
G Ube2d1 ubiquitin-conjugating enzyme E2D 1 increases expression ISO sulindac sulfide results in increased expression of UBE2D1 mRNA CTD PMID:16184548 NCBI chr20:18,547,370...18,580,291
Ensembl chr20:18,547,370...18,580,291
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases activity
increases expression
ISO sulindac sulfide results in increased activity of UGT1A1 protein
sulindac sulfide results in increased expression of UGT1A1 mRNA
CTD PMID:17985343 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Upp1 uridine phosphorylase 1 increases expression ISO sulindac sulfide results in increased expression of UPP1 mRNA CTD PMID:16184548 NCBI chr14:89,314,234...89,334,060
Ensembl chr14:89,314,176...89,334,276
JBrowse link
G Vmp1 vacuole membrane protein 1 increases expression ISO sulindac sulfide results in increased expression of VMP1 mRNA CTD PMID:12734198 NCBI chr10:73,901,988...74,001,900
Ensembl chr10:73,902,837...74,001,895
JBrowse link
G Xrcc6 X-ray repair cross complementing 6 increases expression ISO sulindac sulfide results in increased expression of XRCC6 mRNA CTD PMID:12734198 NCBI chr 7:123,259,881...123,280,613
Ensembl chr 7:123,259,761...123,280,612
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon multiple interactions
decreases expression
ISO [sulindac sulfide results in decreased expression of YWHAE protein] which results in increased localization of BAD protein; PPARD protein affects the reaction [sulindac sulfide results in decreased expression of YWHAE protein]; sulindac sulfide promotes the reaction [BAD protein binds to YWHAE protein]
sulindac sulfide results in decreased expression of YWHAE mRNA; sulindac sulfide results in decreased expression of YWHAE protein
CTD PMID:17409426, PMID:18678619 NCBI chr10:63,884,338...63,921,709
Ensembl chr10:63,884,338...63,921,709
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          apoptosis inducer 10895
            sulindac sulfide 215
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          acetic acid 10697
                                            sulindac 772
                                              sulindac sulfide 215
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.