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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:quinpirole
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Accession:CHEBI:75401 term browser browse the term
Definition:A pyrazoloquinoline that is (4aR,8aR)-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]quinoline substituted by a propyl group at position 5. It acts as a dopamine agonist.
Synonyms:exact_synonym: (4aR,8aR)-5-propyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]quinoline
 related_synonym: (4aR,8aR)-5-propyl-1,4,4a,6,7,8,8a,9-octahydropyrido[2,3-f]indazole;   (4aR-trans)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo(3,4-g)quinoline;   Formula=C13H21N3;   InChI=1S/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/t10-,13-/m1/s1;   InChIKey=FTSUPYGMFAPCFZ-ZWNOBZJWSA-N;   SMILES=CCCN1CCC[C@@H]2Cc3[nH]ncc3C[C@@H]12;   quinpirol;   quinpirolum
 xref: CAS:80373-22-4;   LINCS:LSM-2582
 xref_mesh: MESH:D019257
 xref: PMID:22647577;   PMID:23249525;   PMID:23420100;   PMID:23708948;   PMID:23896526;   Patent:KR20090096682;   Patent:WO2007076601;   Reaxys:4352538;   Wikipedia:Quinpirole



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quinpirole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions
EXP Quinpirole results in increased expression of ABCB1 protein
Clozapine inhibits the reaction [Quinpirole results in increased expression of ABCB1 protein]; Spiperone inhibits the reaction [Quinpirole results in increased expression of ABCB1 protein]
CTD PMID:9111066 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B multiple interactions
increases activity
increases expression
EXP Clozapine inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter]; eticlopride inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter]; Spiperone inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter]
Quinpirole results in increased expression of ABCB1B mRNA
CTD PMID:9111066 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Adcy5 adenylate cyclase 5 multiple interactions ISO ADCY5 protein results in increased susceptibility to [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine co-treated with Quinpirole]; ADCY5 protein results in increased susceptibility to [Colforsin co-treated with Quinpirole]; ADCY5 protein results in increased susceptibility to [dihydrexidine co-treated with Quinpirole]; ADCY5 protein results in increased susceptibility to [Quinpirole co-treated with VIP protein] CTD PMID:12223546 NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974
JBrowse link
G Cfl1 cofilin 1 multiple interactions
increases phosphorylation
ISO DRD2 protein affects the reaction [Quinpirole results in increased phosphorylation of CFL1 protein] CTD PMID:27717053 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
increases response to substance
affects response to substance
increases activity
ISO
EXP
[Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium; [Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Quinpirole co-treated with DRD2 protein alternative form] results in increased activity of RHOA protein; DRD2 protein promotes the reaction [Quinpirole results in decreased expression of POU5F1 mRNA]; epigallocatechin gallate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; JB-788 inhibits the reaction [Quinpirole binds to and results in increased activity of DRD2 protein]; Quinpirole binds to and results in increased activity of DRD2 protein; Sulpiride inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]
DRD2 affects the susceptibility to [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole]; DRD2 protein affects the reaction [Quinpirole results in increased phosphorylation of CFL1 protein]
DRD2 results in increased susceptibility to Quinpirole
DRD2 protein affects the susceptibility to Quinpirole
[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine; cypermethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; decamethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]; estradiol 3-benzoate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; Haloperidol inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; Mirtazapine inhibits the reaction [Quinpirole binds to DRD2 protein]; Nifedipine inhibits the reaction [DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]]; Quinpirole binds to and results in increased activity of DRD2 protein; tautomycin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]
DRD2 protein results in increased susceptibility to Quinpirole
Quinpirole results in increased activity of DRD2 protein
CTD PMID:1724532 PMID:8032591 PMID:9547254 PMID:10936494 PMID:11124974 More... NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 multiple interactions ISO
EXP
Quinpirole binds to and results in increased activity of DRD3 protein
mirtazapine inhibits the reaction [Quinpirole binds to DRD3 protein]
CTD PMID:10683862 PMID:12523492 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Drd4 dopamine receptor D4 affects binding EXP quinpirole binds to Drd4 protein RGD PMID:17314300 RGD:1625010 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Quinpirole inhibits the reaction [Reserpine results in increased expression of EGR1 mRNA] CTD PMID:9729266 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
increases expression
multiple interactions
EXP Quinpirole results in decreased expression of FOS mRNA; Quinpirole results in decreased expression of FOS protein
Quinpirole results in increased expression of FOS protein
8-(3-chlorostyryl)caffeine promotes the reaction [Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]]; [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole] results in increased expression of FOS protein; [SK&F 81297 co-treated with Quinpirole] results in increased expression of FOS protein; Cocaine promotes the reaction [[SK&F 81297 co-treated with Quinpirole] results in increased expression of FOS protein]; Quinpirole inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FOS mRNA]; Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]; Quinpirole promotes the reaction [Reserpine results in increased expression of FOS protein]; Reserpine inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole] results in increased expression of FOS protein]; Reserpine promotes the reaction [Quinpirole results in increased expression of FOS protein]
CTD PMID:7845612 PMID:7914358 PMID:8102797 PMID:8577368 PMID:8864302 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions ISO Quinpirole inhibits the reaction [Ovalbumin results in increased expression of GRIA1 protein modified form] CTD PMID:34624383 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions ISO Quinpirole inhibits the reaction [Ovalbumin results in increased expression of GRIA2 protein modified form] CTD PMID:34624383 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [SK&F 81297 co-treated with Quinpirole] results in increased expression of JUNB protein; Cocaine promotes the reaction [[SK&F 81297 co-treated with Quinpirole] results in increased expression of JUNB protein] CTD PMID:12122080 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Quinpirole results in increased phosphorylation of MAPK1 protein CTD PMID:27717053 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Quinpirole results in increased phosphorylation of MAPK3 protein CTD PMID:27717053 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases secretion ISO Quinpirole results in decreased secretion of MMP9 protein CTD PMID:27920206 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Npy neuropeptide Y multiple interactions ISO NPY protein results in decreased susceptibility to [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole] CTD PMID:12183048 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Odc1 ornithine decarboxylase 1 increases activity ISO Quinpirole results in increased activity of ODC1 protein CTD PMID:10354516 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression
multiple interactions
ISO Quinpirole results in decreased expression of POU5F1 mRNA
DRD2 protein promotes the reaction [Quinpirole results in decreased expression of POU5F1 mRNA]
CTD PMID:27920206 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions ISO Quinpirole affects the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Quinpirole affects the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein] CTD PMID:11880652 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
JBrowse link
G Rgs9 regulator of G-protein signaling 9 affects response to substance ISO RGS9 affects the susceptibility to Quinpirole CTD PMID:15728856 NCBI chr10:94,195,265...94,270,892
Ensembl chr10:94,197,054...94,270,892
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO [Quinpirole co-treated with DRD2 protein alternative form] results in increased activity of RHOA protein CTD PMID:27717053 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Slc18a2 solute carrier family 18 member A2 affects response to substance ISO SLC18A2 protein affects the susceptibility to Quinpirole CTD PMID:12716422 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
JBrowse link
G Slc6a3 solute carrier family 6 member 3 increases expression
affects localization
EXP
ISO
Quinpirole results in increased expression of SLC6A3 mRNA
Quinpirole affects the localization of SLC6A3 protein
CTD PMID:20875051 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Reserpine co-treated with Quinpirole] results in increased expression of TAC1 mRNA CTD PMID:9751140 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Trex1 three prime repair exonuclease 1 increases expression EXP Quinpirole results in increased expression of TREX1 mRNA CTD PMID:20298760 NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796
JBrowse link
G Vip vasoactive intestinal peptide multiple interactions ISO ADCY5 protein results in increased susceptibility to [Quinpirole co-treated with VIP protein] CTD PMID:12223546 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
JBrowse link

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                quinpirole 26
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                                  organic heteropolycyclic compound 18301
                                    organic heterotricyclic compound 15641
                                      pyrazoloquinoline 26
                                        quinpirole 26
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