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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:calmidazolium
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Accession:CHEBI:75400 term browser browse the term
Definition:An imidazolium ion that is imidazolium cation substituted by a bis(4-chlorophenyl)methyl group at position 1 and a 2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl group at position 3. It acts as an inhibitor of calmodulin, a calcium binding messenger protein.
Synonyms:exact_synonym: 1-[bis(4-chlorophenyl)methyl]-3-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazol-3-ium
 related_synonym: Formula=C31H23Cl6N2O;   InChI=1S/C31H23Cl6N2O/c32-23-6-1-20(2-7-23)31(21-3-8-24(33)9-4-21)39-14-13-38(19-39)17-30(27-12-11-26(35)16-29(27)37)40-18-22-5-10-25(34)15-28(22)36/h1-16,19,30-31H,17-18H2/q+1;   InChIKey=CTKNMSVWMRRCPW-UHFFFAOYSA-N;   R24571;   SMILES=Clc1ccc(cc1)C(c1ccc(Cl)cc1)n1cc[n+](CC(OCc2ccc(Cl)cc2Cl)c2ccc(Cl)cc2Cl)c1
 xref: CAS:95013-41-5;   LINCS:LSM-5017
 xref_mesh: MESH:C031938
 xref: PMID:10637138;   PMID:6319141;   PMID:6319599;   Patent:DE4014540;   Patent:ES2142703;   Reaxys:4073265


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calmidazolium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO calmidazolium results in increased activity of CASP3 protein CTD PMID:27247146 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 multiple interactions ISO calmidazolium inhibits the reaction [Potassium results in increased expression of CYP11B2 mRNA] CTD PMID:12193581 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G F2 coagulation factor II multiple interactions ISO calmidazolium affects the reaction [F2 protein results in increased secretion of Adenosine Triphosphate] CTD PMID:2030746 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO calmidazolium inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:19281832 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mt1 metallothionein 1 increases expression EXP calmidazolium results in increased expression of MT1A mRNA CTD PMID:8128501 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO calmidazolium results in decreased expression of MYC CTD PMID:27247146 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myl9 myosin light chain 9 decreases phosphorylation EXP calmidazolium results in decreased phosphorylation of MYL9 protein CTD PMID:17272349 NCBI chr 3:152,857,573...152,863,961
Ensembl chr 3:152,857,592...152,863,960
JBrowse link
G Ngf nerve growth factor multiple interactions EXP calmidazolium inhibits the reaction [NGF protein results in increased uptake of Calcium] CTD PMID:1374475 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nos3 nitric oxide synthase 3 decreases activity EXP calmidazolium results in decreased activity of NOS3 protein CTD PMID:1374468 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO calmidazolium results in decreased phosphorylation of RB1 protein CTD PMID:12901840 PMID:15708436 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 decreases phosphorylation ISO calmidazolium results in decreased phosphorylation of RBL2 protein CTD PMID:15708436 NCBI chr19:17,300,088...17,346,865
Ensembl chr19:17,300,089...17,346,808
JBrowse link
G Slc5a6 solute carrier family 5 member 6 multiple interactions ISO calmidazolium inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] CTD PMID:15561972 NCBI chr 6:26,685,823...26,697,110
Ensembl chr 6:26,686,033...26,697,116
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO calmidazolium inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:19281832 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        inhibitor 18241
          calmidazolium 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      p-block molecular entity 19696
                        carbon group molecular entity 19599
                          organic molecular entity 19588
                            organic ion 8333
                              organic cation 7151
                                imidazolium ion 13
                                  calmidazolium 13
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