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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:NU 1025
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Accession:CHEBI:75399 term browser browse the term
Definition:A member of the class of quinazolines that is quinazolin-4(1H)-one substituted by a hydroxy group at position 8 and a methyl group at position 2. It has been shown to exhibit inhibitory activity against poly(ADP-ribose) polymerase.
Synonyms:exact_synonym: 8-hydroxy-2-methylquinazolin-4(1H)-one
 related_synonym: Formula=C9H8N2O2;   InChI=1S/C9H8N2O2/c1-5-10-8-6(9(13)11-5)3-2-4-7(8)12/h2-4,12H,1H3,(H,10,11,13);   InChIKey=YJDAOHJWLUNFLX-UHFFFAOYSA-N;   SMILES=Cc1nc(=O)c2cccc(O)c2[nH]1
 xref: CAS:90417-38-2;   DrugBank:DB02690;   LINCS:LSM-4643
 xref_mesh: MESH:C115774
 xref: PMID:10069454;   PMID:10914735;   PMID:9823965;   PMID:9857092;   Reaxys:10249307


show annotations for term's descendants           Sort by:
NU 1025 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc6 ERCC excision repair 6, chromatin remodeling factor multiple interactions
affects response to substance		 ISO NU 1025 inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]
ERCC6 gene mutant form affects the susceptibility to NU 1025		 CTD PMID:25440059 NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    chemical entity 19851
      molecular entity 19851
        polyatomic entity 19808
          heteroatomic molecular entity 19763
            hydroxides 19325
              organic hydroxy compound 18956
                phenols 18652
                  NU 1025 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19797
                    p-block element atom 19797
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            organic molecule 19685
                              organic cyclic compound 19496
                                organic heterocyclic compound 18871
                                  organic heteropolycyclic compound 18299
                                    organic heterobicyclic compound 17246
                                      quinazolines 550
                                        NU 1025 1
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