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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Y-27632
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Accession:CHEBI:75393 term browser browse the term
Definition:A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It has been shown to exhibit inhibitory activity against Rho-associated protein kinase (ROCK) enzyme.
Synonyms:exact_synonym: trans-4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexanecarboxamide
 related_synonym: (R)-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide;   4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-1-carboxamide;   Formula=C14H21N3O;   InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1;   InChIKey=IYOZTVGMEWJPKR-IJLUTSLNSA-N;   SMILES=C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1
 xref: CAS:146986-50-7;   DrugBank:DB08756
 xref_mesh: MESH:C108830
 xref: PMID:10686302;   PMID:10973620;   PMID:17105828;   PMID:17157292;   PMID:17428993;   Reaxys:9134889;   Wikipedia:Y-27632


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Y-27632 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL1A1 mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL1A2 mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL3A1 mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL4A1 mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL5A1 mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL6A1 mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of ELN mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of FN1 mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of MMP14 mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of MMP2 mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of PDGFB mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of TGFB1 mRNA] CTD PMID:30682444 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO Y 27632 results in increased expression of ABCC2 mRNA CTD PMID:20878077 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression		 ISO
EXP		 Y 27632 inhibits the reaction [Oxygen results in increased expression of ACTA2 mRNA]; Y 27632 inhibits the reaction [Oxygen results in increased expression of ACTA2 protein]
Y 27632 inhibits the reaction [Oxygen results in increased expression of ACTA2 protein]; Y 27632 inhibits the reaction [Soot results in increased expression of ACTA2 mRNA]; Y 27632 inhibits the reaction [Soot results in increased expression of ACTA2 protein]
Y 27632 affects the reaction [Dibutyl Phthalate affects the expression of ACTA2 mRNA]; Y 27632 affects the reaction [Dibutyl Phthalate affects the expression of ACTA2 protein]; Y 27632 inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Y 27632 inhibits the reaction [Dibutyl Phthalate results in increased expression of ACTA2 mRNA]; Y 27632 inhibits the reaction [Dibutyl Phthalate results in increased expression of ACTA2 protein]
Y 27632 results in decreased expression of ACTA2 mRNA		 CTD PMID:11035001 PMID:13678700 PMID:23517783 PMID:32860865 PMID:33792148 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases activity
increases expression		 ISO Y 27632 results in increased activity of AKT1 protein
Y 27632 results in increased expression of AKT1 mRNA		 CTD PMID:17322126 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alcam activated leukocyte cell adhesion molecule decreases expression ISO Y 27632 results in decreased expression of ALCAM mRNA CTD PMID:35388712 NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954 		JBrowse link
G App amyloid beta precursor protein multiple interactions
affects cleavage
increases secretion		 ISO
EXP		 ROCK1 protein affects the reaction [Y 27632 affects the cleavage of APP protein]
Y 27632 inhibits the reaction [aluminum maltolate results in decreased expression of and results in decreased secretion of APP protein modified form]
Y 27632 results in increased secretion of APP protein modified form		 CTD PMID:14615541 PMID:19741129 PMID:20395307 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Arhgef17 Rho guanine nucleotide exchange factor 17 multiple interactions ISO Y 27632 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of ARHGEF17 protein] CTD PMID:23195829 NCBI chr 1:155,230,607...155,290,163
Ensembl chr 1:155,233,168...155,290,498 		JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 increases expression ISO Y 27632 results in increased expression of ATP1B2 mRNA CTD PMID:20878077 NCBI chr10:54,318,698...54,324,933
Ensembl chr10:54,318,701...54,324,933 		JBrowse link
G Atp5f1d ATP synthase F1 subunit delta multiple interactions EXP Y 27632 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in decreased expression of ATP5F1D protein] CTD PMID:25305180 NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression
multiple interactions		 ISO Y 27632 results in decreased expression of BAD mRNA
Y 27632 inhibits the reaction [Cisplatin results in increased expression of BAD mRNA]		 CTD PMID:20878077 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression		 ISO Y 27632 inhibits the reaction [Cisplatin results in decreased expression of BCL2 mRNA]
Y 27632 results in increased expression of BCL2 mRNA		 CTD PMID:20878077 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bik BCL2-interacting killer multiple interactions
decreases expression		 ISO Y 27632 inhibits the reaction [Cisplatin results in increased expression of BIK mRNA]
Y 27632 results in decreased expression of BIK mRNA		 CTD PMID:20878077 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO Y 27632 inhibits the reaction [Asbestos, Crocidolite results in increased secretion of CASP1 protein modified form]; Y 27632 inhibits the reaction [Nanotubes, Carbon results in increased secretion of CASP1 protein modified form] CTD PMID:24760326 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO		 Y 27632 inhibits the reaction [1-Butanol results in increased activity of and results in increased cleavage of CASP3 protein]; Y 27632 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased cleavage of CASP3 protein]
Y 27632 inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]		 CTD PMID:22564901 PMID:25305180 PMID:28743511 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO Y 27632 inhibits the reaction [TNF protein results in increased cleavage of CASP8 protein] CTD PMID:28743511 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP Y 27632 inhibits the reaction [1-Butanol results in increased activity of and results in increased cleavage of CASP9 protein] CTD PMID:22564901 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Y 27632 inhibits the reaction [Soot results in increased expression of CCL2 protein] CTD PMID:33792148 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO Y 27632 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of CCL4 mRNA] CTD PMID:29033935 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP Y 27632 inhibits the reaction [lysophosphatidic acid results in increased expression of CCN2 protein] CTD PMID:15200425 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccna2 cyclin A2 decreases expression
multiple interactions		 ISO Y 27632 results in decreased expression of CCNA2 protein
Y 27632 promotes the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in decreased expression of CCNA2 protein]		 CTD PMID:32417439 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression		 EXP Y 27632 promotes the reaction [EGF protein results in increased expression of CCND1 protein]
Y 27632 results in increased expression of CCND1 mRNA		 CTD PMID:16799973 PMID:20578043 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd3 cyclin D3 decreases expression
multiple interactions		 ISO Y 27632 results in decreased expression of CCND3 protein
Y 27632 promotes the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in decreased expression of CCND3 protein]		 CTD PMID:32417439 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Cd14 CD14 molecule increases expression
multiple interactions		 ISO Y 27632 results in increased expression of CD14 protein
Y 27632 promotes the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of CD14 protein]		 CTD PMID:32417439 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd86 CD86 molecule multiple interactions ISO Y 27632 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of CD86 mRNA] CTD PMID:29033935 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cdh1 cadherin 1 decreases activity
multiple interactions		 ISO
EXP		 Y 27632 results in decreased activity of CDH1 protein
Y 27632 affects the reaction [Dibutyl Phthalate affects the expression of CDH1 mRNA]; Y 27632 affects the reaction [Dibutyl Phthalate affects the expression of CDH1 protein]; Y 27632 inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 mRNA]; Y 27632 inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 protein]		 CTD PMID:16030252 PMID:32860865 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression EXP Y 27632 results in decreased expression of CDK4 mRNA CTD PMID:20578043 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
multiple interactions		 ISO Y 27632 results in decreased expression of CDKN1A mRNA
Y 27632 inhibits the reaction [Cisplatin results in increased expression of CDKN1A mRNA]		 CTD PMID:20878077 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP Y 27632 results in increased expression of CDKN1B mRNA CTD PMID:20578043 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cfl1 cofilin 1 decreases phosphorylation
decreases expression		 EXP
ISO		 Y 27632 results in decreased phosphorylation of CFL1 protein
Y 27632 results in decreased expression of CFL1 protein modified form		 CTD PMID:17138966 PMID:20610540 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Y 27632 results in increased activity of and results in increased phosphorylation of CHUK protein CTD PMID:17322126 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Col17a1 collagen type XVII alpha 1 chain affects localization ISO Y 27632 affects the localization of COL17A1 protein CTD PMID:14691950 NCBI chr 1:246,530,589...246,577,559
Ensembl chr 1:246,531,367...246,577,632 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL1A1 mRNA]; Y 27632 inhibits the reaction [Oxygen results in increased expression of COL1A1 mRNA] CTD PMID:21439370 PMID:23517783 PMID:30682444 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO Y 27632 inhibits the reaction [Oxygen results in increased expression of COL1A2 mRNA]
Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL1A2 mRNA]; Y 27632 inhibits the reaction [Oxygen results in increased expression of COL1A2 mRNA]		 CTD PMID:21439370 PMID:23517783 PMID:30682444 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL3A1 mRNA] CTD PMID:30682444 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions ISO Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL4A1 mRNA] CTD PMID:30682444 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412 		JBrowse link
G Col5a1 collagen type V alpha 1 chain multiple interactions ISO Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL5A1 mRNA] CTD PMID:30682444 NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain multiple interactions ISO Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL6A1 mRNA] CTD PMID:30682444 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO Y 27632 inhibits the reaction [Asbestos, Crocidolite results in increased secretion of CTSB protein modified form]; Y 27632 inhibits the reaction [Nanotubes, Carbon results in increased secretion of CTSB protein modified form] CTD PMID:24760326 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO Y 27632 inhibits the reaction [CXCL12 protein results in increased phosphorylation of MYL9 protein] CTD PMID:11751986 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Dst dystonin affects localization ISO Y 27632 affects the localization of DST protein CTD PMID:14691950 NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Y 27632 inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA] CTD PMID:11739382 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Egf epidermal growth factor multiple interactions EXP Y 27632 promotes the reaction [EGF protein results in increased expression of CCND1 protein] CTD PMID:16799973 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Eln elastin multiple interactions ISO Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of ELN mRNA] CTD PMID:30682444 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928 		JBrowse link
G Eng endoglin decreases expression ISO Y 27632 results in decreased expression of ENG mRNA CTD PMID:35388712 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit increases expression ISO Y 27632 results in increased expression of ERCC1 mRNA CTD PMID:20878077 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit increases expression ISO Y 27632 results in increased expression of XPD mRNA CTD PMID:20878077 NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102 		JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease increases expression ISO Y 27632 results in increased expression of ERCC5 mRNA CTD PMID:20878077 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472 		JBrowse link
G Ezr ezrin increases phosphorylation EXP Y 27632 deficiency results in increased phosphorylation of EZR protein CTD PMID:14732730 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505 		JBrowse link
G F2 coagulation factor II, thrombin multiple interactions
decreases activity		 ISO Y 27632 inhibits the reaction [F2 protein results in increased phosphorylation of MYL9 protein]
[Y 27632 results in decreased activity of ROCK1 protein] which results in decreased activity of F2 protein		 CTD PMID:15284075 PMID:16675616 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO Y 27632 results in increased expression of FABP4 mRNA CTD PMID:35388712 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Y 27632 inhibits the reaction [Cisplatin results in increased expression of FAS mRNA] CTD PMID:20878077 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand decreases expression
multiple interactions		 ISO Y 27632 results in decreased expression of FASLG mRNA
Y 27632 inhibits the reaction [Cisplatin results in increased expression of FASLG mRNA]		 CTD PMID:20878077 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP
ISO		 Y 27632 inhibits the reaction [Glucose results in increased expression of FN1 protein]
Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of FN1 mRNA]		 CTD PMID:23376009 PMID:30682444 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Gata4 GATA binding protein 4 multiple interactions EXP Y 27632 inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein] CTD PMID:11739382 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Y 27632 inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Y 27632 promotes the reaction [cobaltous chloride affects the localization of HIF1A protein] CTD PMID:16772336 PMID:30831131 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO
EXP		 Y 27632 inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]
Y 27632 inhibits the reaction [Glucose results in increased expression of ICAM1 protein]		 CTD PMID:22226621 PMID:23376009 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Y 27632 promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP Y 27632 inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; Y 27632 inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]] CTD PMID:15705589 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Y 27632 inhibits the reaction [Asbestos, Crocidolite results in increased expression of and results in increased secretion of IL1B protein]; Y 27632 inhibits the reaction [Nanotubes, Carbon results in increased expression of and results in increased secretion of IL1B protein]; Y 27632 promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
Y 27632 inhibits the reaction [Soot results in increased expression of IL1B protein]		 CTD PMID:12799187 PMID:24760326 PMID:33792148 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Y 27632 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of IL6 mRNA]; Y 27632 inhibits the reaction [Soot results in increased expression of IL6 protein]; Y 27632 promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein] CTD PMID:17729120 PMID:29033935 PMID:33792148 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itga3 integrin subunit alpha 3 multiple interactions ISO Y 27632 affects the localization of [ITGA3 protein binds to ITGB1 protein] CTD PMID:14691950 NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118 		JBrowse link
G Itga6 integrin subunit alpha 6 multiple interactions ISO Y 27632 affects the localization of [ITGA6 protein binds to ITGB4 protein] CTD PMID:14691950 NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428 		JBrowse link
G Itgam integrin subunit alpha M increases expression
multiple interactions		 ISO Y 27632 results in increased expression of ITGAM protein
Y 27632 promotes the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of ITGAM protein]		 CTD PMID:32417439 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO Y 27632 affects the localization of [ITGA3 protein binds to ITGB1 protein] CTD PMID:14691950 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Itgb4 integrin subunit beta 4 multiple interactions ISO Y 27632 affects the localization of [ITGA6 protein binds to ITGB4 protein] CTD PMID:14691950 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012 		JBrowse link
G Kirrel1 kirre like nephrin family adhesion molecule 1 multiple interactions ISO Y 27632 inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of KIRREL1 mRNA] CTD PMID:18367845 NCBI chr 2:172,521,644...172,615,057
Ensembl chr 2:172,525,245...172,615,299 		JBrowse link
G Lama3 laminin subunit alpha 3 affects localization ISO Y 27632 affects the localization of LAMA3 protein CTD PMID:14691950 NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353 		JBrowse link
G Limk1 LIM domain kinase 1 decreases expression ISO Y 27632 results in decreased expression of LIMK1 protein modified form CTD PMID:17138966 NCBI chr12:22,026,697...22,060,605
Ensembl chr12:22,026,672...22,060,606 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO		 Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Y 27632 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]		 CTD PMID:11739382 PMID:22226621 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Y 27632 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein] CTD PMID:22226621 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP		 Y 27632 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]		 CTD PMID:11739382 PMID:22226621 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP Y 27632 inhibits the reaction [methylmercuric chloride results in decreased expression of MAPT protein] CTD PMID:20869980 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mbp myelin basic protein increases expression EXP Y 27632 results in increased expression of MBP mRNA CTD PMID:20578043 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
decreases expression		 ISO Y 27632 promotes the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in decreased expression of MKI67 protein]
Y 27632 results in decreased expression of MKI67 protein		 CTD PMID:32417439 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions ISO Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of MMP14 mRNA] CTD PMID:30682444 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions		 ISO [Y 27632 results in decreased expression of RHOA protein] which results in decreased expression of MMP2 protein
Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of MMP2 mRNA]		 CTD PMID:19896475 PMID:30682444 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression		 ISO Y 27632 inhibits the reaction [4-cresol results in increased expression of MMP9 protein]; Y 27632 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]
[Y 27632 results in decreased expression of RHOA protein] which results in decreased expression of MMP9 protein		 CTD PMID:15728660 PMID:19896475 PMID:30910523 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Msn moesin increases phosphorylation
multiple interactions		 EXP Y 27632 deficiency results in increased phosphorylation of MSN protein
Y 27632 inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MSN protein]		 CTD PMID:14732730 PMID:30783172 NCBI chr  X:60,996,043...61,064,011
Ensembl chr  X:60,995,951...61,065,628 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [Everolimus co-treated with Y 27632] inhibits the reaction [4-cresol results in increased phosphorylation of MTOR protein]; Y 27632 inhibits the reaction [4-cresol results in increased phosphorylation of MTOR protein] CTD PMID:30910523 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myh2 myosin heavy chain 2 affects localization ISO Y 27632 affects the localization of MYH2 protein CTD PMID:16030252 NCBI chr10:51,856,738...51,883,236
Ensembl chr10:51,856,738...51,883,236 		JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Y 27632 inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA] CTD PMID:11739382 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Myl7 myosin light chain 7 multiple interactions
decreases phosphorylation		 ISO Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]
Y 27632 results in decreased phosphorylation of MYL7 protein		 CTD PMID:15621049 NCBI chr14:80,780,684...80,783,259
Ensembl chr14:80,779,776...80,783,244 		JBrowse link
G Myl9 myosin light chain 9 multiple interactions
decreases phosphorylation		 ISO
EXP		 Y 27632 inhibits the reaction [CXCL12 protein results in increased phosphorylation of MYL9 protein]; Y 27632 inhibits the reaction [F2 protein results in increased phosphorylation of MYL9 protein]; Y 27632 inhibits the reaction [TNF protein results in increased phosphorylation of MYL9 protein]
Y 27632 results in decreased phosphorylation of MYL9 protein
Y 27632 inhibits the reaction [[Escin affects the susceptibility to Calcium] which results in increased phosphorylation of MYL9 protein]; Y 27632 inhibits the reaction [[Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased phosphorylation of MYL9 protein]		 CTD PMID:11751986 PMID:12745062 PMID:15034928 PMID:15284075 PMID:29660437 NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Y 27632 inhibits the reaction [arsenic trioxide results in increased phosphorylation of and affects the localization of NCF1 protein] CTD PMID:18424721 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization ISO Y 27632 affects the localization of NFKB1 protein CTD PMID:17322126 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP		 Y 27632 results in decreased expression of and results in increased phosphorylation of NFKBIA protein
Y 27632 inhibits the reaction [Glucose results in decreased expression of NFKBIA protein]
Y 27632 inhibits the reaction [Soot results in increased phosphorylation of NFKBIA protein]		 CTD PMID:17322126 PMID:23376009 PMID:33792148 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 Y 27632 promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
Y 27632 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of NOS2 mRNA]; Y 27632 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of NOS2 protein]; Y 27632 promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of NOS2 mRNA]
Y 27632 inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]		 CTD PMID:12799187 PMID:15705589 PMID:17729120 PMID:29033935 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases phosphorylation		 ISO Mevalonic Acid inhibits the reaction [Y 27632 results in increased phosphorylation of NOS3 protein] CTD PMID:17322126 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions ISO Y 27632 inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA] CTD PMID:18367845 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP Y 27632 inhibits the reaction [lysophosphatidic acid results in increased expression of NPPA protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of NPPA protein] CTD PMID:11739382 PMID:25449040 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 decreases expression ISO Y 27632 results in decreased expression of NR4A3 mRNA CTD PMID:16005304 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases expression ISO Y 27632 results in decreased expression of PARP1 protein CTD PMID:24676941 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression
decreases expression		 ISO Mevalonic Acid inhibits the reaction [Y 27632 results in increased expression of PCNA protein]; Y 27632 promotes the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in decreased expression of PCNA protein]
Y 27632 results in decreased expression of PCNA protein		 CTD PMID:17322126 PMID:32417439 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of PDGFB mRNA] CTD PMID:30682444 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions EXP Y 27632 inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA] CTD PMID:30783172 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pkn2 protein kinase N2 decreases activity ISO Y 27632 results in decreased activity of PKN2 protein CTD PMID:10998351 NCBI chr 2:231,793,584...231,898,953
Ensembl chr 2:231,793,584...231,898,953 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP
ISO		 Y 27632 results in increased expression of PPARG mRNA CTD PMID:20578043 PMID:35388712 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions ISO
EXP		 Y 27632 inhibits the reaction [Puromycin Aminonucleoside results in increased phosphorylation of PPP1R12A protein]
Y 27632 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased phosphorylation of PPP1R12A protein]; Y 27632 inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of PPP1R12A protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]		 CTD PMID:18367845 PMID:25305180 PMID:25449040 NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions ISO Y 27632 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of ARHGEF17 protein] CTD PMID:23195829 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Rac1 Rac family small GTPase 1 increases activity EXP Y 27632 results in increased activity of RAC1 protein CTD PMID:12105187 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases expression		 ISO Y 27632 promotes the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in decreased expression of RB1 protein modified form]
Y 27632 results in decreased expression of RB1 protein modified form		 CTD PMID:32417439 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rdx radixin decreases phosphorylation EXP Y 27632 results in decreased phosphorylation of RDX protein CTD PMID:14732730 NCBI chr 8:52,379,494...52,437,673
Ensembl chr 8:52,379,494...52,437,678 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
decreases expression		 ISO
EXP		 Y 27632 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]
Y 27632 inhibits the reaction [Glucose affects the localization of RELA protein]
Y 27632 affects the localization of RELA protein
Y 27632 inhibits the reaction [arachidonyl-2-chloroethylamide affects the localization of RELA protein]; Y 27632 inhibits the reaction [Soot results in increased phosphorylation of RELA protein]
Y 27632 results in decreased expression of RELA mRNA		 CTD PMID:17322126 PMID:22226621 PMID:23376009 PMID:29033935 PMID:33792148 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rhoa ras homolog family member A decreases expression
multiple interactions		 ISO [Y 27632 results in decreased expression of RHOA protein] which results in decreased expression of MMP2 protein; [Y 27632 results in decreased expression of RHOA protein] which results in decreased expression of MMP9 protein; Y 27632 results in decreased expression of RHOA protein
[Everolimus co-treated with Y 27632] inhibits the reaction [4-cresol results in increased expression of RHOA protein]; Y 27632 inhibits the reaction [4-cresol results in increased expression of RHOA protein]		 CTD PMID:19896475 PMID:30910523 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases activity
multiple interactions		 ISO [Y 27632 results in decreased activity of ROCK1 protein] which results in decreased activity of F2 protein
ROCK1 protein affects the reaction [Y 27632 affects the cleavage of APP protein]		 CTD PMID:14615541 PMID:16675616 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 decreases activity
multiple interactions		 EXP Y 27632 results in decreased activity of ROCK2 protein
Y 27632 inhibits the reaction [Carbon Tetrachloride results in increased expression of ROCK2 mRNA]		 CTD PMID:10998351 PMID:30783172 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031 		JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 decreases activity ISO Y 27632 results in decreased activity of RPS6KA3 protein CTD PMID:10998351 NCBI chr  X:35,517,306...35,623,296
Ensembl chr  X:35,517,306...35,623,207 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 decreases activity ISO Y 27632 results in decreased activity of RPS6KA5 protein CTD PMID:10998351 NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224 		JBrowse link
G Rs1 retinoschisin 1 increases secretion ISO Y 27632 results in increased secretion of RS1 protein CTD PMID:21738583 NCBI chr  X:33,962,440...33,992,203
Ensembl chr  X:33,963,657...33,992,115 		JBrowse link
G Runx2 RUNX family transcription factor 2 decreases expression ISO Y 27632 results in decreased expression of RUNX2 mRNA CTD PMID:35388712 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Scn7a sodium voltage-gated channel alpha subunit 7 multiple interactions EXP Y 27632 inhibits the reaction [Carbon Tetrachloride results in increased expression of SCN7A mRNA] CTD PMID:13678700 NCBI chr 3:51,335,841...51,438,308
Ensembl chr 3:51,335,841...51,438,256 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 increases expression ISO Y 27632 results in increased expression of SLC12A2 protein CTD PMID:21474433 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 decreases expression ISO Y 27632 results in decreased expression of SLC31A1 mRNA CTD PMID:20878077 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression ISO Y 27632 results in decreased expression of SLPI mRNA CTD PMID:35388712 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Sox10 SRY-box transcription factor 10 increases expression EXP Y 27632 results in increased expression of SOX10 mRNA CTD PMID:20578043 NCBI chr 7:110,725,274...110,734,651
Ensembl chr 7:110,725,274...110,735,544 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Y 27632 inhibits the reaction [Glucose results in increased cleavage of SREBF1 protein] CTD PMID:22031849 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Tagln transgelin decreases expression EXP Y 27632 results in decreased expression of TAGLN mRNA CTD PMID:11035001 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO		 Y 27632 inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Y 27632 inhibits the reaction [Glucose results in increased expression of TGFB1 protein]
Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of TGFB1 mRNA]
Y 27632 inhibits the reaction [Soot results in increased expression of TGFB1 protein]		 CTD PMID:13678700 PMID:23376009 PMID:30682444 PMID:33792148 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO [cobaltous chloride co-treated with Y 27632] results in increased expression of TH protein CTD PMID:16772336 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Thy1 Thy-1 cell surface antigen decreases expression ISO Y 27632 results in decreased expression of THY1 mRNA CTD PMID:35388712 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659 		JBrowse link
G Tlr4 toll-like receptor 4 decreases expression ISO Y 27632 results in decreased expression of TLR4 mRNA CTD PMID:35388712 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity		 ISO Y 27632 inhibits the reaction [TNF protein affects the localization of and results in increased cleavage of VIM protein]; Y 27632 inhibits the reaction [TNF protein affects the localization of VIM protein modified form]; Y 27632 inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]; Y 27632 inhibits the reaction [TNF protein results in increased cleavage of CASP8 protein]; Y 27632 inhibits the reaction [TNF protein results in increased phosphorylation of MYL9 protein]; Y 27632 promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
Y 27632 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of TNF mRNA]; Y 27632 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of TNF protein]; Y 27632 promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]; Y 27632 promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]; Y 27632 promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of NOS2 mRNA]
Y 27632 results in decreased activity of TNF protein		 CTD PMID:12799187 PMID:15034928 PMID:17560598 PMID:17729120 PMID:28743511 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression ISO Y 27632 results in decreased expression of TNFSF10 mRNA CTD PMID:20878077 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tp53 tumor protein p53 affects response to substance
multiple interactions
decreases expression
increases expression		 ISO TP53 protein affects the susceptibility to Y 27632
TP53 protein promotes the reaction [Y 27632 results in decreased susceptibility to Cisplatin]; Y 27632 inhibits the reaction [Cisplatin results in increased expression of TP53 mRNA]
Y 27632 results in decreased expression of TP53 mRNA
Y 27632 results in increased expression of TP53 protein		 CTD PMID:11839765 PMID:20878077 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 multiple interactions ISO Y 27632 inhibits the reaction [Oxygen deficiency results in increased expression of TRPC1 protein] CTD PMID:30831131 NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions ISO Y 27632 inhibits the reaction [Oxygen deficiency results in increased expression of TRPC6 protein] CTD PMID:30831131 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
G Vim vimentin multiple interactions ISO Y 27632 inhibits the reaction [TNF protein affects the localization of and results in increased cleavage of VIM protein]; Y 27632 inhibits the reaction [TNF protein affects the localization of VIM protein modified form]
Y 27632 inhibits the reaction [Soot results in increased expression of VIM mRNA]; Y 27632 inhibits the reaction [Soot results in increased expression of VIM protein]		 CTD PMID:28743511 PMID:33792148 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Xpa XPA, DNA damage recognition and repair factor increases expression ISO Y 27632 results in increased expression of XPA mRNA CTD PMID:20878077 NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726 		JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor increases expression ISO Y 27632 results in increased expression of XPC mRNA CTD PMID:20878077 NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      application 19630
        NMR chemical shift reference compound 17936
          ammonia 17795
            organic amino compound 17795
              primary amino compound 9297
                Y-27632 128
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carboxylic acid 18594
                                      carboacyl group 17675
                                        univalent carboacyl group 17675
                                          carbamoyl group 17524
                                            carboxamide 17547
                                              monocarboxylic acid amide 15660
                                                Y-27632 128
paths to the root