Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Y-27632
go back to main search page
Accession:CHEBI:75393 term browser browse the term
Definition:A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It has been shown to exhibit inhibitory activity against Rho-associated protein kinase (ROCK) enzyme.
Synonyms:exact_synonym: trans-4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexanecarboxamide
 related_synonym: (R)-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide;   4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-1-carboxamide;   Formula=C14H21N3O;   InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1;   InChIKey=IYOZTVGMEWJPKR-IJLUTSLNSA-N;   SMILES=C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1
 xref: CAS:146986-50-7;   DrugBank:DB08756
 xref_mesh: MESH:C108830
 xref: PMID:10686302;   PMID:10973620;   PMID:17105828;   PMID:17157292;   PMID:17428993;   Reaxys:9134889;   Wikipedia:Y-27632


show annotations for term's descendants           Sort by:
 
Y-27632 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL1A1 mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL1A2 mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL3A1 mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL4A1 mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL5A1 mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL6A1 mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of ELN mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of FN1 mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of MMP14 mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of MMP2 mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of PDGFB mRNA]; Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of TGFB1 mRNA] CTD PMID:30682444 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO Y 27632 results in increased expression of ABCC2 mRNA CTD PMID:20878077 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression
ISO
EXP
Y 27632 inhibits the reaction [Oxygen results in increased expression of ACTA2 mRNA]; Y 27632 inhibits the reaction [Oxygen results in increased expression of ACTA2 protein]
Y 27632 results in decreased expression of ACTA2 mRNA
Y 27632 inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
CTD PMID:11035001, PMID:13678700, PMID:23517783 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases activity
increases expression
ISO Y 27632 results in increased activity of AKT1 protein
Y 27632 results in increased expression of AKT1 mRNA
CTD PMID:17322126 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases secretion
affects cleavage
ISO
EXP
ROCK1 protein affects the reaction [Y 27632 affects the cleavage of APP protein]
Y 27632 results in increased secretion of APP protein modified form
Y 27632 inhibits the reaction [aluminum maltolate results in decreased expression of and results in decreased secretion of APP protein modified form]
CTD PMID:14615541, PMID:19741129, PMID:20395307 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arhgef17 Rho guanine nucleotide exchange factor 17 multiple interactions ISO Y 27632 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of ARHGEF17 protein] CTD PMID:23195829 Ensembl chr 1:165,911,718...165,967,069 JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 increases expression ISO Y 27632 results in increased expression of ATP1B2 mRNA CTD PMID:20878077 NCBI chr10:56,205,622...56,211,879
Ensembl chr10:56,205,625...56,211,891
JBrowse link
G Atp5f1d ATP synthase F1 subunit delta multiple interactions EXP Y 27632 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in decreased expression of ATP5F1D protein] CTD PMID:25305180 NCBI chr 7:12,426,807...12,432,120
Ensembl chr 7:12,426,809...12,432,130
JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression
multiple interactions
ISO Y 27632 results in decreased expression of BAD mRNA
Y 27632 inhibits the reaction [Cisplatin results in increased expression of BAD mRNA]
CTD PMID:20878077 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO Y 27632 inhibits the reaction [Cisplatin results in decreased expression of BCL2 mRNA]
Y 27632 results in increased expression of BCL2 mRNA
CTD PMID:20878077 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bik BCL2-interacting killer multiple interactions
decreases expression
ISO Y 27632 inhibits the reaction [Cisplatin results in increased expression of BIK mRNA]
Y 27632 results in decreased expression of BIK mRNA
CTD PMID:20878077 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Y 27632 inhibits the reaction [Asbestos, Crocidolite results in increased secretion of CASP1 protein modified form]; Y 27632 inhibits the reaction [Nanotubes, Carbon results in increased secretion of CASP1 protein modified form] CTD PMID:24760326 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
Y 27632 inhibits the reaction [1-Butanol results in increased activity of and results in increased cleavage of CASP3 protein]; Y 27632 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased cleavage of CASP3 protein]
Y 27632 inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]
CTD PMID:22564901, PMID:25305180, PMID:28743511 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Y 27632 inhibits the reaction [TNF protein results in increased cleavage of CASP8 protein] CTD PMID:28743511 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Y 27632 inhibits the reaction [1-Butanol results in increased activity of and results in increased cleavage of CASP9 protein] CTD PMID:22564901 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP Y 27632 inhibits the reaction [lysophosphatidic acid results in increased expression of CCN2 protein] CTD PMID:15200425 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
EXP Y 27632 promotes the reaction [EGF protein results in increased expression of CCND1 protein]
Y 27632 results in increased expression of CCND1 mRNA
CTD PMID:16799973, PMID:20578043 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdh1 cadherin 1 decreases activity ISO Y 27632 results in decreased activity of CDH1 protein CTD PMID:16030252 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression EXP Y 27632 results in decreased expression of CDK4 mRNA CTD PMID:20578043 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
multiple interactions
ISO Y 27632 results in decreased expression of CDKN1A mRNA
Y 27632 inhibits the reaction [Cisplatin results in increased expression of CDKN1A mRNA]
CTD PMID:20878077 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP Y 27632 results in increased expression of CDKN1B mRNA CTD PMID:20578043 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cfl1 cofilin 1 decreases phosphorylation
decreases expression
EXP
ISO
Y 27632 results in decreased phosphorylation of CFL1 protein
Y 27632 results in decreased expression of CFL1 protein modified form
CTD PMID:17138966, PMID:20610540 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Y 27632 results in increased activity of and results in increased phosphorylation of CHUK protein CTD PMID:17322126 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Col17a1 collagen type XVII alpha 1 chain affects localization ISO Y 27632 affects the localization of COL17A1 protein CTD PMID:14691950 NCBI chr 1:267,416,681...267,465,049
Ensembl chr 1:267,417,459...267,463,705
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL1A1 mRNA]; Y 27632 inhibits the reaction [Oxygen results in increased expression of COL1A1 mRNA] CTD PMID:21439370, PMID:23517783, PMID:30682444 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO Y 27632 inhibits the reaction [Oxygen results in increased expression of COL1A2 mRNA]
Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL1A2 mRNA]; Y 27632 inhibits the reaction [Oxygen results in increased expression of COL1A2 mRNA]
CTD PMID:21439370, PMID:23517783, PMID:30682444 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL3A1 mRNA] CTD PMID:30682444 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions ISO Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL4A1 mRNA] CTD PMID:30682444 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Col5a1 collagen type V alpha 1 chain multiple interactions ISO Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL5A1 mRNA] CTD PMID:30682444 NCBI chr 3:6,430,180...6,581,010
Ensembl chr 3:6,430,201...6,578,882
JBrowse link
G Col6a1 collagen type VI alpha 1 chain multiple interactions ISO Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL6A1 mRNA] CTD PMID:30682444 NCBI chr20:12,657,913...12,676,370
Ensembl chr20:12,658,065...12,675,561
JBrowse link
G Ctsb cathepsin B multiple interactions ISO Y 27632 inhibits the reaction [Asbestos, Crocidolite results in increased secretion of CTSB protein modified form]; Y 27632 inhibits the reaction [Nanotubes, Carbon results in increased secretion of CTSB protein modified form] CTD PMID:24760326 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO Y 27632 inhibits the reaction [CXCL12 protein results in increased phosphorylation of MYL9 protein] CTD PMID:11751986 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Dst dystonin affects localization ISO Y 27632 affects the localization of DST protein CTD PMID:14691950 NCBI chr 9:37,902,336...38,296,961
Ensembl chr 9:37,902,303...38,196,273
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Y 27632 inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA] CTD PMID:11739382 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egf epidermal growth factor multiple interactions EXP Y 27632 promotes the reaction [EGF protein results in increased expression of CCND1 protein] CTD PMID:16799973 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Eln elastin multiple interactions ISO Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of ELN mRNA] CTD PMID:30682444 NCBI chr12:24,978,478...25,021,864
Ensembl chr12:24,978,483...25,021,863
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit increases expression ISO Y 27632 results in increased expression of ERCC1 mRNA CTD PMID:20878077 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198
JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit increases expression ISO Y 27632 results in increased expression of XPD mRNA CTD PMID:20878077 NCBI chr 1:80,293,574...80,307,334
Ensembl chr 1:80,293,566...80,307,344
JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease increases expression ISO Y 27632 results in increased expression of ERCC5 mRNA CTD PMID:20878077 NCBI chr 9:50,928,847...50,970,962
Ensembl chr 9:50,925,619...50,970,955
JBrowse link
G Ezr ezrin increases phosphorylation EXP Y 27632 deficiency results in increased phosphorylation of EZR protein CTD PMID:14732730 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G F2 coagulation factor II multiple interactions
decreases activity
ISO Y 27632 inhibits the reaction [F2 protein results in increased phosphorylation of MYL9 protein]
[Y 27632 results in decreased activity of ROCK1 protein] which results in decreased activity of F2 protein
CTD PMID:15284075, PMID:16675616 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Y 27632 inhibits the reaction [Cisplatin results in increased expression of FAS mRNA] CTD PMID:20878077 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand decreases expression
multiple interactions
ISO Y 27632 results in decreased expression of FASLG mRNA
Y 27632 inhibits the reaction [Cisplatin results in increased expression of FASLG mRNA]
CTD PMID:20878077 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP
ISO
Y 27632 inhibits the reaction [Glucose results in increased expression of FN1 protein]
Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of FN1 mRNA]
CTD PMID:23376009, PMID:30682444 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Gata4 GATA binding protein 4 multiple interactions EXP Y 27632 inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein] CTD PMID:11739382 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Y 27632 inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Y 27632 promotes the reaction [cobaltous chloride affects the localization of HIF1A protein] CTD PMID:16772336, PMID:30831131 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO
EXP
Y 27632 inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]
Y 27632 inhibits the reaction [Glucose results in increased expression of ICAM1 protein]
CTD PMID:22226621, PMID:23376009 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO Y 27632 promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP Y 27632 inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; Y 27632 inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]] CTD PMID:15705589 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Y 27632 inhibits the reaction [Asbestos, Crocidolite results in increased expression of and results in increased secretion of IL1B protein]; Y 27632 inhibits the reaction [Nanotubes, Carbon results in increased expression of and results in increased secretion of IL1B protein]; Y 27632 promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187, PMID:24760326 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Y 27632 promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein] CTD PMID:17729120 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itga3 integrin subunit alpha 3 multiple interactions ISO Y 27632 affects the localization of [ITGA3 protein binds to ITGB1 protein] CTD PMID:14691950 NCBI chr10:82,855,841...82,887,755
Ensembl chr10:82,855,613...82,887,497
JBrowse link
G Itga6 integrin subunit alpha 6 multiple interactions ISO Y 27632 affects the localization of [ITGA6 protein binds to ITGB4 protein] CTD PMID:14691950 NCBI chr 3:58,442,904...58,515,124
Ensembl chr 3:58,443,101...58,515,124
JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO Y 27632 affects the localization of [ITGA3 protein binds to ITGB1 protein] CTD PMID:14691950 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Itgb4 integrin subunit beta 4 multiple interactions ISO Y 27632 affects the localization of [ITGA6 protein binds to ITGB4 protein] CTD PMID:14691950 NCBI chr10:104,524,000...104,560,180
Ensembl chr10:104,523,996...104,561,078
JBrowse link
G Kirrel1 kirre like nephrin family adhesion molecule 1 multiple interactions ISO Y 27632 inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of KIRREL mRNA] CTD PMID:18367845 NCBI chr 2:186,420,743...186,515,209
Ensembl chr 2:186,420,795...186,515,135
JBrowse link
G Lama3 laminin subunit alpha 3 affects localization ISO Y 27632 affects the localization of LAMA3 protein CTD PMID:14691950 NCBI chr18:3,704,866...3,941,215
Ensembl chr18:3,705,916...3,940,838
JBrowse link
G Limk1 LIM domain kinase 1 decreases expression ISO Y 27632 results in decreased expression of LIMK1 protein modified form CTD PMID:17138966 NCBI chr12:25,036,630...25,070,538
Ensembl chr12:25,036,605...25,070,539
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Y 27632 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD PMID:11739382, PMID:22226621 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Y 27632 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein] CTD PMID:22226621 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
Y 27632 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:11739382, PMID:22226621 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP Y 27632 inhibits the reaction [methylmercuric chloride results in decreased expression of MAPT protein] CTD PMID:20869980 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mbp myelin basic protein increases expression EXP Y 27632 results in increased expression of MBP mRNA CTD PMID:20578043 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions ISO Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of MMP14 mRNA] CTD PMID:30682444 NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions
ISO [Y 27632 results in decreased expression of RHOA protein] which results in decreased expression of MMP2 protein
Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of MMP2 mRNA]
CTD PMID:19896475, PMID:30682444 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO Y 27632 inhibits the reaction [4-cresol results in increased expression of MMP9 protein]; Y 27632 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]
[Y 27632 results in decreased expression of RHOA protein] which results in decreased expression of MMP9 protein
CTD PMID:15728660, PMID:19896475, PMID:30910523 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Msn moesin increases phosphorylation
multiple interactions
EXP Y 27632 deficiency results in increased phosphorylation of MSN protein
Y 27632 inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MSN protein]
CTD PMID:14732730, PMID:30783172 NCBI chr  X:65,226,834...65,294,192
Ensembl chr  X:65,226,748...65,295,810
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [Everolimus co-treated with Y 27632] inhibits the reaction [4-cresol results in increased phosphorylation of MTOR protein]; Y 27632 inhibits the reaction [4-cresol results in increased phosphorylation of MTOR protein] CTD PMID:30910523 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myh2 myosin heavy chain 2 affects localization ISO Y 27632 affects the localization of MYH2 protein CTD PMID:16030252 NCBI chr10:53,711,895...53,738,164
Ensembl chr10:53,713,938...53,848,347
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Y 27632 inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA] CTD PMID:11739382 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Myl7 myosin light chain 7 multiple interactions
decreases phosphorylation
ISO Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]
Y 27632 results in decreased phosphorylation of MYL7 protein
CTD PMID:15621049 NCBI chr14:86,144,770...86,147,075
Ensembl chr14:86,143,862...86,147,553
JBrowse link
G Myl9 myosin light chain 9 multiple interactions
decreases phosphorylation
ISO
EXP
Y 27632 inhibits the reaction [CXCL12 protein results in increased phosphorylation of MYL9 protein]; Y 27632 inhibits the reaction [F2 protein results in increased phosphorylation of MYL9 protein]; Y 27632 inhibits the reaction [TNF protein results in increased phosphorylation of MYL9 protein]
Y 27632 inhibits the reaction [[Escin affects the susceptibility to Calcium] which results in increased phosphorylation of MYL9 protein]; Y 27632 inhibits the reaction [[Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased phosphorylation of MYL9 protein]
Y 27632 results in decreased phosphorylation of MYL9 protein
CTD PMID:11751986, PMID:12745062, PMID:15034928, PMID:15284075, PMID:29660437 NCBI chr 3:152,857,573...152,863,961
Ensembl chr 3:152,857,592...152,863,960
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Y 27632 inhibits the reaction [arsenic trioxide results in increased phosphorylation of and affects the localization of NCF1 protein] CTD PMID:18424721 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization ISO Y 27632 affects the localization of NFKB1 protein CTD PMID:17322126 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP
Y 27632 results in decreased expression of and results in increased phosphorylation of NFKBIA protein
Y 27632 inhibits the reaction [Glucose results in decreased expression of NFKBIA protein]
CTD PMID:17322126, PMID:23376009 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Y 27632 promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
Y 27632 inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]
Y 27632 promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of NOS2 mRNA]
CTD PMID:12799187, PMID:15705589, PMID:17729120 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases phosphorylation
ISO Mevalonic Acid inhibits the reaction [Y 27632 results in increased phosphorylation of NOS3 protein] CTD PMID:17322126 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP Y 27632 inhibits the reaction [lysophosphatidic acid results in increased expression of NPPA protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of NPPA protein] CTD PMID:11739382, PMID:25449040 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 decreases expression ISO Y 27632 results in decreased expression of NR4A3 mRNA CTD PMID:16005304 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression
ISO Mevalonic Acid inhibits the reaction [Y 27632 results in increased expression of PCNA protein] CTD PMID:17322126 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of PDGFB mRNA] CTD PMID:30682444 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions EXP Y 27632 inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA] CTD PMID:30783172 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pkn2 protein kinase N2 decreases activity ISO Y 27632 results in decreased activity of PKN2 protein CTD PMID:10998351 NCBI chr 2:248,735,699...248,840,735
Ensembl chr 2:248,735,699...248,840,735
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP Y 27632 results in increased expression of PPARG mRNA CTD PMID:20578043 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions ISO
EXP
Y 27632 inhibits the reaction [Puromycin Aminonucleoside results in increased phosphorylation of PPP1R12A protein]
Y 27632 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased phosphorylation of PPP1R12A protein]; Y 27632 inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of PPP1R12A protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]
CTD PMID:18367845, PMID:25305180, PMID:25449040 NCBI chr 7:51,404,971...51,515,382
Ensembl chr 7:51,404,919...51,515,373
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions ISO Y 27632 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of ARHGEF17 protein] CTD PMID:23195829 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Rac1 Rac family small GTPase 1 increases activity EXP Y 27632 results in increased activity of RAC1 protein CTD PMID:12105187 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rdx radixin decreases phosphorylation EXP Y 27632 results in decreased phosphorylation of RDX protein CTD PMID:14732730 NCBI chr 8:56,570,728...56,612,851
Ensembl chr 8:56,585,396...56,610,612
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
ISO
EXP
Y 27632 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]
Y 27632 affects the localization of RELA protein
Y 27632 inhibits the reaction [Glucose affects the localization of RELA protein]
CTD PMID:17322126, PMID:22226621, PMID:23376009 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhoa ras homolog family member A decreases expression
multiple interactions
ISO [Y 27632 results in decreased expression of RHOA protein] which results in decreased expression of MMP2 protein; [Y 27632 results in decreased expression of RHOA protein] which results in decreased expression of MMP9 protein; Y 27632 results in decreased expression of RHOA protein
[Everolimus co-treated with Y 27632] inhibits the reaction [4-cresol results in increased expression of RHOA protein]; Y 27632 inhibits the reaction [4-cresol results in increased expression of RHOA protein]
CTD PMID:19896475, PMID:30910523 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases activity
multiple interactions
ISO [Y 27632 results in decreased activity of ROCK1 protein] which results in decreased activity of F2 protein
ROCK1 protein affects the reaction [Y 27632 affects the cleavage of APP protein]
CTD PMID:14615541, PMID:16675616 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 decreases activity
multiple interactions
EXP Y 27632 results in decreased activity of ROCK2 protein
Y 27632 inhibits the reaction [Carbon Tetrachloride results in increased expression of ROCK2 mRNA]
CTD PMID:10998351, PMID:30783172 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 decreases activity ISO Y 27632 results in decreased activity of RPS6KA3 protein CTD PMID:10998351 NCBI chr  X:37,469,736...37,576,055
Ensembl chr  X:37,469,937...37,575,624
JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 decreases activity ISO Y 27632 results in decreased activity of RPS6KA5 protein CTD PMID:10998351 NCBI chr 6:124,557,892...124,735,787
Ensembl chr 6:124,557,913...124,735,778
JBrowse link
G Rs1 retinoschisin 1 increases secretion ISO Y 27632 results in increased secretion of RS1 protein CTD PMID:21738583 NCBI chr  X:35,749,957...35,777,243
Ensembl chr  X:35,749,957...35,777,243
JBrowse link
G Scn7a sodium voltage-gated channel alpha subunit 7 multiple interactions EXP Y 27632 inhibits the reaction [Carbon Tetrachloride results in increased expression of SCN7A mRNA] CTD PMID:13678700 NCBI chr 3:52,775,779...52,877,365
Ensembl chr 3:52,777,214...52,849,907
JBrowse link
G Slc12a2 solute carrier family 12 member 2 increases expression ISO Y 27632 results in increased expression of SLC12A2 protein CTD PMID:21474433 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
JBrowse link
G Slc31a1 solute carrier family 31 member 1 decreases expression ISO Y 27632 results in decreased expression of SLC31A1 mRNA CTD PMID:20878077 NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358
JBrowse link
G Sox10 SRY-box transcription factor 10 increases expression EXP Y 27632 results in increased expression of SOX10 mRNA CTD PMID:20578043 NCBI chr 7:120,393,238...120,403,523
Ensembl chr 7:120,393,254...120,403,523
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Y 27632 inhibits the reaction [Glucose results in increased cleavage of SREBF1 protein] CTD PMID:22031849 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Tagln transgelin decreases expression EXP Y 27632 results in decreased expression of TAGLN mRNA CTD PMID:11035001 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO
Y 27632 inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Y 27632 inhibits the reaction [Glucose results in increased expression of TGFB1 protein]
Y 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of TGFB1 mRNA]
CTD PMID:13678700, PMID:23376009, PMID:30682444 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO [cobaltous chloride co-treated with Y 27632] results in increased expression of TH protein CTD PMID:16772336 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity
ISO Y 27632 inhibits the reaction [TNF protein affects the localization of and results in increased cleavage of VIM protein]; Y 27632 inhibits the reaction [TNF protein affects the localization of VIM protein modified form]; Y 27632 inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]; Y 27632 inhibits the reaction [TNF protein results in increased cleavage of CASP8 protein]; Y 27632 inhibits the reaction [TNF protein results in increased phosphorylation of MYL9 protein]; Y 27632 promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
Y 27632 results in decreased activity of TNF protein
Y 27632 promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]; Y 27632 promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]; Y 27632 promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of NOS2 mRNA]
CTD PMID:12799187, PMID:15034928, PMID:17560598, PMID:17729120, PMID:28743511 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression ISO Y 27632 results in decreased expression of TNFSF10 mRNA CTD PMID:20878077 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tp53 tumor protein p53 affects response to substance
increases expression
decreases expression
multiple interactions
ISO TP53 protein affects the susceptibility to Y 27632
Y 27632 results in increased expression of TP53 protein
Y 27632 results in decreased expression of TP53 mRNA
TP53 protein promotes the reaction [Y 27632 results in decreased susceptibility to Cisplatin]; Y 27632 inhibits the reaction [Cisplatin results in increased expression of TP53 mRNA]
CTD PMID:11839765, PMID:20878077 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 multiple interactions ISO Y 27632 inhibits the reaction [Oxygen deficiency results in increased expression of TRPC1 protein] CTD PMID:30831131 NCBI chr 8:103,503,982...103,554,905
Ensembl chr 8:103,503,985...103,554,468
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions ISO Y 27632 inhibits the reaction [Oxygen deficiency results in increased expression of TRPC6 protein] CTD PMID:30831131 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link
G Vim vimentin multiple interactions ISO Y 27632 inhibits the reaction [TNF protein affects the localization of and results in increased cleavage of VIM protein]; Y 27632 inhibits the reaction [TNF protein affects the localization of VIM protein modified form] CTD PMID:28743511 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Xpa XPA, DNA damage recognition and repair factor increases expression ISO Y 27632 results in increased expression of XPA mRNA CTD PMID:20878077 NCBI chr 5:61,749,767...61,793,641
Ensembl chr 5:61,749,767...61,792,928
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor increases expression ISO Y 27632 results in increased expression of XPC mRNA CTD PMID:20878077 NCBI chr 4:123,134,457...123,161,985
Ensembl chr 4:123,134,457...123,161,985
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        refrigerant 17444
          ammonia 16963
            organic amino compound 16962
              primary amino compound 7874
                Y-27632 111
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        carboacyl group 17369
                                          univalent carboacyl group 17369
                                            carbamoyl group 17156
                                              carboxamide 17156
                                                monocarboxylic acid amide 14573
                                                  Y-27632 111
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.