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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:blebbistatin
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Accession:CHEBI:75379 term browser browse the term
Definition:A pyrroloquinoline that is 1,2,3,3a-tetrahydro-H-pyrrolo[2,3-b]quinolin-4-one substituted by a hydroxy group at position 3a, a methyl group at position 6 and a phenyl group at position 1. It acts as an inhibitor of ATPase activity of non-muscle myosin II.
Synonyms:exact_synonym: 3a-hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
 related_synonym: Formula=C18H16N2O2;   InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3;   InChIKey=LZAXPYOBKSJSEX-UHFFFAOYSA-N;   SMILES=Cc1ccc2N=C3N(CCC3(O)C(=O)c2c1)c1ccccc1
 xref: CAS:674289-55-5;   LINCS:LSM-6195
 xref_mesh: MESH:C472645
 xref: PMID:15205456;   PMID:15240150;   PMID:15641783;   PMID:17994251;   PMID:20498707;   PMID:20956482;   PMID:21593446;   PMID:22507270;   PMID:22990759;   PMID:23291912;   PMID:23315199;   PMID:24662474;   Reaxys:10016269


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blebbistatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcar1 BCAR1 scaffold protein, Cas family member decreases phosphorylation ISO blebbistatin results in decreased phosphorylation of BCAR1 protein CTD PMID:18718759 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Cdh1 cadherin 1 affects localization
decreases activity 		ISO blebbistatin affects the localization of CDH1 protein
blebbistatin results in decreased activity of CDH1 protein 		CTD PMID:16030252 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression 		ISO [blebbistatin results in decreased activity of MYH9 protein] promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
blebbistatin results in increased expression of CYP1A1 mRNA 		CTD PMID:21216307 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Itgb1 integrin subunit beta 1 decreases activity ISO blebbistatin results in decreased activity of ITGB1 protein CTD PMID:16723733 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Myh2 myosin heavy chain 2 decreases activity ISO blebbistatin results in decreased activity of MYH2 protein CTD PMID:16030252 NCBI chr10:51,856,738...51,883,236
Ensembl chr10:51,856,738...51,883,236 		JBrowse link
G Myh9 myosin, heavy chain 9 decreases activity
multiple interactions 		ISO blebbistatin results in decreased activity of MYH9 protein
[blebbistatin results in decreased activity of MYH9 protein] promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] 		CTD PMID:21216307 NCBI chr 7:111,224,291...111,304,963
Ensembl chr 7:109,343,706...109,424,457 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO blebbistatin results in decreased phosphorylation of PTK2 protein CTD PMID:18718759 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      biological role 20814
        inhibitor 19474
          blebbistatin 7
            (R)-blebbistatin 0
            (S)-blebbistatin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbonyl compound 19435
                                    ketone 17451
                                      alpha-hydroxy ketone 8950
                                        tertiary alpha-hydroxy ketone 8653
                                          blebbistatin 7
                                            (R)-blebbistatin 0
                                            (S)-blebbistatin 0
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