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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cathartic
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Accession:CHEBI:75325 term browser browse the term
Definition:Any substance that accelerates defecation. Compare with laxatives, which are substances that ease defecation (usually by softening faeces). A substance can be both a laxative and a cathartic.
Synonyms:related_synonym: cathartics
 xref: Wikipedia:Cathartic



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castor oil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 increases expression
multiple interactions
EXP Castor Oil results in increased expression of PAFAH1B1 protein
isosorbide-5-mononitrate inhibits the reaction [Castor Oil results in increased expression of PAFAH1B1 protein]
CTD PMID:1354728 PMID:2743081 PMID:8738301 NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808
JBrowse link
D-glucitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions
increases abundance
ISO AKR1B1 protein promotes the reaction [Glucose results in increased abundance of Sorbitol]
AKR1B1 protein results in increased abundance of Sorbitol
CTD PMID:25451566 PMID:25541468 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO [Sorbitol co-treated with Calcimycin co-treated with Arachidonic Acid] affects the localization of ALOX5 protein; SB 203580 inhibits the reaction [Sorbitol results in increased activity of ALOX5 protein]; Sorbitol results in increased phosphorylation of and results in increased activity of ALOX5 protein CTD PMID:10779545 PMID:11698504 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Aqp9 aquaporin 9 multiple interactions
increases uptake
ISO
EXP
Sorbitol inhibits the reaction [AQP9 protein results in increased uptake of arsenite]
AQP9 protein results in increased uptake of Sorbitol
CTD PMID:9733774 PMID:19341753 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
EXP Sorbitol results in increased activity of CASP3 protein
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein]
CTD PMID:20609311 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
EXP Sorbitol results in increased activity of CASP8 protein
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]
CTD PMID:20609311 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
EXP Sorbitol results in increased activity of CASP9 protein
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein]
CTD PMID:20609311 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Crk CRK proto-oncogene, adaptor protein increases phosphorylation EXP Sorbitol results in increased phosphorylation of CRK protein CTD PMID:16187300 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO Sorbitol promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] CTD PMID:9545260 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Sorbitol promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] CTD PMID:9545260 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Fmr1 FMRP translational regulator 1 increases abundance ISO FMR1 5' UTR mutant form results in increased abundance of Sorbitol CTD PMID:27385396 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050
JBrowse link
G Mapk10 mitogen activated protein kinase 10 multiple interactions
increases activity
ISO Dicumarol inhibits the reaction [Sorbitol results in increased activity of MAPK10 protein] CTD PMID:10531305 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
JBrowse link
G Mapk12 mitogen-activated protein kinase 12 increases phosphorylation ISO Sorbitol results in increased phosphorylation of MAPK12 protein CTD PMID:15362974 NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation ISO Sorbitol results in increased phosphorylation of MAPK14 protein CTD PMID:15362974 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk7 mitogen-activated protein kinase 7 increases activity ISO Sorbitol results in increased activity of MAPK7 protein CTD PMID:11163183 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 increases activity
increases phosphorylation
multiple interactions
ISO Sorbitol results in increased activity of MAPKAPK2 protein
Sorbitol results in increased phosphorylation of MAPKAPK2 protein
SB 203580 inhibits the reaction [Sorbitol results in increased phosphorylation of MAPKAPK2 protein]
CTD PMID:9545260 PMID:15362974 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
JBrowse link
G Mknk1 MAPK interacting serine/threonine kinase 1 increases activity ISO Sorbitol results in increased activity of MKNK1 protein CTD PMID:9545260 NCBI chr 5:129,318,128...129,357,641
Ensembl chr 5:129,318,170...129,357,639
JBrowse link
G Oat ornithine aminotransferase multiple interactions EXP Sorbitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
JBrowse link
G Pten phosphatase and tensin homolog affects localization ISO
EXP
Sorbitol affects the localization of PTEN protein CTD PMID:16807353 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Sord sorbitol dehydrogenase multiple interactions
increases abundance
increases metabolic processing
ISO [SORD protein results in increased metabolism of Sorbitol] which results in increased abundance of Fructose; epalrestat inhibits the reaction [SORD protein mutant form results in increased abundance of Sorbitol]; ranirestat inhibits the reaction [SORD protein mutant form results in increased abundance of Sorbitol] CTD PMID:32367058 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133
JBrowse link
G Tardbp TAR DNA binding protein increases ubiquitination ISO Sorbitol results in increased ubiquitination of TARDBP protein CTD PMID:31780563 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
JBrowse link
G Ubxn1 UBX domain protein 1 increases phosphorylation ISO Sorbitol results in increased phosphorylation of UBXN1 protein CTD PMID:15362974 NCBI chr 1:205,765,212...205,769,236
Ensembl chr 1:205,745,120...205,816,520
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        biophysical role 13085
          cathartic 22
            D-glucitol + 21
            castor oil 1
            lactitol + 0
            magnesium sulfate heptahydrate 0
            naloxegol 0
            sennoside 0
            sennosides + 0
            sodium sulfate decahydrate 0
paths to the root