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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:excipient
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Accession:CHEBI:75324 term browser browse the term
Definition:A generally pharmacologically inactive substance that is formulated with the active ingredient of a medication.
Synonyms:related_synonym: bulking agent;   bulking agents;   filler;   fillers
 xref: PMID:19709488;   PMID:21086329;   PMID:22707004;   PMID:22877709;   PMID:23450581;   PMID:23525964;   PMID:23657359;   Wikipedia:Excipient


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kaolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F11 coagulation factor XI decreases activity ISO Kaolin results in decreased activity of F11 protein CTD PMID:6604052 NCBI chr 8:45,693,696...45,715,092
Ensembl chr 8:45,694,211...45,715,068 		JBrowse link
G F12 coagulation factor XII (Hageman factor) increases activity ISO Kaolin results in increased activity of F12 protein CTD PMID:6343536 NCBI chr13:55,565,771...55,574,617
Ensembl chr13:55,565,771...55,574,606 		JBrowse link
tyloxapol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO tyloxapol results in decreased activity of ACHE protein CTD PMID:37749825 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Alb albumin multiple interactions
decreases expression		 EXP Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of ALB mRNA]; ferulic acid inhibits the reaction [tyloxapol results in decreased expression of ALB mRNA]; naringenin inhibits the reaction [tyloxapol results in decreased expression of ALB mRNA] CTD PMID:37076581 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Atg5 autophagy related 5 decreases expression
multiple interactions		 EXP tyloxapol results in decreased expression of ATG5 protein
Escin inhibits the reaction [tyloxapol results in decreased expression of ATG5 protein]		 CTD PMID:36905866 NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287 		JBrowse link
G Atg7 autophagy related 7 decreases expression
multiple interactions		 EXP tyloxapol results in decreased expression of ATG7 protein
Escin inhibits the reaction [tyloxapol results in decreased expression of ATG7 protein]; Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of ATG7 protein]		 CTD PMID:36905866 NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575 		JBrowse link
G Bche butyrylcholinesterase increases activity ISO tyloxapol results in increased activity of BCHE protein CTD PMID:37749825 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748 		JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions
decreases expression		 EXP Escin inhibits the reaction [tyloxapol results in decreased expression of BECN1 protein]; Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of BECN1 protein] CTD PMID:36905866 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
decreases expression		 EXP Escin inhibits the reaction [tyloxapol results in decreased expression of GCLC protein]; Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of GCLC protein] CTD PMID:36905866 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble increases expression
multiple interactions		 EXP tyloxapol results in increased expression of GPT protein
Escin inhibits the reaction [tyloxapol results in increased expression of GPT protein]; Fenofibrate inhibits the reaction [tyloxapol results in increased expression of GPT protein]		 CTD PMID:36905866 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gsr glutathione reductase decreases activity ISO tyloxapol results in decreased activity of GSR protein CTD PMID:37749825 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 EXP tyloxapol results in increased expression of IL6 mRNA
Fenofibrate inhibits the reaction [tyloxapol results in increased expression of IL6 mRNA]; ferulic acid inhibits the reaction [tyloxapol results in increased expression of IL6 mRNA]; naringenin inhibits the reaction [tyloxapol results in increased expression of IL6 mRNA]		 CTD PMID:37076581 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 increases expression
multiple interactions		 EXP tyloxapol results in increased expression of KEAP1 protein
Escin inhibits the reaction [tyloxapol results in increased expression of KEAP1 protein]; Fenofibrate inhibits the reaction [tyloxapol results in increased expression of KEAP1 protein]		 CTD PMID:36905866 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases lipidation		 EXP Escin inhibits the reaction [tyloxapol results in increased lipidation of MAP1LC3B protein]; Fenofibrate inhibits the reaction [tyloxapol results in increased lipidation of MAP1LC3B protein] CTD PMID:36905866 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO tyloxapol results in decreased activity of PON1 protein CTD PMID:37749825 NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases expression		 EXP Escin inhibits the reaction [tyloxapol results in decreased expression of PPARA protein] CTD PMID:36905866 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions		 EXP tyloxapol results in increased expression of SQSTM1 protein
Escin inhibits the reaction [tyloxapol results in increased expression of SQSTM1 protein]; Fenofibrate inhibits the reaction [tyloxapol results in increased expression of SQSTM1 protein]		 CTD PMID:36905866 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
increases expression		 EXP Escin inhibits the reaction [tyloxapol results in increased expression of SREBF1 protein]; Fenofibrate inhibits the reaction [tyloxapol results in increased expression of SREBF1 protein] CTD PMID:36905866 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 EXP tyloxapol results in increased expression of TNF mRNA
ferulic acid inhibits the reaction [tyloxapol results in increased expression of TNF mRNA]; naringenin inhibits the reaction [tyloxapol results in increased expression of TNF mRNA]		 CTD PMID:37076581 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression		 EXP ferulic acid inhibits the reaction [tyloxapol results in increased expression of VEGFA mRNA]; naringenin inhibits the reaction [tyloxapol results in increased expression of VEGFA mRNA] CTD PMID:37076581 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      application 21744
        excipient 20
          1,3-dioctanoylglycerol 0
          isomalt 0
          kaolin 2
          lactitol + 0
          tyloxapol 18
paths to the root