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ONTOLOGY REPORT - ANNOTATIONS


Term:tomelukast
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Accession:CHEBI:75310 term browser browse the term
Definition:A member of the class of acetophenones that is 1-phenylethanone substituted at position 2 by a hydroxy group, a propyl group at position 3 and a 4-(1H-tetrazol-5-yl)butoxy group at position 4. A leukotriene antagonist, it exhibits anti-asthmatic activity.
Synonyms:exact_synonym: 1-{2-hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl}ethanone
 related_synonym: 2'-hydroxy-3'-propyl-4'-(4-(1H-tetrazol-5-yl)butoxy)acetophenone;   Formula=C16H22N4O3;   InChI=1S/C16H22N4O3/c1-3-6-13-14(9-8-12(11(2)21)16(13)22)23-10-5-4-7-15-17-19-20-18-15/h8-9,22H,3-7,10H2,1-2H3,(H,17,18,19,20);   InChIKey=MWYHLEQJTQJHSS-UHFFFAOYSA-N;   LY171883;   SMILES=CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O;   tomelukastum
 xref: CAS:88107-10-2 "ChemIDplus";   KEGG:D02851;   LINCS:LSM-3675
 xref_mesh: MESH:C044660
 xref: PMID:12429577 "Europe PMC";   PMID:18031150 "Europe PMC";   Reaxys:4238438 "Reaxys"


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tomelukast term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Cysltr1 cysteinyl leukotriene receptor 1 JBrowse link X 77,671,028 77,700,491 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Rxra retinoid X receptor alpha JBrowse link 3 6,272,560 6,295,354 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        anti-asthmatic agent 9177
          anti-asthmatic drug 8548
            tomelukast 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      ketone 15789
                                        methyl ketone 652
                                          acetophenones 139
                                            tomelukast 6
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