histamine releasing agent - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	histamine releasing agent	go back to main search page
Accession:	CHEBI:75298	browse the term
Definition:	Any substance that can induce the release of histamine from mast cells.
Synonyms:	related_synonym:	histamine releasing agents; histamine releasing compound; histamine releasing compounds; histamine releasing substance; histamine releasing substances

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Rat (14) Mouse (15) Human (15) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (15)

compound 48/80

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 2

increases secretion

p-Methoxy-N-methylphenethylamine results in increased secretion of CCL2 protein

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

C-X-C motif chemokine ligand 8

increases secretion

p-Methoxy-N-methylphenethylamine results in increased secretion of CXCL8 protein

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

G

glucuronidase beta

increases secretion

p-Methoxy-N-methylphenethylamine results in increased secretion of GUSB protein

NCBI chr 7:65,960,684...65,982,213
Ensembl chr 7:65,960,684...65,982,215

G

hexosaminidase subunit alpha

increases secretion
multiple interactions

p-Methoxy-N-methylphenethylamine results in increased secretion of HEXA protein
Apigenin inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased secretion of HEXA protein]

NCBI chr15:72,340,924...72,376,014
Ensembl chr15:72,340,924...72,376,420

G

hexosaminidase subunit beta

increases secretion

p-Methoxy-N-methylphenethylamine results in increased secretion of HEXB protein

NCBI chr 5:74,640,023...74,721,288
Ensembl chr 5:74,640,023...74,722,647

G

5-hydroxytryptamine receptor 1A

increases activity

p-Methoxy-N-methylphenethylamine results in increased activity of HTR1A protein

NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507

G

KIT proto-oncogene, receptor tyrosine kinase

affects response to substance

KIT protein affects the susceptibility to p-Methoxy-N-methylphenethylamine

NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,267...54,740,783

G

kininogen 1

decreases activity

p-Methoxy-N-methylphenethylamine results in decreased activity of KNG1 protein

NCBI chr 3:186,717,359...186,744,410
Ensembl chr 3:186,717,348...186,744,410

G

LCK proto-oncogene, Src family tyrosine kinase

multiple interactions
increases activity

atractylon inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; damnacanthal inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; pyeongwee-san extract inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]

NCBI chr 1:32,251,265...32,286,165
Ensembl chr 1:32,251,244...32,286,165

G

mitogen-activated protein kinase 1

multiple interactions
increases phosphorylation

epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK1 protein]

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

increases phosphorylation
multiple interactions

p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK3 protein
epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK3 protein]

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

MAS related GPR family member X2

affects response to substance

MRGPRX2 protein affects the susceptibility to p-Methoxy-N-methylphenethylamine

NCBI chr11:19,054,455...19,060,717
Ensembl chr11:19,054,455...19,060,717

G

nuclear receptor subfamily 3 group C member 1

decreases activity

p-Methoxy-N-methylphenethylamine results in decreased activity of NR3C1 protein

NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512

G

tumor necrosis factor

increases secretion

p-Methoxy-N-methylphenethylamine results in increased secretion of TNF protein

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

tryptase beta 2

increases secretion

p-Methoxy-N-methylphenethylamine results in increased secretion of TPSB2 protein

NCBI chr16:1,228,336...1,230,184
Ensembl chr16:1,227,272...1,232,757

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26041
role	25957
biological role	25936
biochemical role	25170
histamine releasing agent	15
compound 48/80	15
kinetensin	0
kinetensin (1-8)	0
kinetensin (1-8)(2+)	0
kinetensin(2+)	0

paths to the root