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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:compound 48/80
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Accession:CHEBI:75295 term browser browse the term
Definition:R1, R2 = H or CH2OH; n is normally between 1 and 10. An alternating copolymer resulting from the condensation of N,O-dimethyltyramine with formaldehyde. It is a potent histamine releasing agent, primarily from mast cells, with subsequent depletion of tissue histamine.
Synonyms:xref: CAS:4091-50-3;   CAS:94724-12-6
 xref_mesh: MESH:D003189
 xref: Reaxys:6080255;   Reaxys:8187333;   Reaxys:8388220;   pubmed:19886753;   pubmed:23272218;   pubmed:23468340;   pubmed:6085035
 chemrof_formula: (C11H15NO)n.C21H28N2O2R2
 chemrof_smiles: [1*]c1cc(CCNC)cc(Cc2cc(CCNC)cc(Cc3cc(CCNC)cc([2*])c3OC)c2OC)c1OC
 cyclic_relationship: has_functional_parent CHEBI:16842;   has_functional_parent CHEBI:75143


show annotations for term's descendants           Sort by:
compound 48/80 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of CCL2 protein CTD PMID:34826398 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Gusb glucuronidase, beta increases secretion EXP p-Methoxy-N-methylphenethylamine results in increased secretion of GUSB protein CTD PMID:9545557 NCBI chr12:32,337,281...32,350,838
Ensembl chr12:32,334,075...32,363,024 		JBrowse link
G Hexa hexosaminidase subunit alpha increases secretion
multiple interactions 		ISO p-Methoxy-N-methylphenethylamine results in increased secretion of HEXA protein
Apigenin inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased secretion of HEXA protein] 		CTD PMID:36350155 NCBI chr 8:68,832,524...68,857,462
Ensembl chr 8:68,809,615...68,859,560 		JBrowse link
G Hexb hexosaminidase subunit beta increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of HEXB protein CTD PMID:34774977 NCBI chr 2:30,218,608...30,238,771
Ensembl chr 2:30,218,608...30,238,771 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases activity EXP p-Methoxy-N-methylphenethylamine results in increased activity of HTR1A protein CTD PMID:16415902 NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:38,427,083...38,540,760 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase affects response to substance ISO KIT protein affects the susceptibility to p-Methoxy-N-methylphenethylamine CTD PMID:32871113 NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,903,033...32,978,812 		JBrowse link
G Kng1 kininogen 1 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of KNG1 protein CTD PMID:1371395 NCBI chr11:91,317,354...91,340,148
Ensembl chr11:91,317,355...91,340,148 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions
increases activity 		EXP atractylon inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; damnacanthal inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; pyeongwee-san extract inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein] CTD PMID:27553716 NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:147,172,642...147,201,267 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation 		ISO epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK1 protein] CTD PMID:29402411 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation 		ISO epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK3 protein] CTD PMID:29402411 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mrgprx2 MAS related GPR family member X2 affects response to substance ISO MRGPRX2 protein affects the susceptibility to p-Methoxy-N-methylphenethylamine CTD PMID:32871113 NCBI chr 1:107,252,467...107,271,809 JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of NR3C1 protein CTD PMID:7887964 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843 		JBrowse link
G Tnf tumor necrosis factor increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of TNF protein CTD PMID:34826398 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tpsb2 tryptase beta 2 increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of TPSB2 protein CTD PMID:34826398 NCBI chr10:14,886,310...14,888,102
Ensembl chr10:14,886,360...14,888,100 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        biochemical role 19888
          histamine releasing agent 14
            compound 48/80 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  group 20774
                    polyatomic entity 20745
                      macromolecule 8937
                        copolymer macromolecule 60
                          alternating copolymer 14
                            compound 48/80 14
paths to the root