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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phenanthridone
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Accession:CHEBI:75292 term browser browse the term
Definition:A member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity.
Synonyms:exact_synonym: phenanthridin-6(5H)-one
 related_synonym: 6-Phenanthridinol;   6-Phenanthridinone;   6-Phenanthridone;   Formula=C13H9NO;   InChI=1S/C13H9NO/c15-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)14-13/h1-8H,(H,14,15);   InChIKey=RZFVLEJOHSLEFR-UHFFFAOYSA-N;   SMILES=O=c1[nH]c2ccccc2c2ccccc12
 xref: CAS:1015-89-0;   LINCS:LSM-2229
 xref_mesh: MESH:C040601
 xref: PMID:11202649;   PMID:19447472;   PMID:2858381;   PMID:3464317;   PMID:6302951;   PMID:7672878;   Patent:US2478805;   Reaxys:140641


show annotations for term's descendants           Sort by:
phenanthridone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO phenanthridone inhibits the reaction [Methylnitronitrosoguanidine results in increased localization of AIFM1 protein] CTD PMID:15589979 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO [eprenetapopt co-treated with phenanthridone] results in increased cleavage of CASP7 protein CTD PMID:29416738 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [eprenetapopt co-treated with phenanthridone] results in increased cleavage of CASP9 protein CTD PMID:29416738 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO phenanthridone analog inhibits the reaction [endotoxin, Escherichia coli results in increased expression of CCL3 protein] CTD PMID:12006805 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Cd83 CD83 molecule decreases expression ISO phenanthridone results in decreased expression of CD83 mRNA; phenanthridone results in decreased expression of CD83 protein CTD PMID:17579050 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083 		JBrowse link
G Cd86 CD86 molecule decreases expression ISO phenanthridone results in decreased expression of CD86 mRNA; phenanthridone results in decreased expression of CD86 protein CTD PMID:17579050 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO phenanthridone analog inhibits the reaction [endotoxin, Escherichia coli results in increased expression of CXCL2 protein] CTD PMID:12006805 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions		 ISO phenanthridone results in increased expression of H2AX protein modified form
Acetylcysteine inhibits the reaction [phenanthridone results in increased expression of H2AX protein modified form]; TXNRD1 protein inhibits the reaction [phenanthridone results in increased expression of H2AX protein modified form]		 CTD PMID:29416738 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression		 EXP phenanthridone inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA]
phenanthridone results in decreased expression of IFNG mRNA		 CTD PMID:12411406 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO phenanthridone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] CTD PMID:17579050 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO phenanthridone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:17579050 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1b interleukin 1 beta decreases expression EXP phenanthridone results in decreased expression of IL1B mRNA CTD PMID:12411406 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 decreases expression
multiple interactions		 EXP phenanthridone results in decreased expression of IL2 mRNA
phenanthridone inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA]		 CTD PMID:12411406 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Kif18a kinesin family member 18A increases metabolic processing ISO phenanthridone results in increased metabolism of KIF18A protein CTD PMID:28209915 NCBI chr 3:95,764,388...95,824,756
Ensembl chr 3:95,764,388...95,824,582 		JBrowse link
G Kifc1 kinesin family member C1 increases metabolic processing ISO phenanthridone results in increased metabolism of KIFC1 protein CTD PMID:28209915 NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression EXP phenanthridone results in decreased expression of NOS2 mRNA CTD PMID:12411406 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases activity
multiple interactions		 EXP
ISO		 phenanthridone results in decreased activity of PARP1 protein
[eprenetapopt co-treated with phenanthridone] results in increased cleavage of PARP1 protein		 CTD PMID:12411406 PMID:29416738 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression EXP phenanthridone results in decreased expression of PTGS2 mRNA CTD PMID:12411406 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 EXP
ISO		 phenanthridone inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TNF mRNA]
phenanthridone results in decreased expression of TNF mRNA
phenanthridone analog inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]		 CTD PMID:12006805 PMID:12411406 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions
decreases expression		 ISO TXNRD1 protein inhibits the reaction [phenanthridone results in increased expression of H2AX protein modified form]
phenanthridone results in decreased expression of TXNRD1 mRNA; phenanthridone results in decreased expression of TXNRD1 protein		 CTD PMID:29416738 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        immunomodulator 15063
          immunosuppressive agent 13934
            phenanthridone 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organochalcogen compound 19240
                                organooxygen compound 19155
                                  carbon oxoacid 18613
                                    carboxylic acid 18610
                                      carboacyl group 17699
                                        univalent carboacyl group 17699
                                          carbamoyl group 17549
                                            carboxamide 17549
                                              lactam 8387
                                                phenanthridone 20
paths to the root