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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phenanthridone
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Accession:CHEBI:75292 term browser browse the term
Definition:A member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity.
Synonyms:exact_synonym: phenanthridin-6(5H)-one
 related_synonym: 6-Phenanthridinol;   6-Phenanthridinone;   6-Phenanthridone;   Formula=C13H9NO;   InChI=1S/C13H9NO/c15-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)14-13/h1-8H,(H,14,15);   InChIKey=RZFVLEJOHSLEFR-UHFFFAOYSA-N;   SMILES=O=c1[nH]c2ccccc2c2ccccc12
 xref: CAS:1015-89-0;   LINCS:LSM-2229
 xref_mesh: MESH:C040601
 xref: PMID:11202649;   PMID:19447472;   PMID:2858381;   PMID:3464317;   PMID:6302951;   PMID:7672878;   Patent:US2478805;   Reaxys:140641



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phenanthridone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO phenanthridone inhibits the reaction [Methylnitronitrosoguanidine results in increased localization of AIFM1 protein] CTD PMID:15589979 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Casp7 caspase 7 multiple interactions ISO [2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one co-treated with phenanthridone] results in increased cleavage of CASP7 protein CTD PMID:29416738 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one co-treated with phenanthridone] results in increased cleavage of CASP9 protein CTD PMID:29416738 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO phenanthridone analog inhibits the reaction [endotoxin, Escherichia coli results in increased expression of CCL3 protein] CTD PMID:12006805 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Cd83 CD83 molecule decreases expression ISO phenanthridone results in decreased expression of CD83 mRNA; phenanthridone results in decreased expression of CD83 protein CTD PMID:17579050 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
JBrowse link
G Cd86 CD86 molecule decreases expression ISO phenanthridone results in decreased expression of CD86 mRNA; phenanthridone results in decreased expression of CD86 protein CTD PMID:17579050 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO phenanthridone analog inhibits the reaction [endotoxin, Escherichia coli results in increased expression of CXCL2 protein] CTD PMID:12006805 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions
ISO phenanthridone results in increased expression of H2AX protein modified form
Acetylcysteine inhibits the reaction [phenanthridone results in increased expression of H2AX protein modified form]; TXNRD1 protein inhibits the reaction [phenanthridone results in increased expression of H2AX protein modified form]
CTD PMID:29416738 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
EXP phenanthridone inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA]
phenanthridone results in decreased expression of IFNG mRNA
CTD PMID:12411406 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO phenanthridone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] CTD PMID:17579050 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12b interleukin 12B multiple interactions ISO phenanthridone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:17579050 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP phenanthridone results in decreased expression of IL1B mRNA CTD PMID:12411406 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 decreases expression
multiple interactions
EXP phenanthridone results in decreased expression of IL2 mRNA
phenanthridone inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA]
CTD PMID:12411406 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Kif18a kinesin family member 18A increases metabolic processing ISO phenanthridone results in increased metabolism of KIF18A protein CTD PMID:28209915 NCBI chr 3:95,764,388...95,824,756
Ensembl chr 3:95,764,388...95,824,582
JBrowse link
G Kifc1 kinesin family member C1 increases metabolic processing ISO phenanthridone results in increased metabolism of KIFC1 protein CTD PMID:28209915 NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression EXP phenanthridone results in decreased expression of NOS2 mRNA CTD PMID:12411406 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases activity
multiple interactions
EXP
ISO
phenanthridone results in decreased activity of PARP1 protein
[2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one co-treated with phenanthridone] results in increased cleavage of PARP1 protein
CTD PMID:12411406 PMID:29416738 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression EXP phenanthridone results in decreased expression of PTGS2 mRNA CTD PMID:12411406 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
phenanthridone inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TNF mRNA]
phenanthridone analog inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]
phenanthridone results in decreased expression of TNF mRNA
CTD PMID:12006805 PMID:12411406 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions
decreases expression
ISO TXNRD1 protein inhibits the reaction [phenanthridone results in increased expression of H2AX protein modified form]
phenanthridone results in decreased expression of TXNRD1 mRNA; phenanthridone results in decreased expression of TXNRD1 protein
CTD PMID:29416738 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19763
      biological role 19763
        immunomodulator 14913
          immunosuppressive agent 13739
            phenanthridone 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    p-block element atom 19710
                      carbon group element atom 19631
                        carbon atom 19621
                          organic molecular entity 19621
                            organic group 18730
                              organic divalent group 18721
                                organodiyl group 18721
                                  carbonyl group 18670
                                    carbonyl compound 18670
                                      carboxylic acid 18367
                                        carboacyl group 17487
                                          univalent carboacyl group 17487
                                            carbamoyl group 17303
                                              carboxamide 17303
                                                lactam 8308
                                                  phenanthridone 20
paths to the root