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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:miltefosine
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Accession:CHEBI:75283 term browser browse the term
Definition:A phospholipid that is the hexadecyl monoester of phosphocholine.
Synonyms:related_synonym: Formula=C21H46NO4P;   Hexadecylphosphocholine;   Hexadecylphosphorylcholine;   InChI=1S/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,24)26-21-19-22(2,3)4/h5-21H2,1-4H3;   InChIKey=PQLXHQMOHUQAKB-UHFFFAOYSA-N;   SMILES=CCCCCCCCCCCCCCCCOP([O-])(=O)OCC[N+](C)(C)C;   miltefosina;   miltefosinum;   monohexadecylphosphocholine;   monohexadecylphosphorylcholine
 xref: CAS:58066-85-6;   Drug_Central:1810;   KEGG:D02494
 xref_mesh: MESH:C039128
 xref: PMID:22385017;   PMID:22935677;   PMID:22995097;   PMID:23136856;   PMID:23165465;   PMID:23199340;   PMID:23239091;   PMID:23243111;   PMID:23434530;   PMID:23434716;   PMID:23468121;   PMID:23601234;   PMID:23673723;   PMID:23723490;   PMID:23729024;   PMID:23738749;   PMID:23740007;   PMID:23811261;   PMID:23811637;   PMID:23861311;   PMID:23871798;   PMID:23890327;   PMID:23930349;   Reaxys:3690495;   Wikipedia:Miltefosine


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miltefosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases response to substance
multiple interactions
ISO ABCB1 protein results in decreased susceptibility to miltefosine
miltefosine binds to and results in decreased activity of ABCB1 protein
CTD PMID:11355955 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Prkca protein kinase C, alpha decreases phosphorylation ISO miltefosine results in decreased phosphorylation of PRKCA protein CTD PMID:31265827 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        immunomodulator 13689
          miltefosine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      chalcogen 19360
                        oxygen atom 19321
                          oxygen molecular entity 19321
                            hydroxides 19066
                              oxoacid 18192
                                pnictogen oxoacid 10144
                                  phosphorus oxoacid 9032
                                    phosphoric acids 7794
                                      phosphoric acid 7794
                                        phosphoric acid derivative 7473
                                          phosphate 7473
                                            organic phosphate 7472
                                              phospholipid 289
                                                miltefosine 2
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