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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:miltefosine
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Accession:CHEBI:75283 term browser browse the term
Definition:A phospholipid that is the hexadecyl monoester of phosphocholine.
Synonyms:related_synonym: Formula=C21H46NO4P;   Hexadecylphosphocholine;   Hexadecylphosphorylcholine;   InChI=1S/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,24)26-21-19-22(2,3)4/h5-21H2,1-4H3;   InChIKey=PQLXHQMOHUQAKB-UHFFFAOYSA-N;   SMILES=CCCCCCCCCCCCCCCCOP([O-])(=O)OCC[N+](C)(C)C;   miltefosina;   miltefosinum;   monohexadecylphosphocholine;   monohexadecylphosphorylcholine
 xref: CAS:58066-85-6;   Drug_Central:1810;   KEGG:D02494
 xref_mesh: MESH:C039128
 xref: PMID:22385017;   PMID:22935677;   PMID:22995097;   PMID:23136856;   PMID:23165465;   PMID:23199340;   PMID:23239091;   PMID:23243111;   PMID:23434530;   PMID:23434716;   PMID:23468121;   PMID:23601234;   PMID:23673723;   PMID:23723490;   PMID:23729024;   PMID:23738749;   PMID:23740007;   PMID:23811261;   PMID:23811637;   PMID:23861311;   PMID:23871798;   PMID:23890327;   PMID:23930349;   Reaxys:3690495;   Wikipedia:Miltefosine



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miltefosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases response to substance
multiple interactions
ISO ABCB1 protein results in decreased susceptibility to miltefosine
miltefosine binds to and results in decreased activity of ABCB1 protein
CTD PMID:11355955 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Prkca protein kinase C, alpha decreases phosphorylation ISO miltefosine results in decreased phosphorylation of PRKCA protein CTD PMID:31265827 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        immunomodulator 15082
          miltefosine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      chalcogen 19612
                        oxygen atom 19586
                          oxygen molecular entity 19586
                            hydroxides 19389
                              oxoacid 18783
                                pnictogen oxoacid 13194
                                  phosphorus oxoacid 12437
                                    phosphoric acids 11433
                                      phosphoric acid 11433
                                        phosphoric acid derivative 11242
                                          phosphate 11241
                                            organic phosphate 11241
                                              phospholipid 316
                                                miltefosine 2
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