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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:miltefosine
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Accession:CHEBI:75283 term browser browse the term
Definition:A phospholipid that is the hexadecyl monoester of phosphocholine.
Synonyms:related_synonym: Formula=C21H46NO4P;   Hexadecylphosphocholine;   Hexadecylphosphorylcholine;   InChI=1S/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,24)26-21-19-22(2,3)4/h5-21H2,1-4H3;   InChIKey=PQLXHQMOHUQAKB-UHFFFAOYSA-N;   SMILES=CCCCCCCCCCCCCCCCOP([O-])(=O)OCC[N+](C)(C)C;   miltefosina;   miltefosinum;   monohexadecylphosphocholine;   monohexadecylphosphorylcholine
 xref: CAS:58066-85-6;   Drug_Central:1810;   KEGG:D02494
 xref_mesh: MESH:C039128
 xref: PMID:22385017;   PMID:22935677;   PMID:22995097;   PMID:23136856;   PMID:23165465;   PMID:23199340;   PMID:23239091;   PMID:23243111;   PMID:23434530;   PMID:23434716;   PMID:23468121;   PMID:23601234;   PMID:23673723;   PMID:23723490;   PMID:23729024;   PMID:23738749;   PMID:23740007;   PMID:23811261;   PMID:23811637;   PMID:23861311;   PMID:23871798;   PMID:23890327;   PMID:23930349;   Reaxys:3690495;   Wikipedia:Miltefosine


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miltefosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases response to substance
multiple interactions
ISO ABCB1 protein results in decreased susceptibility to miltefosine
miltefosine binds to and results in decreased activity of ABCB1 protein
CTD PMID:11355955 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Prkca protein kinase C, alpha decreases phosphorylation ISO miltefosine results in decreased phosphorylation of PRKCA protein CTD PMID:31265827 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        immunomodulator 14903
          miltefosine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      chalcogen 19460
                        oxygen atom 19436
                          oxygen molecular entity 19436
                            hydroxides 19175
                              oxoacid 18488
                                pnictogen oxoacid 10688
                                  phosphorus oxoacid 9669
                                    phosphoric acids 8466
                                      phosphoric acid 8466
                                        phosphoric acid derivative 8171
                                          phosphate 8170
                                            organic phosphate 8169
                                              phospholipid 302
                                                miltefosine 2
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