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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:miltefosine
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Accession:CHEBI:75283 term browser browse the term
Definition:A phospholipid that is the hexadecyl monoester of phosphocholine.
Synonyms:related_synonym: Formula=C21H46NO4P;   Hexadecylphosphocholine;   Hexadecylphosphorylcholine;   InChI=1S/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,24)26-21-19-22(2,3)4/h5-21H2,1-4H3;   InChIKey=PQLXHQMOHUQAKB-UHFFFAOYSA-N;   SMILES=CCCCCCCCCCCCCCCCOP([O-])(=O)OCC[N+](C)(C)C;   miltefosina;   miltefosinum;   monohexadecylphosphocholine;   monohexadecylphosphorylcholine
 xref: CAS:58066-85-6;   Drug_Central:1810;   KEGG:D02494
 xref_mesh: MESH:C039128
 xref: PMID:22385017;   PMID:22935677;   PMID:22995097;   PMID:23136856;   PMID:23165465;   PMID:23199340;   PMID:23239091;   PMID:23243111;   PMID:23434530;   PMID:23434716;   PMID:23468121;   PMID:23601234;   PMID:23673723;   PMID:23723490;   PMID:23729024;   PMID:23738749;   PMID:23740007;   PMID:23811261;   PMID:23811637;   PMID:23861311;   PMID:23871798;   PMID:23890327;   PMID:23930349;   Reaxys:3690495;   Wikipedia:Miltefosine



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miltefosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases response to substance
multiple interactions
ISO ABCB1 protein results in decreased susceptibility to miltefosine
miltefosine binds to and results in decreased activity of ABCB1 protein
CTD PMID:11355955 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Prkca protein kinase C, alpha decreases phosphorylation ISO miltefosine results in decreased phosphorylation of PRKCA protein CTD PMID:31265827 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19887
      biological role 19885
        immunomodulator 15073
          miltefosine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19909
          baryon 19909
            nucleon 19909
              atomic nucleus 19909
                atom 19909
                  main group element atom 19859
                    p-block element atom 19859
                      chalcogen 19605
                        oxygen atom 19579
                          oxygen molecular entity 19579
                            hydroxides 19382
                              oxoacid 18779
                                pnictogen oxoacid 13189
                                  phosphorus oxoacid 12433
                                    phosphoric acids 11428
                                      phosphoric acid 11428
                                        phosphoric acid derivative 11236
                                          phosphate 11235
                                            organic phosphate 11235
                                              phospholipid 316
                                                miltefosine 2
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