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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ergosterol biosynthesis inhibitor
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Accession:CHEBI:75282 term browser browse the term
Definition:Any compound that inhibits one or more steps in the pathway leading to the synthesis of ergosterol.
Synonyms:related_synonym: ergosterol biosynthesis inhibitors
 xref: PMID:12604527;   PMID:19835945



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itraconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions EXP Itraconazole inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines] CTD PMID:21056966 NCBI chr 9:93,171,371...93,262,124 JBrowse link
ketoconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A29 cytochrome P450 family 3 subfamily A member 29 multiple interactions EXP Ketoconazole inhibits the reaction [CYP3A29 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [CYP3A29 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A29 protein results in increased oxidation of Nifedipine] CTD PMID:20863320 NCBI chr 3:6,738,502...6,778,121 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 1030
    role 970
      biological role 970
        biochemical role 848
          sterol biosynthesis inhibitor 2
            ergosterol biosynthesis inhibitor 2
              FR171456 0
              conazole antifungal agent + 2
              isavuconazole 0
              isavuconazonium + 0
              isavuconazonium sulfate 0
              miconazole + 0
              miconazole nitrate 0
              myclobutanil 0
              ravuconazole 0
              triarimol 0
paths to the root