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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:splitomicin
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Accession:CHEBI:75272 term browser browse the term
Definition:A benzochromenone that is 2,3-dihydro-1H-benzo[f]chromene substituted by an oxo group at position 3. It has been found to exhibit potential inhibitory activity against Sir2 proteins.
Synonyms:exact_synonym: 1,2-dihydro-3H-benzo[f]chromen-3-one
 related_synonym: 1,2-dihydro-3H-naphtho[2,1-b]-pyran-3-one;   Formula=C13H10O2;   InChI=1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2;   InChIKey=ISFPDBUKMJDAJH-UHFFFAOYSA-N;   SMILES=O=C1CCc2c(O1)ccc1ccccc21
 xref: LINCS:LSM-2607
 xref_mesh: MESH:C444426
 xref: PMID:15115404;   PMID:18269226;   PMID:19327818;   PMID:21315612;   PMID:22634165;   Patent:KR20120128451;   Reaxys:161649


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splitomicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO [splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of ACACA protein]; [splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [resveratrol results in increased phosphorylation of ACACA protein] CTD PMID:18482975 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Casp3 caspase 3 multiple interactions ISO splitomicin promotes the reaction [Antimycin A results in increased cleavage of CASP3 protein] CTD PMID:24040102 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G F2 coagulation factor II multiple interactions ISO splitomicin promotes the reaction [F2 protein results in increased expression of F3 protein] CTD PMID:20978007 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO [Histamine co-treated with splitomicin] results in increased expression of F3 protein; splitomicin promotes the reaction [F2 protein results in increased expression of F3 protein]; splitomicin promotes the reaction [TNF protein results in increased expression of F3 mRNA]; splitomicin promotes the reaction [TNF protein results in increased expression of F3 protein] CTD PMID:20978007 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO splitomicin promotes the reaction [resveratrol results in decreased expression of FABP4 mRNA]; splitomicin promotes the reaction [resveratrol results in decreased expression of FABP4 protein] CTD PMID:23525482 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 decreases expression EXP splitomicin results in decreased expression of KCNA5 mRNA CTD PMID:25447406 NCBI chr 4:159,077,195...159,079,003
Ensembl chr 4:159,077,195...159,079,003
JBrowse link
G Klkb1 kallikrein B1 increases response to substance
multiple interactions
ISO KLKB1 gene mutant form results in increased susceptibility to splitomicin
splitomicin inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]
CTD PMID:25339356 NCBI chr16:50,151,127...50,175,407
Ensembl chr16:50,152,008...50,175,458
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO splitomicin promotes the reaction [resveratrol results in decreased expression of PPARG mRNA]; splitomicin promotes the reaction [resveratrol results in decreased expression of PPARG protein] CTD PMID:23525482 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP splitomicin inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA] CTD PMID:22892143 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO splitomicin promotes the reaction [TNF protein results in increased localization of and results in decreased acetylation of and results in increased activity of RELA protein] CTD PMID:20978007 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sirt1 sirtuin 1 decreases activity
multiple interactions
decreases expression
ISO
EXP
splitomicin results in decreased activity of SIRT1 protein
[splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of ACACA protein]; [splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [resveratrol results in increased phosphorylation of ACACA protein]
splitomicin results in decreased expression of SIRT1 mRNA
CTD PMID:18482975 PMID:20978007 PMID:25447406 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Tf transferrin increases activity ISO splitomicin results in increased activity of TF protein CTD PMID:20978007 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO splitomicin promotes the reaction [TNF protein results in increased expression of F3 mRNA]; splitomicin promotes the reaction [TNF protein results in increased expression of F3 protein]; splitomicin promotes the reaction [TNF protein results in increased localization of and results in decreased acetylation of and results in increased activity of RELA protein] CTD PMID:20978007 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      application 19505
        pharmaceutical 19375
          drug 19375
            hematologic agent 4388
              platelet aggregation inhibitor 3359
                splitomicin 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic group 18580
                              organic divalent group 18571
                                organodiyl group 18571
                                  carbonyl group 18479
                                    carbonyl compound 18479
                                      carboxylic ester 14384
                                        lactone 5997
                                          delta-lactone 3809
                                            splitomicin 13
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