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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
increases expression multiple interactions |
ISO |
Nimustine results in increased expression of ABCC1 mRNA; Nimustine results in increased expression of ABCC1 protein [Nimustine results in increased expression of ABCC1 protein] which results in increased transport of Leukotriene C4 |
CTD |
PMID:9393752 |
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NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114
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G |
Bcl2l11 |
Bcl2-like 11 |
multiple interactions increases expression |
ISO |
BCL2L11 mutant form inhibits the reaction [Nimustine results in increased cleavage of CASP9 protein]; pyrazolanthrone inhibits the reaction [Nimustine results in increased expression of BCL2L11 mRNA] Nimustine results in increased expression of BCL2L11 mRNA; Nimustine results in increased expression of BCL2L11 protein |
CTD |
PMID:26418950 |
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NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068
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G |
Casp1 |
caspase 1 |
increases response to substance |
ISO |
CASP1 results in increased susceptibility to Nimustine |
CTD |
PMID:9491796 |
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NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp3 |
caspase 3 |
increases cleavage |
ISO |
Nimustine results in increased cleavage of CASP3 protein |
CTD |
PMID:26418950 |
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NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases cleavage |
ISO |
Nimustine results in increased cleavage of CASP8 protein |
CTD |
PMID:26418950 |
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NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions increases cleavage |
ISO |
BCL2L11 mutant form inhibits the reaction [Nimustine results in increased cleavage of CASP9 protein] |
CTD |
PMID:26418950 |
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Ensembl chr 5:154,109,046...154,126,626
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G |
Chek1 |
checkpoint kinase 1 |
multiple interactions increases phosphorylation |
ISO |
FOSL1 protein affects the reaction [Nimustine results in increased phosphorylation of CHEK1 protein] |
CTD |
PMID:22609303 |
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NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:36,420,569...36,441,009
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G |
Ddb2 |
damage specific DNA binding protein 2 |
multiple interactions |
ISO |
TP53 affects the reaction [Nimustine results in increased expression of DDB2 mRNA] |
CTD |
PMID:18089819 |
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NCBI chr 3:97,640,923...97,667,617
Ensembl chr 3:77,185,109...77,207,631
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G |
Ercc4 |
ERCC excision repair 4, endonuclease catalytic subunit |
decreases response to substance |
ISO |
ERCC4 protein results in decreased susceptibility to Nimustine |
CTD |
PMID:26418950 |
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NCBI chr10:2,926,085...2,958,176
Ensembl chr10:2,419,038...2,448,369 Ensembl chr10:2,419,038...2,448,369
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G |
Faslg |
Fas ligand |
increases expression multiple interactions |
ISO |
Nimustine results in increased expression of FASLG mRNA pyrazolanthrone inhibits the reaction [Nimustine results in increased expression of FASLG mRNA] |
CTD |
PMID:26418950 |
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NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions decreases response to substance |
ISO |
FOS mutant form inhibits the reaction [Nimustine results in increased expression of TREX1 mRNA] FOS protein results in decreased susceptibility to Nimustine |
CTD |
PMID:23578789 PMID:26418950 |
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NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
multiple interactions increases expression affects response to substance |
ISO |
FOSL1 protein affects the reaction [Nimustine results in increased phosphorylation of CHEK1 protein] Nimustine results in increased expression of FOSL1 mRNA; Nimustine results in increased expression of FOSL1 protein FOSL1 protein affects the susceptibility to Nimustine |
CTD |
PMID:22609303 |
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NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:202,754,529...202,764,930
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G |
Fxn |
frataxin |
increases expression |
ISO |
Nimustine results in increased expression of FXN protein |
CTD |
PMID:23418481 |
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NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression |
ISO |
Nimustine results in increased expression of GCLC mRNA |
CTD |
PMID:9393752 |
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NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
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G |
H2ax |
H2A.X variant histone |
increases phosphorylation |
ISO |
Nimustine results in increased phosphorylation of H2AX protein |
CTD |
PMID:26418950 |
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NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases phosphorylation |
ISO |
JUN mutant form inhibits the reaction [Nimustine results in increased expression of TREX1 mRNA]; Nimustine promotes the reaction [JUN protein binds to TREX1 promoter] Nimustine results in increased phosphorylation of JUN protein |
CTD |
PMID:23578789 PMID:26418950 |
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NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation |
ISO |
Nimustine results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:26418950 |
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NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation |
ISO |
Nimustine results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:26418950 |
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NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
decreases response to substance increases expression multiple interactions increases response to substance |
ISO |
MGMT protein results in decreased susceptibility to Nimustine Nimustine results in increased expression of MGMT mRNA [Nimustine co-treated with Dexamethasone] results in increased expression of MGMT mRNA; [O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to Nimustine; [SP1 protein results in decreased susceptibility to Nimustine] which affects the expression of MGMT protein; Dexamethasone promotes the reaction [MGMT protein results in decreased susceptibility to Nimustine] MGMT gene mutant form results in increased susceptibility to Nimustine |
CTD |
PMID:11023546 PMID:12014639 PMID:15481722 PMID:15809756 PMID:29164620 |
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NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:191,710,930...191,937,756
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G |
Sp1 |
Sp1 transcription factor |
multiple interactions decreases response to substance |
ISO |
[SP1 protein results in decreased susceptibility to Nimustine] which affects the expression of MGMT protein |
CTD |
PMID:29164620 |
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NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961
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G |
Tap1 |
transporter 1, ATP binding cassette subfamily B member |
affects response to substance |
ISO |
TAP1 protein affects the susceptibility to Nimustine |
CTD |
PMID:17523305 |
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NCBI chr20:4,658,171...4,668,543
Ensembl chr20:4,656,263...4,666,901
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G |
Tp53 |
tumor protein p53 |
multiple interactions affects response to substance |
ISO |
TP53 affects the reaction [Nimustine results in increased expression of DDB2 mRNA]; TP53 affects the reaction [Nimustine results in increased expression of XPC mRNA] TP53 protein affects the susceptibility to Nimustine |
CTD |
PMID:15182437 PMID:18089819 |
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NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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G |
Trex1 |
three prime repair exonuclease 1 |
multiple interactions affects response to substance increases expression |
ISO |
FOS mutant form inhibits the reaction [Nimustine results in increased expression of TREX1 mRNA]; JUN mutant form inhibits the reaction [Nimustine results in increased expression of TREX1 mRNA]; Nimustine promotes the reaction [JUN protein binds to TREX1 promoter] TREX1 affects the susceptibility to Nimustine Nimustine results in increased expression of TREX1 mRNA; Nimustine results in increased expression of TREX1 protein |
CTD |
PMID:23578789 |
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NCBI chr 8:118,585,082...118,586,382
Ensembl chr 8:109,706,613...109,708,796
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G |
Xpc |
XPC complex subunit, DNA damage recognition and repair factor |
increases expression multiple interactions |
ISO |
Nimustine results in increased expression of XPC mRNA TP53 affects the reaction [Nimustine results in increased expression of XPC mRNA] |
CTD |
PMID:18089819 |
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NCBI chr 4:125,550,833...125,578,084
Ensembl chr 4:123,993,666...124,021,010
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