Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nimustine
go back to main search page
Accession:CHEBI:75270 term browser browse the term
Definition:An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-amino-2-methylpyrimidin-5-ylmethyl] group. An antineoplastic agent especially effective against malignant brain tumors.
Synonyms:exact_synonym: 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1-(2-chloroethyl)-1-nitrosourea
 related_synonym: 1-(4-Amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea;   3-(4-Amino-2-methyl-5-pyrimidinyl)methyl-1-(2-chloroethyl)-1-nitrosourea;   Formula=C9H13ClN6O2;   InChI=1S/C9H13ClN6O2/c1-6-12-4-7(8(11)14-6)5-13-9(17)16(15-18)3-2-10/h4H,2-3,5H2,1H3,(H,13,17)(H2,11,12,14);   InChIKey=VFEDRRNHLBGPNN-UHFFFAOYSA-N;   SMILES=Cc1ncc(CNC(=O)N(CCCl)N=O)c(N)n1;   nimustina;   nimustinum
 xref: CAS:42471-28-3;   Drug_Central:3384;   KEGG:D08276
 xref_mesh: MESH:D015376
 xref: PMID:21420247;   PMID:23106822;   PMID:23228988;   PMID:23578789;   PMID:23651604;   PMID:23912878;   Reaxys:685903;   Wikipedia:Nimustine
 cyclic_relationship: is_conjugate_base_of CHEBI:75271



show annotations for term's descendants           Sort by:
nimustine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 increases expression
multiple interactions
ISO Nimustine results in increased expression of ABCC1 mRNA; Nimustine results in increased expression of ABCC1 protein
[Nimustine results in increased expression of ABCC1 protein] which results in increased transport of Leukotriene C4
CTD PMID:9393752 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114
JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions
increases expression
ISO BCL2L11 mutant form inhibits the reaction [Nimustine results in increased cleavage of CASP9 protein]; pyrazolanthrone inhibits the reaction [Nimustine results in increased expression of BCL2L11 mRNA]
Nimustine results in increased expression of BCL2L11 mRNA; Nimustine results in increased expression of BCL2L11 protein
CTD PMID:26418950 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Casp1 caspase 1 increases response to substance ISO CASP1 results in increased susceptibility to Nimustine CTD PMID:9491796 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 increases cleavage ISO Nimustine results in increased cleavage of CASP3 protein CTD PMID:26418950 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage ISO Nimustine results in increased cleavage of CASP8 protein CTD PMID:26418950 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
ISO BCL2L11 mutant form inhibits the reaction [Nimustine results in increased cleavage of CASP9 protein] CTD PMID:26418950 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases phosphorylation
ISO FOSL1 protein affects the reaction [Nimustine results in increased phosphorylation of CHEK1 protein] CTD PMID:22609303 NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Ddb2 damage specific DNA binding protein 2 multiple interactions ISO TP53 affects the reaction [Nimustine results in increased expression of DDB2 mRNA] CTD PMID:18089819 NCBI chr 3:97,640,923...97,667,617
Ensembl chr 3:77,185,109...77,207,631
JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit decreases response to substance ISO ERCC4 protein results in decreased susceptibility to Nimustine CTD PMID:26418950 NCBI chr10:2,926,085...2,958,176
Ensembl chr10:2,419,038...2,448,369
Ensembl chr10:2,419,038...2,448,369
JBrowse link
G Faslg Fas ligand increases expression
multiple interactions
ISO Nimustine results in increased expression of FASLG mRNA
pyrazolanthrone inhibits the reaction [Nimustine results in increased expression of FASLG mRNA]
CTD PMID:26418950 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases response to substance
ISO FOS mutant form inhibits the reaction [Nimustine results in increased expression of TREX1 mRNA]
FOS protein results in decreased susceptibility to Nimustine
CTD PMID:23578789 PMID:26418950 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions
increases expression
affects response to substance
ISO FOSL1 protein affects the reaction [Nimustine results in increased phosphorylation of CHEK1 protein]
Nimustine results in increased expression of FOSL1 mRNA; Nimustine results in increased expression of FOSL1 protein
FOSL1 protein affects the susceptibility to Nimustine
CTD PMID:22609303 NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Fxn frataxin increases expression ISO Nimustine results in increased expression of FXN protein CTD PMID:23418481 NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Nimustine results in increased expression of GCLC mRNA CTD PMID:9393752 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO Nimustine results in increased phosphorylation of H2AX protein CTD PMID:26418950 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation
ISO JUN mutant form inhibits the reaction [Nimustine results in increased expression of TREX1 mRNA]; Nimustine promotes the reaction [JUN protein binds to TREX1 promoter]
Nimustine results in increased phosphorylation of JUN protein
CTD PMID:23578789 PMID:26418950 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Nimustine results in increased phosphorylation of MAPK1 protein CTD PMID:26418950 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Nimustine results in increased phosphorylation of MAPK3 protein CTD PMID:26418950 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases response to substance
increases expression
multiple interactions
increases response to substance
ISO MGMT protein results in decreased susceptibility to Nimustine
Nimustine results in increased expression of MGMT mRNA
[Nimustine co-treated with Dexamethasone] results in increased expression of MGMT mRNA; [O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to Nimustine; [SP1 protein results in decreased susceptibility to Nimustine] which affects the expression of MGMT protein; Dexamethasone promotes the reaction [MGMT protein results in decreased susceptibility to Nimustine]
MGMT gene mutant form results in increased susceptibility to Nimustine
CTD PMID:11023546 PMID:12014639 PMID:15481722 PMID:15809756 PMID:29164620 NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions
decreases response to substance
ISO [SP1 protein results in decreased susceptibility to Nimustine] which affects the expression of MGMT protein CTD PMID:29164620 NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member affects response to substance ISO TAP1 protein affects the susceptibility to Nimustine CTD PMID:17523305 NCBI chr20:4,658,171...4,668,543
Ensembl chr20:4,656,263...4,666,901
JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects response to substance
ISO TP53 affects the reaction [Nimustine results in increased expression of DDB2 mRNA]; TP53 affects the reaction [Nimustine results in increased expression of XPC mRNA]
TP53 protein affects the susceptibility to Nimustine
CTD PMID:15182437 PMID:18089819 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trex1 three prime repair exonuclease 1 multiple interactions
affects response to substance
increases expression
ISO FOS mutant form inhibits the reaction [Nimustine results in increased expression of TREX1 mRNA]; JUN mutant form inhibits the reaction [Nimustine results in increased expression of TREX1 mRNA]; Nimustine promotes the reaction [JUN protein binds to TREX1 promoter]
TREX1 affects the susceptibility to Nimustine
Nimustine results in increased expression of TREX1 mRNA; Nimustine results in increased expression of TREX1 protein
CTD PMID:23578789 NCBI chr 8:118,585,082...118,586,382
Ensembl chr 8:109,706,613...109,708,796
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor increases expression
multiple interactions
ISO Nimustine results in increased expression of XPC mRNA
TP53 affects the reaction [Nimustine results in increased expression of XPC mRNA]
CTD PMID:18089819 NCBI chr 4:125,550,833...125,578,084
Ensembl chr 4:123,993,666...124,021,010
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19870
      application 19713
        pharmaceutical 19549
          drug 19549
            antineoplastic agent 17838
              nimustine 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    p-block element atom 19836
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            heteroorganic entity 19537
                              organochalcogen compound 19297
                                organooxygen compound 19215
                                  carbon oxoacid 18693
                                    carboxylic acid 18690
                                      carboacyl group 17730
                                        univalent carboacyl group 17730
                                          carbamoyl group 17575
                                            carboxamide 17575
                                              monocarboxylic acid amide 15750
                                                urea 6237
                                                  ureas 6235
                                                    N-nitrosoureas 2133
                                                      nimustine 24
paths to the root