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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phenylarsine oxide
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Accession:CHEBI:75253 term browser browse the term
Definition:An arsine oxide derived from phenylarsine.
Synonyms:exact_synonym: oxo(phenyl)arsine
 related_synonym: Arsenosobenzene;   Formula=C6H5AsO;   InChI=1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H;   InChIKey=BQVCCPGCDUSGOE-UHFFFAOYSA-N;   Oxophenylarsine;   PhAsO;   Phenyl arsine oxide;   Phenylarsenoxide;   SMILES=O=[As]c1ccccc1
 xref: CAS:637-03-6
 xref_mesh: MESH:C029341
 xref: PDBeChem:PA0;   PMID:22048238;   PMID:22617457;   PMID:23044393;   PMID:23201556;   Reaxys:2935227


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phenylarsine oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP oxophenylarsine inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; oxophenylarsine inhibits the reaction [AGT protein binds to and results in increased localization of AGTR1A protein] CTD PMID:18267125 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP oxophenylarsine inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; oxophenylarsine inhibits the reaction [AGT protein binds to and results in increased localization of AGTR1A protein] CTD PMID:18267125 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of ATF2 protein] CTD PMID:26763395 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member increases phosphorylation
multiple interactions
ISO oxophenylarsine results in increased phosphorylation of BCAR1 protein
[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]; Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]]
CTD PMID:10537051 NCBI chr19:43,932,543...43,967,452
Ensembl chr19:43,932,554...43,955,783
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H decreases activity ISO oxophenylarsine results in decreased activity of CACNA1H protein CTD PMID:18309285 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
JBrowse link
G Casp3 caspase 3 increases activity ISO oxophenylarsine results in increased activity of CASP3 protein CTD PMID:10515888 PMID:19465042 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccr3 C-C motif chemokine receptor 3 multiple interactions ISO oxophenylarsine inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein] CTD PMID:11544337 NCBI chr 8:133,026,539...133,040,999
Ensembl chr 8:133,029,625...133,040,997
JBrowse link
G Cd79a CD79a molecule increases phosphorylation ISO oxophenylarsine results in increased phosphorylation of CD79A protein CTD PMID:8559152 NCBI chr 1:81,763,609...81,768,039
Ensembl chr 1:81,763,614...81,767,980
JBrowse link
G Cd79b CD79b molecule increases phosphorylation ISO oxophenylarsine results in increased phosphorylation of CD79B protein CTD PMID:8559152 NCBI chr10:94,497,445...94,500,591
Ensembl chr10:94,497,448...94,500,591
JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions ISO oxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT1 protein]; oxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT3 protein] CTD PMID:11882386 NCBI chr 1:229,599,009...229,601,032
Ensembl chr 1:229,599,009...229,601,032
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO oxophenylarsine inhibits the reaction [Colforsin results in increased activity of CREB1 protein]; oxophenylarsine inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; oxophenylarsine inhibits the reaction [Isoproterenol results in increased phosphorylation of CREB1 protein]; oxophenylarsine inhibits the reaction [Lipopolysaccharides results in increased activity of CREB1 protein] CTD PMID:17141199 PMID:20512473 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Egf epidermal growth factor multiple interactions ISO oxophenylarsine inhibits the reaction [EGF protein affects the localization of and results in increased activity of STAT3 protein]; oxophenylarsine inhibits the reaction [EGF protein binds to and affects the localization of EGFR protein] CTD PMID:12093727 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO oxophenylarsine inhibits the reaction [EGF protein binds to and affects the localization of EGFR protein] CTD PMID:12093727 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions ISO oxophenylarsine results in increased cleavage of and results in increased phosphorylation of ERBB4 protein CTD PMID:9685416 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase affects localization ISO oxophenylarsine affects the localization of FYN protein CTD PMID:9546377 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G Gh1 growth hormone 1 multiple interactions ISO
EXP
oxophenylarsine inhibits the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]
oxophenylarsine inhibits the reaction [NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]]
CTD PMID:12471042 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Grb2 growth factor receptor bound protein 2 multiple interactions EXP [oxophenylarsine results in decreased phosphorylation of PLCG1 protein] inhibits the reaction [PLCG1 protein binds to GRB2 protein] CTD PMID:9281317 NCBI chr10:104,193,953...104,263,071
Ensembl chr10:104,193,955...104,263,071
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression ISO oxophenylarsine results in increased expression of GSTA1 mRNA CTD PMID:7568053 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
oxophenylarsine results in increased expression of HMOX1 mRNA
Acetylcysteine inhibits the reaction [oxophenylarsine results in increased expression of HMOX1 mRNA]
CTD PMID:8612205 PMID:15368090 PMID:19786557 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein affects binding ISO oxophenylarsine binds to ID3 protein CTD PMID:23523789 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Igf1 insulin-like growth factor 1 decreases localization
multiple interactions
EXP oxophenylarsine results in decreased localization of IGF1 protein
oxophenylarsine inhibits the reaction [IGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid]
CTD PMID:1928324 PMID:9145794 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf2 insulin-like growth factor 2 decreases localization EXP oxophenylarsine results in decreased localization of IGF2 protein CTD PMID:9145794 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Colforsin inhibits the reaction [oxophenylarsine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]]; oxophenylarsine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]; oxophenylarsine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:20512473 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO oxophenylarsine inhibits the reaction [IL1B protein results in increased abundance of Hydrogen Peroxide]; oxophenylarsine inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; oxophenylarsine results in decreased expression of and results in decreased activity of IL1B protein CTD PMID:9266823 PMID:10515888 PMID:10802230 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il3 interleukin 3 multiple interactions ISO oxophenylarsine inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein] CTD PMID:11544337 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
JBrowse link
G Il6 interleukin 6 multiple interactions ISO oxophenylarsine inhibits the reaction [Colforsin results in increased secretion of IL6 protein]; oxophenylarsine inhibits the reaction [Isoproterenol results in increased secretion of IL6 protein]
oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of IL6 mRNA]
CTD PMID:17141199 PMID:26763395 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions EXP Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein]]; oxophenylarsine inhibits the reaction [INS protein affects the localization of SLC2A4 protein]; oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein] CTD PMID:8048502 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insr insulin receptor multiple interactions ISO oxophenylarsine promotes the reaction [Vanadates results in increased phosphorylation of INSR protein] CTD PMID:2458350 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Ip6k1 inositol hexakisphosphate kinase 1 decreases activity ISO oxophenylarsine results in decreased activity of IP6K1 protein CTD PMID:29042286 NCBI chr 8:116,781,957...116,826,152
Ensembl chr 8:116,804,451...116,823,540
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 affects binding ISO oxophenylarsine binds to KEAP1 protein CTD PMID:19786557 PMID:19808700 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
oxophenylarsine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]
oxophenylarsine inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]
CTD PMID:11880281 PMID:12927602 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
oxophenylarsine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]
oxophenylarsine inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]
CTD PMID:11880281 PMID:12927602 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions
increases phosphorylation
ISO
EXP
[oxophenylarsine results in increased activity of MARK1 protein] which results in increased phosphorylation of MAPT protein; Staurosporine inhibits the reaction [oxophenylarsine results in increased phosphorylation of MAPT protein] CTD PMID:10737602 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mark1 microtubule affinity regulating kinase 1 increases activity
multiple interactions
ISO oxophenylarsine results in increased activity of MARK1 protein
[oxophenylarsine results in increased activity of MARK1 protein] which results in increased phosphorylation of MAPT protein; Staurosporine inhibits the reaction [oxophenylarsine results in increased activity of MARK1 protein]
CTD PMID:10737602 NCBI chr13:102,808,254...102,942,863
Ensembl chr13:102,808,253...102,942,863
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO oxophenylarsine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein] CTD PMID:10569804 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO oxophenylarsine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein] CTD PMID:10569804 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mt1 metallothionein 1 increases expression ISO oxophenylarsine results in increased expression of MT1 mRNA CTD PMID:19276070 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mtf1 metal-regulatory transcription factor 1 affects binding ISO oxophenylarsine binds to MTF1 protein CTD PMID:19276070 NCBI chr 5:142,797,340...142,843,896
Ensembl chr 5:142,797,366...142,842,122
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases activity
ISO [oxophenylarsine results in increased activity of MTOR protein] which results in increased phosphorylation of RPS6KB1 protein; Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]]; MTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein] CTD PMID:16183647 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Ncs1 neuronal calcium sensor 1 multiple interactions EXP oxophenylarsine inhibits the reaction [NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]] CTD PMID:12471042 NCBI chr 3:10,556,250...10,602,672
Ensembl chr 3:10,553,589...10,602,672
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity
multiple interactions
ISO oxophenylarsine results in increased activity of NFE2L2 protein
oxophenylarsine binds to and results in increased activity of NFE2L2 protein
CTD PMID:19786557 PMID:19808700 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization
multiple interactions
ISO oxophenylarsine affects the localization of NFKB1 protein
oxophenylarsine promotes the reaction [Viper Venoms affects the localization of NFKB1 protein]; Viper Venoms promotes the reaction [oxophenylarsine affects the localization of NFKB1 protein]
CTD PMID:25417048 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation
multiple interactions
ISO oxophenylarsine results in decreased phosphorylation of NFKBIA protein
oxophenylarsine promotes the reaction [Viper Venoms results in decreased phosphorylation of NFKBIA protein]; Viper Venoms promotes the reaction [oxophenylarsine results in decreased phosphorylation of NFKBIA protein]
CTD PMID:25417048 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos3 nitric oxide synthase 3 affects localization ISO oxophenylarsine affects the localization of NOS3 protein CTD PMID:9546377 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO oxophenylarsine results in increased expression of NQO1 mRNA CTD PMID:19786557 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Ntf4 neurotrophin 4 decreases transport ISO oxophenylarsine results in decreased transport of NTF4 protein CTD PMID:11948662 NCBI chr 1:101,405,314...101,408,145
Ensembl chr 1:101,405,314...101,408,145
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO oxophenylarsine results in increased cleavage of PARP1 protein CTD PMID:10515888 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions
affects localization
decreases phosphorylation
EXP
ISO
[oxophenylarsine results in decreased phosphorylation of PLCG1 protein] inhibits the reaction [PLCG1 protein binds to GRB2 protein]
oxophenylarsine affects the localization of PLCG1 protein
CTD PMID:1325458 PMID:9281317 PMID:9546377 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Pld1 phospholipase D1 multiple interactions ISO oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of PLD1 mRNA]; oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of PLD1 protein] CTD PMID:26763395 NCBI chr 2:113,651,967...113,849,403
Ensembl chr 2:113,652,348...113,849,403
JBrowse link
G Pomc proopiomelanocortin decreases activity
multiple interactions
ISO
EXP
oxophenylarsine results in decreased activity of POMC protein
[oxophenylarsine results in decreased activity of POMC protein] which results in decreased chemical synthesis of Progesterone
oxophenylarsine inhibits the reaction [POMC protein results in increased abundance of Corticosterone]
CTD PMID:10518784 PMID:12530643 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
oxophenylarsine inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]
oxophenylarsine inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
oxophenylarsine inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]
CTD PMID:9266823 PMID:9576062 PMID:9580637 PMID:18267125 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions
increases phosphorylation
ISO [oxophenylarsine co-treated with oxotremorine M] results in increased phosphorylation of PTK2 protein; [oxophenylarsine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of PTK2 protein; [wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]
oxophenylarsine results in increased phosphorylation of PTK2 protein
CTD PMID:10537051 PMID:10569804 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Pxn paxillin multiple interactions
affects localization
increases phosphorylation
ISO [oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]; Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]]
oxophenylarsine affects the localization of PXN protein
CTD PMID:9546377 PMID:10537051 NCBI chr12:46,797,953...46,845,107
Ensembl chr12:46,797,954...46,845,080
JBrowse link
G Rcan1 regulator of calcineurin 1 multiple interactions ISO oxophenylarsine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RCAN1 protein] CTD PMID:12927602 NCBI chr11:32,539,689...32,620,274
Ensembl chr11:32,539,683...32,550,539
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions
ISO oxophenylarsine affects the localization of RELA protein
oxophenylarsine promotes the reaction [Viper Venoms affects the localization of RELA protein]; Viper Venoms promotes the reaction [oxophenylarsine affects the localization of RELA protein]
CTD PMID:25417048 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
increases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; [oxophenylarsine results in increased activity of MTOR protein] which results in increased phosphorylation of RPS6KB1 protein; Dimercaprol inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; MTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid results in decreased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [antimycin results in decreased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [Deoxyglucose results in decreased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [Tosyllysine Chloromethyl Ketone results in decreased phosphorylation of RPS6KB1 protein]; RPTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein] CTD PMID:16183647 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 multiple interactions ISO Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]]; oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]; RPTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein] CTD PMID:16183647 NCBI chr10:108,750,620...109,058,691
Ensembl chr10:108,750,620...109,058,691
JBrowse link
G Slc25a4 solute carrier family 25 member 4 multiple interactions
affects binding
EXP Bongkrekic Acid inhibits the reaction [oxophenylarsine binds to SLC25A4 protein]; carboxyatractyloside inhibits the reaction [oxophenylarsine binds to SLC25A4 protein] CTD PMID:18667415 NCBI chr16:49,266,903...49,270,698
Ensembl chr16:49,266,903...49,270,698
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
affects activity
ISO oxophenylarsine inhibits the reaction [Cytochalasin B binds to SLC2A1 protein]; oxophenylarsine inhibits the reaction [Glucose deficiency results in increased activity of SLC2A1 protein]; oxophenylarsine inhibits the reaction [Methylene Blue results in increased activity of SLC2A1 protein]
oxophenylarsine affects the activity of SLC2A1 protein
CTD PMID:19686715 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions
affects binding
ISO
EXP
oxophenylarsine inhibits the reaction [INS1 protein affects the transport of SLC2A4 protein]
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein]]; oxophenylarsine inhibits the reaction [INS protein affects the localization of SLC2A4 protein]; oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein]
oxophenylarsine binds to SLC2A4 protein
CTD PMID:1536656 PMID:1629198 PMID:8048502 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO oxophenylarsine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31652400 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase affects localization ISO oxophenylarsine affects the localization of SRC protein CTD PMID:9546377 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO oxophenylarsine results in decreased expression of STAR protein CTD PMID:12530643 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO oxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT1 protein] CTD PMID:11882386 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
affects localization
ISO Hydrogen Peroxide promotes the reaction [oxophenylarsine affects the localization of STAT3 protein]; oxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT3 protein]; oxophenylarsine promotes the reaction [Hydrogen Peroxide affects the localization of STAT3 protein]
oxophenylarsine inhibits the reaction [EGF protein affects the localization of and results in increased activity of STAT3 protein]
CTD PMID:10364193 PMID:11882386 PMID:12093727 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP oxophenylarsine inhibits the reaction [TAC1 protein affects the localization of TACR1 protein] CTD PMID:7524481 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions EXP oxophenylarsine inhibits the reaction [TAC1 protein affects the localization of TACR1 protein] CTD PMID:7524481 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
JBrowse link
G Tf transferrin decreases uptake ISO oxophenylarsine results in decreased uptake of TF protein CTD PMID:10865941 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tfrc transferrin receptor affects localization ISO oxophenylarsine affects the localization of TFRC protein CTD PMID:2643384 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases activity
ISO oxophenylarsine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
oxophenylarsine results in decreased activity of TGFB1 protein
CTD PMID:31652400 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO oxophenylarsine inhibits the reaction [TNF protein results in increased abundance of Hydrogen Peroxide]
oxophenylarsine inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]
CTD PMID:9576062 PMID:9580637 PMID:10802230 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 multiple interactions
increases expression
ISO oxophenylarsine promotes the reaction [Viper Venoms results in increased expression of TNFRSF25 protein]; Viper Venoms promotes the reaction [oxophenylarsine results in increased expression of TNFRSF25 protein] CTD PMID:25417048 NCBI chr 5:169,288,419...169,293,137
Ensembl chr 5:169,288,871...169,293,137
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP oxophenylarsine inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; oxophenylarsine inhibits the reaction [Lidocaine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]]; oxophenylarsine inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein] CTD PMID:18172555 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 multiple interactions EXP [oxophenylarsine co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein; Cyclosporine inhibits the reaction [[oxophenylarsine co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein] CTD PMID:16023995 NCBI chr17:35,677,984...35,682,262
Ensembl chr17:35,677,984...35,682,259
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      biological role 19825
        biochemical role 19360
          apoptosis inducer 11013
            phenylarsine oxide 74
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      p-block molecular entity 19763
                        pnictogen molecular entity 18746
                          arsenic molecular entity 10433
                            arsine oxides 105
                              phenylarsine oxide 74
paths to the root