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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phenylarsine oxide
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Accession:CHEBI:75253 term browser browse the term
Definition:An arsine oxide derived from phenylarsine.
Synonyms:exact_synonym: oxo(phenyl)arsine
 related_synonym: Arsenosobenzene;   Formula=C6H5AsO;   InChI=1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H;   InChIKey=BQVCCPGCDUSGOE-UHFFFAOYSA-N;   Oxophenylarsine;   PhAsO;   Phenyl arsine oxide;   Phenylarsenoxide;   SMILES=O=[As]c1ccccc1
 xref: CAS:637-03-6
 xref_mesh: MESH:C029341
 xref: PDBeChem:PA0;   PMID:22048238;   PMID:22617457;   PMID:23044393;   PMID:23201556;   Reaxys:2935227


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phenylarsine oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP oxophenylarsine inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; oxophenylarsine inhibits the reaction [AGT protein binds to and results in increased localization of AGTR1A protein] CTD PMID:18267125 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP oxophenylarsine inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; oxophenylarsine inhibits the reaction [AGT protein binds to and results in increased localization of AGTR1A protein] CTD PMID:18267125 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of ATF2 protein] CTD PMID:26763395 NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member increases phosphorylation
multiple interactions 		ISO oxophenylarsine results in increased phosphorylation of BCAR1 protein
[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]; Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]] 		CTD PMID:10537051 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H decreases activity ISO oxophenylarsine results in decreased activity of CACNA1H protein CTD PMID:18309285 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376 		JBrowse link
G Casp3 caspase 3 increases activity ISO oxophenylarsine results in increased activity of CASP3 protein CTD PMID:10515888 PMID:19465042 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 multiple interactions ISO oxophenylarsine inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein] CTD PMID:11544337 NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990 		JBrowse link
G Cd79a CD79a molecule increases phosphorylation ISO oxophenylarsine results in increased phosphorylation of CD79A protein CTD PMID:8559152 NCBI chr 1:89,621,460...89,625,813
Ensembl chr 1:80,493,581...80,497,935 		JBrowse link
G Cd79b CD79b molecule increases phosphorylation ISO oxophenylarsine results in increased phosphorylation of CD79B protein CTD PMID:8559152 NCBI chr10:91,739,134...91,742,312
Ensembl chr10:91,239,356...91,242,625 		JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions ISO oxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT1 protein]; oxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT3 protein] CTD PMID:11882386 NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO oxophenylarsine inhibits the reaction [Colforsin results in increased activity of CREB1 protein]; oxophenylarsine inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; oxophenylarsine inhibits the reaction [Isoproterenol results in increased phosphorylation of CREB1 protein]; oxophenylarsine inhibits the reaction [Lipopolysaccharides results in increased activity of CREB1 protein] CTD PMID:17141199 PMID:20512473 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO oxophenylarsine inhibits the reaction [EGF protein affects the localization of and results in increased activity of STAT3 protein]; oxophenylarsine inhibits the reaction [EGF protein binds to and affects the localization of EGFR protein] CTD PMID:12093727 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO oxophenylarsine inhibits the reaction [EGF protein binds to and affects the localization of EGFR protein] CTD PMID:12093727 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions ISO oxophenylarsine results in increased cleavage of and results in increased phosphorylation of ERBB4 protein CTD PMID:9685416 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase affects localization ISO oxophenylarsine affects the localization of FYN protein CTD PMID:9546377 NCBI chr20:44,322,635...44,514,498
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Gh1 growth hormone 1 multiple interactions ISO
EXP 		oxophenylarsine inhibits the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]
oxophenylarsine inhibits the reaction [NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]] 		CTD PMID:12471042 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Grb2 growth factor receptor bound protein 2 multiple interactions EXP [oxophenylarsine results in decreased phosphorylation of PLCG1 protein] inhibits the reaction [PLCG1 protein binds to GRB2 protein] CTD PMID:9281317 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions 		EXP
ISO 		oxophenylarsine results in increased expression of HMOX1 mRNA
Acetylcysteine inhibits the reaction [oxophenylarsine results in increased expression of HMOX1 mRNA] 		CTD PMID:8612205 PMID:15368090 PMID:19786557 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Id3 inhibitor of DNA binding 3 affects binding ISO oxophenylarsine binds to ID3 protein CTD PMID:23523789 NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:148,372,762...148,374,349 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases localization
multiple interactions 		EXP oxophenylarsine results in decreased localization of IGF1 protein
oxophenylarsine inhibits the reaction [IGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid] 		CTD PMID:1928324 PMID:9145794 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf2 insulin-like growth factor 2 decreases localization EXP oxophenylarsine results in decreased localization of IGF2 protein CTD PMID:9145794 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Colforsin inhibits the reaction [oxophenylarsine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]]; oxophenylarsine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]; oxophenylarsine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:20512473 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO oxophenylarsine inhibits the reaction [IL1B protein results in increased abundance of Hydrogen Peroxide]; oxophenylarsine inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; oxophenylarsine results in decreased expression of and results in decreased activity of IL1B protein CTD PMID:9266823 PMID:10515888 PMID:10802230 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il3 interleukin 3 multiple interactions ISO oxophenylarsine inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein] CTD PMID:11544337 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO oxophenylarsine inhibits the reaction [Colforsin results in increased secretion of IL6 protein]; oxophenylarsine inhibits the reaction [Isoproterenol results in increased secretion of IL6 protein]
oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of IL6 mRNA] 		CTD PMID:17141199 PMID:26763395 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 affects binding
multiple interactions
decreases degradation
decreases activity 		ISO
EXP 		oxophenylarsine binds to INS1 protein
Dithiothreitol affects the reaction [oxophenylarsine results in decreased activity of INS1 protein]; oxophenylarsine inhibits the reaction [INS1 protein results in increased transport of 3-O-Methylglucose]; oxophenylarsine inhibits the reaction [INS1 protein results in increased transport of Glucose]; oxophenylarsine inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; oxophenylarsine inhibits the reaction [INS1 protein results in increased uptake of Glucose]
oxophenylarsine results in decreased degradation of INS1 protein
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS1 protein results in increased transport of Deoxyglucose]]; Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]]; oxophenylarsine inhibits the reaction [INS1 protein affects the transport of SLC2A4 protein]; oxophenylarsine inhibits the reaction [INS1 protein results in increased transport of Deoxyglucose]; oxophenylarsine inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose] 		CTD PMID:1536656 PMID:1629198 PMID:1847587 PMID:2185640 PMID:2202293 More... NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 multiple interactions EXP Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein]]; oxophenylarsine inhibits the reaction [INS protein affects the localization of SLC2A4 protein]; oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein] CTD PMID:8048502 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Insr insulin receptor multiple interactions ISO oxophenylarsine promotes the reaction [Vanadates results in increased phosphorylation of INSR protein] CTD PMID:2458350 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Ip6k1 inositol hexakisphosphate kinase 1 decreases activity ISO oxophenylarsine results in decreased activity of IP6K1 protein CTD PMID:29042286 NCBI chr 8:108,693,068...108,737,278 JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 affects binding ISO oxophenylarsine binds to KEAP1 protein CTD PMID:19786557 PMID:19808700 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP 		oxophenylarsine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]
oxophenylarsine inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein] 		CTD PMID:11880281 PMID:12927602 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP 		oxophenylarsine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]
oxophenylarsine inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein] 		CTD PMID:11880281 PMID:12927602 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions
increases phosphorylation 		ISO
EXP 		[oxophenylarsine results in increased activity of MARK1 protein] which results in increased phosphorylation of MAPT protein; Staurosporine inhibits the reaction [oxophenylarsine results in increased phosphorylation of MAPT protein] CTD PMID:10737602 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mark1 microtubule affinity regulating kinase 1 increases activity
multiple interactions 		ISO oxophenylarsine results in increased activity of MARK1 protein
[oxophenylarsine results in increased activity of MARK1 protein] which results in increased phosphorylation of MAPT protein; Staurosporine inhibits the reaction [oxophenylarsine results in increased activity of MARK1 protein] 		CTD PMID:10737602 NCBI chr13:96,450,189...96,555,304
Ensembl chr13:96,451,487...96,555,173 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO oxophenylarsine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein] CTD PMID:10569804 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO oxophenylarsine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein] CTD PMID:10569804 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mt1 metallothionein 1 increases expression ISO oxophenylarsine results in increased expression of MT1 mRNA CTD PMID:19276070 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049 		JBrowse link
G Mtf1 metal-regulatory transcription factor 1 affects binding ISO oxophenylarsine binds to MTF1 protein CTD PMID:19276070 NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases activity 		ISO [oxophenylarsine results in increased activity of MTOR protein] which results in increased phosphorylation of RPS6KB1 protein; Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]]; MTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein] CTD PMID:16183647 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Ncs1 neuronal calcium sensor 1 multiple interactions EXP oxophenylarsine inhibits the reaction [NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]] CTD PMID:12471042 NCBI chr 3:14,523,220...14,568,829
Ensembl chr 3:14,523,220...14,568,829 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity
multiple interactions 		ISO oxophenylarsine results in increased activity of NFE2L2 protein
oxophenylarsine binds to and results in increased activity of NFE2L2 protein 		CTD PMID:19786557 PMID:19808700 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization
multiple interactions 		ISO oxophenylarsine affects the localization of NFKB1 protein
oxophenylarsine promotes the reaction [Viper Venoms affects the localization of NFKB1 protein]; Viper Venoms promotes the reaction [oxophenylarsine affects the localization of NFKB1 protein] 		CTD PMID:25417048 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation
multiple interactions 		ISO oxophenylarsine results in decreased phosphorylation of NFKBIA protein
oxophenylarsine promotes the reaction [Viper Venoms results in decreased phosphorylation of NFKBIA protein]; Viper Venoms promotes the reaction [oxophenylarsine results in decreased phosphorylation of NFKBIA protein] 		CTD PMID:25417048 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos3 nitric oxide synthase 3 affects localization ISO oxophenylarsine affects the localization of NOS3 protein CTD PMID:9546377 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO oxophenylarsine results in increased expression of NQO1 mRNA CTD PMID:19786557 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ntf4 neurotrophin 4 decreases transport ISO oxophenylarsine results in decreased transport of NTF4 protein CTD PMID:11948662 NCBI chr 1:95,893,560...95,896,391
Ensembl chr 1:95,893,457...95,897,243 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO oxophenylarsine results in increased cleavage of PARP1 protein CTD PMID:10515888 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions
decreases phosphorylation
affects localization 		EXP
ISO 		[oxophenylarsine results in decreased phosphorylation of PLCG1 protein] inhibits the reaction [PLCG1 protein binds to GRB2 protein]
oxophenylarsine affects the localization of PLCG1 protein 		CTD PMID:1325458 PMID:9281317 PMID:9546377 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Pld1 phospholipase D1 multiple interactions ISO oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of PLD1 mRNA]; oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of PLD1 protein] CTD PMID:26763395 NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692 		JBrowse link
G Pml PML nuclear body scaffold multiple interactions ISO oxophenylarsine results in increased sumoylation of and results in increased ubiquitination of and results in increased degradation of PML protein; oxophenylarsine results in increased sumoylation of and results in increased ubiquitination of and results in increased degradation of PML protein mutant form CTD PMID:28125064 NCBI chr 8:67,523,164...67,557,801
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Pomc proopiomelanocortin decreases activity
multiple interactions 		ISO
EXP 		oxophenylarsine results in decreased activity of POMC protein
oxophenylarsine inhibits the reaction [POMC protein results in increased abundance of Corticosterone]
[oxophenylarsine results in decreased activity of POMC protein] which results in decreased chemical synthesis of Progesterone 		CTD PMID:10518784 PMID:12530643 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO 		oxophenylarsine inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]
oxophenylarsine inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]
oxophenylarsine inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA] 		CTD PMID:9266823 PMID:9576062 PMID:9580637 PMID:18267125 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions
increases phosphorylation 		ISO [oxophenylarsine co-treated with oxotremorine M] results in increased phosphorylation of PTK2 protein; [oxophenylarsine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of PTK2 protein; [wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]
oxophenylarsine results in increased phosphorylation of PTK2 protein 		CTD PMID:10537051 PMID:10569804 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Pxn paxillin multiple interactions
increases phosphorylation
affects localization 		ISO [oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]; Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]]
oxophenylarsine affects the localization of PXN protein 		CTD PMID:9546377 PMID:10537051 NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931 		JBrowse link
G Rcan1 regulator of calcineurin 1 multiple interactions ISO oxophenylarsine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RCAN1 protein] CTD PMID:12927602 NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions 		ISO oxophenylarsine affects the localization of RELA protein
oxophenylarsine promotes the reaction [Viper Venoms affects the localization of RELA protein]; Viper Venoms promotes the reaction [oxophenylarsine affects the localization of RELA protein] 		CTD PMID:25417048 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
increases phosphorylation 		ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; [oxophenylarsine results in increased activity of MTOR protein] which results in increased phosphorylation of RPS6KB1 protein; Dimercaprol inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; MTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid results in decreased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [antimycin results in decreased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [Deoxyglucose results in decreased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [Tosyllysine Chloromethyl Ketone results in decreased phosphorylation of RPS6KB1 protein]; RPTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein] CTD PMID:16183647 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 multiple interactions ISO Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]]; oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]; RPTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein] CTD PMID:16183647 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 multiple interactions
affects binding 		EXP Bongkrekic Acid inhibits the reaction [oxophenylarsine binds to SLC25A4 protein]; carboxyatractyloside inhibits the reaction [oxophenylarsine binds to SLC25A4 protein] CTD PMID:18667415 NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733 		JBrowse link
G Slc25a5 solute carrier family 25 member 5 decreases activity ISO oxophenylarsine results in decreased activity of SLC25A5 protein CTD PMID:16787656 NCBI chr  X:116,031,896...116,034,963
Ensembl chr  X:116,031,803...116,034,967 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
affects activity 		ISO oxophenylarsine inhibits the reaction [Cytochalasin B binds to SLC2A1 protein]; oxophenylarsine inhibits the reaction [Glucose deficiency results in increased activity of SLC2A1 protein]; oxophenylarsine inhibits the reaction [Methylene Blue results in increased activity of SLC2A1 protein]
oxophenylarsine affects the activity of SLC2A1 protein 		CTD PMID:19686715 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions
affects binding 		ISO
EXP 		oxophenylarsine inhibits the reaction [INS1 protein affects the transport of SLC2A4 protein]
oxophenylarsine binds to SLC2A4 protein
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein]]; oxophenylarsine inhibits the reaction [INS protein affects the localization of SLC2A4 protein]; oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein] 		CTD PMID:1536656 PMID:1629198 PMID:8048502 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO oxophenylarsine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31652400 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase affects localization ISO oxophenylarsine affects the localization of SRC protein CTD PMID:9546377 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO oxophenylarsine results in decreased expression of STAR protein CTD PMID:12530643 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO oxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT1 protein] CTD PMID:11882386 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
affects localization 		ISO Hydrogen Peroxide promotes the reaction [oxophenylarsine affects the localization of STAT3 protein]; oxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT3 protein]; oxophenylarsine promotes the reaction [Hydrogen Peroxide affects the localization of STAT3 protein]
oxophenylarsine inhibits the reaction [EGF protein affects the localization of and results in increased activity of STAT3 protein] 		CTD PMID:10364193 PMID:11882386 PMID:12093727 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP oxophenylarsine inhibits the reaction [TAC1 protein affects the localization of TACR1 protein] CTD PMID:7524481 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions EXP oxophenylarsine inhibits the reaction [TAC1 protein affects the localization of TACR1 protein] CTD PMID:7524481 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733 		JBrowse link
G Tf transferrin decreases uptake ISO oxophenylarsine results in decreased uptake of TF protein CTD PMID:10865941 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tfrc transferrin receptor affects localization ISO oxophenylarsine affects the localization of TFRC protein CTD PMID:2643384 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases activity 		ISO oxophenylarsine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
oxophenylarsine results in decreased activity of TGFB1 protein 		CTD PMID:31652400 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO oxophenylarsine inhibits the reaction [TNF protein results in increased abundance of Hydrogen Peroxide]
oxophenylarsine inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA] 		CTD PMID:9576062 PMID:9580637 PMID:10802230 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 multiple interactions
increases expression 		ISO oxophenylarsine promotes the reaction [Viper Venoms results in increased expression of TNFRSF25 protein]; Viper Venoms promotes the reaction [oxophenylarsine results in increased expression of TNFRSF25 protein] CTD PMID:25417048 NCBI chr 5:167,904,377...167,909,052
Ensembl chr 5:162,622,075...162,626,341 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP oxophenylarsine inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; oxophenylarsine inhibits the reaction [Lidocaine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]]; oxophenylarsine inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein] CTD PMID:18172555 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 multiple interactions EXP [oxophenylarsine co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein; Cyclosporine inhibits the reaction [[oxophenylarsine co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein] CTD PMID:16023995 NCBI chr17:33,977,908...33,982,478
Ensembl chr17:33,977,921...33,982,479 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20845
    role 20805
      biological role 20803
        biochemical role 20250
          apoptosis inducer 13726
            phenylarsine oxide 76
Path 2
Term Annotations click to browse term
  CHEBI ontology 20845
    subatomic particle 20843
      composite particle 20843
        hadron 20843
          baryon 20843
            nucleon 20843
              atomic nucleus 20843
                atom 20843
                  main group element atom 20766
                    p-block element atom 20766
                      p-block molecular entity 20766
                        pnictogen molecular entity 19672
                          arsenic molecular entity 15009
                            arsine oxides 107
                              phenylarsine oxide 76
paths to the root