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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:insulin-like growth factor receptor 1 antagonist
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Accession:CHEBI:75252 term browser browse the term
Definition:An antagonist at the insulin-like growth factor receptor 1.
Synonyms:related_synonym: IGF-1R antagonist;   IGF-1R antagonists;   insulin-like growth factor receptor 1 antagonists
 xref: Wikipedia:Insulin-like_growth_factor_1_receptor



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aurintricarboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lig1 DNA ligase 1 decreases activity ISO Aurintricarboxylic Acid results in decreased activity of LIG1 protein CTD PMID:15134906 NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases activity ISO Aurintricarboxylic Acid results in decreased activity of OGG1 protein CTD PMID:26218629 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
picropodophyllotoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO picropodophyllin inhibits the reaction [Cadmium Chloride results in increased cleavage of AKT1 protein] CTD PMID:25118938 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO picropodophyllin results in decreased expression of BIRC5 protein CTD PMID:16166596 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases activity ISO picropodophyllin results in decreased activity of CDK1 protein CTD PMID:16166596 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO [picropodophyllin results in decreased activity of IGF1R protein] inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]; [picropodophyllin results in decreased activity of IGF1R protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein] CTD PMID:23673518 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [picropodophyllin co-treated with IGF1 protein] results in increased expression of TNF mRNA; [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of IL1B mRNA]; [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of IL6 mRNA]; [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of TLR4 mRNA]; [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of TNF mRNA]; picropodophyllin inhibits the reaction [IGF1 protein results in decreased expression of TLR4 mRNA]; picropodophyllin inhibits the reaction [IGF1 protein results in increased expression of IL1B mRNA]; picropodophyllin promotes the reaction [IGF1 protein results in increased expression of IL6 mRNA] CTD PMID:21371294 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases activity
multiple interactions
ISO picropodophyllin results in decreased activity of IGF1R protein
[picropodophyllin results in decreased activity of IGF1R protein] inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]; [picropodophyllin results in decreased activity of IGF1R protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]
picropodophyllin binds to and results in decreased activity of IGF1R protein
CTD PMID:16166596 PMID:21371294 PMID:23673518 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of IL1B mRNA]; [picropodophyllin co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA; picropodophyllin inhibits the reaction [IGF1 protein results in increased expression of IL1B mRNA] CTD PMID:21371294 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of IL6 mRNA]; [picropodophyllin co-treated with Lipopolysaccharides] results in increased expression of IL6 mRNA; picropodophyllin promotes the reaction [IGF1 protein results in increased expression of IL6 mRNA]
picropodophyllin results in increased expression of IL6 mRNA
CTD PMID:21371294 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO picropodophyllin results in decreased phosphorylation of MAPK1 protein CTD PMID:16166596 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO picropodophyllin results in decreased phosphorylation of MAPK3 protein CTD PMID:16166596 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO picropodophyllin results in decreased expression of MCL1 protein CTD PMID:16166596 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO picropodophyllin inhibits the reaction [[perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased activity of MMP2 protein] CTD PMID:33571556 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Notch1 notch receptor 1 multiple interactions ISO picropodophyllin inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein] CTD PMID:25118938 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO picropodophyllin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of TLR4 mRNA]; picropodophyllin inhibits the reaction [IGF1 protein results in decreased expression of TLR4 mRNA] CTD PMID:21371294 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [picropodophyllin co-treated with IGF1 protein] results in increased expression of TNF mRNA; [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of TNF mRNA] CTD PMID:21371294 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 20057
    role 20023
      biological role 20010
        pharmacological role 19105
          antagonist 16728
            insulin-like growth factor receptor 1 antagonist 18
              N(2)-[3-methoxy-4-(morpholin-4-yl)phenyl]-N(4)-(quinolin-3-yl)pyrimidine-2,4-diamine 0
              PQIP 0
              aluminon 0
              aurintricarboxylic acid 2
              chrome violet CG 0
              picropodophyllotoxin 16
paths to the root